• Journal of Microbiology and Biotechnology
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• 제28권7호
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• pp.1199-1208
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• 2018

Osteoarthritis is a disease that affects the articular cartilage and osseous tissue, and can be worsened by aging, overweight status, and post-traumatic arthritis. The present study aimed to evaluate the effect of ID-CBT5101 (tyndallized Clostridium butyricum) on bone metabolism and the inflammatory response in a monosodium iodoacetate-induced rat model of osteoarthritis. ID-CBT5101 was administered orally at doses of $10^8$ or $10^{10}CFU/day$ for 2 weeks before direct injection of monosodium iodoacetate ($3mg/50{\mu}l$ of 0.9% saline) into the intra-articular space of the rats' right knees. The rats subsequently received the same doses of oral ID-CBT5101 for another 4 weeks. We evaluated the treatment effects based on serum biomarkers, mRNA expression, morphological and histopathological analyses of the knee joints, and weight-bearing distribution analysis. Compared with those in control rats, the ID-CBT5101 treatments significantly reduced the serum concentration of inflammation and bone metabolism markers (i.e., COX-2, IL-6, $LTB_4$, and COMP), and significantly increased the concentration of $IFN-{\gamma}$ and glycosaminoglycans. In addition, the ID-CBT5101 treatments inhibited the mRNA expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases (i.e., MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1, and TIMP-2). Furthermore, the ID-CBT5101 treatments effectively preserved the knee cartilage and synovial membrane, and significantly decreased the amount of fibrous tissue. Moreover, compared with that of the negative control group, the ID-CBT5101 treatments increased the weight-bearing distribution by ${\geq}20%$. The results indicate that ID-CBT5101 prevented and alleviated osteoarthritis symptoms. Thus, ID-CBT5101 may be a novel therapeutic option for the management of osteoarthritis.

• Archives of Plastic Surgery
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• 제36권2호
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• pp.188-193
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• 2009

Purpose: Several authors reported about the post - traumatic nasal aesthetic complications. However, the study for functional or intra - nasal complications has been reported not enough. The aim of this study is to observe the incidence of intranasal synechia. Methods: We reviewed the data from 401 consecutive patients with nasal bone fracture from september 2006 to December 2007. We enforced evaluation with preoperative CT in all patients but postoperative CT within complicated patients. We classified the nasal bone fracture according to the anatomy and severity of fracture. Type I is nasal tip fracture(15%, n = 59), Type II is simple lateral without septal injury(38%, n = 152), Type III is simple lateral with septal injury(23%, n = 92), Type IV is closed comminuted(20%, n = 82), Type V is open comminuted or complicated(4%, n = 16). We studied 98 patients with nasal bone fracture who had postoperative symptoms or undergone postoperative endoscopic evaluation. And then we evaluated the postoperative endoscopic finding and nasal synechal formation after operation. Results: The incidence of intranasal synechiae was 15%(n = 62). According to the endoscopic findings, the incidence of intranasal synechiae was 10%(n = 6) in Type I, 8%(n = 12) in Type II, 16%(n = 15) in Type III, 24%(n = 20) in Type IV, and 56%(n = 9) in Type V. Additionally, the incidence of subjective nasal obstruction and olfactory dysfunction is 18%(n = 72) and 13%(n = 51). But the incidence of symptomatic synechiae of nasal obstruction and olfactory dysfunction is 92%(57/62) and 55%(34/62). Conclusion: We identified relatively high prevalence of nasal obstruction and olfactory dysfunction in nasal synechiae. Based on the results of this study, intranasal synechiae really caused airway obstruction(92%). Our data showed significant relationship between intranasal synechiae and severity of the fracture, because of increasing mucosal handling and destructive closed reductional procedures. First of all, education of delicate procedure regarding this subject should be empathized accordingly.

