• 지능정보연구
• /
• 제24권3호
• /
• pp.157-176
• /
• 2018

관리종목은 상장폐지 가능성이 높은 기업들을 즉시 퇴출하기 보다는 시장 안에서 일정한 제약을 부여하고, 그러한 기업들에게 상장폐지 사유를 극복할 수 있는 시간적 기회를 주는 제도이다. 뿐만 아니라 이를 투자자 및 시장참여자들에게 공시하여 투자의사결정에 주의를 환기시키는 역할을 한다. 기업의 부실화로 인한 부도 예측에 관한 연구는 많이 있으나, 부실화 가능성이 높은 기업에 대한 사회, 경제적 경보체계라 할 수 있는 관리종목에 관한 연구는 상대적으로 매우 부족하다. 이에 본 연구는 코스닥 기업들 가운데 관리종목 지정 기업과 비관리종목 기업을 표본으로 삼아 로지스틱 회귀분석과 의사결정나무 분석을 이용하여 관리종목 지정 예측 모형을 개발하고 검증하였다. 분석결과에 따르면 로지스틱 회귀분석 모형은 ROE(세전계속사업이익), 자기자본현금흐름률, 총자산회전율을 사용하여 관리종목 지정을 예측하였으며, 전체 평균 예측 정확도는 검증용 데이터셋에 대해 86%의 높은 성능을 보여주었다. 의사결정나무 모형은 현금흐름/총자산과 ROA(당기순이익)를 통한 분류규칙을 적용하여 약 87%의 예측 정확도를 보여주었다. 로지스틱 회귀분석 기반의 관리종목 탐지 모형의 경우 ROE(세전계속사업이익)와 같은 구체적인 관리종목 지정 사유를 반영하면서 기업의 활동성에 초점을 맞추어 관리종목 지정 경향성을 설명하는 반면, 의사결정 관리종목 탐지 모형은 기업의 현금흐름을 중심으로 하여 관리종목 지정을 예측하는 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권1호
• /
• pp.117-122
• /
• 2012

Aim: To elucidate the effects of hyperthermic $CO_2$ pneumoperitoneum on human gastric AGS cells. Methods: Based on a newly devised in vitro study model, we evaluated the anti-cancer effects of HT-$CO_2$ ($42-44^{\circ}C$ for 2-4h) on human gastric cancer cells, and also the corresponding mechanisms. Results: HT-$CO_2$ ($42-44^{\circ}C$ for 2-4h) severely inhibited cell proliferation as assessed by Cell Counting Kit-8 assay, while inducing apoptosis in a temperature- and time-dependent manner demonstrated by annexin-V/PI flow cytometry and morphological analysis (Hoechst/PI fluorescence). In addition, it was found that HT-$CO_2$ ($42-44^{\circ}C$ for 2-4h) promoted the up-regulation of Bax by western blotting. Significantly, it could also suppress gastric cancer cell invasion and metastasis by in vitro invasion and motility assay. Conclusion: In conclusion, HT-$CO_2$ had an efficacious cytotoxic effect on gastric cancer cells through Bax-induced mitochondrial apoptotic signaling. Our studies indicate that it may serve as a potential therapy for peritoneal carcinomatosis of gastric cancer. Further investigations in vivo using animal models are now urgently needed.

• 한국토양비료학회지
• /
• 제45권1호
• /
• pp.112-117
• /
• 2012

The Revised Universal Soil Loss Equation (RUSLE) is a revision of the Universal Soil Loss Equation (USLE). However, changes for each factor of the USLE have been made in RUSLE which can be used to compute soil loss on areas only where significant overland flow occurs. RUSLE which requires standardized methods to satisfy new data requirements estimates soil movement at a particular site by utilizing the same factorial approach employed by the USLE. The rainfall erosivity in the RUSLE expressed through the R-factor to quantify the effect of raindrop impact and to reflect the amount and rate of runoff likely is associated with the rain. Calculating the R-factor value in the RUSLE equation to predict the related soil loss may be possible to analyse the variability of rainfall erosivity with long time-series of concerned rainfall data. However, daily time step models cannot return proper estimates when run on other specific rainfall patters such as storm and daily cumulative precipitation. Therefore, it is desirable that cross-checking is carried out amongst different time-aggregations typical rainfall event may cause error in estimating the potential soil loss in definite conditions.

