• Molecules and Cells
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• v.43 no.2
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• pp.188-197
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• 2020

Cells are designed to be sensitive to a myriad of external cues so they can fulfil their individual destiny as part of the greater whole. A number of well-characterised signalling pathways dictate the cell's response to the external environment and incoming messages. In healthy, well-ordered homeostatic systems these signals are tightly controlled and kept in balance. However, given their powerful control over cell fate, these pathways, and the transcriptional machinery they orchestrate, are frequently hijacked during the development of neoplastic disease. A prime example is the Wnt signalling pathway that can be modulated by a variety of ligands and inhibitors, ultimately exerting its effects through the β-catenin transcription factor and its downstream target genes. Here we focus on the interplay between the three-member family of RUNX transcription factors with the Wnt pathway and how together they can influence cell behaviour and contribute to cancer development. In a recurring theme with other signalling systems, the RUNX genes and the Wnt pathway appear to operate within a series of feedback loops. RUNX genes are capable of directly and indirectly regulating different elements of the Wnt pathway to either strengthen or inhibit the signal. Equally, β-catenin and its transcriptional co-factors can control RUNX gene expression and together they can collaborate to regulate a large number of third party co-target genes.

• Journal of the Korean housing association
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• v.26 no.2
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• pp.1-12
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• 2015

The era of globalization has ushered in dramatic changes in the past decade covering a wide range of distinct political, economic and cultural trends whereby people adapt their houses to suit their needs and desires. This paper discusses the process of change analytically, emphasizing the importance of understanding the transformation of Lao traditional houses and its impact factors to the transformation and adaptation to suit with globalization trend, and conservation of the characteristics of traditional houses. This study takes place in Luangprabang, an ancient city of Lao PDR, which was designated as a world heritage city in 1995 as it is rich with diverse, tangible and intangible values. Five cases of traditional house in Luangprabang are examined to understand their transformation through time, by analyzing the basic spatial formation, components and elements, especially to find out the impact factors to such transformation. The study revealed that the transformation of the traditional house is subject to not just one single factor, but to a number of factors, where globalization, regulation, economy, and social aspect factors play a prime role and are the root for all these changes. The case study also indicates that these changes are connected to the benefits of income generation as a survival strategy for the low and middle-income people in Luangprabang as well as the housing demands. In the transition period a new residential type appeared accordingly, in which living spaces were categorized according to their general functions. There was a harmony between people's needs and the physical characteristics of the house.

• Journal of dental hygiene science
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• v.18 no.5
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• pp.280-287
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• 2018

Dental hygienists are important members of any dental clinic. They are recognized as reflecting the dental clinic's image because they spend a lot of time with patients. The longer the dental hygienist is employed, the better the relationship with the patients and the medical service provided. The purpose of the present study was to develop a scale to measure factors of long-term employment among dental hygienists. The basic questions were constructed by analyzing tools used to measure job embeddedness and satisfaction. Forty-one questions were developed that measured organizational fit (13), interpersonal relationships (8), job satisfaction (7), duty satisfaction (6), recognition (4), and self-esteem (3). A questionnaire survey was conducted, and the responses from 297 dental hygienists in dental clinics, after the exclusion of 20 incomplete surveys, were used for the exploratory and confirmatory factor analyses. As revealed by exploratory factor analysis, long-term employment intention was composed of 7 factors consisting of 29 items after the exclusion of 12. The subsequent confirmatory factor analysis revealed 4 factors ("organizational fit," "professional identity," "job connectivity," and "interpersonal relationship") consisting of 16 items, after the exclusion of 13. $Cronbach^{\prime}s\;{\alpha}$ were 0806, 0.836, 0.700, and 0.684 for the four factors. This study is meaningful in that it developed a long-term employment factor measurement tool that can be applied to domestic dental hygienists. Future studies will need to focus more on professional identity and job outcomes. The results of this study and future related ones could be used to improve dental hygienist's continuous service.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.9
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• pp.3841-3857
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• 2020

