• International Journal of Control, Automation, and Systems
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• v.1 no.4
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• pp.453-458
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• 2003

The anomaly-detection algorithm based on negative selection of T cells is representative model among self-recognition methods and it has been applied to computer immune systems in recent years. In immune systems, T cells are produced through both positive and negative selection. Positive selection is the process used to determine a MHC receptor that recognizes self-molecules. Negative selection is the process used to determine an antigen receptor that recognizes antigen, or the nonself cell. In this paper, we propose a novel self-recognition algorithm based on the positive selection of T cells. We indicate the effectiveness of the proposed algorithm by change-detection simulation of some infected data obtained from cell changes and string changes in the self-file. We also compare the self-recognition algorithm based on positive selection with the anomaly-detection algorithm.

• Korea Journal of Hospital Management
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• v.27 no.3
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• pp.1-14
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• 2022

Purposes: This purpose of this study was to check how much the online word of mouth influences on customer's hospital selection according to Kano's model. Methodology: Kano classified the attributes that affect customer's satisfaction into attractive, one-dimensional, indifferent, must-be, and reverse attributes. Among them, attractive and one-dimensional attributes make up the largest portion in hospital selection. Based on this, the influence of positive or negative online reviews on the selection of hospitals was investigated. Differentiated service was selected as the attractive attributes, and a kind, sufficient explanation was selected as the one-dimensional attributes. Then a questionnaire was conducted how much the positive or negative online reviews influence on hospital selection, respectively. It was conducted from August 7 to September 7, 2021 for medical consumers in their 20s and older who have used medical services for the past 3 years, and the final 142 questionnaires were analyzed. All data was analyzed by chi-square and two-way ANOVA using SPSS ver 25.0. Findings: The results showed that, in one-dimensional attributes, the difference between positive and negative reviews was not statistically significant, but in attractive attributes, positive and negative reviews showed a statistically significant difference. It suggests that positive reviews on attractive attributes had a greater influence on hospital selection. In terms of hospital selection, when the experimental participants were exposed to the positive reviews, the hospital selection ratio did not differ by Kano's attributes, but to the negative reviews it differed. The hospital selection ratio, even after they were exposed to negative reviews, was higher in the attractive attributes than in the one-dimensional attributes. Practical Implication: This study confirmed that hospital selection is influenced differently depending on the Kano's attributes and the direction of the reviews, and suggests that marketers should respond differently to each Kano's attributes when they deal with online reviews of hospitals.

• Culinary science and hospitality research
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• v.22 no.8
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• pp.109-121
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• 2016

This study analyzed the effect of five sub-variables' attribute of HMR: features of information, diversity, promptness, price and convenience, on the consumer purchasing intention. In addition, the regulation effect of positive reviews and negative reviews of consumers' online reviews between HMR selection attribute and purchasing intention was also tested. Results are following. First, convenience feature (B=.577, p<.001) and diversity feature (B=.093, p<.01) among the effect of HMR selection attribute had a positive (+) effect on purchasing intention. On the other hand, promptness feature (B=.235, p<.001) and price feature (B=.161, p<.001), and information feature (B=.288, p<.001) were not significant effect on purchasing intention. Second, result of regulation effect of the positive reviews of consumer's online review between the selection attribute of the HMR product and consumers' purchasing intention, in the first-stage model in which the selection attribute of the HMR product is input as an independent variable, there was a significant positive (+) effect on all the features of convenience, diversity, promptness, price, and information. In addition, there was significant positive (+) main effect (B=.472, p<.001) in the second step model in which the consumers' positive reviews, that is a regulation variable. Furthermore, the feature of price (B=.068, p<.05) had a significant positive (+) effect in the third stage in which the selection attribute of the HMR product that is an independent variable and the interaction of the positive review. However, the feature of information (B=-.063, p<.05) showed negative (-) effect, and there was no effect on the features of convenience, diversity, and promptness. Third, as a result of testing the regulation effect of the negative reviews of consumers' online reviews between HMR product selection attribute and consumers' purchasing intention, in the first-stage model in which the selection attribute of the HMR product was a positive (+) effect on all the features of convenience, diversity, promptness, price, and information. In the second-stage model in which consumers' negative reviews (B=-.113, p<.001) had negative (-) effect. In the third-stage in which the selection attribute of the HMR product and the interactions of the negative reviews was a positive (+) effect with the feature of price (B=.113, p<.01). Last, there was no effect at all on the features of convenience, promptness, and information.