• Archives of Reconstructive Microsurgery
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• 제16권2호
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• pp.113-118
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• 2007

Purpose: The purpose of this work was to describe the results of treatment for motor vehiclerelated crushing injuries among children and adolescents under sixteen years in Korea. Materials and Methods: A retrospective analysis was conducted of data from children who were under sixteen year and injured foot by motor vehicles. Cases were documented 1) age at the time of injury, 2) injured site, 3) the area of accident, 4) the kind of vehicle, 5) associated injuries, 6) methods of treatment for soft tissue reconstruction and 7) complications. The relationships between the area of accident and associated injuries, and the kind of vehicle and associated injuries were analyzed using Chi-square test and Fisher exact test. Results: There were 97 children who were 15 year and younger. The mean age was 7.4 years, and 65% were boys. The left foot was more dominant side of injury (57%). Seasonal variation was seen with the number of injuries peaking during the summer (43%, p<0.05). Among the vehicles, 78.3% were the large vehicles (bus, truck or van). The where of accident was more frequent at an alley or less than two lanes of traffic. But, the relationships between the place of accident and associated injury or the kind of vehicles and associated injury were not statistically significant. The associated injury were fracture or dislocation (23 cases, 35.9%), injury of tendon (21 cases, 32.8%). There were amputation or disarticulation of foot in 8 cases (8.2%) and post-traumatic deformities such as flatfoot, hindfoot varus or valus deformities by tendon injury in 7 cases (7.2%). Conclusion: More than 50% of crushing or degloving injuries of child's foot by traffic accidents happened in boys between 5 to 9 years old. The associated injury was unrelated with size of vehicles or accident place at the time of accident. But, even though foot injury happened in an alley or one lane by small vehicles, child who hurt feet by car need thorough investigation about associated injury. If a surgeon keep in mind and treat child to associated injury necessarily, can minimize complication. Microsurgical reconstruction for soft tissue defect was prior to other methods.

• 대한족부족관절학회지
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• 제7권2호
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• pp.208-217
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• 2003

Introduction: Soft-tissue impingement syndrome is now increasingly recognized as a significant cause of the chronic ankle pain. As a method to detect soft-tissue ankle impingement, a characteristic history and physical examination, routine MR imaging, and direct MR arthrography were used. The efficacy of routine MR imaging has been controversial for usefulness because of low sensitivity and specificity. Direct MR artrhography was recommaned for diagnosis because of the highest sensitivity, specificity and accuracy, but it requires an invasive procedure. The purpose of this study is to investigate the diagnostic accuracy of Fat suppressed, contrast enhanced, three-dimensional fast gradient recalled acquisition in the steady state with rediofrequency spoiling magnetic resonance imaging(CE 3D-FSPGR MRI) and to evaluate the clinical outcome of the arthroscopic treatment in assessing soft-tissue impingement associated with trauma of the ankle. Materials and Methods: We reviewed 38 patients who had arthroscopic evaluations and preoperative magnetic resonance imaging studies(3D-FSPGR MRI) for post-traumatic chronic ankle pain between January 2000 and August 2002. Among them, 24 patients had osteochondral lesion, lateral instability, loose body, malunion of lateral malleoli, and peroneal tendon dislocation. The patient group consisted of 23 men and 15 women with the average age of 34 years(16-81 years). The mean time interval from the initial trauma to the operation was 15.5 months(3 to 40 months), The mean follow-up duration of the assessment was 15.6months(12-48 months). MRI was simultaneously reviewed by two radiologists blinded to the clinical diagnosis. The sensitivity, specificity and accuracy of MRI was obtained from radiologic and arthroscopic finding. Arthroscopic debridement and additional operation for associated disease were performed. We used a standard protocol to evaluate patients before the operation and at follow-up which includes American Orthopedic Foot and Ankle Society Ankle-Hindfoot Score. Results: For the assessment of the synovitis and soft tissue impingement, fat suppressed CE 3D-FSPGR MR imaging had the sensitivity of 91.9%, the specificity of 84.4 and the accuracy of 87.5%. AOFAS Ankle-Hindfoot Score of preoperative state was 69.2, and the mean score of the last follow-up was 89.1. These were assessed as having 50% excellent(90-100) and 50% good(75-89). The presence of other associated disease didn't show the statistically significant difference(>0.05). Conclusion: Fat suppressed CE 3D-FSPGR MR imaging is useful method comparable to MR arthrography for diagnosis of synovitis or soft-tissue impingement, and arthroscopic debridement results in good clinical outcome.

