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A Systematic Review of Clinical Studies for Herbal Medicine of Dementia - based on Korean Literature - (치매의 한약물 치료에 대한 체계적 임상논문 고찰 - 국내문헌을 중심으로 -)

  • Kwon, Yong-Ju;Cho, Hye-Young;Whang, Wei-Wan;Cho, Seung-Run
    • Journal of Oriental Neuropsychiatry
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    • v.21 no.4
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    • pp.151-161
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    • 2010
  • Objectives : This study aimed to evaluate any clinical studies regarding the herbal medicine for dementia focusing on Korean literature for future rigorous clinical research. Methods: Every article relevant to dementia was initially obtained from oriental medical related journals by electronic search at journal web sites or manual searches. Journals were limited to those registered with the Korea Research Foundation. From initial findings. two independent reviewers selected clinical articles and these articles were further analyzed separately by predefined criteria according to prospective and retrospective studies. For randomized controlled trial and non randomized controlled trial. quality assessment was also conducted. Results: From ninety seven patients initially obtained articles. twenty three patients were finally analyzed. One article was randomized controlled study. Four articles were prospective whereas eighteen patients were retrospective. In the qualitative evaluation of prospective articles. there was deduction regarding pre-calculated study size and prospective data collecting. Assessment measurement most frequently used was Mini Mental State Examination. The order of frequency of use herbs were identified. Conclusions : According to our study. the herbal medicine for dementia in general showed a positive effect in the cognitive aspects of dementia patients. Further well-designed randomized controlled studies should be conducted.

Membrane Topology of Helix 0 of the Epsin N-terminal Homology Domain

  • Kweon, Dae-Hyuk;Shin, Yeon-Kyun;Shin, Jae Yoon;Lee, Jong-Hwa;Lee, Jung-Bok;Seo, Jin-Ho;Kim, Yong Sung
    • Molecules and Cells
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    • v.21 no.3
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    • pp.428-435
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    • 2006
  • Specific interaction of the epsin N-terminal homology(ENTH) domain with the plasma membrane appears to bridge other related proteins to the specific regions of the membrane that are invaginated to form endocytic vesicles. An additional $\alpha$-helix, referred to as helix 0 (H0), is formed in the presence of the soluble ligand inositol-1,4,5-trisphosphate [$Ins(1,4,5)P_3$] at the N terminus of the ENTH domain (amino acid residues 3-15). The ENTH domain alone and full-length epsin cause tubulation of liposomes made of brain lipids. Thus, it is believed that H0 is membrane-inserted when it is coordinated with the phospholipid phosphatidylinositol-4,5-bisphosphate [$PtdIns(4,5)P_2$], resulting in membrane deformation as well as recruitment of accessory factors to the membrane. However, formation of H0 in a real biological membrane has not been demonstrated. In the present study, the membrane structure of H0 was determined by measurement of electron paramagnetic resonance (EPR) nitroxide accessibility. H0 was located at the phosphate head-group region of the membrane. Moreover, EPR line-shape analysis indicated that no pre-formed H0-like structure were present on normal acidic membranes. $PtdIns(4,5)P_2$ was necessary and sufficient for interaction of the H0 region with the membrane. H0 was stable only in the membrane. In conclusion, the H0 region of the ENTH domain has an intrinsic ability to form H0 in a $PtdIns(4,5)P_2$-containing membrane, perhaps functioning as a sensor of membrane patches enriched with $PtdIns(4,5)P_2$ that will initiate curvature to form endocytic vesicles.

Thematic Map Construction of Erosion and Deposition in Rivers Using GIS-based DEM Comparison Technique

