• Title/Summary/Keyword: potential efficacy

Search Result 1,126, Processing Time 0.027 seconds

Anti-inflammatory activity of Scutellaria Baicalensis root extract in lipopolysaccharide-induced RAW 264.7 cells (LPS로 유도된 RAW264.7세포주에서 황금뿌리 물추출물의 항염증활성)

  • Lee, Ye Eun;Park, Hong Jin;Park, Chung-berm;Hwang, Seung-mi
    • Korean Journal of Food Science and Technology
    • /
    • v.53 no.2
    • /
    • pp.115-120
    • /
    • 2021
  • Scutellaria baicalensis has been used as a traditional medicine for diarrhea, dysentery, hypertension, hemorrhaging, insomnia, inflammation, and respiratory infections. This study examined the anti-inflammatory effect of Scutellaria baicalensis water extract (SWE) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. To evaluate the anti-inflammatory effect of SWE, RAW 264.7 macrophages were stimulated with LPS to induce the production of inflammation-related factors, which were measured by western blotting. In RAW 264.7 cells, SWE inhibited the production of nitric oxide (NO) without causing cell toxicity. SWE also reduced the expression of inducible NO synthase and cyclooxygenase-2 protein, as well as the production of pro-inflammatory cytokines (such as tumor necrosis factor-α). The phosphorylation levels of the mitogen-activated protein kinase family members, such as JNK and p38, were also reduced by SWE. Thus, SWE could be used as a potential anti-inflammatory agent.

Effect of Perceived Relational Supports on Entrepreneurial Motivation of Korean and Chinese University Students: Focused on mediating role of self-efficacy (지각된 관계적 지원이 한·중 대학생의 기업가적 동기에 미치는 영향: 자기효능감의 매개효과를 중심으로)

  • Yang, Jun Hwan
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
    • /
    • v.10 no.3
    • /
    • pp.1-13
    • /
    • 2015
  • Strong ties such as family members, relatives and close friends have been widely acknowledged as a vital factor when a potential entrepreneur attempts to initiate entrepreneurial activity. Recent theoretical arguments focus that family social capital, a form of social capital, that is embedded in family relationships can contribute to venture creation as well as to the development of competitive advantage for established firms. Meantime, there have been arguments that the most dominant single entrepreneurial ethnic group in the world is the Chinese people, while the People's Republic of China is widely recognized as fast growing economic power that is driven by entrepreneurial ventures in a large scale. This study tests the effect of perceived relational supports typically being provided by family members, close relatives and friends on forming self-efficacy and entrepreneurial motivation of university students by using samples collected from 4 Korean Universities(Wonkwang, Baekseok, Soongsil and Dankook university) and Guangzhou University in China. The mediating of self-efficacy was also tested to gain better understanding of the role of the variable. The results of the study suggest that 1) both self-efficacy and entrepreneurial motivation are influenced positively by the perceived relational supports, 2) self-efficacy of university students affects their entrepreneurial motivation positively, 3) self-efficacy is appeared to be mediated partially for China in between perceived relational supports and entrepreneurial motivation, but the same variable is exhibited a full mediation in the same path of the research model for Korea, which was a distinction between the students of two countries in this study. Discussion and practical implication on the results are provided.

  • PDF

Psychosocial Predictors of Breast Self-Examination among Female Students in Malaysia: A Study to Assess the Roles of Body Image, Self-efficacy and Perceived Barriers

  • Ahmadian, Maryam;Carmack, Suzie;Samah, Asnarulkhadi Abu;Kreps, Gary;Saidu, Mohammed Bashir
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.17 no.3
    • /
    • pp.1277-1284
    • /
    • 2016
  • Background: Early detection is a critical part of reducing the burden of breast cancer and breast self-examination (BSE) has been found to be an especially important early detection strategy in low and middle income countries such as Malaysia. Although reports indicate that Malaysian women report an increase in BSE activity in recent years, additional research is needed to explore factors that may help to increase this behavior among Southeastern Asian women. Objective: This study is the first of its kind to explore how the predicting variables of self-efficacy, perceived barriers, and body image factors correlate with self-reports of past BSE, and intention to conduct future breast self-exams among female students in Malaysia. Materials and Methods: Through the analysis of data collected from a prior study of female students from nine Malaysian universities (n=842), this study found that self-efficacy, perceived barriers and specific body image sub-constructs (MBSRQ-Appearance Scales) were correlated with, and at times predicted, both the likelihood of past BSE and the intention to conduct breast self-exams in the future. Results: Self-efficacy (SE) positively predicted the likelihood of past self-exam behavior, and intention to conduct future breast self-exams. Perceived barriers (BR) negatively predicted past behavior and future intention of breast self-exams. The body image sub-constructs of appearance evaluation (AE) and overweight preoccupation (OWP) predicted the likelihood of past behavior but did not predict intention for future behavior. Appearance orientation (AO) had a somewhat opposite effect: AO did not correlate with or predict past behavior but did correlate with intention to conduct breast self-exams in the future. The body image sub-constructs of body area satisfaction (BASS) and self-classified weight (SCW) showed no correlation with the subjects' past breast self-exam behavior nor with their intention to conduct breast self-exams in the future. Conclusions: Findings from this study indicate that both self-efficacy and perceived barriers to BSE are significant psychosocial factors that influence BSE behavior. These results suggest that health promotion interventions that help enhance self-efficacy and reduce perceived barriers have the potential to increase the intentions of Malaysian women to perform breast self-exams, which can promote early detection of breast cancers. Future research should evaluate targeted communication interventions for addressing self-efficacy and perceived barriers to breast self-exams with at-risk Malaysian women. and further explore the relationship between BSE and body image.

