• 소성∙가공
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• 제7권1호
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• pp.81-93
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• 1998

Identification of forming limits of sheet metals is an important task to be done before the sheet metal forming processes. The information of the forming limit is indispensable for design of deformed shapes and related forming processes. This procedure becomes more important than ever as the auto-body becomes complicated and the number of auto-body parts is reduced for lower production cost. To identify the forming limit of sheet metals stretching with a hemispherical punch has gained popularity because of the convenient experimental procedure. The stretching experiment however has localized deformation or the shear band is originated from the non-unifrom deformation in the critical circum-stance instead of the absolute criterion. More accurate information of the forming limit therefore could be obtained by a more appropriate experiment to the real process. In this papaer an experiment program is devised to practivally identify the forming limits of sheet metals for auto-body parts. The experiment program contains not only stretching but deep-drawing Both forming experiments use the same hemispherical punch while they use different specimens. Deep-drawing experiments use speci-mens cut out in circular arc on both sides of circular blank to make it torn during the deep-drawing They also use speciments cut out straight in one side of a circular blank to make it deformed unevenly which causes local deformation during the deep-drawing. The experimental result demonstrates that the forming limit diagrams in the two cases show difference in their effective magnitude. The forming limit curve from deep-drawing is located lower than that from stretching. It is noted from the result that the deep-drawing process causes acceleration of localized deformation in comparison with the stretching process. From the experimental result the maximum value of forming limit could be pre-dicted for safe design.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권2호
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• pp.118-126
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• 2018

Purpose: Classical criteria for diagnosis of autoimmune hepatitis (AIH) are intended as research tool and are difficult to apply at patient's bedside. We aimed to study the accuracy of simplified criteria and the concordance with the expert diagnosis based on the original criteria. Methods: A cohort of children under study for liver disorder was selected through consecutive sampling to obtain the prevalence of AIH within the group of differential diagnoses. AIH was defined, based on classical criteria, through committee review of medical reports. Validity indicators of the simplified criteria were obtained in an intention to diagnose approach. Optimal cut-off and the area under the receiver operating characteristic (ROC) curve were calculated. Results: Out of 212 cases reviewed, 47.2% were AIH. For the optimal cut-off (6 points), the simplified criteria showed a sensitivity of 72.0% and a specificity of 96.4%, with a 94.7% positive and a 79.4% negative predictive value. The area under the ROC curve was 94.3%. There was a good agreement in the pre-treatment concordance between the classical and the simplified criteria (kappa index, 0.775). Conclusion: Simplified criteria provide a moderate sensitivity for the diagnosis of AIH, but may help in indicating treatment in cases under suspicion with 6 or more points.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2647-2650
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• 2014

Background: Colorectal cancers(CRC) are the third most common cancer in the western world, with surgery preferred for management of non-metastatic disease and post surgical treatment usually arranged according to the TNM staging system. However, there is still prognostic variation between patients who have the same stage. It is increasingly recognized that variations within disease course and clinical outcome in colorectal cancer patients are influenced by not only oncological characteristics of the tumor itself but also host response factors. Recent studies have shown correlation between the inflammatory response and clinical outcomes in various cancers. The neutrophil/lymphocyte ratio (NLR) has been described as a marker for immune response to various stimuli including cancer. Material-Methods: Two hundred eighty-one CRC patients were included in our retrospective analysis, separated into two groups according to a cut-off value for the NLR. Patient data including age, gender, vertical penetration, anatomic location, and differentiation of the tumor, TNM stage, survival rate, and disease-free survival were analyzed for correlations with the NLR. Results: Using ROC curve analysis, we determined a cut-off value of 2.2 for NLR to be best to discriminate between patient survival in the whole group. In univariate analysis, high pretreatment NLR (p=0.001, 95%CI 1.483-4.846), pathologic nodal stage (p<0.001, 95%CI 1.082-3.289) and advanced pathologic TNM stage (p<0.001, 95%CI 1.462-4.213) were predictive of shorter survival. In multivariate analysis, advanced pathologic TNM stage (p=0.001, 95%CI 1.303-26.542) and high pretreatment NLR (p=0.005, 95%CI 1.713-6.378) remained independently associated with poor survival. Conclusions: High pre-treatment NLR is a significant independent predictor of shorter survival in patients with colorectal cancer. This parameter is a simple, easily accessible laboratory value for identifying patients with poorer prognosis.

