• Title/Summary/Keyword: prediction of fracture risk

Search Result 16, Processing Time 0.037 seconds

Usefulness of Fracture Risk Assessment Tool Using Lumbar Bone Mineral Density in Prediction of Osteoporotic Vertebral Fracture

  • Lee, Heui Seung;Lee, Sang Hyung;Chung, Young Seob;Yang, Hee-Jin;Son, Young-Je;Park, Sung Bae
    • Journal of Korean Neurosurgical Society
    • /
    • v.58 no.4
    • /
    • pp.346-349
    • /
    • 2015
  • Objective : To investigate the value of lumbar bone mineral density (BMD) in fracture risk assessment (FRAX) tool. Methods : One hundred and ten patients aged over 60 years were enrolled and divided into 2 groups as non-osteoporotic vertebral fracture (OVF) and OVF groups. The 10-year-risk of major osteoporotic vertebral fracture of each group was calculated by FRAX tool with femoral and lumbar spine BMDs to compare the usefulness of lumbar spine BMD in prediction of OVF. The blood level of osteocalcin and C-terminal telopeptide (CTX) as markers of activities of osteoblast and osteoclast, respectively were analyzed using the institutional database. Results : In the OVF group, the ratio of patients with previous fracture history or use of glucocorticoid was higher than those in non-OVF group (p=0.000 and 0.030, respectively). The levels of T-score of femur neck and lumbar spine in OVF group were significantly lower than those in non-OVF group (p=0.001 and 0.000, respectively). The risk of OVF in FRAX using femur BMD in non-OVF and OVF groups was $6.7{\pm}6.13$ and $11.4{\pm}10.06$, respectively (p=0.007). The risk of using lumbar BMD in the 2 groups was $6.9{\pm}8.91$ and $15.1{\pm}15.08$, respectively (p=0.002). The areas under the receiver operator characteristic curve in the FRAX risk with lumbar and femur neck BMD were 0.726 and 0.684, respectively. The comparison of osteocalcin and CTX was not significant (p=0.162 and 0.369, respectively). Conclusion : In our study, the 10-year risk of major osteoporotic fracture in the OVF group of our study was lower than the recommended threshold of intervention for osteoporosis. Hence, a lower threshold for the treatment of osteoporosis may be set for the Korean population to prevent OVF. In the prediction of symptomatic OVF, FRAX tool using lumbar spine BMD may be more useful than that using femur neck BMD.

CAE based risk prediction for sharp edge improvement (샤프엣지 개선을 위한 해석적 리스크 검토법)

  • Nam, Byeung Gun;Park, Shin Hee;Kim, Hyun Sup
    • Journal of Auto-vehicle Safety Association
    • /
    • v.6 no.2
    • /
    • pp.36-42
    • /
    • 2014
  • In order to prevent the sharp edge during the side impact, a cause analysis and CAE based risk prediction were carried out in this study. It was found that sharp edge occurs mainly because of stiffness difference between the major parts and structural stress concentration. It could be improved by directly reinforcing the crack initiation region or by weakening the joints connecting the parts. The fracture criterion based on major in-plain strain was suggested and the risk prediction process for sharp edge prevention was established.

Analysis of Fracture Risk due to Alterations of Bone Quality by Metastatic Bone Tumor (전이성 골암으로 인한 골질 변화와 이로 인한 골절 위험성 분석)

  • Lim, Dohyung
    • Journal of Biomedical Engineering Research
    • /
    • v.33 no.4
    • /
    • pp.213-222
    • /
    • 2012
  • While much has been learned about the mechanisms of metastatic spread of cancer to bone, there has been little headway in establishing guidelines for monitoring the alteration in bone quality and estimating fracture risk. The aims of this study are, therefore, 1) to evaluate bone quality induced by metastatic bone tumor by analyzing the characteristics on bone microarchitecture and degree of bone mineralization and 2) analyze fracture risk increased secondary to the bone quality changes by metastatic bone tumor through calculating mechanical rigidities based on in-vivo micro CT images. For this study, eighteen female SD rats (12 weeks old, approximate 250 g) were randomly allocated in Sham and Tumor groups. W256 (Walker carcinosarcoma 256 malignant breast cancer cell) was inoculated in the right femur (intraosseous injection) in Tumor group, while 0.9% NaCl (saline solution) was injected in Sham group. The right hind limbs of all rats were scanned by in-vivo micro-CT to acquire structural parameters and degree of bone mineralization at 0 week, 4 weeks, 8 weeks, and 12 weeks after surgery. At the same time, urine was collected by metabolic cages for a biochemical marker test in order to evaluate bone resorption. Then, bone metastasis had been directly identified by positron emission tomography. Finally, axial, bending and torsional rigidities had been calculated based on in-vivo micro CT images for predict fracture risk. The results of this study showed that metastatic bone tumor might induce significant decrease in bone quality and increase of fracture risk. This study may be helpful to monitoring a degree of bone metastasis and predicting fracture risk due to metastatic bone tumor. In addition, this noninvasive diagnostic methodology may be utilized for evaluating other bone metabolic diseases such as osteoporosis.

