• Biomolecules & Therapeutics
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• 제1권2호
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• pp.280-283
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• 1993

Single subcutaneous injection to SD rats of both sexes was performed to investigate the acute toxicity of new skin allergy-remedy ointment, Banaron. Banaron is composed of lidocaine hydrochloride, chloro-pheniramine maleate, prednisolone acetate, chlorohexidine hydrochloride, methyl salicylate, 1-menthol and d-camphor. The results were as fellows. $LD_{50}$, /TEX> values of Banaron were 8373.6 mg/kg for male and 8260.1 mg/kg for females. Death occurred within 24 hours after administration at doses up to 6600 mg/kg. The main cause of deaths seemed to be respiratory disturbance. General symptoms decreased of activity and respiratory rate, salivation, tremor and loss of consciousness which were commonly observed by some survived animals and all dead animals. No significant gross findings of internal organs and body weight changes in treatment groups in comparison with these of control group were observed at the maximum dose levels in Banaron.

• 대한안과학회지
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• 제59권12호
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• pp.1195-1200
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• 2018

목적: 상직근 비대가 동반된 환자에서 상직근 및 하직근 수술 이후 발생한 전안부허혈을 경험하였으며, 현재까지 두 개의 직근수술 이후 발생한 전안부허혈은 국내에서 보고된 바 없어 이를 보고하고자 한다. 증례요약: 80세 남자 환자가 3년 전부터 발생한 복시를 주소로 내원하였다. 제일눈위치에서 30프리즘디옵터의 우안 상사시를 보였고, 눈운동검사에서 우안의 하전운동장애가 관찰되었다. 안와 전산화단층촬영검사에서 우안 상직근 비대 소견이 관찰되었다. 우안 상직근 후전술 및 하직근절제술을 시행하였다. 수술 후 2일째 전안부 검사상 우안의 미만성 각막부종과 데스메막주름이 관찰되었고, 전방 방수흐림 및 동공산대가 관찰되었다. 전안부허혈 진단하에 경구 스테로이드 45 mg으로 치료를 시작하였으며, 1% prednisolone acetate와 0.5% levofloxacin 점안약을 사용하였다. 수술 후 1개월째 제일눈위치에서 정위를 보였고 각막부종, 동공이상이나 전방의 염증은 관찰되지 않았다. 결론: 본 증례를 통해 두 개의 직근을 수술할 때도 전안부허혈의 발생 가능성을 항상 염두에 두어야 함을 알 수 있으며, 고령의 환자에서 수직근수술을 시행할 때 더욱 주의할 것을 권유한다.

• Journal of Photoscience
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• 제9권2호
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• pp.530-533
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• 2002

We present a case of The Miller Fisher Syndrome (MFS), showing a remission during a recently developed noninvasive therapy. Two weeks after an appearance of cough and fever, a 35 years old Japanese male developed diplopia, ataxia and numbness of his fingers and toes. He was diagnosed as MFS, and a fixed dose of prednisolone acetate (60mg/day) was administered for 3 months, but little improvement was observed. In addition to this administration, we tried 20 minutes of Photic Feedback (PFB) treatment daily for 40 days. The PFB system detects brain waves from the subject's forehead, and extracts alpha waves by the band-pass filter with a center frequency set at 10.0Hz. It also simultaneously modulates the augmentation of a red light-emitting diode, corresponding with the amplitudes of the extracted alpha waves. In this treatment, this adjusted photic stimulation was given to the subject's closed eyes, resulting in the effective alpha enhancement by photic driving response. The numbness increased during each of PFB treatment, but the symptoms started to improve gradually after 10 days. Other symptoms disappeared after 40 days. CD20 levels increased with this treatment. This case suggests that the PFB treatment may speed the natural remission of MFS. This treatment may be worth considering in patients who suffer polyneuropathy.

