• Journal of Korean Society for Quality Management
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• v.49 no.2
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• pp.145-159
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• 2021

Purpose: A statistical similarity evaluation to compare pharmacokinetics(PK) profile data between nonclinical and clinical experiments has become a significant issue on many drug development processes. This study proposes a new similarity index by considering important parameters, such as the area under the curve(AUC) and the time-series profile of various PK data. Methods: In this study, a new profile similarity index(PSI) by using the concept of a process capability index(Cp) is proposed in order to investigate the most similar animal PK profile compared to the target(i.e., Human PK profile). The proposed PSI can be calculated geometric and arithmetic means of all short term similarity indices at all time points on time-series both animal and human PK data. Designed simulation approaches are demonstrated for a verification purpose. Results: Two different simulation studies are conducted by considering three variances(i.e., small, medium, and large variances) as well as three different characteristic types(smaller the better, larger the better, nominal the best). By using the proposed PSI, the most similar animal PK profile compare to the target human PK profile can be obtained in the simulation studies. In addition, a case study represents differentiated results compare to existing simple statistical analysis methods(i.e., root mean squared error and quality loss). Conclusion: The proposed PSI can effectively estimate the level of similarity between animal, human PK profiles. By using these PSI results, we can reduce the number of animal experiments because we only focus on the significant animal representing a high PSI value.

• Proceedings of the KSME Conference
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• 2000.11a
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• pp.590-595
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• 2000

On the contrary to the increasing needs of shape qualities, most of quality inspections are carried out by manual or operator's insight. To find the causes of shape inferiority, it is required to gather and analyze the shape measurement data. As a result the winding profile measurement system ($TELE-SCANNER^{(R)}$) is developed to analyze the coiling process and automate the manual measuring process for winding profile of hot-rolled coils. The winding profile measurement system measures and analyzes winding profile shapes of hot-rolled coils, and classifies them into several dominant patterns that are related to normal or abnormal mechanical conditions of down-coiler. The system also contains analysis software to quantify the winding profile shapes and patterns, and to produce statistics to help search the causes of profile shape inferiority.

• Transactions of Materials Processing
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• v.28 no.4
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• pp.190-196
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• 2019

The capability of accurately predicting the roll force profile across a strip in the bite zone in cold rolling process is vital for the calculation of strip profile. This paper presents a derivation of a precision mathematical model for predicting variations in the roll force across a strip in cold rolling. While the derivation is based on an approximate 3-D theory of rolling, this mathematical model also considers plastic deformation in the pre-deformation region which is located close to the roll entrance before the strip enters the bite zone. Finally, the mathematical model is expressed as a boundary value problem, and it predicts the roll force profile and tension profile in addition to lateral plastic strain profile.

• The KIPS Transactions:PartD
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• v.15D no.3
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• pp.313-320
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• 2008

A typical software development life cycle consists of a series of phases, each of which has some ability to insert and detect defects. To achieve desired quality, we should progress the defect removal with the all phases of the software development. The well-known model of phase-based defect profile is Gaffney model. This model assumes that the defect removal profile follows Rayleigh curve and uses the parameters as the phase index number. However, these is a problem that the location parameter cannot present the peak point of removed defects when you apply Gaffney model to the actual situation. Therefore, Gaffney model failed to represent the actual defect profile. This paper suggests two different models: One is modified Gaffney model that introduce the parameter of Putnam's SLIM model to replace of the location parameter, the other is the growth function model because the cumulative defect profile shows S-shaped. Suggested model is analyzed and verified by the defect profile sets that are obtained from 5 different software projects. We could see from the experiment, the suggested model performed better result than Gaffney model.

• Journal of the Korea Institute of Military Science and Technology
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• v.23 no.3
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• pp.213-220
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• 2020

This paper proposes a method on the performance analysis of pulse repetition frequency jitter compensation for generating Doppler profile. Exact phase compensation of each pulse is required to obtain Doppler profiles under pulse repetition frequency jitter. Three parameters such as velocity, pulse repetition frequency, and carrier frequency are examined to cause errors when conducting the pulse repetition frequency jitter compensation, then assuming well-focused Doppler profiles reflect well-conducted pulse repetition frequency jitter compensation, the proposed method in this paper utilizes the contrast to measure how well Doppler profile is generated. These are validated by electromagnetic computation data and computer simulation. Then, it is concluded which parameter is important on the performance analysis of pulse repetition frequency jitter compensation by using the contrast.

