• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.24 no.2
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• pp.219-228
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• 2014

Objectives: The major objective of this study was to develop a tier 2 exposure model combining tier 1 exposure model estimates and worker monitoring data and suggesting narrower exposure ranges than tier 1 results. Methods: Bayesian statistics were used to develop a tier 2 exposure model as was done for the European Union (EU) tier 2 exposure models, for example Advanced REACH Tools (ART) and Stoffenmanager. Bayesian statistics required a prior and data to calculate the posterior results. In this model, tier 1 estimated serving as a prior and worker exposure monitoring data at the worksite of interest were entered as data. The calculation of Bayesian statistics requires integration over a range, which were performed using a Riemann sum algorithm. From the calculated exposure estimates, 95% range was extracted. These algorithm have been realized on Excel spreadsheet for convenience and easy access. Some fail-proof features such as locking the spreadsheet were added in order to prevent errors or miscalculations derived from careless usage of the file. Results: The tier 2 exposure model was successfully built on a separate Excel spreadsheet in the same file containing tier 1 exposure model. To utilize the model, exposure range needs to be estimated from tier 1 model and worker monitoring data, at least one input are required. Conclusions: The developed tier 2 exposure model can help industrial hygienists obtain a narrow range of worker exposure level to a chemical by reflecting a certain set of job characteristics.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.23 no.1
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• pp.19-30
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• 2005

Korean government has constructed a nationwide cadastral map database through the cadastral map computerization project and also produced a variety of spatial data through the NGIS (National Geographic Information Systems) project. Under this circumstance, it is needed to set up the new automatic methodology that effectively solve cadastral non-coincidence problems by using various digital map data instead of expensive field survey methods. This study proposed a new automatic methodology for cadastral non-coincidence surveying and developed a prototype system as a proof of concept. Validation of this proposed method was done with some test areas. Results showed that this methodology could easily detect and assess both regional non-coincidence levels and cadastral map quadrangle non-coincidence levels. We expect that this new methodology can provide many benefits in planning and determining work priority of the forthcoming nationwide cadastral re-surveying project.

• Smart Structures and Systems
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• v.26 no.1
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• pp.89-102
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• 2020

Shape memory alloy (SMA)-based Superelasticity-assisted Slider (SSS) is proposed as an engineering solution to practically exploit the well-accepted advantages of both sliding isolation and SMA-based recentering. Self-centering capability in SSS is provided by austenitic SMA cables (or wire ropes), recently attracting a lot of interest and attention in earthquake engineering and seismic isolation. The cables are arranged in various novel and conventional configurations to make SSS versatile for aseismic design and retrofit of structures. All the configurations are detailed with thorough technical drawings. It is shown that SSS is applicable without the need for Isolation Units (IUs). IUs, at the same time, are devised for industrialized applications. The proof-of-concept study is carried out through the examination of mechanical behavior in all the alternative configurations. Force-displacement relations are determined. Isolation capabilities are predicted based on the decreases in seismic demands, estimated by the increases in effective periods and equivalent damping ratios. Restoring forces normalized relative to resisting forces are assessed as the criteria for self-centering capabilities. Lengths of SMA cables required in each configuration are calculated to assess the cost and practicality. Practical implementation is realized by setting up a small-scale IU. The effectiveness of SSS under seismic actions is evaluated using an innovative computer model and compared to those of well-known Isolation Systems (ISs) protecting a reference building. Comparisons show that SSS seems to be an effective IS and suitable for earthquake protection of both structural and non-structural elements. Further research aimed at additional validation of the system are outlined.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2015-2020
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• 2012