• 대한족부족관절학회지
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• 제20권2호
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• pp.67-72
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• 2016

Purpose: The purpose of this study was to assess the 2-year follow-up results of patients with a trimalleolar fracture, who had undergone an anterior incision cannulated screw fixation of the posterior malleolar fragment, which had more than 25% of articular involvement or had no cortical continuity with the distal tibia. Materials and Methods: Among 28 patients with a trimalleolar fracture who had undergone fixation of the posterior malleolar fragment between February 2005 and February 2010, 14 patients, who underwent an anterior incision cannulated screw fixation of posterior malleolar fragment and were followed-up for more than 2 years, were selected. The postoperative clinical and radiological findings immediately and at the 1- and 2-year follow-up were compared. The clinical findings were evaluated as American Orthopaedic Foot and Ankle Society (AOFAS) score. The radiological assessment was evaluated as the maintenance of reduction, period to bone union, and the presence of nonunion, malunion, and complications. Results: The clinical outcome by mean AOFAS score revealed 83.0 points in the group with preoperative displacement below 2 mm and 80.7 points in the group with preoperative displacement above 2 mm postoperatively. The mean AOFAS score was 91.7 and 93.1 points in the group with preoperative displacement below 2 mm on 1- and 2-year follow-up, respectively, and 89.8 and 91.7 points in group with the preoperative displacement above 2 mm on 1- and 2-year follow-up, respectively. After a 2-year follow-up among 14 cases selected for this study, 13 cases showed an excellent reduction state and only 1 case (7.1%) showed a displacement of more than 2 mm. No complication were encountered in the group with preoperative displacement below 2 mm. On the other hand, among 8 patients in the group with preoperative displacement above 2 mm, there were 3 with limitations of the range of motion of the ankle joint (37.5%) and 1 post-traumatic arthritis (12.5%) at the 2-year follow-up. Conclusion: Anterior incision cannulated screw fixation of the posterior malleolar fragment could be a valuable method for the treatment of trimalleolar fractures that provides satisfactory results.

• 항공우주정책ㆍ법학회지
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• 제25권1호
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• pp.55-95
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• 2010

'lesion corporelle'의 직역에 대한 의견에 있어서 약간의 차이가 있지만, 그것의 의미와 정신 또는 정신적 상해의 다양한 문맥상 적용함에 있어서는 분명하지 못하다. 미국 법원은 Floyed 사건이 바르샤바 협약 제17조에 따라 정신적 상해를 포함하는 범위에 대한 배상을 허용한 이후로 신체적 상해의 관련 또는 동반 여부에 따라 다르게 결정하고 있다. 대부분의 법원은 동 협약에 따라 순수한 감정적 손해에 대해서는 배상이 불가능하다는 의견에는 일치한다. 또한 신체적으로만 나타나는 증상 예를 들어 체중이 감소하거나 불면증과 같은 경우에는 감정적인 손해에 대한 배상을 인정하지 않는데 동의한다. 동시에 감정적 손해가 신체적 상해로부터 야기된 경우에는 그에 대한 배상에 동의한다. 이와 관련하여 현재는 바르샤바 협정의 용어가 그대로 유지되고 있어 많은 국가들의 판례가 상이하게 나타나고 있어 조약의 본래의 목적에 기여하지 못하고 있는 실정이다. 또한 정신적 상해와 관련된 PSTD 등의 사안은 현 바르샤바에 따르든지, ICAO에서 제안한 새로운 협약에 따르든지 그 여하를 불문하고 '신체적 상해'라는 용어 내에서 법원이 정신적 고통과 관련된 과학적 증거와 그 적용문제에 있어서 감당할 준비가 되어 있는지의 여부에 따라 달라질 것이다. 이러한 점들을 종합해 볼 때 현재의 바르샤바 협정 제17조의 '신체적 상해'라는 개념은 '정신적 상해'까지 확대되어야 할 것이다. 따라서 향후 조약에서 '신체적 상해'라는 용어는 '상해' 혹은 '건강훼손'이라는 용어로 개정 내지 교체해야 할 것이다.

