• Journal of Photoscience
• /
• 제9권2호
• /
• pp.29-32
• /
• 2002

Studies till date suggest the existence of a fetal biological clock in suprachiasmatic nuclei entrained by the circadian signal from mother. Melatonin from maternal pineal gland reaches to the fetus by crossing every biological barrier including placenta, hence fetuses were exposed to similar melatonin variation as their mother. Experimental modulations of maternal pineal gland activity of pregnant females either by exposing the them to different photoperiodic schedules or by exogenous melatonin treatments till the date of parturition, regulated the fetal plasma level of melatonin, thereby the prenatal (fetal) growth and development. This clearly suggests the maternal transport of melatonin to their fetus through placenta since fetal retina-hypothalamic tract was incomplete. An extension of experimental schedules till 60 days of post-partum period regulated the neonatal pineal gland activity and gonadal maturation along with their plasma levels of melatonin and sex steroids suggesting clearly the phenomenon of maternal transfer of melatonin to their young ones during the post-natal period, when the neonates were solely dependent on the mother's milk for their nutrition and energetic demands. On the basis of above observations we may suggest that the maternal pineal gland activity regulate the prenatal development by passing its melatonin to fetus via placenta and post-natal growth and sexual maturation by passing maternal melatonin to neonates via milk. Hence, the photoperiod perceived by mother is translated into the maternal plasma level of melatonin which not only regulates the prenatal but also the post-natal growth and sexual maturation of neonates.

• 한국환경성돌연변이발암원학회지
• /
• 제22권2호
• /
• pp.125-132
• /
• 2002

To evaluate the modifying effect of Kwao Kreu, Pueraria mirifica (PM) well-known as a rejuvenating folk medicine from Thailand, peri- and post-natal studies were carried out in rats. PM extract was administered to pregnant Sprague Dawley (SD) rats by oral gavage from gestation 6 (GD 6) to postnatal day 21 (PND 21). The amount of administered in this study was 0.042, 0.42 and 4.2 mg/kg/day, respectively. There were no treatment related changes of dams in deaths, clinical signs, and parturition. Treatment related changes in body weight, food consumption and lactation of dams were not observed. F1 fetuses in external abnormality, physical development, reflex/sensory functions and behavioral development were not found. No adults and F1 fetuses in organ weight was found with the exception of vagina and uterus of F1 fetuses. The results showed that PM extract, up to 4.2 mg, had no adverse effects on the peri- and post-natal development of rats. Therefore, PM extract has no adverse effects on peri- and post-natal development of rats.

• 한국보육지원학회지
• /
• 제11권5호
• /
• pp.113-134
• /
• 2015

본 연구는 산후 1년 이내 어머니의 우울감 수준에 따라 어머니의 자아효능감이 차이 나는지와 산후 1년 이후와 2년 이후의 양육스타일, 만 2세 영아의 의사소통능력에서 차이가 나는지 살펴보았다. 그리고 어머니의 산후 우울감이 영아의 의사소통능력에 영향을 미치는 경로를 추적하였다. 분석 자료로 한국아동패널 2008년(산후 1년 이내), 2009년(산후 1년 이후)과 2010년(산후 2년 이후) 데이터를 사용하였으며 연구대상은 한국아동패널에 참여한 어머니들과 그 자녀들 1,438쌍이었다. 측정도구로 Kessler 등(2002)의 우울 척도(K6), Pearlin, Lieberman, Menaghan과 Mullan(1981)의 자아효능감 척도, Bornstein 등(1996)의 양육스타일 질문지, K-ASQ의 의사소통(communication) 영역 질문지를 사용하였고 자료분석을 위해 t 검증과 경로분석을 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 어머니의 산후 우울감 수준에 따라 어머니의 자아효능감, 양육스타일, 그리고 만 2세 영아의 의사소통능력에서 유의한 차이가 나타났다. 둘째, 어머니의 산후 우울감은 양육스타일을 통해, 그리고 어머니의 자아효능감을 거쳐 양육스타일을 통해 영아의 의사소통능력에 간접적으로 영향을 미쳤다. 이러한 결과로부터 어머니의 산후 우울감은 어머니의 자아효능감, 양육스타일에 직접적으로 영향을 미치고 만 2세 영아의 의사소통능력에 간접적으로 영향을 미치는 변인임을 알 수 있다. 또한 본 연구 결과는 산후 1년 이내 나타난 어머니의 산후 우울감이 영아의 의사소통능력에 미칠 수 있는 부정적 영향을 최소화할 필요성을 시사하며 영아의 의사소통능력 증진을 위한 중재 프로그램 개발에 유용한 자료를 제공할 수 있다.

