• Molecular & Cellular Toxicology
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• v.3 no.4
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• pp.282-291
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• 2007

Although the etiology of schizophrenia is known to be linked with the disturbance of glutamatergic and dopaminergic neurotransmission, little is known about the relationship between gene expression and the disease process. To identify genes related to abnormalities in glutamatergic and dopaminergic function, we investigated the effects of olanzapine in the changes of mRNA levels in the animal model of schizophrenia, using a high-density DNA microarray. Olanzapine (3.0 mg/kg, i.p.) significantly reduced hyperlocomotive activities, which was induced by MK-801 (1.0 mg/kg, i.p.). We identified that the expression of 719 genes were significantly altered more than two folds in the prefrontal cortex of the rats treated with MK-801. We selected 15 genes out of them by the changes of the expression pattern in the treatment of Olanzapine and/or MK801 for the further confirmation in RT-PCR. The administration of MK-801 increased the expression of 7 genes (NOS3, Hspb1, Hspa1a, CRH, Serpine1, Igfbp6, Snf1lk) and decreased the expression of 1 gene (Aldh1a2), which was attenuated by olanzapine. One gene (Prss12) was up-regulated after olanzapine treatment although it did not show the significant changes after MK-801 treatment. These results showed that antipsychotic drug, such as olanzapine, may alter the gene expression patterns, which were accompanied by MK-801-induced psychosis. Our results also provide us high-density DNA microarray technology could be potential approaches to find the candidate molecules for the therapeutics and also for the early diagnosis of psychiatric diseases.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.2 no.2
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• pp.78-87
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• 1999

This study was aimed to establish the method and process of the Biotope Mapping System.(B.M.S.) The main aspects of research for biotope were divided by 4 schemes such as biosphere, geosphere, antroposphere and evaluation informations. The cartographic function of GIS(geographic information system) was also used to mapping them. The B.M.S. had been progressed with 5 steps : (1) making research goals, (2) constructing the graphic and attribute databases, (3) classifying 3 types of biotope such as tree/shrub biotop, grass biotop and wetland biotop. (4) cross-analyzing biotope types against land use, habitat characters, relief characters and danger/disturbance elements, (5) evaluating the biotope's potentialities. Only 3 steps of them were done in this study. The results of applicating the B.M.S on the research site as followings : 1. The interdisciplinary researches were needed to develop the B.M.S in Korea since ecological habitat conditions of Germany, England are differed from them of Korea. 2. The distributions of the land uses in Maejuri, Seunghwan eup in Chonan city were mainly recorded by forest(29.82%), orchard(14.11%) and landscaping around building site(9.05%). 3. The percentages of the Tree/Shrub Biotope type were ranged by the orchard type(23.8%), natural and artificial deciduous type with natural coniferous(23.6%) and etc. 4. The Grass Biotope type was mainly recorded by the wild grassland type(27.99%), garden type(14.21%) and peddy field with wild grassland(13.24%). 5. The distributions of the wetland were pointed high at the wetland type with reed marsh and edge vegetation around wetland(54.79%) and etc.

• Journal of Life Science
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• v.12 no.6
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• pp.786-795
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• 2002

Three-day-old sunfower(Helianthus annuus L.) seedlings were do-rooted and incubated in the nutrient solutions that contained either deficient or sufficient boron supply, and exposure to various pH and temperatures. In the absence of boron, no adventitious roots were formed in the majority of the seedlings. Boron caused the development of numerous adventitious roots in the lower part of the hypocotyl. The low pH damage was ameliorated by the simultaneous application of calcium, implying the involvement of calcium-requiring process in overcoming proton toxicity. Borate showed a strong ameliorative effect with $Ca^{2+}$. These results suggest that the primary target of proton toxicity may be linked to a disturbance of the stability in the pectic polysaccharide network, where calcium plays a key role in plant roots. Maximum temperature for the growth of adventitious roots was $25^{\circ}C$. Although cessation of growth is the most apparent symptom of boron deficiency, exogenous ascorbate improved adventitious root growth in plants in the absence of boron. From the results it is suggested that the inhibition of adventitious root resulting from boron deficiency, low pH and temperature damage may be a consequence of disrupted ascorbate metabolism.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.8
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• pp.707-712
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• 2014

Aircraft fuel indicator is a device to indicate the amount of fuel remained during flight, where accurate and consistent operation of the indicator should be maintained. Previously the Korean Utility Helicopter fuel indicator sporadically displayed abnormal sign by "8888" during flight, jeopardizing flight safety. Inappropriate EMI/EMC performance was detected during trouble shooting process. The cause of the abnormal display was found to be resulted from unstable power induced by electro-magnetic disturbance and CAN communication error. The aircraft fuel indicator design was improved and the design compatibility was verified to avoid abnormal display.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.9
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• pp.103-109
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• 2003

The development of a pulse gun used for the combustion stability rating test(SRT) has been domestically tried out since the SRT should be accompanied in the process of the development of LREs. At the beginning of the development, a rupture problem of the pulse gun body had been solved by changing its material and increasing its thickness. Also, the sealing test was undertaken for a pulse gun equipped with a membrane before conducting a explosion test and by using a specially designed jig after a explosion test. Since it is appropriate to reuse the holder of a pulse gun cavity for an actual SRT, a series of experiments for several variants has been taken to make it reusable. After all, the solution for a reusable holder of a pulse gun has been found and applied for complementing its specification.