• Safety and Health at Work
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• v.4 no.2
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• pp.117-121
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• 2013

This paper describes progress on formulating a national asbestos profile for the country of Vietnam. The Center of Asbestos Resource, Vietnam, formulated a National Profile on Asbestos-related Occupational Health, with due reference to the International Labor Organization/World Health Organization National Asbestos Profile. The Center of Asbestos Resource was established by the Vietnamese Health Environment Management Agency and the National Institute of Labor Protection, with the support of the Australian Agency for International Development, as a coordinating point for asbestos-related issues in Vietnam. Under the National Profile on Asbestos-related Occupational Health framework, the Center of Asbestos Resource succeeded in compiling relevant information for 15 of the 18 designated items outlined in the International Labor Organization/World Health Organization National Asbestos Profile, some overlaps of the information items notwithstanding. Today, Vietnam continues to import and use an average of more than 60,000 metric tons of raw asbestos per year. Information on asbestos-related diseases is limited, but the country has begun to diagnose mesothelioma cases, with the technical cooperation of Japan. As it stands, the National Profile on Asbestos-related Occupational Health needs further work and updating. However, we envisage that the National Profile on Asbestos-related Occupational Health will ultimately facilitate the smooth transition to an asbestos-free Vietnam.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.06a
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• pp.89-94
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• 2004

Profile ring rolling process for large slewing rings of alley steels are developed. A profile ring with a round groove located asymmetrically on the outer surface is rolled. The process is simulated by the finite element method. The general-purpose commercial finite element analysis software, MSC.Superform, was used. Experiments are carried in the ring rolling machine and compared with the analysis.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.281-284
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• 2004

This paper presents studies on the development of an internal measurement system for the footwear using laser sensor. The measurement system gains to the height of the profile at internal footwear. It accomplishes the 3-axises control which uses ball screws, L-M guides and stepping motors. It is used a laser sensor at the measurement of the distance, and Labview is used for the control and the measurement. We can get the profile through reverse engineering for the LAST. The data of profile is fixed a heigh of the LAST. Then, we try to verify as compare the profile with one which is collected by Internal measurement system..

• Journal of the Korean Society for Precision Engineering
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• v.33 no.10
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• pp.781-787
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• 2016

We introduce FEST (Flight Environment Simulation Test) procedures for precise guided missiles to reliably improve systems. Flight vibration specification was established based on power spectral density curves calculated from flight test data of a high speed precise guided missile. A FEST pre-profile was developed according to flight vibration specification and delivered to a precise guided missile assembly. Vibration responses were measured by installing accelerometers on electronic components vulnerable to dynamic forces. The FEST profile was adjusted by comparing the vibration responses and the flight vibration specification. Subsequently, the FEST profile was repeatedly modified through trial and error, because the responses were similar to the flight environment. The modified FEST profile enabled performance testing of assembled precise guided missiles under simulated flight conditions on the ground, where unexpected errors could be corrected before the flight tests, leading to cost and risk reduction in the development of the precise guided missile system.

• Journal of Communications and Networks
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• v.5 no.3
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• pp.215-221
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• 2003

It is expected that per-user customized services are widely used in next generation Personal Communication Network. To provide personalized services for each call, per-user service profiles are frequently referenced and signaling traffic is considerably large. Since the service calls are requested from the places where user stays, we can expect that the traffic is localized. In this paper, we propose a new service profile replication scheme, named Follow-Me Replication with local Anchor (FMRA). By replicating user's service profile in a user-specific location area, local anchor of each region, the signaling traffic for call and mobility can be distributed to local network. We compared the performance of the FMRA with two typical schemes: Intelligent Network-based !Central scheme and IMT-2000 based full replication scheme, as we refer it to Follow-Me Replication Unconditional (FMRU). Performance results indicate that FMRA lies between Central and FMRU schemes according to call to mobility ratio, and we identified the efficient ranges of CMR for FMRA depending on the various network parameters.