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Obstructive sleep apnea syndrome in children: Epidemiology, pathophysiology, diagnosis and sequelae

  • Chang, Sun-Jung;Chae, Kyu-Young
    • Clinical and Experimental Pediatrics
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    • v.53 no.10
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    • pp.863-871
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    • 2010
  • The prevalence of pediatric obstructive sleep apnea syndrome (OSAS) is approximately 3% in children. Adenotonsillar hypertrophy is the most common cause of OSAS in children, and obesity, hypotonic neuromuscular diseases, and craniofacial anomalies are other major risk factors. Snoring is the most common presenting complaint in children with OSAS, but the clinical presentation varies according to age. Agitated sleep with frequent postural changes, excessive sweating, or abnormal sleep positions such as hyperextension of neck or abnormal prone position may suggest a sleep-disordered breathing. Night terror, sleepwalking, and enuresis are frequently associated, during slow-wave sleep, with sleep-disordered breathing. Excessive daytime sleepiness becomes apparent in older children, whereas hyperactivity or inattention is usually predominant in younger children. Morning headache and poor appetite may also be present. As the cortical arousal threshold is higher in children, arousals are not easily developed and their sleep architectures are usually more conserved than those of adults. Untreated OSAS in children may result in various problems such as cognitive deficits, attention deficit/hyperactivity disorder, poor academic achievement, and emotional instability. Mild pulmonary hypertension is not uncommon. Rarely, cardiovascular complications such as cor pulmonale, heart failure, and systemic hypertension may develop in untreated cases. Failure to thrive and delayed development are serious problems in younger children with OSAS. Diagnosis of pediatric OSAS should be based on snoring, relevant history of sleep disruption, findings of any narrow or collapsible portions of upper airway, and confirmed by polysomnography. Early diagnosis of pediatric OSAS is critical to prevent complications with appropriate interventions.

Identification of Bacteriophage K11 Genomic Promoters for K11 RNA Polymerase

  • Han, Kyung-Goo;Kim, Dong-Hee;Junn, Eun-Sung;Lee, Sang-Soo;Kang, Chang-Won
    • BMB Reports
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    • v.35 no.6
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    • pp.637-641
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    • 2002
  • Only one natural promoter that interacts with bacteriophage K11 RNA polymerase has so far been identified. To identify more, in the present study restriction fragments of the phage genome were individually assayed for transcription activity in vitro. The K11 genome was digested with two 4-bp-recognizing restriction enzymes, and the fragments cloned in pUC119 were assayed with purified K11 RNA polymerase. Eight K11 promoter-bearing fragments were isolated and sequenced. We report that the nine K11 promoter sequences (including the one previously identified) were highly homologous from -17 to +4, relative to the initiation site at +1. Interestingly, five had -10G and -8A, while the other four had -10A and -8C. The consensus sequences with the natural -10G/-8A and -10A/-8C, and their variants with -10G/-8C and -10A/-8A, showed nearly equal transcription activity, suggesting residues at -10 and -8 do not regulate promoter activity. Using hybridization methods, physical positions of the cloned promoter-bearing sequences were mapped on SalI-and KpnI-restriction maps of the K11 genome. The flanking sequences of six cloned K11 promoters were found to be orthologous with T7 or T3 genomic sequences.

Roles of cysteine residues in the inhibition of human glutamate dehydrogenase by palmitoyl-CoA