• The Journal of the Korea Contents Association
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• v.20 no.10
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• pp.284-293
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• 2020

The rapid progress of AI technology gives us the expectation to solutions to various problems in our society, and at the same time, it gives us anxiety about the side effects that can occur if AI develops beyond human control. This study was conducted in the early 20s with less objection to advanced devices. We attempted to provide clues to understand thoughts and attitudes of the targets about the future environment that will be brought by AI through the process of finding intent the acceptance of strong AI technology. For this, we applied the Theory of Planned Behavior, and further expanded this research model to identify factors affecting the attitude toward AI. As a result, the attitude toward AI and perceived behavioral control had a significant effect on the intention to use to strong AI. In addition, we found that the expectation of the benefit of improving task performance and the anxiety on the threat of relationship disturbance had a significant effect on the attitude toward AI. This study suggests implications for AI-related companies establishing the direction of technology development and for government setting a policy direction for AI adoption.

• Journal of Korean Society of Rural Planning
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• v.21 no.3
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• pp.145-154
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• 2015

With the rapid change of rural communities and increasing desire for social welfare, the demand for the quality of public spaces and facilities is increasing. However, inefficient location of rural public space and facility has caused problems such as economic inefficiency, inconvenient accessibility, environmental pollution, unsustainable energy use, and disturbance of visual landscape. This study aims to evaluate suitability of public spaces and facilities in three types of rural village: rural downtown village, rural clustered village, and individual village. As a way to measure the suitability of public spaces and facilities, we assessed indicators of suitability in terms of accessibility, usability, biophysical environment, and sustainable management. To evaluate the accessibility, we applied indicators such as distance from residential areas, public transit, market and public facilities. For the evaluation of biophysical environment, we applied indicators such as slope, elevation, aspect, and occurrence of natural disasters. We analyzed digital maps representing the indicators listed above using GIS. We also conducted a survey and face-to-face interviews to evaluate usability and sustainability of management which are not possible to understand through maps. As a result, we identified that suitability of public spaces and facilities in downtown villages is higher than clustered and individual villages. In particular, suitability of infrastructure facilities, social welfare facilities, and income generation facilities in downtown village are higher than those in clustered and individual villages. The suitability of tourism facilities is generally lower than other types of public facility across the three types of villages. Tourism facilities in clustered village have been identified especially unsuitable compared to other types of villages. We expect the outcome of the research is helpful to improve allocation of public spaces and facilities in rural villages.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.8
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• pp.1-10
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• 2008

In this paper, we describe a design of a 128bit MRAM based on a new switching architecture which is Local Field Switching(LFS). LFS uses a local magnetic field generated by the current flowing through an MTJ. This mode reduces the writing current since small current can induce large magnetic field because of close distance between MTJ and the current. It also improves the cell selectivity over using conventional MTJ architecture because it doesn't need a digit line for writing. The MRAM has 1-Transistor 1-Magnetic Tunnel Junction (IT-1MTJ) memory cell structure and uses a bidirectional write driver, a mid-point reference cell block and a current mode sense amplifier. CMOS emulation cell is adopted as an LFS-MTJ cell to verify the operation of the circuit without the MTJ process. The memory circuit is fabricated using a $0.18{\mu}m$ CMOS technology with six layers o) metal and tested on custom board.

• Geotechnical Engineering
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• v.14 no.2
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• pp.67-78
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• 1998

Microtunnelling is a technique applied to install a small-size tunnel in a soft cohesionless ground. In microtunnelling, a series of concrete tubular segments are pushed from a starting pit to power-line tunnel under a runway of JFK international airport at New York. During the microtunneling process, bentonite is jetted with very hyh pressure through a nozzle to advance disturbance in the subgrade caused by the pressurized bentonite in the aspects of subgrade stiffness. SASW measurements were performed on the runway above the center line of the shear wave velocity profiles. Besides the change of subgrade stiffness, the change of subgrade strength was also evaluated by the site-specific relationships between shear wave velocity and N value, which was determined by N values. The estimated N values gave a clue to the understanding of the change of subgrade strength.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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• v.3 no.2
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• pp.113-119
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• 1999

The quality of the effluent from an activated sludge aeration tank can deteriorate when the substrate removal rate decreases due to an abrupt reduction in the DO concentration, which is affected by such operating conditions as the loading rate, temperature, wastewater composition, and so on. In this research, a DO control system that includes a PI (proportional-integral) controller/Hiraoka controller was developed and applied to a pilot-scale activated sludge process, then its acceptability was estimated. The applicability of the respiration rate to DO control was also estimated. The respiration rate indicated a variety of input organic loading rates, which is the main disturbance to the DO concentration in an aeration tank. When the influent concentration incrementally decreased and increased between CODcr 1,000 mg/l and 100 mg/l, the control system with a PI controller exhibited a good llperformance-the average DO concentrations were 2.00$\pm$0.14 mg/l and 1.88$\pm$0.15 mg/l (set value was 2.0 mg/l), respectively, and the settling time was just 10 minites. When the control system was operated for 4 days, the DO concentration was 1.99$\pm$0.18 mg/l and 32.6% of the air flowrate was saved. However, the fluctuations in the respiration rates and air flowrates were severe, which could be harmful to the stability of the biomass and mechanical stability of the blower. A possible approach to solve this problem may be the simultaneous control of the loading rate and DO concentration.