  • Han, Seung Hee
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.34 no.2
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    • pp.153-159
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    • 2016
  • Rivers refer to either natural or artificial structures whose primary functions are flood control and water conservation. Due to recent localized torrential downpours led by climate change, large amounts of eroded soil have been carried away, forming deposits downstream, which in turn degrades the capacity to fulfill these functions. To manage rivers more effectively, we need data on riverbed erosion and deposition. However, environmental factors make it challenging to take measurements in rivers, and data errors tend to prevent researchers from grasping the current state of erosions and deposits. In this context, the aim of the present study is to provide basic data required for river management. To this end, the author made annual measurements with a Real-time Kinematic-Global Positioning System (RTK-GPS) and a total station in Pats Cabin Canyon, Oregon, United States, and also prepared thematic maps of erosion and deposition thickness as well as water depth profiles based on a GIS spatial analysis. Furthermore, the author statistically analyzed the accuracy of three dimensional (3D) measurement points and only used the data that falls within two standard deviations (i.e. ±2σ). In addition, the author determined a threshold for a DEM of Difference (DoD) by installing measurement points in the rivers and taking measurements, and then estimated erosion and deposition thickness within a confidence interval of ±0.1m. Based on the results, the author established reliable data on river depth profiles and thematic maps of erosion and deposition thickness using pre-determined work flows. It is anticipated that the riverbed data can be utilized for effective river management.

The Current State of Food Allergy of Preschool Childcare Facilities in Hanam (하남시 영유아 보육시설의 식품알레르기 현황 조사 - 100인 미만의 어린이 급식소를 중심으로 -)

  • Cho, Wookyoun;Kim, Jinah
    • Korean Journal of Community Nutrition
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    • v.20 no.4
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    • pp.251-258
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    • 2015
  • Objectives: The purpose of this study was to investigate how to manage food allergy of pre-school children, focusing on the current status of the food allergy in childcare facilities in Hanam which have less than 100 children. Methods: Targeting 159 preschool childcare facilities, survey was carried out for a month in March, 2015. Recovery rate was 66.7%. 106 surveys out of 159 were available for analysis using SPSS statistical program version 19.0. Results: Among 106 facilities, 58 (54.7%) reported that none of their children had a food allergy and 48 (45.3%) reported one more children had a food allergy. Total number of children having a food allergy was 71. Among them, the occurrences of food allergy in males were significantly more than that of the females (p<0.001). Further, children under 2 years of age had significantly more food allergy than the other ages (p < 0.001). The allergic inducing foods were nuts (23.3%), egg (17.8%), milk and dairy products (16.4%), fish and shellfish (13.7%), instant foods (12.3%), fruits (8.2%), soybean (4.1%), meat (2.7%), and cereals (1.4%) in order, and 6 children out of 71 were allergic to more than 2 food items. The clinical symptoms of the food allergy were a skin reaction (87.9%) and an oropharyngeal & respiratory reaction (12.1%). Majority of childcare facilities (80.3%) didn't serve alternative foods for children with food allergy. Necessity for food allergy education was significantly higher in facilities with food allergy issues than without such issues. Conclusions: The Center for Children's Foodservice Management need to educate workers of childcare facilities and parents about managing food allergy and enforce a plan to provide alternative menu to children with food allergies.

Psychological analysis of dental orthodontic patients using SCL-90-R (간이정신진단검사를 이용한 치과교정환자의 심리분석)

  • Ko, Hyo-Jin;Lee, So-Young;Yu, Byeng-Chul
    • Journal of Korean society of Dental Hygiene
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    • v.12 no.1
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    • pp.37-46
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    • 2012
  • Objectives : This research was investigated to evaluate the psychological characteristics and changes of psychological state among dental orthodontic patients. Methods : This cross-sectional questionnaire research was conducted with 230 dental orthodontic patients in Busan from December 23, 2009 to March 6, 2010. The psychological analysis of dental orthodontic treatment patients was performed with Symptom checklist-90-revision(SCL-90-R) considering 5 general characteristics and 2 treatment period related characteristics. Estimated psychological results were changed T-score. Data analysis was performed with descriptive analysis, t-test and ANOVA using SAS(ver 9.1) program. Results : The levels of T-score of SCL-90-R were $43.88{\pm}7.50$ in hostility(HOS), $43.38{\pm}4.64$ in phobic anxiety(PHOB), $43.20{\pm}6.24$ in somatization(SOM), $42.13{\pm}6.71$ in paranoid ideation(PAR), $41.39{\pm}8.16$ in interpersonal sensitive(I-S), $41.01{\pm}7.90$ in obsessive-compulsive(O-C), $40.96{\pm}5.37$ in psychoticism(PSY), $40.96{\pm}5.19$ in anxiety(ANX) and $39.81{\pm}6.80$ in depression(DEP), respectively. The T-score of phobic anxiety in before treatment group was higher than that of treatment groups. The T-score of interpersonal sensitive and paranoid ideation in over 36 months treatment period group were higher than that of other treatment period groups. Conclusions : Phobic anxiety(PHOB), interpersonal sensitive(I-S) and paranoid ideation(PAR) were affected in pre-treatment and long-term treatment dental orthodontic patients. Psychological management methods considering treatment period are needed to improve mental health of dental orthodontic patients.

