• Title/Summary/Keyword: posterior probabilities

Search Result 97, Processing Time 0.033 seconds

Bayesian analysis of finite mixture model with cluster-specific random effects (군집 특정 변량효과를 포함한 유한 혼합 모형의 베이지안 분석)

  • Lee, Hyejin;Kyung, Minjung
    • The Korean Journal of Applied Statistics
    • /
    • v.30 no.1
    • /
    • pp.57-68
    • /
    • 2017
  • Clustering algorithms attempt to find a partition of a finite set of objects in to a potentially predetermined number of nonempty subsets. Gibbs sampling of a normal mixture of linear mixed regressions with a Dirichlet prior distribution calculates posterior probabilities when the number of clusters was known. Our approach provides simultaneous partitioning and parameter estimation with the computation of classification probabilities. A Monte Carlo study of curve estimation results showed that the model was useful for function estimation. Examples are given to show how these models perform on real data.

Genotype-Calling System for Somatic Mutation Discovery in Cancer Genome Sequence (암 유전자 배열에서 체세포 돌연변이 발견을 위한 유전자형 조사 시스템)

  • Park, Su-Young;Jung, Chai-Yeoung
    • Journal of the Korea Institute of Information and Communication Engineering
    • /
    • v.17 no.12
    • /
    • pp.3009-3015
    • /
    • 2013
  • Next-generation sequencing (NGS) has enabled whole genome and transcriptome single nucleotide variant (SNV) discovery in cancer and method of the most fundamental being determining an individual's genotype from multiple aligned short read sequences at a position. Bayesian algorithm estimate parameter using posterior genotype probabilities and other method, EM algorithm, estimate parameter using maximum likelihood estimate method in observed data. Here, we propose a novel genotype-calling system and compare and analyze the effect of sample size(S = 50, 100 and 500) on posterior estimate of sequencing error rate, somatic mutation status and genotype probability. The result is that estimate applying Bayesian algorithm even for 50 of small sample size approached real parameter than estimate applying EM algorithm in small sample more accurately.

Evaluation of Reference Evapotranspiration in South Korea according to CMIP5 GCMs and Estimation Methods (CMIP5 GCMs과 추정 방법에 따른 우리나라 기준증발산량 평가)

  • Park, Jihoon;Cho, Jaepil;Lee, Eun-Jeong;Jung, Imgook
    • Journal of Korean Society of Rural Planning
    • /
    • v.23 no.4
    • /
    • pp.153-168
    • /
    • 2017
  • The main objective of this study was to assess reference evapotranspiration based on multiple GCMs (General Circulation Models) and estimation methods. In this study, 10 GCMs based on the RCP (Representative Concentration Pathway) 4.5 scenario were used to estimate reference evapotranspiration. 54 ASOS (Automated Synoptic Observing System) data were constructed by statistical downscaling techniques. The meteorological variables of precipitation, maximum temperature and minimum temperature, relative humidity, wind speed, and solar radiation were produced using GCMs. For the past and future periods, we estimated reference evapotranspiration by GCMs and analyzed the statistical characteristics and analyzed its uncertainty. Five methods (BC: Blaney-Criddle, HS: Hargreaves-Samani, MK: Makkink, MS: Matt-Shuttleworth, and PM: Penman-Monteith) were selected to analyze the uncertainty by reference evapotranspiration estimation methods. We compared the uncertainty of reference evapotranspiration method by the variable expansion and analyzed which variables greatly influence reference evapotranspiration estimation. The posterior probabilities of five methods were estimated as BC: 0.1792, HS: 0.1775, MK: 0.2361, MS: 0.2054, and PM: 0.2018. The posterior probability indicated how well reference evapotranspiration estimated with 10 GCMs for five methods reflected the estimated reference evapotranspiration using the observed data. Through this study, we analyzed the overall characteristics of reference evapotranspiration according to GCMs and reference evapotranspiration estimation methods The results of this study might be used as a basic data for preparing the standard method of reference evapotranspiration to derive the water management method under climate change.

