• Molecules and Cells
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• v.37 no.8
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• pp.569-574
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• 2014

As a scaffold, SLX4/FANCP interacts with multiple proteins involved in genome integrity. Although not having recognizable catalytic domains, SLX4 participates in diverse genome maintenance pathways by delivering nucleases where they are needed, and promoting their cooperative execution to prevent genomic instabilities. Physiological importance of SLX4 is emphasized by the identification of causative mutations of SLX4 genes in patients diagnosed with Fanconi anemia (FA), a rare recessive genetic disorder characterized by genomic instability and predisposition to cancers. Recent progress in understanding functional roles of SLX4 has greatly expanded our knowledge in the repair of DNA interstrand crosslinks (ICLs), Holliday junction (HJ) resolution, telomere homeostasis and regulation of DNA damage response induced by replication stress. Here, these diverse functions of SLX4 are reviewed in detail.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2018.05a
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• pp.343-344
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• 2018

This study proposes a standard method of diagnosis and repair to prevent and maintain the problem of durability deterioration caused by leakage cracks in apartment basement structures in Korea. Following the announcement of the previous maintenance plan section, this is the second part of the study, focusing on inspection of methods for diagnosing and repairing leakage cracks in apartment basement structures. In this thesis, the matters required for the procedures, types, times and equipment of the inspection plan and the inspection methods, records, and decisions required for the actual inspection are described.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.1014-1023
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• 2008

The K-AGT test line is managed similarly to revenue operation and operated automatically 120km per day, total 90,000km from August 2004 to December 2007. To enhance reliability of developed system, maintenance information system based on RCM is applied. The maintenance program applied in test line is based on RCM which prevent a fault before it happens and a fault made in test line is analysed by reliability growth test. Vehicle system, power supply system, signalling system, track and infrastructure are built in test line and it is reviewed enhancing system performance and changing designs to commercialize through reliability growth analysis method.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2018.11a
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• pp.191-192
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• 2018

This study presents the standard methods of diagnosis and repair to prevent and maintain the durability degradation caused by leakage cracks in underground structures in Korea. The third part after the announcement of the existing maintenance plan, The environmental characteristics and leakage condition of underground structures, the causes of deterioration of underground concrete structures, and countermeasures and leakage equipment were described.

• Journal of Agricultural Extension & Community Development
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• v.30 no.2
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• pp.119-129
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• 2023

This study aims to identify the types of safety accidents that occur during maintenance and repair operations and analyze the root causes. We used the logic tree diagramming to extract the root causes of 65 safety incidents specifically related to maintenance and repair work out of a total of 1,024 agricultural safety incidents that occurred between 2007 and 2020 collected by investigation with interviews. The extracted root causes were analyzed by categorizing them into six different safety system classifications. The results of the analysis and suggestions are as follows. Incidents related to maintenance and repair work, which can lead to irreversible safety hazards, have occurred frequently. These incidents were found to be occurring due to the overlapping of various safety system errors such as personal protective system and safety operation procedure. In the short term, it is necessary to emphasize compliance with the use of personal protective equipment, and enhancement of maintenance training. In the long term, it is necessary to establish a legal distinction for maintenance and repair work and clarify the responsible parties. Introducing a maintenance system is also crucial to prevent occupational injuries during maintenance and repair in agriculture.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.2048-2051
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• 2010

Almost all companies have paid much attention to the safety management ranging from maintenance to operation even at the stage of designing in order to prevent accidents, but fatal accidents continue to increase throughout the world. In particular, it is essential to systematically prevent such fatal accidents as fire, explosion or leakage of toxic gas at factories in order to not only protect the workers and neighbors but also prevent economic losses and environmental pollution. In addition, HRA may be used to detect the human errors which may cause accidents or trace back to any mistake on the part of workers. Usually, HRA technique is used in association with other risk assessment techniques. Moreover, it can serve to enumerate the human errors which may occur during operation or down-time or correct the existing system to reduce the mistakes. This work focuses on the coincidence of human error and mechanical failure for management of human error, and on some important performance shaping factors to propose a method for improving safety effectively of the process industries.

• Korean Journal of Animal Reproduction
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• v.23 no.4
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• pp.365-369
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• 1999

Interferon tau (IFN$\tau$), the pregnancy recognition signal in ruminants, suppresses transcription of the estrogen receptor (ER) gene in the endometrial luminal (LE) and superficial glandular epithelium (sGE) to prevent oxytocin receptor (OTR) expression and pulsatile release of luteolytic prostaglandin $F_{2{\alpha}}$ (PGF), Interferon regulatory factors one (IRF-l) and two (IRF-2) are transcription factors induced by IFN$\tau$ that activate and silence gene expression, respectively. Available results suggest that IFN$\tau$ acts directly on LE and sGE during pregnancy to induce sequentially IRF-l and then IRF-2 gene expression to silence transcription of ER and OTR genes, block the luteolytic mechanism to maintenance a functional corpus luteum (CL) and, signal maternal recognition of pregnancy. The theory for maternal recognition of pregnancy in pigs is that the uterine endometrium of cyclic gilts secretes PGF in an endocrine direction, toward the uterine vasculature for transport to the CL to exert its luteolytic effect. However, in pregnant pigs, estrogens secreted by the conceptuses are responsible, perhaps in concert with effects of prolactin and calcium, for exocrine secretion of PGF into the uterine lumen where it is sequestered to exert biological effects and / or be metabolized to prevent luteolysis.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.7 no.4
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• pp.1-11
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• 2011

This paper presents the effects of preventive maintenance schemes on the residual stress distributions in dissimilar metal welds. Dissimilar metal weld is known susceptible to PWSCC and thus, effective maintenance schemes to prevent PWSCC are needed. Three preventive maintenances schemes, i.e. weld overlay, MSIP and inlay weld which are widely used in nuclear power plants, are selected and their effects on welding residual stresses are investigated via finite element analyses. As results, weld overlay and MSIP were proved effective method to mitigate residual stresses and inlay weld, on the other hand, produces strong tensile residual stresses in the inner surface. Although Alloy 690 known to be resistant to PWSCC are used in inlay weld, continuous careful observation are needed since tensile welding residual stresses are key parameter for PWSCC.

• Journal of Korean Tunnelling and Underground Space Association
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• v.24 no.2
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• pp.183-192
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• 2022

Function and performance degradation in tunnel structure can cause road's function loss, proactive maintenance is needed to prevent the initial damage from progressing to intensified damage. Inspection and diagnosis are implemented in accordance with regulations, but it does not fully reflect maintenance processes such as inspection and diagnosis, planning rehabilitation and carrying out. It was carried out for 5,540 cases inspection and diagnosis result in 1,728 tunnels was analyzed to suggest rational maintenance plan in this study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.130-137
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• 2017

To maintain traffic safety during the target lifetime of bridges, it is essential to secure an appropriate maintenance budget and allocate that budget appropriately. This paper proposes a reasonable budget allocation system that considers various impact factors to improve the conventional budget allocation method simply considering the bridge scale. The maintenance action rate model and the unit cost model based on the prior maintenance history were developed to allocate appropriately the bridge maintenance budget for the total bridges of the management organization with the target management level. A method to determine the optimal budget allocation ratio for each management subject was proposed and case analysis was conducted using the proposed model. Proper budget allocation was made considering the bridge types, current safety level, and service life as well as the bridge size as an impact factor of the budget allocation of the bridge. The developed method can prevent budget waste and provide a rational basis for budget allocation by implementing the rational budget distribution.