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Effect of adipose-derived stem cells on bone healing on titanium implant in tibia of diabetes mellitus induced rats (당뇨 유도 백서 경골에 매식한 티타늄 임플란트 주위에 지방조직 유래 줄기세포 적용 시 골치유에 미치는 영향)

  • Kim, Min-Gu;Jung, In-Kyo;Shin, Sang-Hun;Kim, Chul-Hoon;Kim, Bok-Joo;Kim, Jung-Han;Hwang, Young-Sup;Jung, Eu-Gene;Kim, Jin-Woo;Kim, Uk-Kyu
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.36 no.5
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    • pp.392-401
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    • 2010
  • Introduction: Diabetes mellitus, as a major health problem for the elderly has been shown to alter the properties of the bone and impair bone healing around a titanium implant in both humans and animals. The aim of this study was to examine the effect of adipose-derived stem cells on the healing process around a titanium implant in streptozotocin-induced diabetic rats. Materials and Methods: Thirteen rats were divided into two groups: adipose-derived stem cells injected group and a control group. A titanium screw implant (diameter: 2.0 mm, length: 3.5 mm) was placed into both tibia of 13 rats: 13 right tibia as the control group and 13 left tibia as the experimental group. The rats were sacrificed at different intervals (1, 2, and 4 weeks) after implantation for histopathology observations and immunohistochemistric analysis. Results: The histopathological findings revealed earlier new formed bone in the experimental group than the control group. In particular, at 1 week after implantation, the experimental group showed more newly formed bone and collagen around the implant than the control group. In immunohistochemistric analysis, osteoprotegerin (OPG) expression in the experimental group increased early compared to that of the control group until 2 weeks after implantation. However, after 2 weeks, OPG expression in the experimental group was similar to OPG expression in the control group. The receptor activator of nuclear factor ${\kappa}B$ ligand (RANKL) expression in the experimental group increased early compared to that of the control group, and then decreased at 2 weeks. After 2 weeks, the level of RANKL expression was similar in both groups. Conclusion: These results suggest that adipose-derived stem cells in implantation can promote bone healing around titanium, particularly in diabetes mellitus induced animals.

Effect of Hardening Accelerators on the Adiabatic Temperature property Properties of Precast Concrete and FEM analysis for Evaluating the Crack Performance (경화촉진제를 사용한 프리캐스트 콘크리트의 단열온도특성 및 FEM해석에 의한 균열성능 평가에 관한 연구)

  • Min, Tae-Beom;Cho, In-Sung;Mun, Young-Bum;Lee, Han-Seung
    • Journal of the Korea Institute of Building Construction
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    • v.15 no.1
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    • pp.25-33
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    • 2015
  • In this study, initial crack index was evaluated by FEM analysis to find the crack propagation from hydration heat in precast concrete. As results, as the usage of hardening accelerator increased, initial compressive strength increased and setting time was shortened. Additionally, as amounts of hardening accelerators increased, the central temperature of concrete increased and the time to reach the highest temperature was shortened. It was demonstrated that the hardening accelerators accelerated the hydration reaction of cement, and caused the increase of hydration heat within the short period of time. Furthermore, the crack index for evaluating the heat level was performed by FEM. As results, there was no problem about the cracks, despite of the growth of initial high hydration heat. This is because of the increased tensile strength that is large enough to sustain the thermally induced-stress.

Selection of an Optimal Conception Design for the Development of Noise-reduced System Aluminum Form (소음저감형 시스템 알루미늄 거푸집의 최적 개념디자인 선정)

  • Hong, Jong Hyun;Yeom, Dong Jun;Kim, Young Suk
    • Korean Journal of Construction Engineering and Management
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    • v.17 no.2
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    • pp.135-145
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    • 2016
  • In Korea, a series of noise-reduced aluminum forms are being recently used in apartment housing construction. However, their complicated and time-consuming work processes, and the noise which is still generated due to the inherent property of aluminum when especially installing and dismantling them have been pointed out as a problem to be certainly solved for increasing their practical use in construction sites. The primary objectives of this study are proposing an optimal conceptual design of a newly designed noise-reduced aluminum form and verifying the technical feasibility by conducting a working mock-up drive experiment. Thus, conventional noise-reduced aluminum forms have been analyzed and three conceptual designs of a newly noise-reduced aluminum forms have been deducted. AHP has been applied to a survey data collected by interviewing field experts. A trade-off analysis results have shown that 'Noise-reduced System Aluminum Form with a Drop-down Floor Post and Adaptive Beam' the highest weights of safety(0.52), work convenience(0.54) and thus selected. The suggested conceptual design in this study improved problems of conventional system aluminum forms. It is also expected that the suggested design will be used as a reliable guideline for the actual development of an aluminum form that ensures noise-reduce, work convenience and labor safety.

