• Journal of Pharmaceutical Investigation
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• v.19 no.3
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• pp.123-129
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• 1989

A study was made to investigate the effects of various binders on the physical properties of acetaminophen granules and tablets prepared by wet and fluidized bed granulation methods. The binders used were povidone (K-90), hydroxypropylcellulose (HPC-L) and gelatin. The fluidized bed granules were more porous than the wet massed, and the tablets prepared by fluidized system showed improved disintegration and dissolution characteristics. The dissolution rate was fast in the order of gelatin>povidone>hydroxypropylcellulose in tablets prepared by fluidized system, and povidone>hydroxypropylcellulose>gelatin in tablets prepared by wet granulation.

• Journal of Veterinary Clinics
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• v.24 no.3
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• pp.337-341
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• 2007

This study determined the effect of postpartum intrauterine infusion of povidone-iodine solution on the subsequent reproductive performance in dairy cows. Six hundred and fifty-eight dairy cows that were around week 4 postpartum were randomly divided into two groups: (1) Cows in treated group received an intrauterine infusion of 100 to 150 ml 2% povidone-iodine solution (treated group, n=269), or (2) Cows that received no treatment were served as the controls (control group, n=389). The cows were bred at observed estrus more than 50 days after calving. Artificial insemination (AI) was done according to the a.m.-p.m. rule. The conception to AI was determined per rectum 60 days after AI by both ultrasonographical observation and manual palpation. The intervals from calving to first service and conception ($94.2{\pm}2.7$ and $144.1{\pm}4.1$ days vs. $88.0{\pm,}2.1$ and $143.5{\pm}4.6$ days, respectively), number of services per conception ($2.0{\pm}0.1$ vs. $2.1{\pm}0.1$), and cumulative pregnancy rates within 90 and 150 days postpartum (31.9 and 61.7% vs. 29.7 and 62.1%) did not differ between the control and treated groups (P>0.05), while conception rate at first service was lower (P<0.05) in the treated group (40.5%) than in the control group (49.4%). Additionally, we could not find any effect of intrauterine infusion of povidone-iodine solution according to cow parity or calving season on the reproductive performance. These results indicate that intrauterine infusion of povidone-iodine solution at week 4 postpartum does not affect the subsequent reproductive performance in dairy cows.

• Journal of Pharmaceutical Investigation
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• v.19 no.2
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• pp.109-116
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• 1989

Solid dispersion of fenticonazole nitrate (FN) with poloxamer 407, polyethylene glycol 6000, povidone (K-90) were prepared by the solvent method. To characterize the state of the drug in solid dispersions, the x-ray diffractometry and differential scanning calorimetry were carried out. The identification of these systems suggested that FN in the poloxamer 407 system remained in crystalline state, and the drug in the PVP system was amorphous. A marked increase in the dissolution rate of FN was attained by dispersing the drug in the hydrophilic polymers used, and the dispersion with poloxamer 407 was superior to the other two carriers in releasing the drug into solution.