• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1819-1823
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• 2013

Objective: Microarray data were analyzed to explore key genes and their functions in progression of colorectal cancer (CRC). Methods: Two microarray data sets were downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified using corresponding packages of R. Functional enrichment analysis was performed with DAVID tools to uncover their biological functions. Results: 631 and 590 DEGs were obtained from the two data sets, respectively. A total of 32 common DEGs were then screened out with the rank product method. The significantly enriched GO terms included inflammatory response, response to wounding and response to drugs. Two interleukin-related domains were revealed in the domain analysis. KEGG pathway enrichment analysis showed that the PPAR signaling pathway and the renin-angiotensin system were enriched in the DEGs. Conclusions: Our study to systemically characterize gene expression changes in CRC with microarray technology revealed changes in a range of key genes, pathways and function modules. Their utility in diagnosis and treatment now require exploration.

• The Journal of Society for e-Business Studies
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• v.13 no.4
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• pp.125-144
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• 2008

Recently, the main concerns of enterprise management activities is how to strengthen the competitiveness to quickly respond to changes and sustain the growth in business environment. As IT(Information Technology) has become to be viewed as a key driver for the business competitiveness, new paradigms, such as business and IT alignment, IT-driven product/service innovation and so on, are regarded as the hot topic in many industries. However, previous studies related to IT evaluation, which is more critical than any other IT activities, have focused on quantitative IT deployment, utilization and its economical effects. Therefore, this study presents the newly-developed evaluation domains and items based on four pairs of relative concepts in industrial informatization, and their multi-dimensional analysis methodology which explains various types of IT characteristics of enterprises. And finally, pilot tests at 2 companies in financial service sector will be performed in order to verify the practicality of the evaluation system.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.26 no.1
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• pp.20-26
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• 2016

This study investigated noise characteristics of air cleaners and humidifiers in terms of frequency domains and measurement directions. Noise levels of 31 air cleaners and 36 humidifiers were measured in an anechoic chamber according to the related group standards. As for air cleaners, 5 receiving points of 1 m off from front, rear, left, right and top surfaces of the product were considered. In case of humidifiers, 4 receiving points without the rear position were considered in the same manner as air cleaners. In each case, A-weighted equivalent continuous sound level was measured three times for 1 min. As a results, most of the measured air cleaners and humidifiers showed the highest noise levels at top directions due to the air ventilating location. In case of air cleaners, averaged noise levels of top and rear positions were 49.9 and 48.2 dB(A), respectively, whereas averaged noise level of other positions was all 45.2 dB(A). In case of humidifiers, averaged noise level of top position was 44.1 dB(A) whereas averaged noise levels of other positions were 38.7 to 39.1 dB(A). In addition, high frequency content of 1 kHz and 3.15 kHz to 4 kHz for air cleaners and middle frequency content of 500 Hz to 1.6 kHz for humidifiers showed significant contribution to determination of overall noise levels with correlation coefficient of 0.9 and above.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.2
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• pp.272-278
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• 2010

In this study, we cloned, sequenced and characterized porcine y+L Amino Acid Transporter-1 (y+LAT1). By screening a translated EST database with the protein sequence of the human $y^{+}$LAT1 and by using rapid amplification of cDNA ends (RACE), the full-length cDNA encoding porcine $y^{+}$LAT1 was isolated from porcine intestine RNA. It was 2,111 bp long, encoding a 511 amino acid trans-membrane glycoprotein composed of 12 transmembrane domains. The predicted amino acid sequence was found to be 91%, 90%, 87% and 87% identical to those of cattle, human, mouse and rat $y^{+}$LAT1 respectively. Real-time RT-PCR results indicated that the small intestine had the highest $y^{+}$LAT1 mRNA abundance and the lung had the lowest $y^{+}$LAT1 mRNA abundance. Baby hamster kidney (BHK) cells transfected with green fluorescent protein (GFP) tagged porcine $y^{+}$LAT1 cDNA indicated that the cellular localization of the gene product in BHK was on the plasma membrane.

• Journal of KIISE:Software and Applications
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• v.36 no.1
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• pp.30-44
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• 2009

Devices of home network system have different control data formats according to each product company. Therefore, types or protocols of digital devices are various. Also, interaction operating environments are different among various devices. These characteristics of home network system don't support sufficiently functionalities such as data comparability, concurrent control, dynamic plug-in, and so on. That is, the degree of reusability of home network system is very poor. This paper proposes a framework which can be coverable to the scope of reusability widely and a design technique based on framework in order to improve reusability. That is, we extract various parts of home network systems as variation points, classify and define these as variation types, propose a framework which can be reusable those, and proposes a design technique of variability to improve reusability. Finally, proposed technique can be reusable to various domains by applying proposed reusability framework into real home network system's design.

• Journal of Digital Convergence
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• v.11 no.3
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• pp.243-253
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• 2013

As global competition is more intensive, SCM is becoming more and more important in order to achieve competitiveness. It is necessary for firms to understand weak points among the integrated supply chain through supply chain assessment in order to implement SCM successfully and cost-effectively. In this paper, we review previous studies of SCM performance measurements and propose a supply chain assessment framework for shipbuilding industry, which is one of the major ETO industry. Based on 3 supply chain domains which are demand, supply, and product management, we decompose the whole supply chain process into 3 level lower processes and propose capability measurement matric for shipbuilding firms. A case study has been conducted to validate the proposed framework and results are presented at the end.