The Case Study on Performance Measurement Weighting for Efficient Value Engineering Study of Sewage Treatment Facliity (건설사업의 효율적인 리스크관리를 위한 RBES 분석기법과 적용에 대한 연구)

  • Park, Jaeil;Kim, Dongjin;Kim, Gyeonghyun;Lim, Jongkwon;Lee, Minjaee
    • Korean Journal of Construction Engineering and Management
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    • v.17 no.3
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    • pp.125-133
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    • 2016
  • The Project Risk Management is intended to result in the effective management by identifying in advance and mitigating all significant risks including project risks and opportunities during the entire project life cycle - from project inception to completion of construction. It is impossible to predict an exact budget and construction duration before finishing a project. So, Washington Department of Transportation mandates that workshop-based risk management is conducted for projects over specific cost. However, the domestic construction sites have depended on numerical risk analysis without any workshop and efficient risk management have not made. Therefore, in this study, we propose the effective risk management using the RBES program which is very useful for workshop-based risk management and pre & post mitigation, by workshop-based risk management techniques. This proposed risk management approach is applied to a domestic 'A' river recovery project. It is concluded that we may expect the effect to mitigate the total cost overrun problem and the construction duration delay effect in the project by identifying significant risks and by preparing effective risk mitigation strategies.

Pile Load Transition and Ground Behaviour due to Development of Tunnel Volume Loss under Grouped pile in Sand (사질토 지반에서 터널체적손실 증가에 따른 군말뚝의 하중변이와 지반거동)

  • Oh, Dong Wook;Lee, Yong Joo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.37 no.2
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    • pp.485-495
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    • 2017
  • A development of underground space is very useful solution to slove problem occurred from ground surface enlargement in urban areas due to the growth of population, tunnelling is the most popular way and widely used. Researches regarding tunneling-induced pile-soil interactive behaviour have been conducted by many researchers. A study on pile axial force distribution due to tunnelling through laboratory model test, however, is being rarely carried out. In this study, therefore, authors investigate ground behaviour due to tunnelling below grouped pile subjected vertical load as well as pile axial force distribution. A concept of volume loss is used to express tunnel excavation, which is normally applied to 1~2% for tunnelling in soft ground. In this study, however, 10% of that applied to investigate failure mechanism. As a result of laboratory model test, a decrease of pile axial force occurs at 1.5% of volume loss, settlement of grouped pile is 1.2~4.7 times greater than the adjacent ground surface one. Ground deformations at 1.5% of volume loss are measured using Close Range Photogrammetry and compared with results from numerical analysis.

Field Application of a Precast Concrete-panel Retaining Wall Adhered to In-situ Ground (원지반 부착식 판넬옹벽의 현장 적용성 평가)

  • Min, Kyoung-Nam;Lee, Jae-Won;Lee, Jung-Gwan;Kang, In-Kyu;Ahn, Tae-Bong
    • The Journal of Engineering Geology
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    • v.26 no.1
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    • pp.51-61
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    • 2016
  • New building methods are needed to aid increased inner-city redevelopment and industrial construction. A particular area of improvement is the efficient use of cut slopes, with the minimization of associated problems. A retaining wall of precast panels can resist the horizontal earth pressure by increasing the shear strength of the ground and reinforcing it through contact with the panels. Precast panels allow quick construction and avoid the problem of concrete deterioration. Other problems to be solved include the digging of borrow pits, the disposal of material cut from the slope, and degradation of the landscape caused by the exposed concrete retaining wall.This study suggest the methods of improvement of an existing precast panel wall system by changing the appearance of the panels to that of natural rock and improving the process of adhering the panel to a vertical slope. The panels were tested in the laboratory and in the field. The laboratory test verified their specific strength and behavior, and the field test assessed the panels' ground adherence at a vertical cutting. Reinforcement of the cutting slope was also measured and compared with the results of 3D numerical analysis. The results of laboratory test, identified that the shear bar increase the punching resistance of panel. And as a results of test construction, identified the construct ability and field applicability of the panel wall system adhered to in-situ ground. In addition to that, extended measurement and numerical analysis, identified the long-term stability of panel wall system adhered to in-situ ground.

Process Analysis on Mathematical Communication and Analogical Thinking through Trapezoid's Area Obtaining Activity (사다리꼴 넓이 구하기 활동에서 나타나는 수학적 의사소통과 유추적 사고 과정 분석)