Two Factors of Overseas Online Shopping : Self-Efficacy and Impulsivity (해외직접구매의 두 요소 : 자기효능감과 구매충동성)

  • Lee, Han-Suk
    • Journal of Distribution Science
    • /
    • v.16 no.8
    • /
    • pp.79-89
    • /
    • 2018
  • Purpose - This research aims to investigate the factors that influence consumer's overseas online shopping behavior. Consumers adopt overseas online shopping as a new buying way and more and more consumers prefer overseas online shopping than traditional shopping ways. Consumers' behaviors in this shopping experience can be different from other shopping experiences. With the increase of overseas online shopping, we need to find antecedents and results of overseas online shopping. Especially there would be positive or negative factors which influence overseas online shopping motivation. To find the relationship, this study examines self-efficacy and impulsivity as major factors which influence overseas online shopping. We also suggest that several attitude factors increase self-efficacy and it is positively related to customer satisfaction. On the other hand, we assume that overseas online shopping factors influence impulsivity of buying and it will decrease customer satisfaction. Research design, data, and methodology - This empirical study data were collected from Korean people who experience overseas online shopping. The subjects for this study were confined to shoppers who used overseas online shopping within the past six months. A total of 267 responses were gathered. SPSS 23.0, PLS 2.0 software were used in the data analysis. Descriptive statistics were used to show sample characteristics. We examined reliability, validity test for constructs. All measurement items used seven-point scales(1= very strong disagree, 7 = very strongly agree) drawn from previously published papers. Partial Least Square method was applied to find the relationship between antecedent factors and dependent factors and hypotheses were estimated. Results - Results show that perceived superiority, perceived ease of use, perceived transaction safety, perceived behavioral control positively affect self-efficacy. Self-efficacy influences positively to consumer's post purchase satisfaction. Perceived monetary benefit and perceived uniqueness motivated impulse buying. This can make consumer's post purchase dissatisfaction. Conclusions - This paper attempted to confirm the existence of both the positive and negative faces of overseas online shopping. The result reveals that self-efficacy is a major factor which may increase satisfaction in the overseas online shopping. Usually, we can think monetary benefit and uniqueness of products motivate overseas online shopping. But it can also intrigue impulse buying and negatively affect customer relationship. Therefore companies should provide enough products information to their potential customers and they might apply adequate processes such as recommendation, comparing systems to build long term relationship with their customers.

The Effects of Entrepreneurs' Perceived Norm and Self-Efficacy on Entrepreneurial Intention : Focusing on the Mediated Effect of Entrepreneurial Resilience (창업가의 지각된 규범과 자기효능감이 창업의도에 미치는 영향 : 창업가적 탄력성의 매개효과를 중심으로)

  • Kim, Wan-Gi;Suh, Sang-Hyuk
    • Journal of Korea Technology Innovation Society
    • /
    • v.21 no.4
    • /
    • pp.1386-1410
    • /
    • 2018
  • Entrepreneurial resilience is one of the core competencies that young entrepreneurs should own. However, compared to its importance, related studies about this topic are rare, especially in Korea. Therefore, this study, for empirical analysis, included resilience to the research model expanding existing research. The purpose of this study is to identify the direct effects of perceived norms of young entrepreneurs, entrepreneurial self-efficacy, and entrepreneurial resilience on entrepreneurial intentions, and to identify the mediated effects between perceived norm, entrepreneurial self-efficacy, and entrepreneurial intention. The data used in this research were collected through questionnaires from 443 potential young entrepreneurs. Our experimental result show that social norm and entrepreneurial self-efficacy were positively related to entrepreneurial resilience. Moreover, personal norm, entrepreneurial self-efficacy, and entrepreneurial resilience were statistically significant on intention of entrepreneurial. As a result of the indirect effect, entrepreneurial resilience mediates the relationship between social norms, entrepreneurial self-efficacy, and entrepreneurial intention. Finally, this research has significant meaning because it shows the importance of entrepreneurial resilience to entrepreneurial intention of young entrepreneurs. However, the limitation of this study relates to the restriction of sample in certain regions and universities.