• Journal of the Korean Society of Clothing and Textiles
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• v.43 no.2
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• pp.274-287
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• 2019

Most corporations engage in Corporate Social Responsibility (CSR) activities. Consumers are aware of CSR activities in different domains and use the perception and evaluation in purchase decision making. This study reveals how the relationship between consumer perception about a fashion corporation's CSR activities and product evaluation (such as perceived expertise and attractiveness) affects behavioral intention. This study discussed implications for store designs depending on whether it is actively engaging in CSR communication. Two virtual fashion store images of modern or eco design were used as stimuli. The study was conducted from July to August, 2018 based on women in their 20s and 30s. We collected 154 eco designs and 157 modern design responses. The findings of the study show that consumer perceptions of CSR activities affected perceived expertise and attractiveness. Further, perceived expertise and attracti-veness led to purchase intention and time spent in the store. The store design variation had no differences in mean values of consumer perception; however, evaluation and purchase intention indicated that a varied store design emphasized different corporation capabilities.

• The Research Journal of the Costume Culture
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• v.29 no.5
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• pp.679-693
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• 2021

The aim of this study was first to expand participation types in the field of beauty design by examining activities in the field, and second, to seek practical methods for addressing the important issue of social responsibility amid the current pandemic situation. Accordingly, social responsibility in design was examined through a review of previous studies. The features of practice domains and design performance fields were examined comparatively. As a result, it was found that social practices take place in various sectors, with sensibility toward the environment being escalated to a new level in the cosmetics industry. In terms of cosmetics enterprise practices, collecting, recycling, manufacturing, and retail networking has been established to reuse up to 95% of waste resources. Furthermore, ethical responsibility and participation concerning product and service waste resources are recommended, resulting in the supply of eco-friendly products in a virtuous cycle. In terms of systematic policy, even component transformation (such as organic certification and excluding toxic substances) is being carried out. However, it was difficult to identify such responsible activities in Korea; thus, systematic practice is needed. Designers take part in talent donation activities, and it was the sector they prefer the most. However, it is necessary to conduct studies on limitations such as venues equipped with cosmetics procedure equipment and public cosmetics sanitation and make systematic improvement, such that activities can be led with initiative from passive participation.

• Journal of Animal Science and Technology
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• v.64 no.1
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• pp.123-134
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• 2022

Toll-like receptors (TLRs), as a part of innate immunity, plays an important role in detecting pathogenic molecular patterns (PAMPs) which are structural components or product of pathogens and initiate host defense systems or innate immunity. Precise negative feedback regulations of TLR signaling are important in maintaining homeostasis to prevent tissue damage by uncontrolled inflammation during innate immune responses. In this study, we identified and characterized the function of the pancreatic progenitor cell differentiation and proliferation factor (PPDPF) as a negative regulator for TLR signal-mediated inflammation in chicken. Bioinformatics analysis showed that the structure of chicken PPDPF evolutionarily conserved amino acid sequences with domains, i.e., SH3 binding sites and CDC-like kinase 2 (CLK2) binding sites, suggesting that relevant signaling pathways might contribute to suppression of inflammation. Our results showed that stimulation with polyinosinic:polycytidylic acids (Poly [I:C]), a synthetic agonist for TLR3 signaling, increased the mRNA expression of PPDPF in chicken fibroblasts DF-1 but not in chicken macrophage-like cells HD11. In addition, the expression of pro-inflammatory genes stimulated by Poly(I:C) were reduced in DF-1 cells which overexpress PPDPF. Future studies warrant to reveal the molecular mechanisms responsible for the anti-inflammatory capacity of PPDPF in chicken as well as a potential target for controlling viral resistance.

• SUVANNABHUMI
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• v.6 no.1
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• pp.27-65
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• 2014

Flourishing in the Central Dry Zone of Burma during a period from the mid-eleventh to the late-thirteenth century A.D., the historical kingdom of Pagan was one of the major Buddhist centers in Southeast Asia. The significance of Pagan as an important pilgrimage site of the region, where numerous relics of the Buddha were enshrined, had been maintained until long after the fall of its civilization. It is evident that the artistic influences of Pagan, particularly in the architectural and decorative domains, had been transmitted to various other Buddhist civilizations in the area. This study provides a detailed analysis on the relationships between the mural tradition of Pagan and those of its neighboring civilizations in Thailand-of the Ayutthayā, Lānnā and Sukhothai schools-dating from after the Pagan Period in the fourteenth century to the sixteenth century. Surprisingly, as the analysis of this study has suggested, such relationships seemed to be trivial, more on a minor stylistic basis than on substantial ideological and iconographic grounds. They suggest that transmission of the complex idea and superb craftsmanship of the mural tradition would not have been maintained adequately at Pagan after its civilization, probably due to the lack of royal patronage. It would have been extremely difficult for foreign pilgrims who visited Pagan after its dynastic period to appreciate the surviving murals of this lost tradition in terms of their complex programs and associated symbolism. Also, there had been a new center of the Sinhalese Buddhism firmly established in the Martaban area of lower Burma since the mid-fourteenth century that outcompeted Pagan in terms of supplying the new Buddhist ideas and tradition. Its fame spread wide and far among the Buddhist communities of Southeast Asia. Later, these Buddhist communities also established direct contact with Sri Lanka. The Sukhothai murals and the Ayutthayā murals in the crypt of Wat Rātchaburana, dating from the fourteenth/fifteenth century, show obvious Sri Lankan influence in terms of artistic style and Buddhist iconography. They could be a product of these new religious movements, truly active in Southeast Asia during that time.