• Advances in aircraft and spacecraft science
• /
• 제2권2호
• /
• pp.125-168
• /
• 2015

Dynamic aeroelastic behavior of structurally nonlinear Joined Wings is presented. Three configurations, two characterized by a different location of the joint and one presenting a direct connection between the two wings (SensorCraft-like layout) are investigated. The snap-divergence is studied from a dynamic perspective in order to assess the real response of the configuration. The investigations also focus on the flutter occurrence (critical state) and postcritical phenomena. Limit Cycle Oscillations (LCOs) are observed, possibly followed by a loss of periodicity of the solution as speed is further increased. In some cases, it is also possible to ascertain the presence of period doubling (flip-) bifurcations. Differences between flutter (Hopf's bifurcation) speed evaluated with linear and nonlinear analyses are discussed in depth in order to understand if a linear (and thus computationally less intense) representation provides an acceptable estimate of the instability properties. Both frequency- and time-domain approaches are compared. Moreover, aerodynamic solvers based on the potential flow are critically examined. In particular, it is assessed in what measure more sophisticated aerodynamic and interface models impact the aeroelastic predictions. When the use of the tools gives different results, a physical interpretation of the leading mechanism generating the mismatch is provided. In particular, for PrandtlPlane-like configurations the aeroelastic response is very sensitive to the wake's shape. As a consequence, it is suggested that a more sophisticate modeling of the wake positively impacts the reliability of aerodynamic and aeroelastic analysis. For SensorCraft-like configurations some LCOs are characterized by a non-synchronous motion of the inner and outer portion of the lower wing: the wing's tip exhibits a small oscillation during the descending or ascending phase, whereas the mid-span station describes a sinusoidal-like trajectory in the time-domain.

• Journal of Preventive Medicine and Public Health
• /
• 제33권2호
• /
• pp.165-173
• /
• 2000

Objectives : To assess the availability of the glycophorin A (GPA) assay to detect the biological effect of ionizing radiation in workers exposed to low-doses of radiation. Methods : Information on confounding factors, such as age and cigarette smoking was obtained on 144 nuclear power plant workers and 32 hospital workers, by a self-administered questionnaire. Information on physical exposure levels was obtained from the registries of radiation exposure monitoring and control at each facility. The GPA mutant assay was performed using the BR6 method with modification by using a FACScan flow cytometer. Results : As confounders, age and cigarette smoking habits showed increasing trends with GPA variants, but these were of no statistical significance. Hospital workers showed a higher frequency of the GPA variant than nuclear power plant workers in terms of the NO variant. Significant dose-response relationships were obtained from in simple and multiple linear regression models. The slope of the regression equation for nuclear power plant workers was much smaller than that of hospital workers. These findings suggest that there may be apparent dose-rate effects. Conclusion : In population exposed to chronic low-dose radiation, the GPA assay has a potential to be used as an effective biologic marker for assessing the bone marrow cumulative exposure dose.

• Clinical and Experimental Pediatrics
• /
• 제59권9호
• /
• pp.374-380
• /
• 2016

Purpose: Patients with unresectable, relapsed, or refractory osteosarcoma need a novel therapeutic agent. Metformin is a biguanide derivative used in the treatment of type II diabetes, and is recently gaining attention in cancer research. Methods: We evaluated the effect of metformin against human osteosarcoma. Four osteosarcoma cell lines (KHOS/NP, HOS, MG-63, U-2 OS) were treated with metformin and cell proliferation was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell cycle progression and apoptosis were evaluated using flow cytometric analysis, and migration and wound healing assay were performed. Fourteen female Balb/c-nude mice received KHOS/NP cell grafts in their thigh, and were allowed access to metformin containing water (2 mg/mL) ad libitum. Tumor volume was measured every 3-4 days for a period of 4 weeks. Results: Metformin had a significant antiproliferative effect on human osteosarcoma cells. In particular, metformin inhibited the proliferation and migration of KHOS/NP cells by activation of AMP-activated protein kinase and consequent inhibition of the mammalian target of rapamycin pathway. It also inhibited the proliferation of cisplatin-resistant KHOS/NP clone cells. Analysis of KHOS/NP xenograft Balb/c-nude models indicated that metformin displayed potent in vivo antitumor effects. Conclusion: Further studies are necessary to explore metformin's therapeutic potential and the possibilities for its use as an adjuvant agent for osteosarcoma.

• 한국전산유체공학회:학술대회논문집
• /
• 한국전산유체공학회 2003년도 추계 학술대회논문집
• /
• pp.200-205
• /
• 2003

The Canard rotor/wing (CRW) aircraft concepts offer great potential for application by allowing the use of a common propulsion system for high-speed cruise and low-speed powered lift. Using the rotor for lift in both flight modes increases its utility. In the hovering mode, the exhausted gas from an gas turbine engine is accelerated through the duct system and it provides the tipjet power for rotor system enough to lift the aircraft. In the cruise mode, the rotor is fixed and the exhausted gas is extracted through the main nozzle, such that the aircraft is able to flight with high speed. The duct system was designed using 1-D fanno line flow theory and empirical data. However, the empirical data of the pressure loss coefficient for various bending and dividing ducts were not enough to design our duct system adaptively. Therefore, using 3-D CFD analysis we obtained the pressure loss coefficient for our duct models and chose the appropriate bending or diving duct type. In this paper, we used the CFD-ACE+ software package for the CFD analysis and the modeling of duct system. Through the 3-D CFD analysis, we investigated also the pressure loss and the velocity distributions of the designed whole duct system as well as the blade duct. Comparing the 3-D CFD result with 1-D analysis result, we lessened the uncertainty of the designed duct system and speculated the problem that was not concerned in design state.