Development of Prediction Model for 1-year Mortality after Hip Fracture Surgery

  • Konstantinos Alexiou;Antonios A. Koutalos;Sokratis Varitimidis;Theofilos Karachalios;Konstantinos N. Malizos
    • Hip & pelvis
    • /
    • v.36 no.2
    • /
    • pp.135-143
    • /
    • 2024
  • Purpose: Hip fractures are associated with increased mortality. The identification of risk factors of mortality could improve patient care. The aim of the study was to identify risk factors of mortality after surgery for a hip fracture and construct a mortality model. Materials and Methods: A cohort study was conducted on patients with hip fractures at two institutions. Five hundred and ninety-seven patients with hip fractures that were treated in the tertiary hospital, and another 147 patients that were treated in a secondary hospital. The perioperative data were collected from medical charts and interviews. Functional Assessment Measure score, Short Form-12 and mortality were recorded at 12 months. Patients and surgery variables that were associated with increased mortality were used to develop a mortality model. Results: Mortality for the whole cohort was 19.4% at one year. From the variables tested only age >80 years, American Society of Anesthesiologists category, time to surgery (>48 hours), Charlson comorbidity index, sex, use of anti-coagulants, and body mass index <25 kg/m2 were associated with increased mortality and used to construct the mortality model. The area under the curve for the prediction model was 0.814. Functional outcome at one year was similar to preoperative status, even though their level of physical function dropped after the hip surgery and slowly recovered. Conclusion: The mortality prediction model that was developed in this study calculates the risk of death at one year for patients with hip fractures, is simple, and could detect high risk patients that need special management.

Prediction of Thoracic Injury of Older Occupant from Belt Loading (벨트 하중에 따른 고령운전자의 흉곽 상해 예측)

  • Han, In-Seok;Kim, Young-Eun
    • Transactions of the Korean Society of Mechanical Engineers A
    • /
    • v.33 no.8
    • /
    • pp.799-806
    • /
    • 2009
  • Thoracic injury from restraint loading is the principle causative factor of death, which was shown to be particularly significant for older drivers. To characterize thoracic response to belt loading of older drivers, detailed finite element models of the adult and aged thorax were developed. The geometry of the 50th percentile adult male was chosen for the adult FE model. The thoracic FE model was validated against data obtained from results of PMHS pendulum impact tests. The quantified patterns of age-related shape and well-established material changes were applied to the adult model to develop the aged model. Belt force and chest deflection were applied to the developed two types of models. Rib and clavicle fracture risk obviously increased in the aged model. This finding showed that larger rib angle and reduced material properties of the ribcage produced more higher risk of injury in the older driver.

Prediction of Joining Torque for Bit Depth of Subminiature Bolt (초소형 볼트의 비트 깊이에 따른 체결 토크 예측)

  • Lee, Hyun-Kyu;Park, Keun;Ra, Seung-Woo;Kim, Jong-Bong
    • Transactions of the Korean Society of Mechanical Engineers A
    • /
    • v.38 no.8
    • /
    • pp.917-923
    • /
    • 2014
  • Subminiature joining bolts are required for the electronic parts of gadgets such as mobile phones and watch phones. During the miniaturization of bolt heads, it is difficult to obtain sufficient joining force owing to the risk of shear fracture of the bolt head or severe plastic deformation on the bit region. In this study, the maximum joining torque for the bit depth was predicted using finite element analysis. A shear fracture test was conducted on a wire used in bolt forming. The results of this test were subjected to finite element analysis and a fracture criterion was obtained by comparing the experimental and analysis results. The shear fracture of the bolt head during joining was predicted based on the obtained criterion. Furthermore, the maximum joining torque was predicted for various bit depths. Fracture on the boundary between the bolt head and thread was found to occur in lower joining torque as bit depth increases.

Structural Reliability Evaluation on Solder Joint of BGA and TSSOP Components under Random Vibration using Reliability and Life Prediction Tool of Sherlock (신뢰성 수명예측 도구 Sherlock을 활용한 랜덤진동에서의 BGA 및 TSSOP 솔더 접합부의 구조 신뢰성 평가)

  • Park, Tae-Yong;Park, Jong-Chan;Park, Hoon;Oh, Hyun-Ung
    • Journal of the Korean Society for Aeronautical & Space Sciences
    • /
    • v.45 no.12
    • /
    • pp.1048-1058
    • /
    • 2017
  • One of the failure mechanism of spaceborne electronics is a fatigue fracture on solder joint under launch random vibration. Thus, a necessity of early diagnosis through the fatigue life evaluation on solder joint arises to prevent such potential risk of failure. The conventional life prediction methods cannot assure the accuracy of life estimation results if the packaging type changes, and also requires much time and effort to construct the analysis model of highly integrated PCB with various packaging types. In this study, we performed life prediction of PCB based on a reliability and life prediction tool of sherlock as a new approach for evaluating the structural reliability on solder joint, and those prediction results were validated by fatigue tests. In addition, we also investigated an influence of solder height on the fatigue life of solder joint. These results indicated that the Sherlock is applicable tool for evaluating the structural reliability of spaceborne electronic.