The Role of Intensity Modulated Radiotherapy in Cancer Treatment

  • Cheung, Kin-Yin
    • Proceedings of the Korean Society of Medical Physics Conference
    • /
    • 2002.09a
    • /
    • pp.6-8
    • /
    • 2002
  • Intensity modulated radiotherapy (IMRT) is an advanced but expensive form of 3-dimensional conformal radiation therapy technique. While the initial clinical data appear to be promising for some treatment sites, the cost effectiveness of the treatment modality has yet to be justified by long-term clinical outcome. This presentation reviews the potential efficacy and limitation of IMRT in respect of the practicality, dosimetry, and resource aspects. It tries to explore and draw conclusions on the strategies for using this sophisticated and expensive treatment technique from AFOMP perspective.

  • PDF

Position estimation using combined vision and acceleration measurement

  • Nam, Yoonsu
    • 제어로봇시스템학회:학술대회논문집
    • /
    • 1992.10b
    • /
    • pp.187-192
    • /
    • 1992
  • There are several potential error sources that can affect the estimation of the position of an object using combined vision and acceleration measurements. Two of the major sources, accelerometer dynamics and random noise in both sensor outputs, are considered. Using a second-order model, the errors introduced by the accelerometer dynamics are reduced by the smaller value of damping ratio and larger value of natural frequency. A Kalman filter approach was developed to minimize the influence of random errors on the position estimate. Experimental results for the end-point movement of a flexible beam confirmed the efficacy of the Kalman filter algorithm.

  • PDF

Effect of Azone on Penetration of Antiviral Agents through Hairless Mouse Skin (무모(無毛) 마우스의 피부를 통한 항바이러스제의 투과와 Azone의 영향)

  • Choi, Seung-Ho;Kim, Johng-Kap
    • Journal of Pharmaceutical Investigation
    • /
    • v.20 no.4
    • /
    • pp.205-208
    • /
    • 1990
  • 1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous penetration of a number of different chemicals. BVDU and FEAU were evaluated for their potential efficacy in the treatment of cutaneous herpes simplex virus infections by in vitro studies through hairless mouse skin. This study demonstrates the value of penetration enhancing agent (Azone) and the need for a predictable evaluations in the development of topical antiviral agents.

  • PDF

Chitosan-Iron casein succinylate nanoparticles as oral delivery systems: increasing the stability and enhancing the absorption of iron nanoparticles.

  • Cho, Jung-Hye;Oungbho Kwunchit;Park, Jeong-Sook;Kim, Chong-Kook
    • Proceedings of the PSK Conference
    • /
    • 2003.10b
    • /
    • pp.249.1-249.1
    • /
    • 2003
  • The objective of the study was to develop an oral delivery system to increase the stability and efficacy of iron casein succinylate. Aqueous nanoparticles were prepared using complex coacervation of the oppositely charged chitosan and iron casein succinylate with polyethyleneglycol (PEG). The physicochemical properties of nanoparticles were investigated using dynamic light scattering, zeta potential and scanning electron microscopy. Chitosan-iron casein succinylate interactions were investigated in solid state by differential scanning calorimetry (DSC) and FT-IR spectrometry. (omitted)

  • PDF

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

  • Sak, Katrin
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.19
    • /
    • pp.8007-8018
    • /
    • 2014
  • Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeutic strategies and anticancer agents is an urgent priority. Plants have remained an important source in the search for novel cytotoxic compounds and several polyphenolic flavonoids possess antitumor properties. In this review article, data about potential anticarcinogenic activity of common natural flavonoids on various human cervical cancer cell lines are compiled and analyzed showing perspectives for the use of these secondary metabolites in the treatment of cervical carcinoma as well as in the development of novel chemotherapeutic drugs. Such anticancer effects of flavonoids seem to differentially depend on the cellular type and origin of cervical carcinoma creating possibilities for specific targeting in the future. Besides the cytotoxic activity per se, several flavonoids can also contribute to the increase in efficacy of conventional therapies rendering tumor cells more sensitive to standard chemotherapeutics and irradiation. Although the current knowledge is still rather scarce and further studies are certainly needed, it is clear that natural flavonoids may have a great potential to benefit cervical cancer patients.