RSA is one of the best well-known public key cryptosystems. This methodology is widely used at present because there is not any algorithm which can break this system that has all strong parameters within polynomial time. However, it may be easily broken when at least one parameter is weak. In fact, many weak parameters are already found and are solved by some algorithms. Some examples of weak parameters consist of a small private key, a large private key, a small prime factor and a small result of the difference between two prime factors. In this paper, the new weakness of RSA is proposed. Assuming Euler's totient value, Φ (n), can be rewritten as Φ (n) = ad + b, where d is the private key and a, b ∈ ℤ, if a divides both of Φ (n) and b and the new exponent for the decryption equation is a small integer, this condition is assigned as the new weakness for breaking RSA. Firstly, the specific algorithm which is created for this weakness directly is proposed. Secondly, two equations are presented to find a, b and d. In fact, one of two equations must be implemented to find a and b at first. After that, the other equation is chosen to find d. The experimental results show that if this weakness has happened and the new exponent is small, original plaintext, m, will be recovered very fast. Furthermore, number of steps to recover d are very small when a is large. However, if a is too large, d may not be recovered because m which must be always written as m = h^a is higher than modulus.

• Journal of Biosystems Engineering
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• v.3 no.1
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• pp.33-46
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• 1978

To get the goal of self-supply of food grain, improvement of post-harvest grain operations in rural area is under consideration as an important task of agriculture in Korea. This is study is focused on elimination of losses and deteriorations of grain and reduction of labour requirements and funds for post-harvest grain operations. The purpose of this study are presentation of basic data referring to conventional post-harvest grain operations in rural area and suggestion of improving methods for the operations, and also finding out reasonable operating processes of the operations. The result of this study are follows; 1. Grain drying in-the-filed which is performed before threshing has major factors of grain loss during drying, and so should be restrained as possible. Combine harvesting system is recommended among other king of mechanized harvesting systems for restraining in-the-field drying and securing available labors for drying. 2. It is predicted that mechanical grain drying could be prevalent when combine harvesting is taken place. Recommended grain drier for pre-combine harvesting system and for combine harvesting system is batch-type drier and circulating -type drier, respectively. 3. As existing farm storages for grain have insufficient spaces and offer poor conditions for grain storing , it is greatly needed to build up new storage which store only grains. And it is concluded that storing grain in community common storages in desirable. 4. Power supplying system for milling machinery in local milling plants, that a large capacity prime mover supplies power to 4 to 6 kinds of milling machinery simultaeously, should be converted to a system of several small capacity prime movers supplying power to each machiner y for the purpose of reducing extra consumption of energy. 5. Governmental grain, of which Korean farms produced, should be milled and stored in the local milling plant successively for the purpose of reducing transportation fee and stroing facilities. 6. Furture post-havest grain operations-drying, storing and milling should be periormed successively in he community common plant. And average optimum processing capacity of the plant is estimated about 300 metric ton of grain every year.

• The Journal of the Korea Contents Association
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• v.18 no.7
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• pp.253-261
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• 2018

The purpose of this study is to find the theories of public policy in Confucian politics during Choson Dynasty. As a result of the analysis, there are five implications. First, the area of Confucian policy of Choson consisted in authority, organization, financial policy, affection for the people, and li(ritual propriety). Second, major political context had been maintained from King Se-Jong, through King Sung-Jong and King Yeong-Jo to King Jeong-Jo in the perspective of dynasties' characteristic. Third, there were major ideas on Confucius's idea for li in early period, $Zh{\bar{u}}z{\check{i}}^{\prime}s$ idea for the authority in late period and Mencius's idea for financial policy in major risk situation. Fourth, there were five periods with establishment, foundation, crisis, restoration and collapse in the change of public policy. Fifth, $Zh{\bar{u}}z{\check{i}}^{\prime}$ and $Ch{\acute{e}}ng{\cdot}zi$ had influenced bigger than Confucius as a factors of policy making. This study has been promoted the complement of context analysis and understanding of semantic analysis with implementing dictionary using two language with Korean and Chinese.