Oleanolic acid (OA) is a naturally occurring triterpenoid in food materials and is a component of the leaves and roots of Olea europaea, Viscum album L., Aralia chinensis L. and more than 120 other plant species. There are several reports validating its antitumor activity against different cancer cells apart from its hepatoprotective activity. However, antitumor activity against skin cancer has not beed studied well thus far. Hence the present study of effects of OA against HaCaT (immortalized keratinocyte) cells - a cell-based epithelial model system for toxicity/ethnopharmacology-based studies - was conducted. Radical scavenging activity ($DPPH{\cdot}$) and FRAP were determined spectrophotometrically. Proliferation was assessed by XTT assay at 24, 48 and 72 hrs with exposure to various concentrations (12.5-200 ${\mu}M$) of OA. Apoptotic induction potential of OA was demonstrated using a cellular DNA fragmentation ELISA method. Morphological studies were also carried out to elucidate its antitumor potential. The results revealed that OA induces apoptosis by altering cellular morphology as well as DNA integrity in HaCaT cells in a dose-dependent manner, with comparatively low cytotoxicity. The moderate toxicity observed in HaCaT cells, with induction of apoptosis, possibly suggests greater involvement of programmed-cell death-mediated mechanisms. We conclude that OA has relatively low toxicity and has the potential to induce apoptosis in HaCaT cells and hence provides a substantial and sound scientific basis for further validation studies.

• Journal of the Korean Dietetic Association
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• v.12 no.2
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• pp.200-215
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• 2006

This study carried out to assess the quality of the information presented on the internet about nutrition specifically in the field of health functional food by monitoring with 10 panels from May, 2004 to October. Four hundred seven relevant websites were initially selected from a process using 5 search engines and the keywords ‘food’ and ‘nutrition’, and 404 sites actually met all inclusion criteria. Most of the sites evaluated 219 (54.20%) were commercial sites and then distributed noncommercial organization site 93 (23.0%), individual site 92(22.8%). Assessment quality indicator was carried out using the 17 necessary requisites, which has been developed to enable users and information providers to judge the quality of food and nutrition information. The mean score for quality grade was 11.07, five site out of a maximum score of 17 and two sites with the lowest total scores for the quality of food and nutrition information. Noncommercial organization site assessed achieved the highest score in accurate and useful informations to the public. Low ranked sites had the most inaccurate or misleading information, emphasizing only the positive aspects of the information, with little or no evidence. Many commercial sites used personal testimony as the most popular ‘proof’ for the effectiveness of product. This was anecdotal rather than scientific evidence based on which the objective validation was difficult to be made. Therefore, it can be challenging for both public and health professionals, to sort out useful information from a plethora of advertisements and promotions on the web sites. Our results suggest that nutrition professionals should talk about useful information of health, food and nutrition with public and help them find the best available information when using the internet.

• Korean Journal of Veterinary Service
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• v.44 no.4
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• pp.283-290
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• 2021

This is a study on the improvement of the chemical treatment method of the livestock carcass treatment newly introduced in the livestock infectious disease prevention method in order to improve the problems of the existing burial-centered carcass treatment method when a livestock infectious disease occurs. It was conducted to establish detailed treatment standards for the chemical treatment method of pig carcasses based on the results of proof of the absence of infectious diseases in pigs. After inoculating pig carcasses with 10 pathogens (6 viruses [FMDV, ASFV, CSFV, PCV2, PRRSV, PEDV] and 4 bacteria [Lawsonia intracellularis, Clostridium perfringens type C, E. coli, Salmonella Typhimurium]) It was treated at 90℃ for 5 hours in a potassium hydroxide (KOH) liquid solution corresponding to 15% of the body weight. This method liquefies all cadaveric components and inactivates all inoculated pathogens. Based on these results, it was possible to prove that chemical treatment of pig carcasses is effective in killing pathogens and is a safe method without the risk of disease transmission. Although there are problems to be solved in the processing and operation of the chemical treatment products of livestock carcasses, the chemical treatment method of livestock carcasses can be suggested as an alternative to the current domestic burial-centered livestock carcass treatment method, preventing environmental pollution, and contributing to public health.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.1256-1263
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• 2022

