• 한국자동차공학회논문집
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• 제3권3호
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• pp.9-18
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• 1995

The substitution of conventional fuel oil by alternative fuels is of immense interest due to liquid oil shortage and requirements of emission control standard. Among the alternative fuels, natural gas may be the most rational fuel, because of its widespread resource and clean est burning. Meanwhile, engine simulation is of great importance in engine development. Hence a zero-dimensional combustion model was developed for dual-fuel system. Natural gas was injected directly into the cylinder and small amount of distillate was used to provide the ignition kernel for natural gas burning. The intake air and exhaust gas flow was modeled by filling and emptying method. Although the single zone approach has an inherent limitation, the model showed promise as a predictive tool for engine performance. Its simulation was also made to see how the engine performance was influenced by the fuel injection timings and amount of each fuel.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 추계학술대회논문집
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• pp.903-912
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• 2007

One of the crucial factors which determine the quality and the accuracy of SEA model is how subsystems are defined. Experimental SEA technique had been a unique way to divide entire systems accurately for mid-frequency range, until FEA based virtual FRF response technique, virtual SEA method presented. Virtaul SEA has been developed for predictive SEA tool in early design process. In this study, Modal analysis results from modified crash FE model is used for Statistical transfer matrix. Observation nodes on the cockpit are grouped by attractive substructuring method based on point to point transfer and correlation matrix. Complex cockpit structure is divided into subsystems by automatic substructuring. Comparison with experimental SEA results validates the application of Virtual SEA to cockpit.

• International Journal of Korean Welding Society
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• 제5권1호
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• pp.44-52
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• 2005

The purpose of this study is to establish a design tool for the shrinkage margin of a deckhouse caused by welding and flame straightening. In order to do it, the effects of heat intensity and internal/external restraint condition on the shrinkage of the simple weldments were investigated, in order to identity the principal factors controlling shrinkage caused by welding process and flame straightening. Based on the results, predictive equations for longitudinal and transverse shrinkage at the welded structure were formulated as the function of heat intensity and in-plane rigidity. These equations were verified by comparing predicted results with the measured results at a panel structure of deckhouse.

• 한국항공운항학회지
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• 제18권2호
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• pp.54-59
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• 2010

The flight deck crew must manage complexity during daily flight operations. The Airline may obtain data regarding threats and errors through LOSA(Line Operations Safety Audits) on normal flights as predictive safety tool in Safety Management System of the Airline to actively improve the systems such as SOP(Standard Operation Procedure), training, evaluation and the TEM(Threat and Error Management) for the flight deck crew. The flight deck crew make errors when they fail managing threats. The crew mismanage around ten percent of threats and commit errors. The major mismanaged threats are aircraft malfunction, ATC(Air Traffic Communication), and wether threats. The effective countermeasures of TEM for manageing threats are leadership, workload management, monitor & cross check, Vigilance, communication environment and cooperation of the crew. It is important that organizations must monitor for the hazards of threats and improve system for the safer TEM environments.

• 한국산업융합학회 논문집
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• 제3권1호
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• pp.77-82
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• 2000

The stereoselective ligand exchange reaction of trans-$[Co(SS-epm)Cl_2]^+$ and racemic propane-1,2-diamine (rac-pn) produces the complex that is identified as $[CO(N)_6]^{3+}$ type of $[Co(SS-epm)(pn)]^{3+}$ by absorption spectrum. It is conceivable that the reaction mechanism involves substitution and isomerization. The calculated and experimentally determined ratios of the complexed enantiomeric substrates at equilibrium were as follows: $[Co(SS-epm)(pn)]^{3+}$,calcd 32 % / 68 %, exptl 19 % / 81 % R-pn / S-pn. It has been shown that the employment of molecular mechanics calculations as a predictive tool may lead to the design of chiral complexes that may be applied to the separation of racemic mixtures of simple bidentate ligands.