A Study on Revision & Development on the 'Model -Curriculum of the Library Science of the Junior College (전문대학도서관과의 모형교육과정 수정개발에 관한 연구)

  • So Si Joong
    • Journal of the Korean Society for Library and Information Science
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    • v.18
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    • pp.213-276
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    • 1990
  • To revise and develop a 'Model' Curriculum for training the middle standing professionals equipped with professional technology and theories at the spot of the library, such process were executed as research on bibliographic material and literature, utilization of examination of various questionnaires, interviews with middle standing librarians at the spot of the library, a review on the operational state of the Professor's Association of Library Science of Junior Colleges, some consultation with the Research & Deliberation Committee on Curriculums, etc., and to review the present department of library science at the two-year course's short-term colleges or institutes in foreign countries, Germany which is thought to be similar to our nation's situations and its level of economy and Singapore which is considered to be a newly emerging nation were looked into typically. In particular, since studies on the curriculums of the Library Science Dept. of colleges had already preceded, thereby the framework of the 'Model' curriculum was already achieved, however to review how well such framework is applied to the spot of education and give some improvement on that, some unrelistic findings of different subjects in consideration with reality, while comparing those curriculum schedules of each Library Science Dept. with the 'Model' curriculum schedule, were supplemented or revised to be fit to reality. For some supplementing or revising proposals on the pre studied 'Model' curriculum, some tentative plans which focussed on each field respectively and some tentative plans which focussed on cultural subjects, required major subjects and elective subjects were suggested in duality to be referred to. On such a process of forming a harmony of educational theories and practice, it was planned to revise and develop curriculum in a sense emphasizing on practical exercise, and tried not to neglect on each of the fields of the curriculum centered on the areas of materials organization, linguistics, information resource, information science, library organization, & administration, etc. The study on curriculums should be performed flexible to be applied to the accelerating transition of sciences, and be good examples in instruction.

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Insights into the state of radiation protection among a subpopulation of Indian dental practitioners

  • Binnal, Almas;Rajesh, Gururaghavendran;Denny, Ceena;Ahmed, Junaid;Nayak, Vijayendra
    • Imaging Science in Dentistry
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    • v.43 no.4
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    • pp.253-259
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    • 2013
  • Purpose: Radiographs is an integral part of patient management in dentistry, despite their detrimental effects. As the literature pertaining to radiation protection among Indian dental practitioners is sparse, exploring such protection is needed. Materials and Methods: All private dental practitioners in Mangalore, India were included in the study. A structured, pre-tested, self-administered questionnaire was employed to assess the knowledge, attitudes, practices, previous training, perceptions towards the need to spread awareness, and willingness to gain and implement knowledge about radiation hazards and protection. Information regarding each respondent's age, gender, education, and type and duration of practice was collected. Results: Overall, 87 out of 120 practitioners participated in the study. The mean knowledge, attitude, and practice scores were $9.54{\pm}2.54$, $59.39{\pm}7.01$, and $5.80{\pm}3.19$, respectively. Overall, 25.3% of the respondents had undergone training in radiation protection, 98.9% perceived a need to spread awareness, and 94.3% were willing to improve their knowledge. Previous training showed a significant correlation with age, sex, and duration of practice; attitude was significantly correlated with education and type of practice; and knowledge scores showed a significant correlation with type of practice. Conclusion: Although the knowledge and practices of respondents were poor, they had a positive attitude and were willing to improve their knowledge. Age, sex, and duration of practice were associated with previous training; education and type of practice with attitude scores; and type of practice with knowledge scores. The findings of this study suggest a policy is needed to ensure the adherence of dental practitioners to radiation protection guidelines.

