• The Korean Journal of Physiology and Pharmacology
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• v.2 no.4
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• pp.461-469
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• 1998

Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethy-lamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions are supposed to be essential to exert ?${\beta}-receptor$ activities. However, it is not clear whether -OH at 6,7 substitution of THIs also shows ?${\alpha}-adrenoceptor$ activities. In the present study, we investigated whether -OH or $-OCH_3$ substitutions of 6,7 position of THIs differently affect the ?1-adrenoceptor affinity. We synthesized two 1-naphthylmethyl THI alkaloids, $1-{\beta}-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline$ HBr (YS 51) and $1-{\beta}-naphthylmethyl-6, 7-dimethoxy-1,2,3,4-tetrahydroisoquinoline$ HCl (YS 55), and their pharmacological actions on ?${\alpha}_1-adrenoceptor$ were compared. YS 51 and YS 55, concentration-dependently relaxed endothelium-denuded rat thoracic aorta precontracted with phenylephrine (PE, 0.1 ${\mu}M$) in which $pEC_{50}$ were $5.89{\pm}0.21$ and $5.93{\pm}0.19$, respectively. Propranolol (30 nM) did not affect the relaxation-response curves to YS 51 and YS 55. Concentration-response curves to PE were shifted to right by the pretreatment with YS 51 or YS 55. The $pA_2$ values of YS 51 and YS 55 showed $6.05{\pm}0.24$ and $5.88{\pm}0.16$, respectively. Both probes relaxed KCl (65.4 mM)-contracted aorta and inhibited $CaCl_2-induced$ contraction of PE-stimulated endothelium- denuded rat thoracic aorta in $Ca^{2+}-free$ solutions. In isolated guinea pig papillary muscle, 1 and 10 ${\mu}M$ YS 51 increased contractile force about 4- and 8- fold over the control, respectively, along with the concentration-dependent increment of cytosolic $Ca^{2+}$ ions. While, 10 ${\mu}M$ YS 55 reduced the contractile force about 50 % over the control and lowered the cytosolic $Ca^{2+}$ level, in rat brain homogenates, YS 51 and YS 55 displaced $[^3H]prazosin$ binding competitively with Ki 0.15 and 0.12 ${\mu}M$, respectively. However, both probes were ineffective on $[^3H]nitrendipine$ binding. Therefore, it is concluded that two synthetic naphthylmethyl-THI alkaloids have considerable affinity to ?1-adrenenoceptors in rat aorta and brain.

• Journal of Radiation Protection and Research
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• v.39 no.4
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• pp.159-167
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• 2014

In Korea, July 2012, the law as called 'Act on Safety Control of Radioactive Rays Around Living Environment' was implemented to control the consumer product containing Naturally Occurring Radioactive Material (NORM), but, there are no appropriate database and effective dose calculation system. The aim of this study was to develop evaluation technique of the exposure dose with the use of the consumer products containing NORM and to understand the characteristics of the exposed dose according to the radiation type and energy. For the evaluate of exposure dose, the ICRP reference phantom was simulated by the MCNPX code based on Monte Carlo method, and the minimum, medium, maximum energy of alphas, betas, gammas from the representative NORM of Uranium decay series were used as the source term in the simulation. The annual effective doses were calculated by the exposure scenario of the consumer product usage time and position. Short range of the alpha and beta rays are mostly delivered the dose to the skin. On the other hand, the gamma rays mostly delivered the similar dose to all of the organs. The results of the annual effective dose with $1Bq{\cdot}g^{-1}$ radioactive stone-bed and 10% radioactive concentration were employed with the usage time of 7 hours 50 minute per day, the maximum annual effective dose of alphas, betas, gammas were calculated 0.0222, 0.0836, $0.0101mSv{\cdot}y^{-1}$, respectively.

