• YAKHAK HOEJI
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• v.44 no.4
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• pp.293-299
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• 2000

Biodegradable microspheres made from poly-lactide-co-glycolide polymers have been considered as a new delivery system for single-dose vaccine. Purified tetanus toxoid (TT) was encapsulated in poly-lactide(PLA) and poly-lactide-co-glycolide (PLGA) microparticles using a solvent evaporation method in a multiple emulsion system (water-in oil-in water). The morphology of 77-loaded microparticles was spherical and the suface of them was smooth. The particle size was in a range of 2-10. Protein loading efficiency was 68-97.8%. PLGA (85:15) microparticle showed the highest efficiency. Protein release pattern was influenced by polymer molecular weight and composition. The release rate of PLA(Mw 100,000) microsphere was higher than any other microspheres. In consequence of the hydrolysis of PLGA(50:50) microspheres, environmental pH decreased from 7.4 to 5.0. The PLA, PLGA (75:25) and PLGA (85:15) microshperes showed no significant pH change. The antigenicity or n in microshperes was assayed by indirect sandwich ELISA using equine polyclonal tetanus antitoxin for capture antibody and human polyclonal tetanus antitoxin for primary antibody. The antigenicity of TT in PLA (Mw 100,000), PLGA(50:50, Mw 100,000) and PLGA (75:25, Mw 73,300) after 30 days incubation showed 54, 40.9 and 76.7%, respectively.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.05a
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• pp.471-474
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• 2005

This study investigates the nano/microstructure, the aging response, and the mechanical/tribological properties of the eutectic regions in rheoformed A356 alloy-T5 parts using nano/micro-indentation and mechanical scratching, combined with optical microscopy and atomic force microscope (AFM). Most eutectic Si crystals in the A356 alloy showed a modified morphology as fine-fibers. The loading curve for the eutectic region was more irregular than that of the primary Al region due to the presence of various particles of varying strength. The aging responses of the eutectic regions in the rheoformed A356 alloys aged at $150^{\circ}C$ for different times (0, 2, 4, 8, 10, 16, 24, 36, and 72 h) were investigated. Both Victors hardness $(H_v)$ and indentation $(H_{IT})$ test results showed a similar trend of aging curves, and the peak was obtained at the same aging time of 10 h. A remarkable size-dependence of the tests was found.

• Radiation Oncology Journal
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• v.9 no.2
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• pp.319-324
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• 1991

In our institution, a 76-year-old woman with primary urethral carcinoma was treated with remote afterloading high dose rate (HDR) interstitial brachytherapy using micro selectron Ir-192. In this paper, authors described the technical aspect of remote afterloading HDR interstitial brachytherapy for female urethal cancer.

• Structural Engineering and Mechanics
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• v.15 no.2
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• pp.159-180
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• 2003

In this paper spacing and width of flexural cracks in reinforced concrete beams are determined using two-dimensional finite element analysis. At early loading stages on the beam the primary crack spacing is based on the slip length, which is the development length required to resist the steel stress increment that occurs at a cracked section on the formation of the first flexural crack. A semi-empirical formula is presented in this paper for the determination of the slip length for a given beam. At higher load levels, the crack spacing is based on critical crack spacing, which is defined as the particular crack spacing that would produce a concrete tensile stress equal to the flexural strength of concrete. The resulting crack width is calculated as the relative difference in extensions of steel reinforcement and adjacent concrete evaluated at the cracked section. Finally a comparative study is undertaken, which indicates that the spacing and width of cracks calculated by this method agree well with values measured by other investigators.

• International Journal of High-Rise Buildings
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• v.7 no.4
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• pp.397-408
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• 2018

In a recent tragic fire incident, the Plasco Tower collapsed after an intense outburst of fire lasting for three and a half hours and claiming the lives of 16 firefighters and 6 civilians. This paper will present continuing collaborative work between Hong Kong Polytechnic University and Queen's University in Canada to model the progressive collapse of the tower. The fire started at the 10th floor and was observed to have travelled along the floor horizontally and through the staircase and windows vertically. Plasco Tower was steel structure and all the steel sections were fabricated by welding standard European channel or angle profiles and no fire protection was applied. Four internal columns carried the loads transferred by the primary beams, and box columns were constructed along the perimeter of the building as a braced tube for resisting seismic loading. OpenSees fibre-based sections and displacement-based beam-column elements are used to model the frames, while shell elements are used for the reinforced concrete floor slabs. The thermal properties and elevated temperature mechanical properties are as recommended in the Eurocodes. The results in this preliminarily analysis are based on rough estimations of the structure's configuration. The ongoing work looks at modeling the Plasco Tower based on the most accurate findings from reviewing many photographs and collected data.

