• 대한한의학회지
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• 제40권4호
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• pp.29-40
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• 2019

Objectives: To analyze the prescription frequency of various herbs as either individual or major herbs (in terms of dosage) and their usage patterns in the treatment of different diseases for standardization of traditional Korean medicine. Methods: We analyzed the prescription database of patients at the Pusan National University Korean Medicine Hospital from the date of establishment of the hospital to February 2013. The complete prescription data were extracted from the electronic medical records of patients, and the prescription frequencies of individual herbs, particularly, of major herbs, were analyzed in terms of gender, age, and international classification of diseases (ICD) code. Results: The prescription frequency of individual herbs based on age and gender showed a similar pattern. Herbal mixtures were also distributed in a similar manner. The use of some herbs differed according to age and gender (Table 1.). The herbs that were used at high frequencies for a given ICD code had similar usage patterns in different categories. However, some major herbs in the "Jun (King)" category were used uniquely for a given ICD code (Table 2.). There was significant difference between male and female on ICD code E and N, but the other ICD codes had small differences. The ratio of herbal medicine by gender showed different usage patterns in each gender. Conclusions: The findings of our study provide fundamental data that reflect the real clinical conditions in South Korea, and therefore, can contribute to the standardization of TKM.

• 대한한방내과학회지
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• 제42권4호
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• pp.628-644
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• 2021

Objectives: This study analyzed, through network analysis and data mining analysis, the relationship between herbs used in osteoporosis prescriptions, diversified the analysis of osteoporosis-related prescriptions, and analyzed the combination of herbs used in osteoporosis-related prescriptions. Methods: The prescriptions used in osteoporosis treatment and experiments were established by conducting a full survey of the papers published by the OASIS site. A database for osteoporosis-related prescriptions was established, herbs were extracted, and the frequency of frequent herbs and prescriptions were investigated using Excel (MS offices ver. 2013). Using the freeware R version 4.0.3 (2020-10-10), igraph, and arules package, network analysis was performed in the first second of prescription composition. Results: Among the osteoporosis-related prescriptions, the most studied prescriptions are as follows.: Yukmijihwang-tang (六味地黃湯) and Samul-tang (四物湯). In the osteoporosis prescription network, herbs with connection centrality, proximity centrality, mediation centrality, and eigenvector centrality appeared in the order of Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Poria Sclerotium, Paeoniae Radix, and Glycyrrhizae Radix et Rhizoma. After extracting the herbal combination network, including the corresponding herbs, and clustering it, it can be divided into drugs of the Yukmijihwang-tang (六味地黃湯) series and the Samul-tang (四物湯). Conclusions: This study could assist researchers in diversifyingy formula analysis in future studies. Moreover, the herbal combination used in osteoporosis prescriptions could be used to search for osteoporosis prescriptions in other databases or to create a new prescription.

• 대한한의학원전학회지
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• 제32권1호
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• pp.61-74
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• 2019

Objectives : The purpose of this study is to help select an appropriate word embedding method when analyzing East Asian traditional medicine texts as data. Methods : Based on prescription data that imply traditional methods in traditional East Asian medicine, we have examined 4 count-based word embedding and 2 prediction-based word embedding methods. In order to intuitively compare these word embedding methods, we proposed a "prescription generating game" and compared its results with those from the application of the 6 methods. Results : When the adjacent vectors are extracted, the count-based word embedding method derives the main herbs that are frequently used in conjunction with each other. On the other hand, in the prediction-based word embedding method, the synonyms of the herbs were derived. Conclusions : Counting based word embedding methods seems to be more effective than prediction-based word embedding methods in analyzing the use of domesticated herbs. Among count-based word embedding methods, the TF-vector method tends to exaggerate the frequency effect, and hence the TF-IDF vector or co-word vector may be a more reasonable choice. Also, the t-score vector may be recommended in search for unusual information that could not be found in frequency. On the other hand, prediction-based embedding seems to be effective when deriving the bases of similar meanings in context.