• Journal of Bio-Environment Control
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• v.28 no.3
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• pp.225-233
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• 2019

In the summer season, natural ventilation is commonly used to reduce the inside air temperature of greenhouse when it rises above the optimal level. The greenhouse shape, vent design, and position play a critical role in the effectiveness of natural ventilation. In this study, computational fluid dynamics (CFD) was employed to investigate the effect of different roof vent designs along with side vents on the buoyancy-driven natural ventilation. The boussinesq hypothesis was used to simulate the buoyancy effect to the whole computational domain. RNG K-epsilon turbulence model was utilized, and a discrete originates (DO) radiation model was used with solar ray tracing to simulate the effect of solar radiation. The CFD model was validated using the experimentally obtained greenhouse internal temperature, and the experimental and computed results agreed well. Furthermore, this model was adopted to compare the internal greenhouse air temperature and ventilation rate for seven different roof vent designs. The results revealed that the inside-to-outside air temperature differences of the greenhouse varied from 3.2 to $9.6^{\circ}C$ depending on the different studied roof vent types. Moreover, the ventilation rate was within the range from 0.33 to $0.49min^{-1}$. Our findings show that the conical type roof ventilation has minimum inside-to-outside air temperature difference of $3.2^{\circ}C$ and a maximum ventilation rate of $0.49min^{-1}$.

• Journal of the Korean Society of Radiology
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• v.17 no.4
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• pp.573-579
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• 2023

This study compares dose difference between the presence or absence of grid in Chest PA radiography using auto exposure control and compares image quality among presence, absence or virtual grid, and proposes a new clinically useful grid combination for chest radiography. The human body phantom was placed Chest PA position and the dosimeter was placed at T6. The same irradiation conditions and field size were applied. 30 images were obtained in the state in which grid was applied and in the state in which grid was not applied, and an additional 30 images in which the virtual grid was applied to the image without the grid were obtained. Radiation dose was presented to entrance surface dose. The image quality was analyzed by comparing the signal-to-noise and contrast-to-noise ratio. ESD decreased by 48% when the grid was not used, compared to when the grid was used. SNR and CNR increased by 32% and 30% compared to grid use when grid was not used, respectively. In the case of using the virtual grid, it increased by 18% and 16% respectively, compared to the case of using the grid. As a result of this study, it is believed that when using a virtual grid instead of a grid, the quality of the image can be maintained while reducing the patient dose.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.253-260
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• 2023

The germanium-68/gallium-68 (⁶⁸Ge/⁶⁸Ga) generator has high spatial utilization and requires little maintenance, making it economical and easy to produce. Thus, the frequency of use of ⁶⁸Ga radiopharmaceuticals is rapidly increasing worldwide. Therefore, this study attempted to develop an automated synthesizer for the routine clinical application of ⁶⁸Ga radiopharmaceuticals. The automated synthesizer was based on a fixed tubing system and the structure was designed after adjusting the position of the parts to reflect the synthesis method. Using various components that can be supplied in Korea, the automated synthesizer was manufactured at a much lower price cost than that of a commercialized automated synthesizer sold by companies. ⁶⁸Ga-DOTA-[Tyr3]-octreotide (⁶⁸Ga-DOTATOC) was synthesized to evaluate the performance of the automated synthesizer. ⁶⁸Ga-DOTATOC could be synthesized with about 65% of non-decay corrected yield, and the synthesized ⁶⁸Ga-DOTATOC met all quality control standards. We have synthesized ⁶⁸Ga-DOTATOC more than 100 times, and only faced a few problems caused by mechanical errors. In this study, we successfully developed a simple automated synthesizer for ⁶⁸Ga radiopharmaceuticals with high reproducibility. As various ⁶⁸Ga radiopharmaceuticals have recently been developed, it is expected that the automated synthesizer developed in this study will be useful for routine clinical use.

