• Journal of Pharmaceutical Investigation
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• v.27 no.1
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• pp.39-49
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• 1997

Nicotinic acid was mixed with glass powders such as controlled pore glass (CPG), glyceryl controlled pore glass (GPG) and glass beads (GB) at room temperature. The physicochemical properties of nicotinic acid in the various mixtures were examined by differential thermal analysis, X-ray diffraction study. Infrared spectroscopy and BET gas adsorption measurements. The peak area at the melting point from the various mixtures of nicotinic acid and CPG was increased with an increase of nicotinic acid concentration while the broad peak area was remained unchanged in the DTA curve. As shown in the powder X-ray diffraction patterns, the crystalline peaks of nicotinic acid disappeared in mixture with CPG, suggesting the interaction of nicotinic acid and porous powders. It was found that the larger the content of CPG, the higher the ratio of an amorphous state to a crystalline state. BET isotherm showed that as the amount of nicotinic acid was increased, the specific surface area was reduced proportionally to nicotinic acid content of up to 40% and remained constant thereafter. Sublimation of nicotinic acid from the mixture of nicotinic acid and CPG was examined. A large quantity of nicotinic acid was retained in the mixture when stored on various temperatures in vacuo for 10 hours. The nicotinic acid mixtures with CPG or GPG showed a high dissolution rates of nicotinic acid in aqueous solution, especially in the initial dissolution stage. CPG is expected to be a good pharmaceutical excipient to reduce the crystallinity of drugs and to prevent sublimation of drugs.

• Microbiology and Biotechnology Letters
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• v.41 no.2
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• pp.176-182
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• 2013

Several types of mesoporous alumina adsorbents with different physical properties were prepared by spray pyrolysis and were used for the separation/purification of the anticancer agent paclitaxel. The pore diameter of the adsorbents had a greater effect than did the surface area and the pore volume on the removal of plant-derived impurities. An appropriate pore diameter (~10.8 nm) was required for effective impurity removal. At a constant pore diameter, the surface area of the adsorbent affected not only the purity but also the yield of paclitaxel. Also, increasing the surface area of the adsorbent resulted in an increase in the adsorption of paclitaxel and impurities (biomass-derived tar and wax components). Removal of these impurities was confirmed by HPLC analysis of the absorbent after the treatment and TGA of the organic substances that were bound to the adsorbent.

• Membrane Journal
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• v.5 no.3
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• pp.119-128
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• 1995

The effects of coarsening on microstructure formation in polystyrene-cyclohexane solutions and membranes made from them were studied by scanning electron miccoscopy(SEM). Thermal analysis of the polymer solutions was carried out with a differential scanning calorimeter and the binodal curve was determined from the onset temperature of the heat of demixing peak. Using thermally induced phase separation(TIPS) and a freeze drying technique, it was demonstrated that polymer membrane microstructure can be changed significantly by controlling coarsening time and quench route. For systems undergoing phase separation by spinodal decomposition, resulting in a well interconnecmd, microporous structure with nearly uniform pore sizes, it was found that extending the phase separation time prior m freezing and solvent removal can result in a significant increase in pore or cell size which is highly dependent on both quench depth and coarsening time. Also this study has revealed the important role of polymer concentration in dictating the material continuity of the membranes.

• Journal of the Korean Ceramic Society
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• v.31 no.10
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• pp.1218-1230
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• 1994