• Genomics & Informatics
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• v.13 no.4
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• pp.137-145
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• 2015

Selective sweep can cause genetic differentiation across populations, which allows for the identification of possible causative regions/genes underlying important traits. The pig has experienced a long history of allele frequency changes through artificial selection in the domestication process. We obtained an average of 329,482,871 sequence reads for 24 pigs from three pig breeds: Yorkshire (n = 5), Landrace (n = 13), and Duroc (n = 6). An average read depth of 11.7 was obtained using whole-genome resequencing on an Illumina HiSeq2000 platform. In this study, cross-population extended haplotype homozygosity and cross-population composite likelihood ratio tests were implemented to detect genes experiencing positive selection for the genome-wide resequencing data generated from three commercial pig breeds. In our results, 26, 7, and 14 genes from Yorkshire, Landrace, and Duroc, respectively were detected by two kinds of statistical tests. Significant evidence for positive selection was identified on genes ST6GALNAC2 and EPHX1 in Yorkshire, PARK2 in Landrace, and BMP6, SLA-DQA1, and PRKG1 in Duroc. These genes are reportedly relevant to lactation, reproduction, meat quality, and growth traits. To understand how these single nucleotide polymorphisms (SNPs) related positive selection affect protein function, we analyzed the effect of non-synonymous SNPs. Three SNPs (rs324509622, rs80931851, and rs80937718) in the SLA-DQA1 gene were significant in the enrichment tests, indicating strong evidence for positive selection in Duroc. Our analyses identified genes under positive selection for lactation, reproduction, and meat-quality and growth traits in Yorkshire, Landrace, and Duroc, respectively.

• BMB Reports
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• v.51 no.1
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• pp.1-2
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• 2018

Positive selection on a new beneficial mutation generates a characteristic pattern of DNA sequence polymorphism when it reaches an intermediate allele frequency. On genome sequences of African Drosophila melanogaster, we detected such signatures of selection at 37 candidate loci and identified "sweeping haplotypes (SHs)" that are increasing or have increased rapidly in frequency due to hitchhiking. Based on geographic distribution of SH frequencies, we could infer whether selective sweeps occurred starting from de novo beneficial mutants under simple constant selective pressure. Single SHs were identified at more than half of loci. However, at many other loci, we observed multiple independent SHs, implying soft selective sweeps due to a high beneficial mutation rate or parallel evolution across space. Interestingly, SH frequencies were intermediate across multiple populations at about a quarter of the loci despite relatively low migration rates inferred between African populations. This invokes a certain form of frequency-dependent selection such as heterozygote advantage. At one locus, we observed a complex pattern of multiple independent that was compatible with recurrent frequency-dependent positive selection on new variants. In conclusion, genomic patterns of positive selection are very diverse, with equal contributions of hard and soft sweeps and a surprisingly large proportion of frequency-dependent selection in D. melanogaster populations.

• Fashion & Textile Research Journal
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• v.21 no.1
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• pp.46-58
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• 2019

This study analyzes the effects of lifestyle on wetsuits purchasing behavior and identifies various characteristics among lifestyle groups. A questionnaire survey of 213 domestic consumers with water sport activity and wetsuits experience indicated the following results: 1) Lifestyle factors were analyzed as 6 factors: social relation ships, development orientation, trend & appearance, domestic, positive acknowledgement of hobbies, pursuit of practicality. And the wetsuits selection criteria was 4 factors: wearing fitness, product information, design, reputation. 2) Social relationships, development orientation, positive acknowledgement of hobbies and pursuit of practicality factors had a positive effect fitness. Trend & appearance, development orientation, and pursuit of practicality factors had a positive effect on product information factors ; in addition, development orientation, and trend & appearance, a positive acknowledgement of hobbies factors had a positive effect design factors. Social relationships, trend & appearance, and pursuit of practicality factors had a positive effect on reputation factors. However, trend & appearance factors negatively affected the wearing fitness factors and the positive acknowledgement of hobbies factors had negative effect on product information, reputation factors. 3) The three groups of lifestyle factors showed differences in monthly average purchasing of clothes, average annual purchasing expenditures for water sports related products, number of water sport activity days and frequency, product selection criteria.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.7
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• pp.912-919
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• 2017