• Korean Security Journal
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• no.14
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• pp.413-429
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• 2007

The Guard over the royal household in the "Goryeo" era was the same as if was over the President or Ruler of a nation today. In those days, a king represented a nation and any threat to the safety of a king could bring the destruction of a nation and the dispersion of the people. by reviewing the change of the 2-Gun 6-Wi system of the era, it can be, summed up as follow, Ther will be suggestions. The Guard might focus on a king's personal safety in the wake of the system of the Silla and Taebong dynasties until the establishment of the Goryeo Dynasty's unique political system. "Goryeo" rebuilt the royal palace in Gyeonyeong-gun to take the shape of unified country after its accomplishment of unification of the late three countries, Then it was afraid of the rebellion and uprising of local powerful clans, The country put them under control and organized the local army with them in the era of Kings, Seongjong, through the kings, Seongjong and Gwangjong. The army system of "Goryeo" consisted of 2-Gun and 6-Wi, and 2-Gun placed above the 6-Wi played the role of the Royal guards, and among the organizations a certain army under the specific name of "Gyeonyong-gun" guarded the kings in the nearest position. An aristocratic culture enjoyed its golden age in the period of stability of the aristocracy of "Goryeo", but afterward in the confusion of the aristocratic disruption and incompatible confrontation the country lost its control, and faced military rebellions by treating civil officials well and ill-treating military officials The safety of kings become unstable with the grasping political power by the military officials, and "Dobang" was established in the era of Choi's family to grasp political power. In the era of Choi Woo, he gathered his men and organized his familys army with them and managed the personnel administration with the civil officials of "Jeongbang and Seobang under his command. Such a fact shows the similarity to today's task of guarding. Considering the facts that "Sambyeolcho, the military ground of the military-men-rule, was at the center of the struggling against Mongolia and that even after the fall of the military regime, they rebelled and fought against Mongolia to the end, we came to know that the nationalism in the era of the military era was great. In the transition of external situations from "Myeong" to "Won"(Chinese dynasties), the conflict between the old "Won"-friendly power and the new "Myeong"-friendly power caused the weakness of the power to guard the royal household, and "Goryeo" at last gave way to the newly rising "Joseon" led by Lee, Seong Gye who won the people's confidence.

• Radiation Oncology Journal
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• v.25 no.1
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• pp.54-61
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• 2007

[ $\underline{Purpose}$ ]: The purpose of this study is to develop a practical method for determining accurate marker positions for prostate cancer radiotherapy using CT images and kV x-ray images obtained from the use of the on- board imager (OBI). $\underline{Materials\;and\;Methods}$: Three gold seed markers were implanted into the reference position inside a prostate gland by a urologist. Multiple digital image processing techniques were used to determine seed marker position and the center-of-mass (COM) technique was employed to determine a representative reference seed marker position. A setup discrepancy can be estimated by comparing a computed $COM_{OBI}$ with the reference $COM_{CT}$. A proposed algorithm was applied to a seed phantom and to four prostate cancer patients with seed implants treated in our clinic. $\underline{Results}$: In the phantom study, the calculated $COM_{CT}$ and $COM_{OBI}$ agreed with $COM_{actual}$ within a millimeter. The algorithm also could localize each seed marker correctly and calculated $COM_{CT}$ and $COM_{OBI}$ for all CT and kV x-ray image sets, respectively. Discrepancies of setup errors between 2D-2D matching results using the OBI application and results using the proposed algorithm were less than one millimeter for each axis. The setup error of each patient was in the range of $0.1{\pm}2.7{\sim}1.8{\pm}6.6\;mm$ in the AP direction, $0.8{\pm}1.6{\sim}2.0{\pm}2.7\;mm$ in the SI direction and $-0.9{\pm}1.5{\sim}2.8{\pm}3.0\;mm$ in the lateral direction, even though the setup error was quite patient dependent. $\underline{Conclusion}$: As it took less than 10 seconds to evaluate a setup discrepancy, it can be helpful to reduce the setup correction time while minimizing subjective factors that may be user dependent. However, the on-line correction process should be integrated into the treatment machine control system for a more reliable procedure.