On Multiple Comparison of Geometric Means of Exponential Parameters via Graphical Model (그래프 모형을 이용한 지수분포 모수들의 기하평균 비교에 관한 연구)

  • Kim, Dae-Hwang;Kim, Hea-Jung
    • The Korean Journal of Applied Statistics
    • /
    • v.19 no.3
    • /
    • pp.447-460
    • /
    • 2006
  • This paper develops a multiple comparison method for finding an optimal ordering of K geometric means of exponential parameters. This is based on the paired comparison experimental arrangement whose results can naturally be represented by a completely oriented graph. Introducing posterior preference probabilities and stochastic transitivity conditions to the graph, we obtain a new graphical model that yields criteria for the optimal ordering in the multiple comparison. Necessary theories involved in the method and some computational aspects are provided. Some numerical examples are given to illustrate the efficiency of the suggested method.

Sensitive, Accurate PCR Assays for Detecting Harmful Dinoflagellate Cochlodinium polykrikoides Using a Specific Oligonucleotide Primer Set

  • Kim Chang-Hoon;Park Gi-Hong;Kim Keun-Yong
    • Fisheries and Aquatic Sciences
    • /
    • v.7 no.3
    • /
    • pp.122-129
    • /
    • 2004
  • Harmful Cochlodinium polykrikoides is a notorious harmful algal bloom (HAB) species that is causing mass mortality of farmed fish along the Korean coast with increasing frequency. We analyzed the sequence of the large subunit (LSD) rDNA D1-D3 region of C. polykrikoides and conducted phylogenetic analyses using Bayesian inference of phylogeny and the maximum likelihood method. The molecular phylogeny showed that C. polykrikoides had the genetic relationship to Amphidinium and Gymnodinium species supported only by the relatively high posterior probabilities of Bayesian inference. Based on the LSU rDNA sequence data of diverse dinoflagellate taxa, we designed the C. polykrikoides-specific PCR primer set, CPOLY01 and CPOLY02 and developed PCR detection assays for its sensitive, accurate HAB monitoring. CPOLY01 and CPOLY02 specifically amplified C. polykrikoides and did not cross-react with any dinoflagellates tested in this study or environmental water samples. The effective annealing temperature $(T_{p})$ of CPOLY01 and CPOLY02 was $67^{\circ}C$. At this temperature, the conventional and nested PCR assays were sensitive over a wide range of C. polykrikoides cell numbers with detection limits of 0.05 and 0.0001 cells/reaction, respectively.

Identifying differentially expressed genes using the Polya urn scheme

  • Saraiva, Erlandson Ferreira;Suzuki, Adriano Kamimura;Milan, Luis Aparecido
    • Communications for Statistical Applications and Methods
    • /
    • v.24 no.6
    • /
    • pp.627-640
    • /
    • 2017
  • A common interest in gene expression data analysis is to identify genes that present significant changes in expression levels among biological experimental conditions. In this paper, we develop a Bayesian approach to make a gene-by-gene comparison in the case with a control and more than one treatment experimental condition. The proposed approach is within a Bayesian framework with a Dirichlet process prior. The comparison procedure is based on a model selection procedure developed using the discreteness of the Dirichlet process and its representation via Polya urn scheme. The posterior probabilities for models considered are calculated using a Gibbs sampling algorithm. A numerical simulation study is conducted to understand and compare the performance of the proposed method in relation to usual methods based on analysis of variance (ANOVA) followed by a Tukey test. The comparison among methods is made in terms of a true positive rate and false discovery rate. We find that proposed method outperforms the other methods based on ANOVA followed by a Tukey test. We also apply the methodologies to a publicly available data set on Plasmodium falciparum protein.

Spatial-Temporal Frough Analysis of South Korea Based On Neural Networks (신경망을 이용한 우리나라의 시공 간적 가뭄의 해석)

  • 신현석
    • Proceedings of the Korea Water Resources Association Conference
    • /
    • 1998.05b
    • /
    • pp.7-13
    • /
    • 1998
  • A methodology to analyze and quantify regional meteorological drough based on annual precipitation data has been introduced in this paper In this study, based on posterior probability estimator and Bayesian classifier in Spatial Analysis Neural Network ISANN), point drought probabilities categorized as extreme, severe, mild, and non drought events has been defined, and a Bayesian Drought Severity Index (BPSI) has been introduced to classify the region of interest into four drought serverities. For example, the proposed methodology has been applied to analyze the regional drought of South Korea. This is a new method to classify and quantify the spatial or regional drought based on neural network pattern recognition technique and the results show that it may be apprepriate and valuable to analyze the spatial drought.