• Biomolecules & Therapeutics
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• 제9권1호
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• pp.40-45
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• 2001

The activity of taurine transporter is affected by various extracellular stimuli such as ion, hormone and stress. To assess effects of steroid hormones antral cyclosporin A (CsA) on the taurine transporter activity, murine monocytic RAW264.7 cell line was stimulated with dexamethasone (DM), triamcinolone (TA), cortisone (CS), hydrocortisone (HCS), prednisone (PSN), prednisolone (PSL) and methylprednisolone (MPSL) in the presence of 12-0-tetradecanoylphorbol-13-acetate(TPA). Treatment of TPA on the cell line led to significant reduction of taurine transporter activity. However, in case of stimulation of the cells with steroid hormones in the presence of TPA, all of them recovered TPA-induced reduction of the taurine transporter activity. Treatment of the cells with CsA led to significant reduction of the taurine transporter activity. Ionomycin (IM) recovered the reduced taurine transporter activity by CsA, but failed in the presence of EDTA, a calcium chelating agent. These results showed that glucocorticoid hormone recovered TPA-induced reduction of taurine transporter activity and that IM recovered CsA-induced reduction of the transporter activity by increasing intracellular free $Ca^{++}$ concentration.n.

• Archives of Pharmacal Research
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• 제29권6호
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• pp.503-507
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• 2006

Flavonoids are known as natural anti-inflammatory agents. In this investigation, an anti-inflammatory potential of new topical preparation (SK Ato $Formula^{\circledR}$) containing flavonoid mixtures from Scutellaria baicalensis Georgi roots and Ginkgo biloba L. leaves with an extract of Gentiana scabra Bunge roots was evaluated in an animal model of chronic skin inflammation. Multiple 12-O-tetradecanoylphorbol-13-acetate treatments for 7 consecutive days on ICR mouse ear provoked a chronic type of skin inflammation: dermal edema, epidermal hyperplasia and infiltration of inflammatory cells. When topically applied in this model, this row formulation $(5-20\;{\mu}L/ear/treatment)$ reduced these responses. Furthermore, it inhibited prostaglandin $E_2$ generation (17.1-33.3%) and suppressed the expression of proinflammatory genes, cyclooxygenase-2 and $interleulin-1{\beta}$ in the skin lesion. Although the potency of inhibition was lower than that of prednisolone, all these results suggest that Ato $Formula^{\circledR}$ may be beneficial for treating chronic skin inflammatory disorders such as atopic dermatitis.

• Parasites, Hosts and Diseases
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• 제36권3호
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• pp.171-182
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• 1998

반추동물에 있어서 쥐와포자충의 감염 동태에 관한 지식에는 불충분한 점이 많다. 그래서 11마리의 1~20일령의 재래산양과 면양에 $2{\;}{\times}{\;}10^7$의 쥐와포자충 (MCR주) 난포낭 (oocyst)을 한 번에 경구투여한 다음 분변 내의 난포낭 배설 양상을 관찰하였다. 11마리의 재래산양과 면양 중 4마리에서만 분턴에서 억대 (108/day/head)에 이르는 난포낭이 검출되었는데 반해 3마리에서 천만대, 나머지 예에서는 극히 적은 수만이 검출되었다. 전기생충증명기는 19-35일로서 평균 $28.1{\;}{\pm}{\;}5.8일$, 기생충증명기는 16-85일로서 평균 $47.8{\;}{\pm}{\;}21.1일$, 분변 내 난포낭 배설량은 최고가 $613.5{\;}{\times}{\;}10^6$, 평균 $156.6{\;}{\times}{\;}10^6{\;}{\pm}{\;}253.6{\;}{\times}{\;}10^$이었으며, 이 원충에 대한 연령의존성 저항은 인정 할 수 없었다 한편, 감염 후 44일째 난포낭 배설 극기에 희생시킨 재래산양의 제4위 점액세포의 미세융모 내에서 이 원충의 모든 단계의 발육기를 관찰할 수 있었다. 모든 발육기에서 바깥쪽이 숙주세포의 두터운 사상돌기로 둘러싸여 있는 쥐와포자충 특유의 전단 돌출부를 볼 수 있었다. 또, 이 원충의 재래산양/마우스 모델 감염실험에서 마우스 고유의 난포낭 배설 양상이 인정되었다. 이 원충의 면역원성과 난포낭의 재생산이 도전감염실험과 면역억제에 의하여 증명되었다. 이상의 실험 결과로 반추수에 있어서 쥐와포자충의 내생발육을 입증하였다.