• 대한환경공학회지
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• 제38권3호
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• pp.128-134
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• 2016

S 매립장 매립가스 발전시설을 대상으로 발전량에 미치는 주요 요소와 그 영향도를 분석하였다. 50 MWh 24시간의 정상가동 일수는 2007년부터 2014년까지의 총 운전기간 일수대비 70.9%이었으며, 실제 생산한 전력은 이론적인 최대 발전 가능량 3,428,400 MW의 79.3%이었다. 발전효율에 영향을 미치는 주요 요소는 정기점검 등이 44.0%, 황화수소로 인한 감축운전이 37.4% 그리고 공기예열기 세정 18.6% 순이었다. 그러나 황화수소 감축운전 기간이 2년인 점을 감안하면 고농도 황화수소 발생이 매립가스 발전에 가장 큰 영향을 미치고 있었다. 장기적인 발전 가능량 분석결과 매립종료 해인 2018년 35.9 MWh 이었으며 이후 지속적으로 감소하여 2028년 16.6 MWh, 2038년에는 8.4 MWh 이하가 될 것으로 예측되었다.

• Journal of Nutrition and Health
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• 제36권10호
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• pp.1071-1082
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• 2003

The objective of this study was to evaluate and improve the microbiological quality of HACCP application in school foodservice operations. The microbiological quality of foods and utensils were evaluated two times at each critical control point (CCP) with 3M petrifilm in five Daegu elementary schools. Two processes were evaluated: Heating process and after-heating process. The CCPs of the heating process were receiving, cooking and serving temperatures. The CCPs of the after-heating process were personal hygiene, cross contamination avoidance and serving temperature. After the first experiment, 31 employees of five schools were classroom educated, trained on-site, and pre- and post-tested on HACCP-based sanitation with the goal of improving the microbiological quality of the foodservice. Scores representing knowledge of holding, thawing, washing, food temperature, sanitizing and food-borne illness increased after education. In the heating process, internal food temperatures in the first and second experiments were higher than 74$^{\circ}C$, the holding temperature in the first experiment was less than 6$0^{\circ}C$. In the second experiment, the serving temperature improved to a satisfactory level. The microbiological quality in the second experiment improved by decreasing the time from cooking to serving. In the after-heating process, the ingredients were boiled before being cut in the first experiment. In the second experiment, ingredients were cut before being boiled, improving microbiological quality. Also in the second experiment, cooking just before serving food improved its microbiological quality through time-temperature control. These results strongly suggest it is essential to measure microbiological quality regularly and to educate employees on HACCP continuously, especially time-temperature control and cross contamination avoidance in order to improve foodservice quality.

• The Plant Pathology Journal
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• 제24권3호
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• pp.309-316
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• 2008

Mycelium of Ophiostoma quercus albino strain cultured in liquid culture media was harvested, lyophilized, and stored for examining biocontrol efficacy against wood discoloration by staining fungi in the laboratory and field conditions. Dry weight of mycelium grown in brown sugar yeast extract broth(BYB) showed 3.8 times higher than that grown in potato dextrose broth(PDB). The optimum culture period in BYB was 4 weeks. In vitality test of the albino strain, the lyophilized mycelium stored in liquid nitrogen($-196^{\circ}C$) or in a refrigerator($4^{\circ}C$) kept the vitality until 13 months after storage; however, the mycelium stored at room temperature lost the vitality completely after 13 months. The mycelium stored in liquid nitrogen or in a refrigerator protected wood chips from the discoloration by pretreating mycelial suspension on pine wood chips. The mycelium stored at room temperature for 7 months also showed complete protection. These results suggest that the lyophilized mycelium have a biocontrol efficacy only if it keeps the least vitality. In the field conditions, both albino strain and $Woodguard^{(R)}$(commercial chemical protectant) showed significant differences(p=0.05) in discoloration rate as compared to the non-treated control when these were treated on the wood logs of Pinus rigida. The albino strain showed better protection than $Woodguard^{(R)}$. Isolation frequency of blue stain fungi from the chips of wood logs treated with the albino strain was 0% at three months after treatment, while that treated with $Woodguard^{(R)}$ was 76.7%. In another experiment, pre-treatment of mycelial suspension on the cut surface of wood logs also showed significant protection from wood discoloration. Spraying of both albino strain on the cut surface and insecticides on the bark also showed relatively good control effects as compared to insecticide alone on the bark or nontreated control.

• Journal of Korean Neurosurgical Society
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• 제50권5호
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• pp.426-433
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• 2011