  • PDF

Trajectory Recognition and Tracking for Condensation Algorithm and Fuzzy Inference (Condensation 알고리즘과 퍼지 추론을 이용한 이동물체의 궤적인식 및 추적)

  • Kang, Suk-Bum;Yang, Tae-Kyu
    • Journal of the Korea Institute of Information and Communication Engineering
    • /
    • v.11 no.2
    • /
    • pp.402-409
    • /
    • 2007
  • In this paper recognized for trajectory using Condensation algorithm. In this pater used fuzzy controller for recognized trajectory using fuzzy reasoning. The fuzzy system tract to the three-dimensional space for raw and roll movement. The joint angle ${\theta}_1$ of the manipulator rotate from $0^{\circ}\;to\;360^{\circ}$, and the joint angle ${\theta}_2$ rotate from $0^{\circ}\;to\;180^{\circ}$. The moving object of velocity display for recognition without error using Condensation algorithm. The tracking system demonstrated the reliability of proposed algorithm through simulation against used trajectory.

Optimal Radiation Port Arrangements for Hepatic Tumor using 3-dimensional Conformal Radiotherapy Planning (3차원입체조형방사선치료 계획 시 간종괴의 위치에 따른 최적 조사 방향의 결정)

  • Lee, Ik-Jae;Seong, Jin-Sil;Shim, Su-Jung;Jeong, Kyoung-Keun;Cho, Kwang-Hwan
    • Journal of Radiation Protection and Research
    • /
    • v.31 no.4
    • /
    • pp.187-195
    • /
    • 2006
  • The purpose of this study was to investigate the optimal beam arrangements for hepatic tumors, according to the location of the hepatic tumor and its relationship to organs at risk (OARs). The virtual gross tumor volumes were divided into four groups according to the Couinaud's classification. Several plans were made for each virtual target, and these plans were compared for the normal tissue complication probabilities (NTCP). For group I, NTCP improved as the number of the beam ports increased. However, plans with more than 5 ports had little advantage. For group II, plans with the beam directions from the anterior side showed better results. Group III contained many OARs near the target, which placed restrictions on the beam-directions. Multi-directional plans yielded a higher dose to the OARs than a simple two-port plan using right anterior oblique and posterior beam (RAO/PA). For group IV, a simple RAO/PA port plan was adequate for protection of remaining liver. NTCP can significantly vary between radiotherapy plans when the location of the tumor and its neighboring OARs are taken into consideration. The results in this study of optimal beam arrangements could be a useful set of guidelines for radiotherapy of hepatic tumors.

Agency Problems in Banks and the Efficiency of Restructuring Distressed Firms (은행의 대리문제와 부실기업에의 출자전환)

  • Lee, Sang-Woo;Park, Rae-Soo
    • The Korean Journal of Financial Management
    • /
    • v.24 no.2
    • /
    • pp.113-145
    • /
    • 2007
  • In this paper, we examine whether the poor performance of distressed firms where banks take equity may occur due to agency problems in banks. By adopting the debt-equity swap, the bank can effectively postpone the occurrence of bad loans form the failure of the distressed firm. As a result, firms with more debt will be more likely to obtain debt-equity swap, regardless of their probabilities of revival. This is not because they are more profitable, but because they have more debt and thus it poses greater risk to the bank. We empirically look into these predictions with the data of 44 workout firms and find the following results. First, debt-equity swap appears to be more applicable especially when the distressed firms are large and when BIS of related banks is low. Specifically, the conditional probability of 'large firms' based on debt-equity swap is 65.52% and the conditional probability of 'bad banks' based on debt-equity swap is 75.86%. Also, as predicted, the performance of these debt-equity firms is poorer than that of non debt-equity firms. The conditional probability of 'large firms' based on posterior failure is 84.62% and the conditional probability of 'bad banks' based on posterior failure is 84.62%. This is consistent with our predictions and is also confirmed through results of the logit regression analysis. Second, when the restructuring is led by 'good banks', the performance of equity-swap firms is superior to that of non equity-swap firms. This result is consistent with that of James(1995). Hence, we can conclude that there may be some agency problems in restructuring distressed firm-especially when distressed firms are large and banks are bad. And these agency problems can reconcile the difference between James' results and Park, Lee, and Jang's.

  • PDF