  • You, Sanghwuy;Song, Sang Hun
    • Journal of Educational Research in Mathematics
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    • v.23 no.2
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    • pp.253-267
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    • 2013
  • The newly revised mathematics curriculum of 2007 speaks of ultimate goal to develop ability to think and communicate mathematically, in order to develop ability to rationally deal with problems arising from the life around, which puts emphasize on mathematical communication. In this study, analysis on mathematical communication and analogical thinking process of group of students with similar level of academic achievement and that with different level, and thus analyzed if such communication has affected analogical thinking process in any way. This study contains following subjects: 1. Forms of mathematical communication took placed at the two groups based on achievement level were analyzed. 2. Analogical thinking process was observed through trapezoid's area obtaining activity and analyzed if communication within groups has affected such process anyhow. A framework to analyze analogical thinking process was developed with reference of problem solving procedure based on analogy, suggested by Rattermann(1997). 15 from 24 students of year 5 form of N elementary school at Gunpo Uiwang, Syeonggi-do, were selected and 3 groups (group A, B and C) of students sharing the same achievement level and 2 groups (group D and E) of different level were made. The students were led to obtain areas of parallelogram and trapezoid for twice, and communication process and analogical thinking process was observed, recorded and analyzed. The results of this study are as follow: 1. The more significant mathematical communication was observed at groups sharing medium and low level of achievement than other groups. 2. Despite of individual and group differences, there is overall improvement in students' analogical thinking: activities of obtaining areas of parallelogram and trapezoid showed that discussion within subgroups could induce analogical thinking thus expand students' analogical thinking stage.

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Applicability Evaluation of Tailing Admixture as Grout Material (그라우트 재료로서 광물찌꺼기 혼화재의 활용 가능성 평가)

  • Kim, Daehyeon;Noh, Jeongdu;Kang, Seong-Seung
    • Tunnel and Underground Space
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    • v.26 no.2
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    • pp.110-119
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    • 2016
  • The purpose of this study is to evaluate the applicability of tailing in the ${\bigcirc}{\bigcirc}$ mine as a grout material. For the purpose, XRD analysis was performed for mineralogical properties of tailing. In addition, flow, velocity, and uniaxial compressive strength tests were carried out for physical and mechanical properties of a grout material with the mixing ratio of cement and tailing and curing periods. By the result of XRD analysis, tailing of the mine was found to mostly consist of quartz, galena, and pyrite. The flow observed by the flow test showed decreasing tendency with increasing the mixing ratio of tailing. The velocity was also lowered with increasing the mixing ratio of tailing regardless of curing periods. The uniaxial compressive strength as well as Young's modulus also show a tendency to decrease with increasing the mixing ratio of tailing independently on the curing periods. Considering only the physical and mechanical properties of a grout material with tailing, the results are considered to be sufficiently used as a grout material. However, since metallic minerals such as galena and pyrite in tailing contents and these are causing environmental contamination, countermeasures should be considered for this problem in future.

Effect of Various Parameters on Stress Distribution around Holes in Mechanically Fastened Composite Laminates (기계적으로 체결된 복합재료 평판에서 다양한 인자의 영향에 따른 원공 주위의 응력분포)

  • Choi Jae-Min;Chun Heoung-Jae;Byun Joon-Hyung
    • Composites Research
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    • v.18 no.6
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    • pp.9-18
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    • 2005
  • With the wide applications of fiber-reinforced composite material in aero-structures and mechanical parts, the design of composite joints have become a very important research area because the joints are often the weakest areas in composite structures. This paper presents an analytical study of the stress distributions in mechanically single-fastened and multi-fastened composite laminates. The finite element models which treat the pin and hole contact problem using a contact stress analysis are described. A dimensionless stress concentration factor is used to compare the stress distributions in composite laminates quantitatively In the case of single-pin loaded composite laminate, the effects of stacking sequence, the ratio of a hole diameter and the width of a laminate (W/D ratio), the ratio of hole diameter and distance from edge to hole (E/D ratio), friction coefficient and clamping force are considered. In the case of multi-pin loaded composite laminate, the influence of the number of pins, pitch distance, number of rows, row spacing and hole pattern are considered. The results show that P/D ratio and E/D ratio affect more on stress distributions near the hole boundary than the other factors. In the case of multi-pin loaded composite laminate, the stress concentration in the double column case is better than the other cases of multi-pin loaded composite laminate.

Stability Evaluation of Multi-storied Stone Pagoda in the Daewonsa Temple using Three-dimensional Image Analysis (3차원 영상분석을 이용한 대원사다층석탑의 안정성 평가)

  • Jun, Byung-Kyu;Lee, Chan-Hee;Suh, Man-Cheol
    • Journal of Conservation Science
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    • v.22
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    • pp.31-42
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    • 2008
  • A stone cultural heritage often lacks design drawing and detailed geometric informations, thus it becomes more difficult to conservation and restoration. Even though there is active database of detail shape information and numerical measurement for stone monuments, most of the data is in hard-to-utilize two-dimensional images. The new technology developed to overcome this problem is three-dimensional image scanning system. The multi-storied stone pagoda of the Daewonsa temple was analysed with 3D scanning image data then survey map with orientation displacement was evaluated. The difference of each side became apparent with the members of the stone properties was measured, also horizontal and vertical displacement occurred. Horizontal displacement occurred in increasing severity from left to right and from body section to upper part. The 8th roof stones are leaning toward northwest direction due to lateral displacement. The evaluation and measurement of displacement could cause a little errors due to the characteristics uneven surface of stone monuments, computer program and mistakes from the researcher. In future, more precise measurement and stability studies should be done to suggest that accurate data for conservation and understanding of damage condition can be provided.

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