• Biomedical Science Letters
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• v.9 no.4
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• pp.231-240
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• 2003

Deciphering the molecular interactions of proteins forming Z-lines is pivotal for understanding the regulation of myofibril assembly, sarcomeric organization, and mechanical properties of striated muscle. The purpose of this study is to searched for potential novel ligands of the Z-line portion of nebulin. In this study interacting proteins with intra-Z-line region of nebulin were screened using a yeast two-hybrid approach. The interaction was conformed by GST pull-down assay. We identified 269 residues within villin/gelsolin homology domain of supervillin that intreacts with the serine rich region of nebulin. The specific interactions of nebulin and supervillin were confirmed in vitro by GST pull-down experiments. Our data suggest that supervillin attaches directly to the Z-line through its interaction with the serine rich domain of nebulin in skeletal muscles. This interaction may link myofibrillar Z-discs to the membrane-associated complexes, costameres.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.25 no.2
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• pp.53-60
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• 2011

The available power generated from the FC power plant may not be sufficient to meet sustained load demand, peak demand or transient events. An supercapacitor bank(SCB) can supply a large burst of power, but it cannot store a significant amount of energy. The combined use of FC and SCB has the potential for the better energy efficiency, reducing the cost of FC technology and improved dynamic response. In this paper, A single PEMFC and PEMFC operated in parallel with a SC bank are presented, A new dynamic model of PEMFC system, the converter and controller has been developed for stand-alone applications. The simulation results are presented using Matlab/Simulink, and SimPowerSystems environments. It is confirmed that the results show a good performance and stable DC-link voltage for proposed dynamic and mathematical models developed for the combined FC/SCB.

• Magazine of the Korean Society of Agricultural Engineers
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• v.39 no.2
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• pp.9-18
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• 1997

Abstract This paper presents a heuristic method for optimal design of water distribution system with multiple sources and potential links. In multiple source pipe network, supply rate at each source node affects the total cost of the system because supply rates are not uniquely determined. The Linear Minimum Cost Flow (LMCF) model may be used to a large scale pipe network with multiple sources to determine supply rate at each source node. In this study the heuristic method based on the LMCF is suggested to determine supply rate at each source node and then to optimize the given layout. The heuristic method in turn perturbs links in the longest path of the network to obtain the supply rates which make the optimal design of the pipe network. Once the best tree network is obtained, the frequency count of reconnecting links by considering link failure is in turn applied to form loop to enhance the reliability of the best tree network. A sample pipe network is employed to test the proposed method. The results show that the proposed method can yield a lower cost design than the LMCF alone and that the proposed method can be efficiently used to design irrigation systems or rural water distribution systems.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.357_358
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• 2009

According to the 4th BPE(Basic Plan for long-term Electricity Supply and Demand), Electricity demand of Jeju island in 2012 will be reached to 682MW. Jeju island will be faced with severe shortage of electricty, also needed to find transport route to supply green energy which will be made from "Carbon free island" energy policy toward land at that time. For that reason, The plan which construct 400MW size HVDC connection line was decided for potential supply stabilization and transportation of green energy. KEPCO organized special construction office not only to observe the successful project completion which aims 2011 December but also to build up professional manpower. KEPCO is putting spur to the HVDC project these days. Construction site of converter stations has been already confirmed and contracts of cable, converter have done as per turn-key early this year. On this report, we would like to discuss about project scheme, main characteristics of system, and the furture progress plan of "Jindo~Jeju HVDC construction project expecially converter station part" which is being pushed by KEPCO.

• The Journal of Asian Finance, Economics and Business
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• v.5 no.3
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• pp.51-63
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• 2018

The study aims to articulate a definition of luxury brands, to propose a framework for consumer luxury brand relationships and to provide empirical evidence of the proposed model. The study conducted two surveys in Portugal and the United States in 2009 and 2013 for selected luxury brands. The study employs factor analysis and structural equation modelling techniques to test the hypotheses. The study finds a link between luxury products and consumer's psychological association represents in a hierarchical order of: cognitive attributes at its base level, extrinsic attributes on a secondary level and intrinsic attributes at the advance level. The findings suggest a concept for luxury brands from three dimensions of: luxury product characteristics, consumer's psychological characteristics, and consumer's psychological association with the luxury product. The research was conducted in Portugal and the United States so that there is always a potential criticism concerning the ability to generalize research results to a broader international population. The findings provide a holistic perspective in the understanding of luxury brand constructs and a definition of luxury brands in the way why consumers involve symbolic consumption. The successful application of the findings in a brand setting would be of particular interest to marketers and brand strategists.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.6
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• pp.483-489
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• 2009

Despite the potential importance of the human regulator of calcineurin 1 (RCAN-1) gene in the modulation of cell survival under stress, little is known about its role in death-inducing signal pathways. In this study, we addressed the effects of RCAN1.4 knockdown on cellular susceptibility to apoptosis and the activation of death pathway proteins. Transfection of siRNAs against RCAN1.4 resulted in enhanced Fas- and etoposide-induced apoptosis, which was associated with increased expression and translocation of Bax to mitochondria. Our results suggest that enhanced expression and activation of p53 was responsible for the upregulation of Bax and the increased sensitivity to apoptosis, which could be reversed by p53 knockdown. To explain the observed upregulation of p53, we propose a downregulation of the ubiquitin ligase HDM2, probably translationally. These findings show the importance of appropriate RCAN1.4 expression in the modulation of cell survival and reveal a link between RCAN1.4 and p53.