• Horticultural Science & Technology
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• v.29 no.3
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• pp.211-216
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• 2011

This study was carried out to clarify precise $CO_2$ demands of paprika plants (Capsicum annumm L.) by measuring photosynthesis rates of the leaves in high, low positions, and the $CO_2$ consumption of a whole plant in a large sealed chamber. A photosynthesis measuring system (LI-6400) was used to measure the photosynthetic rates of the leaves located in different positions. A large sealed chamber that can control inside environmental factors was developed for measuring $CO_2$ consumption by a whole paprika plant. With increase of radiation, photosynthetic rates of the leaves in higher position became larger than those in lower position. The $CO_2$ consumption by the plant was estimated by using decrement of $CO_2$ concentration from initial level of 1500 ${\mu}mol{\cdot}mol^{-1}$ in the chamber with increase of integrated radiation. A regression model for estimating $CO_2$ consumption by the plant (leaf area = 7,533.4 $cm^2$) was expressed with integrated radiation (x) and was suggested as $y=-0.06234+3.671^*x/(2.589+x)$ ($R^2=0.9966^{***}$). The photosynthetic rate of the whole plant measured in the chamber was 3.4 ${\mu}mol\;CO_2{\cdot}m^{-2}{\cdot}s^{-1}$ under 300 ${\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ light intensity, which is in-between photosynthetic rates of the leaves in high and low positions. For this reason, some differences between required and supplied $CO_2$ amounts in greenhouses might occur when depending too much on photosynthetic rates of leaves. Therefore, we can estimate more accurately $CO_2$ amount required in commercial greenhouses by using $CO_2$ consumption model of a whole plant obtained in this study in addition to leaf photosynthetic rate.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.31B no.11
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• pp.63-77
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• 1994

This paper describes the real-time system which, through analyzing a sequence of images, can extract motional information on a moving object and can contol servo equipment to always locate the moving object at the center of an image frame. An image is a vast amount of two-dimensional signal, so it takes a lot of time to analyze the whole quantity of a given image. Especially, the time needed to load pixels from a memory to processor increase exponentially as the size of an image increases. To solve such a problem and track a moving object in real-time, this paper addresses how to selectively search the spatial and time domain. Based on the selective search of spatial and time domain, this paper suggests various types of techniques which are essential in implementing a real-time tracking system. That is, this paper describes how to detect an entrance of a moving object in the field of view of a camera and the direction of the entrance, how to determine the time interval of adjacent images, how to determine nonstationary areas formed by a moving object and calculated velocity and position information of a moving object based on the determined areas, how to control servo equipment to locate the moving object at the center of an image frame, and how to properly adjust time interval(${\Delta}$t) to track an object taking variable speed.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.26 no.4
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• pp.365-371
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• 1990

In this paper, the authors calculate GDOP(Geometric Dilution of Precision) with the mast and slave transmitting stations at the past and present and simulation positions in the 9970 chain and 5970 chain of the loran C system, and analyzed variations of the GDOP and effective ranges in accordance with the shifting of transmitting stations. The results obtained are as follows; 1) The line 3.0 of equi-GDOP map that the Z slave station of 9970 chain is Guam island is falled on with line 2.0 of it's map that it is Yap island approximately, and units of GDOP of calculating with Guam island are increased then them with Yap island on the south parts of mast station. 2) If the control right of Z slave station of 9970 chain could be not transfered to japan and be closed on account of the territorial problems, the units of GDOP to calculate without it's station at any positions are very increased and the accuracy is down on the south parts of mast station. The line 5.0 of it's map is falled on with line 2.0 in case of Yap island, its Z station, and line 3.0 in case of Guam island with Z slave station approximately. 3) The X slave station of 9970 chain and 5970 chain are required rearrangement for the purpose of accurating position fix and expending service area in view of propagation route of wave and arrangement of transmitting station.