• Journal of Information Processing Systems
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• v.6 no.3
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• pp.335-346
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• 2010

The present study investigates the difficulty of solving the mathematical problem, namely the DLP (Discrete Logarithm Problem) for ephemeral keys. The DLP is the basis for many public key cryptosystems. The ephemeral keys are used in such systems to ensure security. The DLP defined on a prime field $Z^*_p of random prime is considered in the present study. The most effective method to solve the DLP is the ICM (Index Calculus Method). In the present study, an efficient way of computing the DLP for ephemeral keys by using a new variant of the ICM when the factors of p-1 are known and small is proposed. The ICM has two steps, a pre-computation and an individual logarithm computation. The pre-computation step is to compute the logarithms of a subset of a group and the individual logarithm step is to find the DLP using the precomputed logarithms. Since the ephemeral keys are dynamic and change for every session, once the logarithms of a subset of a group are known, the DLP for the ephemeral key can be obtained using the individual logarithm step. Therefore, an efficient way of solving the individual logarithm step based on the newly proposed precomputation method is presented and the performance is analyzed using a comprehensive set of experiments. The ephemeral keys are also solved by using other methods, which are efficient on random primes, such as the Pohlig-Hellman method, the Van Oorschot method and the traditional individual logarithm step. The results are compared with the newly proposed individual logarithm step of the ICM. Also, the DLP of ephemeral keys used in a popular password key exchange protocol known as Chang and Chang are computed and reported to launch key recovery attack.

• Korean Journal of Veterinary Research
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• v.49 no.4
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• pp.345-349
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• 2009

Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two benzene rings and well known environmental pollutants. This study examined the effect of persistent exposure to 2,$3^{\prime}$,4,$4^{\prime}$,5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection. The effect of PCB118 on the expression of cyclooxygenase 2 (COX-2), cytosolic phospholipase A2 (cPLA2), peroxisome proliferator-activated receptor gamma, Bcl and Bcl-2-associated X protein (BAX) was investigated. The level of COX-2 and cPLA2 expression was higher in the PCB118-treated rats than the control. These results suggest that PCB118 has a proinflammatory effect in rats.

• The Journal of the Korea institute of electronic communication sciences
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• v.11 no.7
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• pp.693-700
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• 2016

It is important that we can calculate the order of non-supersingular elliptic curves with large prime factors over the finite field GF(q) to guarantee the security of public key cryptosystems based on discrete logarithm problem(DLP). Schoof algorithm, however, which is used to calculate the order of the non-supersingular elliptic curves currently is so complicated that many papers are appeared recently to update the algorithm. To avoid Schoof algorithm, in this paper, we propose an algorithm to calculate orders of elliptic curves over finite composite fields of the forms $GF(2^m)=GF(2^{rs})=GF((2^r)^s)$ using Weil's theorem. Implementing the program based on the proposed algorithm, we find a efficient non-supersingular elliptic curve over the finite composite field $GF(2^5)^{31})$ of the order larger than $10^{40}$ with prime factor larger than $10^{40}$ using the elliptic curve $E(GF(2^5))$ of the order 36.

• Journal of Korean Society for Atmospheric Environment
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• v.30 no.5
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• pp.423-433
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• 2014

This study examined the short-term variability of $CO_2$ concentrations measured at the Gosan site ($33^{\circ}17^{\prime}N$, $126^{\circ}10^{\prime}E$) in Jeju, Korea for the last 9 years from 2002 to 2010. The weekly distribution shows higher $CO_2$ concentrations during weekends than weekdays which implies the impact of local emissions because Jeju Island is one of the top tourist attraction in Korea. In diurnal variation, $CO_2$ concentration reached the maximum at 6 am and the minimum at 1 pm. The high $CO_2$ concentrations were mostly associated with lower wind speed (below 4 m/s) and easterlies, which was typical of summer night. In other seasons, however, the high concentrations were encountered under strong westerlies (8~16 m/s), which implies the influence of Chinese outflows. $CO_2$ concentrations were found to be highly correlated with meteorological parameters including wind speed, temperature, humidity, and solar radiation except for winter.