• Journal of Korean Library and Information Science Society
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• v.22
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• pp.61-93
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• 1995

This paper discussed which of the three basic entries of serials that changed their titles-earliest, latest, or successive entry cataloging-is the most efficient, informative, and economical in a manual and an online environment. The results of the study are as follow: 1. Earliest entry cataloging or as an alternative, successive entry cataloging advocated by Cutter in 1976 was replaced in ALA Cataloging Rules by latest entry cataloging and with AACR1 and AACR2, latest entry cataloging was replaced by successive entry cataloging again. 2. Entry method of serial cataloging should be determined in consideration of goals of catalog, efficiency of catalog retrieval, theoretical and practical standpoint of entry methods, average cataloging time and cost, the state of adaption. 3. In a card catalog environment, if the numbering and class number of the serial that title proper changed into initials itself continue and the title history must not be too complicated, the serial is desirable to entry under the latest title. Except for above case, successive entry cataloging enables serials to be more quickly and economically made available to users than with either earliest or latest entry cataloging. 4. In an automated catalog environment, successive entry cataloging has more potential of satisfying and impairs the efficiency of both accessing and processing a library's serials collection. However, when initial cataloging by MARC format is done, careful screen design and complex programming will be needed. And subfield containing the local record number should be added to the programming means to link the various records together, i.e., 780 (preceding title) and 785 (succeeding title) fields for all related titles.

• Wind and Structures
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• v.22 no.1
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• pp.89-106
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• 2016

With an aim to assess the wind damage to urban trees in more realistic conditions, the nonlinear dynamics of structured trees subjected to strong winds with different levels is investigated in the present paper. For the logical treatment of dynamical behavior of trees, material nonlinearities of green wood associated with tree biomechanics and geometric nonlinearity of tree configuration are included. Applying simulated fluctuating wind velocity to the numerical model, the dynamical behavior of the structured tree is explored. A comparative study against the linear dynamics analysis usually involved in the previous researches is carried out. The failure wind velocity of urban trees is then defined, whereby the failure percentages of the tree components are exposed. Numerical investigations reveal that the nonlinear dynamics analysis of urban trees results in a more accurate solution of wind-induced response than the classical linear dynamics analysis, where the nonlinear effect of the tree behavior gives rise to be strengthened as increasing of the levels of wind velocity, i.e., the amplitude of 10-min mean wind velocity. The study of relationship between the failure percentage and the failure wind velocity provides a new perspective towards the vulnerability assessment of urban trees likely to fail due to wind actions, which is potential to link with the practical engineering.

• Preventive Nutrition and Food Science
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• v.22 no.1
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• pp.1-8
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• 2017

About 20 chemical elements are nutritionally essential for humans with defined molecular functions. Several essential and nonessential biometals are either functional nutrients with antidiabetic actions or can be diabetogenic. A key question remains whether changes in the metabolism of biometals and biominerals are a consequence of diabetes or are involved in its etiology. Exploration of the roles of zinc (Zn) in this regard is most revealing because 80 years of scientific discoveries link zinc and diabetes. In pancreatic ${\beta}$- and ${\alpha}$-cells, zinc has specific functions in the biochemistry of insulin and glucagon. When zinc ions are secreted during vesicular exocytosis, they have autocrine, paracrine, and endocrine roles. The membrane protein ZnT8 transports zinc ions into the insulin and glucagon granules. ZnT8 has a risk allele that predisposes the majority of humans to developing diabetes. In target tissues, increased availability of zinc enhances the insulin response by inhibiting protein tyrosine phosphatase 1B, which controls the phosphorylation state of the insulin receptor and hence downstream signalling. Inherited diseases of zinc metabolism, environmental exposures that interfere with the control of cellular zinc homeostasis, and nutritional or conditioned zinc deficiency influence the pathobiochemistry of diabetes. Accepting the view that zinc is one of the many factors in multiple gene-environment interactions that cause the functional demise of ${\beta}$-cells generates an immense potential for treating and perhaps preventing diabetes. Personalized nutrition, bioactive food, and pharmaceuticals targeting the control of cellular zinc in precision medicine are among the possible interventions.

• Journal of Communications and Networks
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• v.10 no.2
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• pp.186-193
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• 2008

A two-hop multiple-input multiple-output (MIMO) relay network which comprises a multiple antenna source, an amplify-and-forward MIMO relay and many potential users are studied in this paper. Consider the achievable sum rate as the performance metric, a joint design method for the processing units of the BS and relay node is proposed. The optimal structures are given, which decompose the multiuser MIMO relay channel into several parallel single-input single-output relay channels. With these structures, the signal-to-noise ratio at the destination users is derived; and the power allocation is proved to be a convex problem. We also show that high sum rate can be achieved by pairing each link according to its magnitude. The sum rate of three broadcast strategies, time division multiple access (TDMA) to the strongest user, dirty paper coding (DPC), and beamforming (BF) are investigated. The sum rate bounds of these strategies and the sum capacity (achieved by DPC) gain over TDMA and BF are given. With these results, it can be easily obtained that how far away TDMA and BF are from being optimal in terms of the achievable sum rate.