Objective: Identification of the candidate genes that play key roles in phenotypic variations can provide new information about evolution and positive selection. Interleukin (IL)-32 is involved in many biological processes, however, its role for the immune response against various diseases in mammals is poorly understood. Therefore, the current investigation was performed for the better understanding of the molecular evolution and the positive selection of single nucleotide polymorphisms in IL-32 gene. Methods: By using fixation index ($F_{ST}$) based method, IL-32 (9375) gene was found to be outlier and under significant positive selection with the provisional combined allocation of mean heterozygosity and $F_{ST}$. Using nucleotide sequences of 11 mammalian species from National Center for Biotechnology Information database, the evolutionary selection of IL-32 gene was determined using Maximum likelihood model method, through four models (M1a, M2a, M7, and M8) in Codeml program of phylogenetic analysis by maximum liklihood. Results: IL-32 is detected under positive selection using the $F_{ST}$ simulations method. The phylogenetic tree revealed that goat IL-32 was in close resemblance with sheep IL-32. The coding nucleotide sequences were compared among 11 species and it was found that the goat IL-32 gene shared identity with sheep (96.54%), bison (91.97%), camel (58.39%), cat (56.59%), buffalo (56.50%), human (56.13%), dog (50.97%), horse (54.04%), and rabbit (53.41%) respectively. Conclusion: This study provides evidence for IL-32 gene as under significant positive selection in goat.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.51 no.9
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• pp.460-466
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• 2002

A reliable fault phase selection algorithm plays a very important role in transmission line protection, Particularly in Extra High Voltage (EHV) networks. The conventional fault phase selection algorithm used the phase difference between positive and negative sequence current excluding load current. But, it is difficult to pick out only fault current since we can not know when a fault occurs and select the fault phase in weak-infeed conditions that dominate zero-sequence current in phase current. The proposed algorithm can select the accurately fault phase using the sum of unit vectors which are calculated by positive-sequence voltage and negative-sequence voltage.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2002.12a
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• pp.254-257
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• 2002

인터넷 보급의 확산과 전자상거래의 활성화와 유.무선 인터넷의 보급에 따른 악의적인 사이버 공격의 시도의 성공사례가 증가하고 있다. 미로 인해 점차 더 많은 문제가 야기될 것으로 예상된다. 현재 일반적인 인터넷상의 시스템은 악의적인 공격에 적절하게 대응해오지 못하고 있으며, 다른 범용의 시스템들도 기존의 백신 프로그램에 의존하며 그 공격에 대응해오고 있다. 따라서 새로운 침입에 대하여는 대처하기 힘든 단점을 가지고 있다. 본 논문에서는 생체 자율분산시스템의 일부분인 T세포의 positive selection과 negative selection을 이용한 자기/비자기 인식 알고리즘을 제안한다. 제안한 알고리즘은 네트워크 환경에서 침입탐지 시스템에 적용하여 기존에 알려진 침입뿐만 아니라 새로운 침입에 대해서도 대처할 수 있다

• International Journal of Computer Science & Network Security
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• v.21 no.5
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• pp.129-132
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• 2021

Two feature selection approaches are analyzed in this study. First Approach used in this paper is Filter Approach which comprises of correlation technique. It provides two reduced feature sets using positive and negative correlation. Secondly Approach used in this paper is the wrapper approach which comprises of Sequential Forward Selection technique. The reduced feature set obtained by positive correlation results comprises of Rate of Acceleration, Intensity and Formant. The reduced feature set obtained by positive correlation results comprises of Rasta PLP, Log energy, Log power and Zero Crossing Rate. Pitch, Rate of Acceleration, Log Power, MFCC, LPCC is the reduced feature set yield as a result of Sequential Forwarding Selection.