Effect Of Tetracycline And Root Planing Methods On The Root Surface (치주과용 쿠렛과 Roto bur를 이용한 치근면 활택술을 시행한 치근의 변화 및 치근에 도포된 Tetracycline HC1의 효과에 대한 비교 연구)

  • Park, Hae-Seung;Lim, Sung-Bin;Chung, Chin-Hyung
    • Journal of Periodontal and Implant Science
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    • v.27 no.1
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    • pp.191-203
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    • 1997
  • Recently, alteration on chemical treatment on the root and removal of pathologic bacteria, which is the main reason for periodontal disease, by complete removal of infected cementum layer was been emphasied In this study, teeth extracted due to periodontal disease were root planed using periodontal curette and roto bur. Then they were treated with different concentration of Tetracycline HCI at different time. The state of root surface and change in the pre and post treatment was observed. The results were as follows. 1. The group treatment with periodontal curette and saline showed remaining plaque, debris and irregular surface and no dentianl tubule orifice could be seen. 2. The group treatment with periodontal curette and tetracycline HCI showed process compoed with decacified material and there was concanity seemed to be a lacunae of cementocyte. 3. The group treatment with roto bur and saline, there was no remaning plaque and partial dentinal tubule orifice could be seen but smear layer covering them.4. The group treatment with roto bur and tetracycline HCI showed various shape and size dentinal tubule orifice could be seen. From the results, roto bur showed cleaner surfaces than treatment with periodontal curette. But still smear layer existed. Thus for regeneration of periodontal tissue, chemical treatment using tetracycline HCI should follow roto bur treatment. And it is considered that the treatment time is more important than the concentration of tetracycline HCl.

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Analysis of Research Trends in Papers Published in the Journal of Korean Academy of Child Health Nursing (2005-2009) (아동간호학회지 게재논문의 연구동향 분석(2005-2009년))

  • Kim, Jin-Sun;Lim, Ji-Young;Kwon, In-Soo;Kim, Tae-Im;Park, Ho-Ran;Ahn, Hae-Young;Lee, Soo-Yeon;Jung, Hyang-Mi
    • Child Health Nursing Research
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    • v.17 no.2
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    • pp.100-110
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    • 2011
  • Purpose: The purpose of this study was to analyze papers published in the Journal of Korean Academy of Child Health Nursing (JKACHN) to identify the current state of child health nursing research and recommend directions for future research. Methods: Using analysis criteria developed by the researchers, 233 papers published in JKACHN between 2005 and 2009 were reviewed. Results: Both quantity and quality of these papers showed significant improvement compared to before 2005. The number of published papers, the proportion of intervention studies, and studies that involved children directly as participants had increased. However, published papers still leave much to be desired. Quantitative studies were dominant (91.4%) and many of these studies were survey designs (65.7%). Children, especially young children were still less likely to be direct participants. All experimental studies were quasi or pre-experimental studies. There were few qualitative research studies. Conclusion: Findings of this study indicate that strengthening peer review according to review guidelines will improve the quality of published papers and promote JKACHN as an international journal. Instead of proxy accounts from parents or nurses, research involving direct accounts by children is needed. Child-friendly data collection methods need to be developed and used by child health nurse researchers.

An Efficient Channel Feedback Method for Zeroforcing Beamforming Based Multi-User Multiple-Input Multiple-Output System (ZFBF 기반 다중 사용자 MIMO 시스템을 위한 효과적인 채널 피드백 기법)

  • Oh, Tae-Youl;Ahn, Sung-Soo;Choi, Seung-Won
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.34 no.9A
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    • pp.673-678
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    • 2009
  • This paper presents a feedback method for improving the system capacity of MU-MIMO system for downlink channel environments. In a typical conventional feedback method, CVQ, in order to enhance the channel capacity, not only the feedback load is increased but also the quantization of the channel vector is increased, because the channel parameter of each user has to be fed back after quantizing one of the pre-defined N-codebook vectors. In this paper, a novel feedback method is proposed which provides an improved system capacity by transferring the channel state information without increasing the feedback load. Performance of the proposed method is compared to the conventional CVQ method through computer simulations. The simulation results show that the proposed method with 3-bit feedback provides a system capacity comparable to the CVQ method of 6-bit feedback when the number of transmit antennas is 2.