• 아동학회지
• /
• 제27권1호
• /
• pp.183-203
• /
• 2006

The purpose of this study is to assess the effectiveness of a parental education program developed to 295 single university students based on pre-test and the post test on the program. The data is interpreted using statistical methods such as the Percentage, T -Test, Anova test, and the Turkey test. The major results were as follows : First, significant difference regarding the knowledge on parenthood existed among students before and after the tests, with the post-test students showing more knowledge on the matter. Among the six sub-categories of parenthood education program, the effects of the post-testing were most visible in pregnancy, delivering, pre-natal and infant development, parents attitude, and sex education for their children in the form of increased awareness and knowledge. However, no significant effects were detected in pre-natal education. In terms of socio-demographic variable, effects were more visible in female students than in male students. Second, the program also resulted in positive effects in both male and female students.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
• /
• pp.177.1-177.1
• /
• 2000

• BMB Reports
• /
• 제41권12호
• /
• pp.875-880
• /
• 2008

Mbu-3 is a novel mouse brain unigene that was identified by digital differential display. In this study, expression of the gene was chased through developmental stages and the protein product was identified in the brain. The cDNA sequence was 3,995-bp long and contained an ORF of 745 AA. Database searches revealed that the chicken SST273 gene containing LRR- and Ig-domain was an mbu-3 orthologue. Tissue specificity for the gene was examined in embryos and in brains at post-natal and adult stages. During the embryonic stages, mbu-3 was localized to the central nervous system in the brain and spinal cord. In the early post-natal stages, the gene was evenly expressed in the brain. However, with aging, expression was confined to specific regions, particularly the hippocampus. The protein was approximately 95 kDa as determined by Western blot analysis of brain extracts.

• Neonatal Medicine
• /
• 제25권4호
• /
• pp.144-152
• /
• 2018

Purpose: The aim of this study was to investigate the clinical characteristics of Respiratory syncytial virus (RSV) infection during the neonatal period to provide information that is useful in clinical practice and suggest extension of the palivizumab administration. Methods: Neonates admitted to the National Health Insurance Service Ilsan Hospital neonatal intensive care unit due to respiratory symptoms and for whom multiplex reverse transcription-polymerase chain reaction and multiplex real time-polymerase chain reaction tests were performed between October 2011 and May 2016 were included in this study. Medical records were retrospectively reviewed, and data was collected for 156 neonates. Results: Among the 156 neonates, RSV was detected in 114 (73.1%), non-RSV in 25 (16%), and no virus in 17 (10.9%). The majority were full term infants (92.4%) and peak incidence of RSV infection was in January. Post-natal care center infection was more common in the RSV group (46.6%) than that in the other virus groups (24%, P=0.0243). Clinical symptoms were severe in the RSV group in contrast to that in the non-RSV or others groups. The RSV group frequently needed oxygen therapy (P=0.0001) and the duration of hospital stays were longer (P=0.0001). Conclusion: RSV is a significant cause of respiratory infection in neonates and the severity is higher in contrast to that with other viral causes of infection. Infants in post-natal care centers have a high-risk of developing RSV infections; therefore, palivizumab administration may be considered in this group to prevent hospitalization and reduce the duration of hospital stay.

• Toxicological Research
• /
• 제3권1호
• /
• pp.55-63
• /
• 1987

A Peri-and Postnatal Study was Carried out to examine the effects of rHuIFN-${\alpha}A$, produced by gene-manipulated E. coli, on offsprings of Wistar rats. The substance was administered intraperitoneally to dams at dose levels of $1{\times}10^5$, $4{\times}10^5$ and $1.2{\times}10^6$ I.U/kg/day during the period from day 17 of gestation to day 21 after delivery. All the pregnant dams were allowed to deliver naturally, and the postnatal development of the offsprings was observed. No noticeable toxic effects and pathological changes on dams were observed, and no detectable variations in postnatal development of offsprings occured.