  • Son, Hyo Jeong;Ha, Seung Cheol;Hwang, Eun Young;Kim, Eun-A;Ahn, Jee-Yin;Choi, Soo Young;Cho, Sung-Woo
    • BMB Reports
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    • v.45 no.12
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    • pp.707-712
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    • 2012
  • Human glutamate dehydrogenase isozymes (hGDH1 and hGDH2) have been known to be inhibited by palmitoyl-CoA with a high affinity. In this study, we have performed the cassette mutagenesis at six different Cys residues (Cys59, Cys93, Cys119, Cys201, Cys274, and Cys323) to identify palmitoyl-CoA binding sites within hGDH2. Four cysteine residues at positions of C59, C93, C201, or C274 may be involved, at least in part, in the inhibition of hGDH2 by palmitoyl-CoA. There was a biphasic relationship, depending on the levels of palmitoyl-CoA, between the binding of palmitoyl-CoA and the loss of enzyme activity during the inactivation process. The inhibition of hGDH2 by palmitoyl-CoA was not affected by the allosteric inhibitor GTP. Multiple mutagenesis studies on the hGDH2 are in progress to identify the amino acid residues fully responsible for the inhibition by palmitoyl-CoA.

A System for Measuring 3D Human Bodies Using the Multiple 2D Images (다중 2D 영상을 이용한 3D 인체 계측 시스템)

  • 김창우;최창석;김효숙;강인애;전준현
    • Journal of the Korean Society of Costume
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    • v.53 no.5
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    • pp.1-12
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    • 2003
  • This paper proposes a system for measuring the 3D human bodies using the multiple 2D images. The system establishes the multiple image input circumstance from the digital camera for image measurement. The algorithm considering perspective projection leads us to estimate the 3D human bodies from the multiple 2D images such as frontal. side and rear views. The results of the image measurement is compared those of the direct measurement and the 3D scanner for the total 40 items (12 heights, 15 widths and 13 depths). Three persons measure the 40 items using the three measurement methods. In comparison of the results obtained among the measurement methods and the persons, the results between the image measurement and the 3D scanner are very similar. However, the errors for the direct measurement are relatively larger than those between the image measurement and the 3D scanner. For example, the maximum errors between the image measurement and the 3D scanner are 0.41cm in height, 0.39cm in width and 0.95cm in depth. The errors are acceptable in body measurement. Performance of the image measurement is superior to the direct. because the algorithm estimates the 3D positions using the perspective projection. In above comparison, the image measurement is expected as a new method for measuring the 3D body, since it has the various advantages of the direct measurement and 3D scanner in performance for measurement as well as in the devices, cost, Portability and man power.

A Study on Awareness and Responses of Korean Textile Firms against Korea-US FTA (한·미 FTA에 대한 한국섬유업체의 인식 및 대응방안에 관한 연구)

  • Ha, Ju-Young;Lee, Hyun-Ok;Ku, Yang-Suk
    • Fashion & Textile Research Journal
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    • v.17 no.6
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    • pp.978-987
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    • 2015
  • This study investigates the awareness levels of Korean textile companies and develops appropriate response plans for the Korea-US Free Trade Agreement. The study also explores practical and realistic directions that the Korean textile industry must initiate. A qualitative study was conducted on 10 individuals for a more in-depth and demonstrative understanding that provide a better awareness on the responses of the textile industry towards the Korea-US FTA. The results of this study are as follows. First, the effect of the Korea-US FTA on the textile industry was insignificant. Second, industry members determined that fabric sectors and specialized fabrics (such as industrial materials and finished clothing products) could realize benefits through the Korea-US FTA. Third, industry members emphasize that the current focus is on FTAs by countries that have solidified their positions as manufacturing and sewing bases for the US and Europe (such as Southeast Asia) and not the Korea-US FTA. Based on results acquired through this study, the response measures to enter the U.S. market are as follows. First, the industry must develop high-performance and high value-adding direct export products suited to the needs of the US market in order to realize the benefits of the Korea-US FTA. Second, the industry and government must cooperate to actively host and participate in overseas trade shows that can actively open sales channels within the US. Third, the self-sustainability of textile companies must be cultivated through continuous and focused government training.