• 한국의사학회지
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• 제35권2호
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• pp.19-34
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• 2022

Objectives : The purpose of this study was to compare the prescriptions used for insomnia in Uihagimmun and Donguibogam. Methods : In Uihagimmun, 17 prescriptions were selected. If there was a change in the medicinal material, the altered herbal medicine was indicated along with the prescription name. In Donguibogam, 14 prescriptions were selected. Each prescription was analyzed by dividing it into prescription composition, and herbal medicine. Medications constituting a prescription were classified according to the classification of Korean herbal medicines and arranged based on their frequency of appearance. Result : The causes of insomnia were classified mainly as exhaustion in Uihagimmun and as exhaustion, stress, low energy, aging and discomfort in Donguibogam. In Uihagimmun, numerous medicines were used to relieve fever, and in Donguibogam, the use of stabilizers increased. More warm medicines were used in Donguibogam than in Uihagimmun, and the taste trend was similar in each. Conclusions : The types of causes of insomnia increased more in Donguibogam than Uihagimmun. Accordingly, the two books showed differences in drug classification and properties of a medicine. However, in terms of taste and action of medicinal herbs, they showed similar patterns, and there was only a difference in the order of frequency.

• 한국의사학회지
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• 제28권1호
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• pp.93-102
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• 2015

Objectives : The aim of this paper is finding the combinations of the medicinal herbs that are used frequently by analyzing the details of the herbal medicinal prescriptions used by the patients who were diagnosed with M54 code diseases. In addition, I will seek to assess the demonstrative pattern that frequently manifest in the M54 code disease patients by using the combinations of the medicinal herbs that are used frequently. Methods : After having extracted the prescription administered to the patients with the diagnostic code of M54, find the relevance with the demonstrative pattern by analyzing the combination for each of the medicinal herb effectiveness. Use the list of medicinal herbs utilized in the corresponding prescription to examine the most frequent combination of the medicinal herbs through the generation of up to 25 arbitrary combinations of the medicinal herbs. Results & Conclusions : As the results of the analysis of the details of the use of the prescribed herbal medicine packages by the Korean Medicine Hospital of Pusan National University, regarding the back pain of the diagnostic code M54, the prescriptions that corresponded to the kidney deficiency pattern, static blood pattern, wind pattern, dampness pattern, food accumulation pattern, qi depression pattern and phlegm-retained fluid pattern back pain among the back pain classifications under the Dongeuibogam (東醫寶鑑) were used frequently, and, regarding the Nape Pain, prescriptions that corresponded to the pain arising from the wind-dampness and phlegm the 'Taeyang meridian' was most frequent.

• 동의생리병리학회지
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• 제24권3호
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• pp.367-372
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• 2010

The purpose of this study is to make a basis of in vivo or clinical study about alopecia. We investigated the prescriptions of alopecia by researching oriental medicine literature. We found the prescriptions used for alopecia. And we surveyed the frequency and classification of the herbs used for alopecia. The results of this study were recorded as follows. The most frequently used single herbs in the prescriptions were Angelicae Gigantis Radix(當歸), Glycyrrhizae Radix(甘草), Poria(茯笭), Paeoniae Radix Alba(白芍藥). Herbs specifically frequently used in the prescriptions of alopecia were as follows. Polygoni Multiflori Radix(何首烏), Rehmanniae Radix(生地黃), Cuscutae Semen(菟絲子), Bupleuri Radix(柴胡), Scutellariae Radix(黃芩), Viticis Fructus(蔓荊子), Aconiti Iateralis Preparata Radix(附子). Herbs frequently used were classified by property. The result was as follows. (()-The number of herbs) 補益藥(32), 解表藥(18), 淸熱藥(15) 收澀藥(9), 活血祛瘀藥(8), 利水滲濕藥(8).

• 동의생리병리학회지
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• 제25권5호
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• pp.759-764
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• 2011

Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "wenrejingwei(溫熱經緯)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 187 medicinal herbs in 113 prescriptions, and found meaningful combinations of 273. Among these, the most meaningful combinations are the one of 7 herbs, Glycyrrhiza uralensis Fischer, Zingiber Rhizoma, Ziziphus jujube Mille, Pinellia ternata Breitenbach, Panax ginseng C.A.Meyer, Cyprinus carpio, Coptis chineis Franch. These are the same medicinal herbs which consist of Banhasasim-tang(banxiaxiexin-tang). It means these combinations are effective in stuffiness caused by stomach deficiency. In conclusion, prescriptions of "wenrejingwei(溫熱經緯)" involve herbs mostly used to treat stuffiness caused by stomach deficiency, and this is the author's important one of medical view points.