• Structural Monitoring and Maintenance
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• 제4권2호
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• pp.133-151
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• 2017

The paper describes the results of an experimental and numerical investigation into the structural and damage response of sandwich composites to low-velocity impact. Sandwich panels consisting of laminated composite skins with three different layups bonded to a PVC foam core were subjected to impact at various energy levels corresponding to barely visible impact damage (BVID) in the impacted skins. Damage assessment analyses were performed on the impacted panels to characterise the extent and the nature of the major failure mechanisms occurring in the skins. The data collected during the experimental analyses were finally used to assess the predictive capabilities of an FE tool recently developed by the authors for detailed simulation of impact damage in composite sandwich panels. Good agreement was observed between experimental results and model predictions in terms of structural response to impact, global extent of damage and typical features of individual damage mechanisms.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2004년도 춘계학술대회 논문집
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• pp.206-212
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• 2004

This paper is application of System Assurance(SA) for the rolling stock. As railway systems become more complex, design teams are increasingly under pressure to deliver, design solutions, which integrate both technical and Systems Assurance(SA). Systems Assurance is the application of management methods and analysis techniques to ensure that a design meets Reliability, Availability, Maintainability and Safety (RAMS) criteria. It should be clearly understood that the intent of System Assurance is not just to provide analytical techniques as a metric on performance, but more importantly it should provide a management tool with which to co-ordinate and assure the whole design. System Assurance encompasses the ongoing requirement to consider safety, and RAM through each stage of a Project, from feasibility study through to commissioning and operation. If System Assurance is undertaken properly at feasibility study at the design stages of a Project, the benefits of such analyses can be significant in identifying potential problems early enough for action to be taken before manufacture or installation. At commissioning, RAMS demonstration activities are undertaken to validate the predictive and analytical techniques undertaken during the design.

• 통합자연과학논문집
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• 제4권3호
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• pp.210-215
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• 2011

Holographic quantitative structure-activity relationships (HQSAR) is a useful tool to correlates structures with their biological activities. HQSAR is a two dimensional (2D) QSAR methodology, which generates QSAR equations through 2D fingerprint and correlates it with biological activity. Here, we report a 2D-QSAR model for a series of fifty-one 3,4-dihydroxychalcones derivatives utilizing HQSAR methodology. We developed HQSAR model with 6 optimum numbers of components (ONC), which resulted in cross-validated correlation coefficient ($q^2$) of 0.855 with 0.283 standard error of estimate (SEE). The non-cross-validated correlation coefficient (r2) with 0.966 indicates the model is predictive enough for analysis. Developed HQSAR model was binned in to a hologram length of 257. Atomic contribution map revealed the importance of dihydroxy substitution on phenyl ring.

• 전자공학회논문지A
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• 제33A권5호
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• pp.172-179
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• 1996

In the paper, QCELP (qualcomm code excited linear predictive), CDMA (code division multiple access)'s vocoder algorithm, was analyzed. And then, a ptich parameter seaarch architecture for 16-bit programmable DSP(digital signal processor) for QCELP was designed. Because we speed up the parameter search through high speed DSP using two MACs, we can satisfy speech codec specifiction for the digital celluar. Also, we implemented in FIFO(first-in first-out) memory using register file to increase the access time of data. This DSP was designed using COMPASS, ASIC design tool, by top-down design methodology. Therefore, it is possible to cope with rapid change at mobile communication market.

• Biomolecules & Therapeutics
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• 제22권4호
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• pp.267-274
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• 2014

Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive and efficient tools are required to discover high quality targets and increase the probability of success in the process of new drug development. One such solution to the challenges faced in the development of new drugs and combination therapies is the use of low-cost and experimentally manageable in vivo animal models. Since the 1980's, scientists have been able to genetically modify the mouse genome by removing or replacing a specific gene, which has improved the identification and validation of target genes of interest. Now genetically engineered mouse models (GEMMs) are widely used and have proved to be a powerful tool in drug discovery processes. This review particularly covers recent fascinating technologies for drug discovery and preclinical trials, targeted transgenesis and RNAi mouse, including application and combination of inducible system. Improvements in technologies and the development of new GEMMs are expected to guide future applications of these models to drug discovery and preclinical trials.