• Journal of Acupuncture Research
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• v.17 no.3
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• pp.140-150
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• 2000

In order to investigate the effect of the Aqua-acupuncture of the Pakukchun treated on Shinsu(BL23) loci on the estrogen-deficiency osteoporosis induced by ovariectomy in rats, serum osteocalcin estradiol progesterone follicular stimulating hormone(FSH) calcium(Ca) and phosphorous(P) levels were monitored. The Aqua-acupuncture of Pakukchun treated on Shinsu loci have favorable effect on treatment and prevention of osteoporosis induced by ovariectomy in rats.

• Journal of Preventive Medicine and Public Health
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• v.54 no.6
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• pp.404-411
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• 2021

Objectives: Given the increase in osteoporosis among health volunteers and the effect of health literacy on the adoption of nutritional preventive behaviors, this study aimed to determine the effects of an educational intervention on health literacy and the adoption of nutritional preventive behaviors related to osteoporosis among health volunteers. Methods: This was a quasi-experimental, interventional study of health volunteers conducted in 2020. In this study, 140 subjects (70 in both intervention and control groups) were selected using the random multi-stage sampling method. An educational intervention was conducted using the Telegram application, and educational messages were sent to the health volunteers in the intervention group across 6 sessions. Data were collected via a demographic questionnaire, the Health Literacy for Iranian Adults survey, and a nutritional performance questionnaire, which were completed before and 3 months after the intervention. The data were collected and analyzed using SPSS version 23. Results: Before the intervention, there were no significant differences in the mean scores for health literacy variables and the adoption of nutritional preventive behaviors between the intervention and control groups (p>0.05). After the intervention, there was a significant change in the mean scores for health literacy and the adoption of preventive behaviors in the intervention group (p<0.05) as opposed to the control group. Conclusions: Interventions aimed at increasing health literacy are effective for promoting the adoption of preventive and healthy nutritional behaviors related to osteoporosis.

• Journal of Korean Academy of Nursing
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• v.32 no.1
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• pp.89-99
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• 2002

This study was to examine the relationships between knowledge, health belief and self-efficacy of osteoporosis with the women residents in an island. Method: The subjects were 64 women who lived in an island located in Incheon metropolitan city. Data collection was performed by using questionnaire that included Osteoporosis Knowledge Test, Osteoporosis Self-Efficacy Scale and Osteoporosis Health Belief Scale by Kim, Horan & Gendler (1991). The Data were analyzed using SAS computer program that included descriptive statistics, t-test, ANOVA, Pearson correlation coefficient. Result: 1) The mean of osteoporosis knowledge was 10.03 in the range of 0 to 24, shows the relatively lower score than mean score. The mean of osteoporosis health belief variables were susceptibility 18.95, seriousness 19.05, benefits of exercise 22.35, benefits of calcium 21.81, barriers to exercise 16.95, barriers to calcium 13.13, and health motivation 19.75 in every range of 6 to 30. The mean of osteoporosis self-efficacy was 37.95 in the range of 12 to 60, shows a relatively higher score than mean score. 2) There were statistically significant differences in the degree of osteoporosis knowledge according to age, education. But There was no significant difference in the degree of osteoporosis and self-efficacy according to general characteristics. There were statistically significant differences in the degree of susceptibility according to religion, family income. There were statistically significant differences in the degree of seriousness, health motivation according to family income. There was statistically significant difference in the degree of barriers to exercise according to education. 3) There were statistically significant positive correlations between osteoporosis knowledge and benefits to exercise, benefits of calcium intake. There was statistically no significant correlation between osteoporosis knowledge and osteoporosis self- efficacy. There was statistically a significant positive correlation between osteoporosis self-efficacy and barriers to exercise. There was statistically a significant negative correlation between osteoporosis self-efficacy and health motivation. Conclusion: According to the result, osteoporosis education program including exercise, calcium intake should be operated to increase benefits to exercise and calcium intake for osteoporosis prevention. In addition, the program of improving self-efficacy should be designed and operated to decrase the perception of barriers to exercise and to increase the perception of health motivation of women in island.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.2
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• pp.426-432
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• 2009