Objective : The Histoculture Drug Response Assay (HDRA), which measures chemosensitivity using minced tumor tissue on drug-soaked gelfoam, has been expected to overcome the limitations of in vitro chemosensitivity test in part. We analyzed interim results of HDRA in malignant gliomas to see if the test can deserve further clinical trials. Methods : Thirty-three patients with malignant gliomas were operated and their tumor samples were examined for the chemosensitivity to 10 chosen drugs by HDRA. The most sensitive chemotherapy regimen among those pre-established was chosen based on the number of sensitive drugs or total inhibition rate (IR) of the regimen. The response was evaluated by 3 month magnetic resonance image. Results : Among 13 patients who underwent total resection of the tumor, 12 showed no evidence of disease and one patient revealed progression. The response rate in 20 patients with residual tumors was 55% (3 complete and 8 partial responses). HDRA sensitivity at the cut-off value of more than one sensitive drug in the applied regimen showed a sensitivity of 100%, specificity of 60% and predictability of 70%. Another cut-off value of >80% of total IR revealed a sensitivity of 100%, specificity of 69%, and predictability of 80%. For 12 newly diagnosed glioblastoma patients, median progression-free survival of the HDRA sensitive group was 21 months, while that of the non-sensitive group was 6 months ($p$=0.07). Conclusion : HDRA for malignant glioma was inferred as a feasible method to predict the chemotherapy response. We are encouraged to launch phase 2 clinical trial with chemosensitivity on HDRA.

• 터널과지하공간
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• 제15권5호
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• pp.359-368
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• 2005

NATM 터널을 굴착하기에 토피가 너무 낮은 경우에는 보통 개착터널공법이 적용된다. 그러나 토피가 매우 낮거나 없는 계곡부에서 개착터널을 시공하기 위해서는 추가적인 두 곳의 갱구 형성과 복토가 이루어질 때까지 임시 사면에 대한 유지관리가 필요하다. 이런 경우에는 복토를 통해 토피를 확보한 후 터널을 굴착하는 방안이 유효하다. 이 연구는 터널 굴착이전에 소일시멘트로 복토한 후 굴착작업이 이루어진 대만고속철도 C240현장에 대한 사례 연구이다. 소일시멘트의 포틀랜드 시멘트 함유량은 $2\~4\%$이고, 1회 복토층의 두께는 $130\~250\;mm$ 범위가 되도록 시공하였다. 터널 굴착에 따른 소일시멘트 사면 및 터널내 최종 구조물인 콘크리트 라이닝에 대한 수치해석을 통해 안정성을 평가하였다.

• 한국의류학회지
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• 제35권2호
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• pp.218-229
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• 2011

Dyeing properties of cotton and ramie fabrics with pine needles colorants were studied by investigating the analysis of pine needles colorants, the effect of dyeing conditions (such as dye concentration, dyeing temperatures and times on dye uptakes), effect of mordants, and color change. The various colorfastness of dyed fabrics were evaluated for practical use; in addition, the antimicrobial ability, ultraviolet-cut ability, and deodorant ability were estimated. In the UV-Visible spectrum, the wavelength of the maximum absorption for pine needles extract was 285nm, and pine needles colorants produced a yellow color. From FT-IR and GC-MS results, it was assumed that chromophoric substance from pine needles extracts were mixed with flavonol tannin and flavanol tannin. An increased dyeing concentration resulted in a larger dye uptake and a Freundlich absorption isotherm was obtained. A larger dye uptake occurred as the dyeing time and temperature increased. Post-mordanting was more effective than pre-mordanting and the dye uptake of fabrics improved by mordanting. The colorfastness of dyed fabrics showed a low rating; however, colorfastness to washing and dry cleaning of cotton fabrics mordanted with N.Cu, and friction fastness of ramie fabric mordanted with Cu improved. The dyed fabrics showed very good antimicrobial abilities of 99.9%. In addition, the ultraviolet-cut ability and deodorant ability improved in fabrics dyed with pine needles extracts.

• 한국의류학회지
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• 제35권2호
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• pp.206-217
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• 2011

The dyeing properties of cotton fabrics with bamboo colorants were studied by investigating the analysis of bamboo colorants, the effect of dyeing conditions (dye concentrations, dyeing temperatures and times on dye uptakes), effect of mordants, and color change. The various colorfastness of dyed fabrics were evaluated for practical use; in addition, the antimicrobial ability, ultraviolet-cut ability, and deodorant ability were also estimated. In the UV-Visible spectrum, the wavelength of the maximum absorption for bamboo stems and leaves extracts was found to be 280nm and 295nm, respectively; in addition, bamboo colorants produced a yellow color. From the FT-IR and GC-MS results, it was assumed that the chromophoric substance from bamboo extracts was composed of flavones substances with tricin. An increased dyeing concentration resulted in a larger dye uptake and a Freundlich absorption isotherm was obtained. A larger dye uptake occurred as the dyeing time and temperature increased. The post-mordanting was more effective than pre-mordanting. Mordants, Fe and N.Fe, were effective for an increased dye uptake. The color of fabrics mordanted with Cu and N.Cu changed to GY. Regardless of mordanting, the colorfastness on the washing of dyed fabrics showed a low rating compared to other fastness. Mordanting adversely affected the lightfastness of dyed fabric. The dyed fabric showed very good antimicrobial abilities of 99.9%. In addition, the ultraviolet-cut ability and deodorant ability improved in cotton fabric dyed with bamboo extracts.