With the advent of the Fourth Industrial Revolution, the amount of energy used in buildings has been increasing due to changes in the energy use structure caused by the massive spread of information-oriented equipment, climate change and greenhouse gas emissions. For the efficient use of energy, it is necessary to have a plan that can predict and reduce the amount of energy use according to the type of energy source and the use of buildings. To address such issues, this study presents a model embedded in a digital twin that predicts energy use in buildings. The digital twin is a system that can support a solution of urban problems through the process of simulations and analyses based on the data collected via sensors in real-time. To develop the energy use prediction model, energy-related data such as actual room use, power use and gas use were collected. Factors that significantly affect energy use were identified through a correlation analysis and multiple regression analysis based on the collected data. The proof-of-concept prototype was developed with an exhibition facility for performance evaluation and validation. The test results confirm that the error rate of the energy consumption prediction model decreases, and the prediction performance improves as the data is accumulated by comparing the error rates of the model. The energy use prediction model thus predicts future energy use and supports formulating a systematic energy management plan in consideration of characteristics of building spaces such as the purpose and the occupancy time of each room. It is suggested to collect and analyze data from other facilities in the future to develop a general-purpose energy use prediction model.

• Therapeutic Science for Rehabilitation
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• v.8 no.4
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• pp.77-92
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• 2019

Objective : This study aims to obtain the validation of Korean version of HOME FAST using the translation-back translation process and to evaluate the reliability. Methods : Total three stages were conducted which includes forward translation to Korean, test for degree of understanding of translated version, back translation to English, and then review and proof reading process. 21 occupational therapists were participated in the evaluation of understanding of Korean-translated HOME FAST, then some of expressions were modified for better understanding. Korean version was went through back-translation to English. Similarity between the original version and re-translated version were evaluated. Total 75 data from community dwelling elderly group were collected to assess internal consistency. Two occupational therapists simultaneously evaluated for the inter-rater reliability. Results : 11 items of Korean-translated scale were responded as having confused meaning by occupational therapists. There was some modification on expression. In the evaluation of similarity between original version and re-translated version, 3 items were selected as dissimilar items in terms of syntax and 6 items were selected in terms of semantic similarity. After the repetitive modification process, items were obtained conceptual equivalence between two different languages. Internal consistency was .62(KR20) (p<.01) and inter-rater reliability was .97(ICC) (p<.01). Conclusion : Korean version of HOME FAST was finalized through translation-retranslation process. The conceptual equivalence was established and Korean version showed highly reliable. In further study, The modification of items reflecting Korean house and life style should be conducted.

• Analytical Science and Technology
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• v.34 no.6
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• pp.259-266
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• 2021

Cannabis (Marijuana) is one of the most widely used drugs in the world, and its distribution has been controlled in South Korea since 1976. Identification of 11-nor-Δ⁹-carboxy-tetrahydrocannabinol (THCCOOH) in urine can provide important proof of cannabis use, and it is considered scientific evidence in the forensic field. In this study, we describe a simultaneous quantitative method for identifying THCCOOH and THCCOOH-glucuronide in urine, using simple liquid-liquid extraction (LLE), and liquid chromatography-tandem mass spectrometry (LC-MS/MS). THCCOOH-D₃ and THCCOOH-glucuronide-D₃ were used as internal standards. Validation results of the matrix effect, as well as recovery, linearity, precision, accuracy, process efficiency, and stability were all satisfactory. No carryover, endogenous or exogenous interferences were observed. The limit of detection (LOD) of THCCOOH and THCCOOH-glucuronide were 0.3 and 0.2 ng/mL, respectively. The developed method was applied to 28 authentic human urine samples that tested positive in immunoassay screening and gas chromatography/mass spectrometry (GC/MS) tests. The ranges of concentrations of THCCOOH and THCCOOH-glucuronide in the samples were less than LOQ~266.90 ng/mL and 6.43~2133.03 ng/mL, respectively. The concentrations of THCCOOH-glucuronide were higher than those of THCCOOH in all samples. This method can be effectively and successfully applied for the confirmation of cannabinoid use in human urine samples in the forensic field.