• 복식문화연구
• /
• 제23권2호
• /
• pp.337-352
• /
• 2015

This study suggests designs of maternity clothes wearable after childbirth and aims at confirming that maternity wear is continuously wearable during a post-natal period. As for research methods, theoretical and empirical studies with research on a production of work were conducted, focusing on the design development of the maternity dress which may be worn even after childbirth. The results of theoretical and empirical studies possibly presented various designs which require fashionability going with the trend of time. The maternity wear also requires the adaptability for a changing body shape to enable a woman to wear it during a pregnancy period and after childbirth. Besides, the convenience of dressing and undressing with wearing comfort is considered. 6 sets of one-piece dress were made as the result of the study and three factors of fashionability, adaptability and convenience were considered. The conclusions are as follows : Firstly, it verified that the maternity wear is fashionable clothes not to cover protruded abdomen but to satisfy women's desire of self expression. Secondly, it overcame the limit of dress design through fitting it to completely different two body sizes and shapes with design factors and patterns. Lastly, it suggested a research model of maternity wear corresponding to economical, environmental and ethical principles as giving an effect of "two" dresses with one. This study presented a new direction of design study with meaningful actions of fashion designing in the aspects of economical, environmental and ethical consumption unlike artificial disposal on SPA brands.

• Pediatric Infection and Vaccine
• /
• 제4권2호
• /
• pp.240-256
• /
• 1997

목 적 : 초등학생의 성별, 연령별, 예방 접종률, 접종 완성률, 접종 시기를 비교하고, 간염 표지자 양성률을 검토하여 경기도 지역에서 과거 15년 동안 영아, 유아 및 초등학생을 대상으로 병의원, 보건소 및 학교 등에서 실시한 B형 간염 예방 접종 실태를 파악하고자 하였다. 방 법 : 1993년에 경기도 지역 초등학교 학생들을 집락 추출(cluster sampling)하여 실시하였다. 학교마다 각 학년별로 한 학급을 선정하여 총 2,072 명을 대상으로 혈청학적 검사와 설문 조사를 실시하였다. 결 과 : 1) 성별 HBsAg 양성률은 남자 3.7%, 여자 2.7%였고, 평균 3.4%였다. 연령별 HBsAg 양성률은 7세 3.5%, 12세 5.2%로 연령이 증가함에 따라 높아지는 경향을 보였다. 2) 어머니들의 B형 간염 출산 전 수검율은 10.2%, 출산 후 수검율은 42.5% 였다. 부모의 학력이 높을수록, 아버지의 직업이 사무직인 경우에 출산 전, 출산 후 수검율이 높았다. 3) 전체 예방 접종률은 82.6%, 접종 완성률은 69.8%, 추가 접종률은 42.8%였다. 연령이 증가함에 따라 예방 접종률, 접종 완성률, 추가 접종률이 모두 감소하였다. 부모의 학력이 높을 수록 예방 접종률, 접종 완성률, 추가 접종률이 증가하였다. 연령이 어릴수록 1 세 미만에 접종한 비율이 증가하였고, 7세 이상에 접종한 비율은 감소하였다. 부모의 학력이 높을수록, 아버지의 직업이 사무직인 경우에 1세 미만에 접종한 비율이 높았다. 4) 예방 접종 시기에 따른 간염 표지자 양성률에서 HBsAg과 Anti-HBc 양성률은 1~6세, 7세 이후, 1 세 미만의 순서로 높았다. 접종회수가 증가함에 따라 Anti-HBs 양성률은 유의하게 증가하였다. 기본 3회 접종 후 5년째 된 군에서 Anti-HBs 양성률은 85.7%, 유효 역가율은 69.6% 로 가장 낮았다. 결 론 : 이상의 결과를 통하여 전체 접종률은 82.6%, 접종 완성률은 69.8% 로 아직 낮은 수준으로 나타났다. 특히 부모의 학력이 낮고 아버지 직업의 사회적 지위가 낮은 계층은 출산 전 출산 후 산모의 HBV 수검율, 자녀의 백신 접종률, 접종 완성률이 모두 낮은 것으로 보아 의료 기관의 접근도가 떨어지고 예방 접종의 중요성에 대한 인식도 낮은 것으로 생각된다. 앞으로 B 형 간염 예방 접종 사업은 지속적인 보건 교육과 함께 이러한 사회적 지위가 낮은 계층 자녀의 접종률을 높이는 특별 관리 대책이 필요하리라 생각된다.