The overall purpose of this study was to investigate the effects of level of isoflavones supplementation on bone metabolism in osteoporosis rats. The effects of level of isoflavones supplementation on calcium and osteocalcin blood level, femur/body weight, bone mineral density(BMD) and bone strength were inspected in this study. This study classified 28 of 12 weeks-old male Sprague Dawley rats which have osteoporosis caused by ovariectomy into four groups of 7 rats and made the subjects medicated them isoflavone. Group I was non-treatment after osteoporosis(control); Group II was low-dose isoflavone(20 mg/kg) feeding after osteoporosis; Group III was middle-dose isoflavone(40 mg/kg) feeding after osteoporosis; Group IV was high-dose isoflavone(80 mg/kg) feeding after osteoporosis; In the calcium and osteocalcin level as one of bone formation indexes, there was a statistically significant difference between the group II, III, IV compared to group I. In respect to the femur/body weight, there was a statistically significant difference between the group II, III, IV compared to group I. In the bone mineral density and bone strength test, there was a statistically significant difference between the group II, III, IV compared to group I. The above results suggests that isoflavone medicated is effective to prevention and treatment of osteoporosis.

• YAKHAK HOEJI
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• v.53 no.4
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• pp.206-216
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• 2009

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (Statins) are potent inhibitors of cholesterol biosynthesis. Cholesterol-lowering therapy using statins significantly reduces the risk of coronary heart disease. Various discovery of statins as bone anabolic agents has spurred a great deal of interest among both basic and clinical bone researchers. In-vitro and some animal studies suggest that statins increase the bone mass by enhancing bone morphogenetic protein-2 (BMP-2)-mediated osteoblast expression. Clinical and animal test results of statins focusing on the prevention and treatment of bone fractures was collected. Three independent literature searches were performed by using from January 1, 2002 to September 2008 for clinical and animal test results. Search term included statins, HMG-CoA reductase inhibitors, pleiotropic effects, fracture, osteoporosis and clinical and animal test. No consensus has been reached whether clinical use of statins has beneficial effects on bone health, partly due to lower statin concentrations because of first-pass metabolism by the liver. Experimental use of statins as stimulators of bone formation suggests that they may have widespread applicability in the field of orthopaedics. With their combined effects on osteoblasts and osteoclasts, statins have the potential to enhance resorption of synthetic materials and improve bone ingrowth. In conclusion, The use of statins in the prevention and treatment of bone fractures requires further study. But observational studies suggest that statins for decreasing bone fractures including osteoporosis have to be considered local direct administration like transdermal or subcutaneous type over oral adminstration.

• International Journal of Industrial Entomology and Biomaterials
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• v.48 no.3
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• pp.99-106
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• 2024

Functional foods, introduced in the early 1980s, offer health benefits beyond basic nutrition and are increasingly demanded due to growing consumer awareness of diet-health relationships. This review explores insect-based functional foods, highlighting their nutritional benefits, health implications, and applications. Edible insects, such as crickets, mealworms, and locusts, are rich in protein, healthy fats, vitamins, and minerals, making them a promising solution for food security and sustainability. Insect-based foods contribute to weight management, cardiovascular health, anti-inflammatory properties, gut health, and potential anti-cancer benefits. Despite most insects being low in calcium and potassium, they are high in phosphorus and, to a lesser extent, magnesium. Active components like royal jelly, bee pollen, and extracts from Tenebrio molitor and Periplaneta americana L. have shown potential in osteoporosis prevention by improving bone density and reducing bone resorption. Silk sericin-based functional foods also exhibit preventive and therapeutic effects against bone loss. However, challenges such as regulatory barriers, food safety concerns, consumer acceptance, potential allergenicity, and the need for standardization and quality control must be addressed. This review underscores the potential of insect-based functional foods in enhancing health and well-being, particularly for osteoporosis prevention, and highlights the need for further research and regulatory harmonization to facilitate their adoption.