• 수면정신생리
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• 제12권1호
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• pp.64-67
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• 2005

폐쇄성 수면무호흡증은 이비인후과영역에서 흔하게 관찰되는 질환 중 하나로 수면 중에 상기도의 폐쇄로 인한 호흡정지가 주요한 병인이며 상기도를 구성하는 비강, 구강, 인두, 후두 중 어느 한 부분에서 폐쇄가 일어나도 질환의 원인이 될 수 있다. 비폐색의 가능한 원인들로는 주로 비중격 만곡, 비용, 기포성 갑개, 후비공 폐쇄, 종양, 이물, 술 후 또는 외상 후 발생한 유착, 여러 가지 비염, 기타 질환 등이 있다. 폐쇄성 수면무호흡증의 수술적 치료에는 비강수술, 구개인 두수술, 편도 및 아데노이드 절제술, 설부 축소수술, 기관절개술 등 여러 가지가 있는데 문헌들을 고찰한 결과 지금까지 성인에서 수면무호흡증 치료로 시행한 비강수술의 효과에 대해서는 아직 논란의 여지가 있는 상태이다. 최근 저자들은 비폐색과 동반된 코골이 및 수면무호흡증 환자에서 비폐색과 수면무호흡증의 원인으로 생각되는 비중격 만곡증 및 비후성비염을 교정하기 위해 비중격 교정술 및 하비갑개 절제술을 시행한 결과 수술 전, 후의 증상 및 수면 다원검사 비교에서 뚜렷한 호전을 경험하였기에 보고하는 바이다.

• 대한교통학회지
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• 제28권5호
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• pp.17-29
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• 2010

본 연구는 도로교통사고 비용의 추계에 있어 미국, 일본, 영국 등 일부선진국에서 추계항목에 포함된 고용주 비용(미국의 고용주 비용, 일본의 사업주체의 비용, 영국의 인간적 비용)의 도입 필요성을 검토하고, 이를 저감시키기 위한 대책마련을 진행하였다. 이를 위해, 교통사고 발생 시 상대적으로 관심권 밖에 위치한 교통사고 가해자의 PTSD (Posttraumatic Stress Disorder) 심각성과 현황을 파악하고, 개인별 특성이 반영된 PTSD 심각도 수준별 대책을 마련하였다. 그 결과를 정리하면, 첫째, 교통사고 가해자를 대상으로 추정만 해 오던 교통사고 PTSD 현황과 심각성을 설문조사를 통해 파악할 수 있었다. 둘째, PTSD 특성별 유 무에 따른 판별분석모형을 구축하였는바, 판별식의 변수로는 '사고로 인한 불면증', '사고 상황 또는 유사 상황에서 운전 중 심리적 위축'이 변수로 선정되었다. 셋째, PTSD의 심각도를 추정할 수 있는 순서형 프로빗 모형 구축 결과, 주요변수는 '최대피해자 심각도', '사고 상황 악몽', '불면증 경험', '운전 중 위축', '성별', '주요 운전 지역'으로 나타났으며, 실제 추정치가 실제 응답치에 근접함을 확인할 수 있었다. 넷째, 성별, 지역별 특성이 반영된 PTSD 심각도별로 선호하는 치료방법을 제시할 수 있었다. 이렇게 분석된 결과를 통해 교통사고 가해자의 사회 업무 복귀를 앞당기고 작업능률의 저하와 같은 피해를 최소한으로 저감 시킬 수 있는 방법을 제시할 수 있었으며, 이는 결국 이들 운전자들이 몸담고 있는 직장의 고용주에게 발생할 수 있는 직 간접적인 피해를 최소한으로 줄일 수 있을 것이라 사료된다.