• 대한한의학원전학회지
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• 제24권4호
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• pp.55-67
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• 2011

Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "Bangyakhappyeon(方藥合編)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 324 medicinal herbs in 467 prescriptions, and found meaningful combinations of 5,045. Among these, the most meaningful combination is the one of 10 herbs, Glycyrrhiza uralensis Fischer, Angelica gigas Nakai, Ziziphus jujube Mille, Atractylodes japonica Koidzumi, Poria cocas Wolf, Zingiber officinale, Rehmanniae radix preparata, Cinnamomum loureirii, Panax ginseng C.A.Meyer, Astragalus membranaceus. This combination is Sibjeondaebo-tang(Shiquandabu-tang) without Cnidium officinale and Paeonia japonica which compose Samul-tang(Siwu-tang). It means this combination is kind of modified Sibjeondaebo-tang(Shiquandabu-tang), which is more effective in tonifying qi than tonifying blood. Prescriptions of "Bangyakhappyeon(方藥合編)" involve herbs mostly used to improve weak and frail health and the herbs which are more effective in tonifying qi than tonifying blood. Through this study, we know the author' s one of medical view points on tonifying qi and blood, attaching importance to tonifying qi relatively to tonifying blood.

• 대한한의학원전학회지
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• 제31권4호
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• pp.69-78
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• 2018

Objectives : The aim of this study was to diversify the interpretation of formulas used for insomnia treatment by searching and analyzing herbal combinations in formulas used for insomnia treatment in Korean medicine. Methods : Frequency analysis was conducted on herbal combinations of 255 formulas related with insomnia, along with network analysis using Netminer 4.2.1. Results : This study has found herbal combinations used frequently in Korean medicine formulas used for insomnia treatment, and a result of network analysis composed of four communities. Each community consisted of herbs in affiliation of Yookmijihwangtang(六味地黃湯) and Samultang(四物湯), Bohyulchunghwatang(補血淸火湯) and Ondamtang(溫膽湯), Jungjihwan(定志丸) and Sanjointang(酸棗仁湯). Conclusions : This study could help in assisting researchers to diversify formula analysis in future studies. Moreover, the herbal combination in insomnia formulas could be used to search for insomnia formulas in other databases or creating a new prescription.

• 한국의사학회지
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• 제34권2호
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• pp.89-96
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• 2021

This research aims to find a way to utilize the literature to select the herbs to be added or subtracted according to the condition of the patient after determining the basic prescription to be used for the patient. The study is based on data concerning the herbal composition and application of prescriptions described in the Donguibogam. The composition herbs was expressed as a weight ratio, the standard deviation of the weight ratio was calculated for each prescription, and the case where the weight ratio was greater than the base value (highest weight ratio - standard deviation) was designated as a principal herb. The various expressions of applications were changed to representative terms by the researcher and used to calculate the frequency. Of the 4,373 prescriptions for Donguibogam, 3,307 were able to be expressed in terms of weight ratios with 640 prescriptions using Rehmannia glutinosa, Cnidium officinale, Angelica gigas and Paeonia lactiflora as the principle herb. Of the 640 prescriptions, 508 prescriptions included applied information. Rehmannia glutinosa can also be used for symptoms such as fetal leakage(胎漏), short ingestion(食少), fever(發熱), dazed expression(眼花). Cnidium officinale can also be used for symptoms such as migraine(偏頭痛), stroke(中風癱瘓), tetanus(破傷風). Angelica gigas can also be used for symptoms such as forgetfulness(健忘), incontinence of urination(小便不通), palpitations(驚悸). Paeonia lactiflora can also be used for symptoms such as heart pain and abdominal pain(心腹痛), cough(咳嗽).