• International Journal of Naval Architecture and Ocean Engineering
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• v.11 no.1
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• pp.52-58
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• 2019

Marine emissions of Volatile Organic Compounds (VOCs) have received much attention because the International Maritime Organization (IMO) requires the installation of vapour emission control systems for the loading of crude oils or petroleum products onto ships. It was recently recognised that significant corrosion occurs inside these vapour emission control systems, which can cause severe clogging issues. In this study, we analysed the chemical composition of drain water sampled from currently operating systems to investigate the primary causes of corrosion in vapour recovery systems. Immersion and electrochemical tests were conducted under simulated conditions with various real drain water samples, and the impact of corrosion on the marine vapour recovery system was carefully investigated. Moreover, corrosion tests on alternative materials were conducted to begin identifying appropriate substitutes. Thermodynamic calculations showed the effects of environmental factors on the production of condensed sulphuric acid from VOC gas. A model of sulphuric acid formation and accumulation by the characteristics of VOC from crude oil and flue gas is suggested.

• Steel and Composite Structures
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• v.42 no.3
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• pp.315-323
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• 2022

Shear connectors are key elements that ensure integrity in a composite system. The primary purpose of a shear connector is to bring a high degree of interaction between composite elements. A wide variety of connectors are available for hot-rolled composite construction, connected to the beam through welding. However, with cold-formed members being very thin, welding of shear connectors is not desirable in cold-formed composite constructions. Shear connectors for cold-formed elements are limited in studies as well as in the market. Hence in this study, three different types of shear connectors, namely, single-channel, double channel, and self-tapping screw, were considered, and their performance assessed by the Push-out test as per Eurocode 4. The connection between channel shear connectors and the beam was made using self-tapping screws to avoid welding. The performance of the connectors was analyzed based on their ultimate capacity, characteristic capacity, ductility, and slippage during loading. Strength to weight ratio was also carried out to understand the proposed connectors' suitability for conventional ones. The results showed relatively higher initial stiffness and ductility for double channel connectors than other connectors. Also, self-tapping screws had a higher strength to weight ratio with low ductility.

• Journal of the Earthquake Engineering Society of Korea
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• v.26 no.2
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• pp.83-93
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• 2022

In this study, to verify the structural performance of the Composite Joint System (CJS) hybrid structural model, a cyclic load test was performed and evaluated and verified through the test. To verify the structural performance of the CJS hybrid structural systems' joint and evaluate the seismic performance, four three-dimensional real-size specimens were developed with three internal beam-column specimens and one external beam-column specimen. The three interior column specimens were classified by different methods of joining the upper column and lower column, and the same bonding method as the primary specimen was used for the exterior column. The structural performances in terms of drift, strength, and energy dissipation capacity were analyzed and compared based on the experimental results. From the displacement-based loading experiment, all specimens showed a lateral drift of 4.0% without any significant strength drop and stable energy dissipation capacity.

• Structural Engineering and Mechanics
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• v.86 no.4
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• pp.535-546
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• 2023

In the present paper, multiple interface cracks between a functionally graded orthotropic coating and an orthotropic half-plane substrate under concentrated loading are considered by means of the distribution dislocation technique (DDT). With the use of integration of Fourier transform the problem is reduced to a system of Cauchy-type singular integral equations which are solved numerically to compute the dislocation density on the surfaces of the cracks. The distribution dislocation is a powerful method to calculate accurate solutions to plane crack problems, especially this method is very good to find SIFs for multiple unequal cracks located at the interface. Hence this technique allows considering any number of interface cracks. The primary objective of this paper is to investigate the effects of the interaction of multiple interface cracks, load location, material orthotropy, nonhomogeneity parameters and geometry parameters on the modes I and II SIFs. Numerical results show that modes I/II SIFs decrease with increasing the nonhomogeneity parameter and the highest magnitude of SIF occurs where distances between the load location and crack tips are minimal.

• Steel and Composite Structures
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• v.50 no.2
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• pp.237-247
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• 2024

Research on interfacial crack formation in orthotropic bi-materials has experienced a notable increase in recent years, driven by growing concerns about structural integrity and reliability. The existence of a crack at the interface of bi-materials has a substantial impact on mechanical strength and can ultimately lead to fracture. The primary objective of this article is to introduce a comprehensive analytical model and establish stress relationships for investigating interfacial crack between two non-identical orthotropic materials with desired crack-fiber angles. In this paper, we present the application of the Interfacial Maximum Tangential Stress (IMTS) criterion, in combination with the Reinforcement Isotropic Solid (RIS) model, to investigate the behavior of interfacial cracks in orthotropic bi-materials under mixed-mode I/II loading conditions. We analytically characterize the stress state at the interfacial crack tip using both Stress Intensity Factors (SIFs) and the T-stress term. Orthotropic materials, due to their anisotropic nature, can exhibit complex crack tip stress fields, making it challenging to predict crack initiation behavior. The secondary objective of this study is to employ the IMTS criterion to predict the crack initiation angle and explore the notable impact of the T-stress term on fracture behavior. Furthermore, we validate the effectiveness of our approach in evaluating Fracture Limit Curves (FLCs) for interfacial cracks in orthotropic bi-materials by comparing our FLCs with relevant experimental data from existing literature.