A Study on Establishing of Fit Test Conditions for Slacks (슬랙스 맞음새 평가 도구 설계에 관한 연구)

  • Kim, Seon-Young;Nam, Yun-Ja
    • Fashion & Textile Research Journal
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    • v.14 no.3
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    • pp.454-464
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    • 2012
  • In this study, fitness tests for slacks were divided into shape fitness test and motion fitness test, and the fitness test conditions for slacks were designed as the first step for standardization of measuring scales. Shape fitness test consisted of analyzing the parameters of appearance sensory tests as described in preceding studies, performing a simulated appearance sensory test, collecting and considering apparel experts' opinions about the test parameters, and establishing test conditions in terms of test regions, descriptions and faces. For the regions of the abdomen, hip, crotch, thighs, and knees, the parameter of unnecessary wrinkle/stretch was observed from the anterior and posterior body, and then evaluated; for waist, hip, crotch, knee and hem circumference, the parameters of ease and horizontality were observed from the anterior body and posterior body followed by evaluation; and, at the levels of waist, hip, crotch, knee and hem circumference, the division of the lateral line were observed from the lateral body followed by evaluation. Motion fitness test was composed of reviewing and analyzing comparatively the methods of motion fitness tests as mentioned in preceding studies, and establishing test conditions in terms of test motions and test regions. For each of the waist, abdomen, hip, crotch, and knees, wear sensation was tested in the positions as follows: upright standing, moderate walking, chairsitting, bending forward to the maximum, and kneeling down, provided that as the measured points of garment pressure, anterior waist, abdominal protrusion, buttock protrusion, crotch, and midpatella were set and tested.

Korean Medicine Interventions for Benign Paroxysmal Positional Vertigo: A Systematic Review of Clinical Studies Published in Korea (양성 돌발성 체위성 현훈(Benign Paroxysmal Positional Vertigo)에 관한 임상 문헌 고찰 - 국내에 출판된 한의약 임상 논문을 중심으로 -)

  • Jung, Jun-su;Jung, Sung-heon;Kim, Min-joo;Park, Jang-kyung;Bae, Kwang-ho;Kong, Kyung-hwan;Ko, Ho-yeon
    • The Journal of Internal Korean Medicine
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    • v.38 no.4
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    • pp.479-490
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    • 2017
  • Objectives: This study provides evidence for clinical practices by analyzing present clinical Korean medicine articles about benign paroxysmal positional vertigo (BPPV). Methods: Articles published up to July, 2017 were found by searching "BPPV", "Benign positions", and "Vertigo" as keywords in three domestic electric databases (i.e., OASIS, NDSL, RISS). Results: The initial search resulted in 228 articles; however, only 20 articles satisfied the selection criteria and were analyzed. Of these, 40% were published in the Journal of Korean Oriental Internal Medicine, and 35% were published in 2003. When diagnosing BPPV patients, VAS scores are primarily used for clinical assessments rather than objective diagnostic tools. Banhabaekchulcheonmatang was the most frequent herbal medicine used to treat BPPV, and the most commonly used therapeutic acupuncture point was Jok-samni (ST36). The most common diagnosis of BPPV was dam-eum according to nine studies. Conclusions: Systematic and large-scale research for the standardization of BPPV treatment is needed.

Evaluation of Effectiveness of Anatomical Rotation Change Image by Aid Tool in Shoulder MRArthrography (Shoulder MRArthography 검사 시 보조기구를 이용한 해부학적 회전 변화 영상에 대한 유용성 평가)

  • Kim, Hyeong-Gyun;Jung, Jae-Eun;Jung, Hong-Moon
    • Journal of the Korean Society of Radiology
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    • v.6 no.4
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    • pp.299-303
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    • 2012
  • Shoulder MRArthrography was performed to get an accurate diagnosis about complex anatomical structure in shoulder joint. We carried out how the changes of anatomical rotations in shoulder joint could bring certain diagnosis effects on MRI images for various shoulder humerus positions; Neutral position, Internal rotation position and External rotation position. In addition, we prepared an aid tool in oder to maintain the right posture of a patient. This aid tool was made by adapting Modeling Design Program. By virtue of this aid, we obtained the following result. Shoulder MR Arthrography by the External rotation position for anatomical structure diagnosis was the most suitable in diagnostic evaluations of important anatomical structures in shoulder joint such as Biceps tendon, Supera-spiatus tendon, Sub-scapularis tendon, Labrum and Sub-acromial space.