• 대한관절경학회지
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• 제8권2호
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• pp.98-102
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• 2004

목적: 외상으로 인한 슬관절 외측 및 후외측 불안정성을 보이는 환자에게 있어 동시 외측 보강술 및 슬와근 건고정술을 시행하는 방법으로 그 치료결과를 보고하고자 한다. 대상 및 방법: 1996년 7월부터 2003년 7월까지 슬관절 외측 및 후외측 불안정성으로 진단 받고 외측보강술 및 슬와근 건고정술 후 1년 이상 추시 관찰이 가능했던 21예를 대상으로 하였다. 남자가 15예, 여자가 6예이었으며 평균연령은 38.5세였다. 손상 후 수술까지의 평균기간은 6.8개월이었다. 슬관절 외측 및 후외측 불안정성의 치료에 있어 본원에서는 대퇴부 외상과에서, 3예에서는 아킬레스 동종건 이식을 시행하였고 18예에서 내측부 인대용 ABC인조인대(Active Bioprosthetic Composite Polyester Ligament, Surgicraft, U. K. )를 이용하여 외측 측부인대의 보강 및 슬와근 건고정술을 동시에 시행하였다 결과: 최종 추시상 슬관절 90도 굴곡 후방 부하 방사선 촬영상 후방 전위의 정도는 건측에 비해 평균 5.6 mm에서 2.5 mm로 개선되었다. 슬관절 30도 굴곡상태의 내반 검사는 전위정도가 건측에 비해 수술 전 평균 8.2 mm의증가소견을 보였으나, 수술 후에는 평균 2 mm의 증가소견만을 보였다. Lysholm score는 수술 전 평균 52.5점에서 수술 후 평균 86.7점으로 34.2점 증가하였고 자가건 이식과 ABC 인조인대를 사용한 군에서 결과는 유의한 차이점은 없었다. 결론: 슬관절의 외측 및 후외측 불안전성에 대한 외측 보강술 및 슬와건 건고정술은 수기 및 수술 후 치료방법이간단하며, 임상적, 방사선학적 평가 결과로 미루어 보아 효과적인 치료 방법 중의 하나로 판단된다.

• 대한두개안면성형외과학회지
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• 제12권2호
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• pp.81-85
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• 2011

Purpose: Nasal bone fracture is the most common facial fracture. Although nasal bone fractures are considered to be minor injuries, the incidence of post-traumatic nasal deformity remains high. This study is designed to support management and patient satisfaction by classifying the simple nasal bone fracture, and survey the care method and result, which is compared with other studies. Methods: From May 2008 to April 2010, 334 patients with simple nasal bone fractures visited our hospital. The incidence, cause, types of nasal bone fracture, treatment, and complications are analyzed according to clinical examination, patient's record and radiographic images. Results: The mean age of patients was 30 years old, with 74% of the patients having been male, and 26% were female. The highest incidence of this fracture was between late teens to late twenties. The causes of nasal bone fracture were the following: having slipped or fallen down (39%), violence (16%), sports accident (14%), traffic accident (11%), industrial accident (6%), and others (16%). Patient's radiographic images were analyzed by Stranc and Robertson classification, frontal impact plane I was 38%, plane II was 16%, plane III was 1%, lateral impact plane I was 21%, plane II was 21%, and plane III was 3%. On average, surgical treatment was performed 7.2 days after trauma under general anesthesia. Closed reduction of nasal bone fracture was performed in 99% of patients. In patients with septal injuries, septal management was performed in 76.7% of cases. Aesthetic surgery was done on same time in 24% of patients. There were some complications, such as residual nasal deformity (7.2%), nasal obstruction (0.9%) and hyposmia (0.3%). Conclusion: According to this study, nasal bone fractures occurred commonly in physically active age groups (age 15~29 years), as a result of having slipped or fallen down, at afternoon and at night time. And it could be treated successfully by closed reduction and septoplasty by 7 days after trauma.