• 한국수자원학회:학술대회논문집
• /
• 한국수자원학회 2010년도 학술발표회
• /
• pp.1079-1083
• /
• 2010

하절기에 집중되는 강우로 인해 국내의 경우 저수지와 댐 건설이 불가피 하였으며, 이들 구조물에 의한 수체의 거동 및 수질의 분포 또한 일반 하천과는 다른 특성을 지니고 있다. 특히, 흐름 방향보다 수심 방향으로의 특성이 강하게 작용하는 호소에서는 3차원 수리 수질 모델링을 적용함으로써 모의 결과에 대한 신뢰성을 높일 수 있다. 하천의 발원지로서의 댐(저수지)과 하천과 하천사이에 위치한 저수지의 특성이 다르며, 하천 사이에 위치한 저수지의 경우, 하천과 하천을 이어주며 그 흐름특성과 수질의 분포 및 변화의 양상의 바뀐다는 점에서 독립적이며, 연계되는 구조의 특징을 동시에 반영할 수 있어야 한다. 본 논문에서는 낙동강에 위치한 남강댐(진양호)를 중심으로 연구를 진행하였으며, 안동댐 등처럼 하천의 발원지가 아닌 하천과 하천 사이에 위치한 호소(댐)으로 이와 같은 특징을 반영하여 수질오염총량관리제에서의 목표수질 달성여부와 점 및 비점오염원에서 발생되는 오염부하량의 변화에 따른 저수지 내의 수리 수질 모의를 EFDC-WASP의 연계 모델을 통해 연구하고자 하였다.

• Biomolecules & Therapeutics
• /
• 제23권4호
• /
• pp.350-356
• /
• 2015

Functional dyspepsia (FD) is a prevalent idiopathic upper gastrointestinal (GI) disorder characterized by diverse symptomatology including epigastric pain or discomfort, postprandial fullness, and early satiety. Although its pathophysiological mechanisms have not yet been fully established, the available studies suggest that the etiology of FD is invariably multifactorial. Benachio-F$^{(R)}$ (BF) is a proprietary liquid formulation of 7 herbal extracts that has been proposed to address this multifactorial etiology using multi-drug phytotherapy. The pharmacological effects of BF, in comparison with those of two other herbal products (Whalmyungsu$^{(R)}$; WM and Iberogast$^{(R)}$; IB) were evaluated in rats. In a laparotomy-induced rat model of delayed GI transit, BF significantly accelerated the delayed gastric emptying caused by morphine, apomorphine, and cisplatin, and also significantly increased mean gastric transit, as compared to the control animals. BF markedly increased gastric accommodation in rats and produced higher gastric volume values than did the control treatment. The effects of BF were generally comparable or superior to those of WM and IB in these models. Furthermore, BF significantly stimulated biliary flow, as compared to the control treatment. These results indicated that BF might have great potential as an effective phytotherapeutic agent capable of reducing GI symptoms and increasing quality of life in FD patients.

• Geomechanics and Engineering
• /
• 제11권1호
• /
• pp.1-39
• /
• 2016

The finite element method (FEM), discrete element method (DEM), and Discontinuous deformation analysis (DDA) are among the standard numerical techniques applied in computational geo-mechanics. However, in some cases there no possibility for modelling by traditional finite analytical techniques or other mesh-based techniques. The solution presented in the current study as a completely Lagrangian and mesh-free technique is smoothed particle hydrodynamics (SPH). This method was basically applied for simulation of fluid flow by dividing the fluid into several particles. However, several researchers attempted to simulate soil-water interaction, landslides, and failure of soil by SPH method. In fact, this method is able to deal with behavior and interaction of different states of materials (liquid and solid) and multiphase soil models and their large deformations. Soil indicates different behaviors when interacting with water, structure, instrumentations, or different layers. Thus, study into these interactions using the mesh based grids has been facilitated by mesh-less SPH technique in this work. It has been revealed that the fast development, computational sophistication, and emerge of mesh-less particle modeling techniques offer solutions for problems which are not modeled by the traditional mesh-based techniques. Also it has been found that the smoothed particle hydrodynamic provides advanced techniques for simulation of soil materials as compared to the current traditional numerical methods. Besides, findings indicate that the advantages of applying this method are its high power, simplicity of concept, relative simplicity in combination of modern physics, and particularly its potential in study of large deformations and failures.