Molecular Phylogenetics of Trichostrongylus Species (Nematoda: Trichostrongylidae) from Humans of Mazandaran Province, Iran

  • Sharifdini, Meysam;Heidari, Zahra;Hesari, Zahra;Vatandoost, Sajad;Kia, Eshrat Beigom
    • Parasites, Hosts and Diseases
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    • v.55 no.3
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    • pp.279-285
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    • 2017
  • The present study was performed to analyze molecularly the phylogenetic positions of human-infecting Trichostrongylus species in Mazandaran Province, Iran, which is an endemic area for trichostrongyliasis. DNA from 7 Trichostrongylus infected stool samples were extracted by using in-house (IH) method. PCR amplification of ITS2-rDNA region was performed, and products were sequenced. Phylogenetic analysis of the nucleotide sequence data was performed using MEGA 5.0 software. Six out of 7 isolates had high similarity with Trichostrongylus colubriformis, while the other one showed high homology with Trichostrongylus axei registered in GenBank reference sequences. Intra-specific variations within isolates of T. colubriformis and T. axei amounted to 0-1.8% and 0-0.6%, respectively. Trichostrongylus species obtained in the present study were in a cluster with the relevant reference sequences from previous studies. BLAST analysis indicated that there was 100% homology among all 6 ITS2 sequences of T. colubriformis in the present study and most previously registered sequences of T. colubriformis from human, sheep, and goat isolates from Iran and also human isolates from Laos, Thailand, and France. The ITS2 sequence of T. axei exhibited 99.4% homology with the human isolate of T. axei from Thailand, sheep isolates from New Zealand and Iran, and cattle isolate from USA.

The Effect of Teaching Experience in After-School Learning Programs: Implication for the Development of Mathematics Teacher Education Program (대학생 교사제의 효과 분석: 사범대학 수학교사교육 프로그램 개발을 위한 제언)

  • Ju Mi-Kyung
    • The Mathematical Education
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    • v.45 no.3 s.114
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    • pp.295-313
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    • 2006
  • University teacher education programs have sought for ways of how to improve student teaching in order to supply mathematics teachers with practical theory to achieve the goals of the current educational reform in school mathematics. In this context, the purpose of this research is to investigate the effect of student teachers' teaching experience in the after-school mathematics programs and the ways of how to develop the after-school learning programs as an effective site for learning to teach based on the inquiry into student teachers' own teaching experience. For the purpose, data were collected through the interviews with the student teachers who had taught after-school mathematics class. In addition, data were collected through survey, class observation, and seminal meetings with the student teachers in order to supplement the findings from the interview analysis. Data analysis focused on the student teachers' experience with teaching in after-school mathematics classes, that is, what and how they had learned as teachers, what kinds of difficulties they encountered in their teaching and supports that they expect to improve their learning through teaching. The analysis shows that the teaching experience in the after-school programs had positively contributed to their development as future mathematics teachers. Specifically, the after-school programs provide the site for learning through teaching at the early stage of teacher education program. The after-school programs provided the students teachers for the opportunity to participate peripherally in educational practice of school. Through the participation, the student teachers developed positive attitudes toward teaching career and became to have more solid ideas about how to teach mathematics. Based on the analysis, this research provides following suggestions concerning how to improve student teaching. First, it is necessary to provide student teachers to participate into the practice of teaching at the early stage of teacher education programs. Second, it is important to give students teacher opportunity to participate in teaching at peripheral and legitimate positions. Finally, it is necessary to construct mentoring networks to support student teachers to move from a peripheral position toward a center of teaching practice.

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