• Korean Journal of Exercise Nutrition
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• v.24 no.3
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• pp.19-24
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• 2020

[Purpose] Although physical activity is required to prevent or ameliorate osteoporosis, medicine prescription should precede it, since it may be limited in severe osteoporosis patients. Furthermore, osteoporosis has a great effect on physical activity disorders that accompany fractures and pain, and therefore, research on treatment or prevention to decrease the number of patients is required. The purpose of this study was to discover candidate substances from natural products with an effective pharmacological action and to prepare basic data to help patients. [Methods] To prepare the osteoporosis model, ovariectomy (OVX) was performed using surgical methods. The prepared prescription [Shinkiwhan (SKH), a Korean medicine] was administered orally at a dose of 210 mg/kg/day for 8 weeks. After completion of the animal experiment, the bone mineral density (BMD) was analyzed using double-energy X-ray absorptiometry. The analysis of the effect of drugs on bones was performed using histological analysis and immunostaining. [Results] SKH increased the BMD in the OVX rats. Furthermore, SKH significantly increased the expression of osteoprotegerin and downregulated receptor activator of nuclear factor kappa B ligand and phosphorylation of c-jun N-terminal kinases in the bones of the OVX model. [Conclusion] Our findings suggest a protective effect of SKH against BMD loss in the OVX model.

• Physical Therapy Korea
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• v.13 no.1
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• pp.1-8
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• 2006

Osteoporosis is the most prevalent metabolic bone disease and is characterized by diminished bone strength predisposing to an increased risk of fracture. Thus, this study was performed (1) to examine the effect of aquatic exercise on osteoporosis caused by an ovariectomy in the rats, and (2) to elucidate involvement of histopathologic findings in mediating these actions. The results of this study were as follows: 1. Body weight of the subjects increased after the experiment. There was a statistically significant difference (p<.05) between Group I (sham operated) and Group II (control group). 2. In respect to the length, circumference and weight of the femur, there was no statistically significant difference between the control group and the other groups (p>.05). 3. With the osteocalcin level used as one of the bone formation indexes the bone mineral density increased in every group in comparison with the control group, and in particular, there was a statistically significant difference between Group III and Group IV. The above results suggest that aquatic exercise treatment is effective in the prevention and treatment of osteoporosis.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.1
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• pp.1-15
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• 2008

Purpose: Osteoporosis that occurred after menopause is one of the most common metabolic disease. and it is that bone mass significant decrease in comparison with normal people. Its symptoms are fracture, decrease of height, etc. The purpose of this study is to examine what are the effects of the Gamisoyosan on the aged ovariectomized rat model of postmenopausal osteoporosis. Methods: 24 female rats were ovariectomized and divided into normal group(normal), ovariectomized group(control), and treated with Gamisoyosan group(treated). During 8 weeks we dosed D.W to sham and control group, and dosed Gamisoyosan(105 mg/100 g) to experimental group. After 8 weeks we sacrificed rats and measured the body weight, albumin, P, Calcium, ALP, total cholesterol, triglyceride, AST, ALT, T4, estradiol, the femur weight, the tibia ash weight, trabecular bone area, trabecular thickness, osteoclast number. Results: The level of serum albumin, calcium, AST, ALT, estradiol in Gamisoyosan group showed significant increase in comparison with control group. The level of serum triglyceride in Gamisoyosan group showed significant decrease in comparison with control group. Trabecular bone area and osteoclast number in Gamisoyosan group showed significant increase in comparison with control group. Conclusions: Reviewing these experimental results, Gamisoyosan has shown to activate osteogenesis and prevent bone resorption, and it should show efficacy on prevention and improvement of osteoporosis after menopause.

• Journal of Acupuncture Research
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• v.15 no.2
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• pp.437-454
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• 1998

Osteopotosis is a disease characterized by reduced amount of bone mass leading to enhanced bone flagility. The number of patients with osteoporotic vertebral fracture is increasing and it is one of the leading causes of morbidity in the elderly and postmenopausal women. It is a condition in which bone mass decrease, causing bones to be more susceptible to fracture. A trivial trauma can easily cause one or more bones to break in a person with severe osteoporosis. So it is a major health problem. Pysicians and patients are concerned with the optimum approach to the treatment and prevention of osteoporosis. Until a recent date, many oriental medicine studies were performed to find the preventive and curative efficacy on the osteoporosis, which is differ from therapeutics of Western-medicine. The proper use of Herb-med and role of Accupuncture are issues that have generated major research efforts. This study was carried out to investigate evaluation of clinical and experimental study on the osteoporosis. So, these are to be mentioned in this paper.