In manufacturing process of porous glass-ceramics by the filler method, the sintering behaviour of crystallizable glass powder mixed with various salts was studied and also the effects of precipitated crystal phases on the properties of porous glass-ceramics were investigated. Fine-grained crystallizable glass powder was homogeneously mixed with various slat having grain size 100~200 ${\mu}{\textrm}{m}$ and sintered for densification. After washing out the inorganic salt with distilled water, the porous sintered body was heat treated additionly for crystallization. The MgO-Al2O3-SiO2 base glass was used as crystallizable glass powder and the water soluble salts such as K2SO4 and MgSO4 were used as filler. When K2SO4 was used, leucite crystal phase was formed as a result of the ion exchange and porous glass-ceramics which exhibit high temperature resistance and high thermal expansion coefficient of 17$\times$10-6/$^{\circ}C$ could be obtained. On the contrary, when MgSO4 was used, only slight ion exchange is observed and $\mu$-cordierite and $\alpha$-cordierite crystal phases were formed and porous glass-ceramics which exhibit low thermal expansion coefficient schedule were determined with the results of DTA curves, thermal shrinkage curves and XRD patterns analysis. From DTA curves and thermal shrinkage curves, it was found that the sintering densification have been completed at the temperature range of exothermic peak for crystallization. The pore size distributions and pore diameters were measured by mercury porosimeter. The pore diameter of porous glass-ceramics was 10~15 ${\mu}{\textrm}{m}$ when 100~200${\mu}{\textrm}{m}$ grain size of K2SO4 was used and it was 25~30 ${\mu}{\textrm}{m}$ when the same grain size of MgSO4 was used. The porous glass-ceramics K2SO4 used shows bimodal pore size distribution and its porous skeleton structure was ascertained by SEM observation.

• Carbon letters
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• v.12 no.4
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• pp.236-242
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• 2011

The oxyfluorination effects of activated carbon nanofibers (OFACFs) were investigated for $CO_2$ storage. Electrospun CFs were prepared from a polyacrylonitrile/N,N-dimethylformamide solution via electrospinning and heat treatment. The electrospun CFs were chemically activated in order to generate the pore structure, and then oxyfluorination was used to modify the surface. The samples were labeled CF (electrospun CF), ACF (activated CF), OFACF-1 ($O_2:F_2$ = 7:3), OFACF-2 ($O_2:F_2$ = 5:5) and OFACF-3 ($O_2:F_2$ = 3:7). The functional group of OFACFs was investigated using X-ray photoelectron spectroscopy analysis. The C-F bonds formed on surface of ACFs. The intensities of the C-O peaks increased after oxyfluorination and increased the oxygen content in the reaction gas. The specific surface area, pore volume and pore size of OFACFs were calculated by the Brunauer-Emmett-Teller and density functional theory equation. Through the $N_2$ adsorption isotherm, the specific surface area and pore volume slightly decreased as a result of oxyfluorination treatment. Nevertheless, the $CO_2$ adsorption efficiency of oxyfluorinated ACF improved around 16 wt% due to the semi-ionic interaction effect of surface modificated oxygen functional groups and $CO_2$ molecules.

• Journal of Technologic Dentistry
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• v.29 no.1
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• pp.23-34
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• 2007

The quantity of MgO in the Zirconia of 20wt% Frit has been varied and the sintering temperature has been differentiated to monitor the changes in the mechanical features. The rise of sintering temperature from 1100$^{\circ}C$ to 1300$^{\circ}C$ was followed by higher sintering density. And, at a sintering temperature, the increase of the quantity of MgO was followed by lower sintering density. The bending strength has been lowered as the quantity of MgO increases in the Zirconia of 20wt% Frit, which seems to be because the MgO functions as impurities degrading the mechanical features. In terms of micro-structure analysis, the pore has been greatly enlarged, while the density varied very little, when the MgO of 3wt% was added. The size of pore became smaller as the added quantity of MgO increased larger in the sequence of 5wt% and 7wt%. But, the pore-generating rate became higher as the added quantity of MgO increased in the sequence of 3wt%, 5wt% and 7wt%. Thus, it is possible to summarize that the small quantity of MgO, say, of 3wt%, promotes the grain growth, and the large quantity of MgO, say, of 7wt%, hinders the grain growth. Also, if the quantity of MgO exceeds some level, the MgO hinders substances from moving, which, ultimately, keeps blowholes from becoming enlarged or extinct, and makes pores small and dispersed in broad area. In conclusion, the study on the change in the size of pore shows that the larger the quantity of MgO is, the more the micro pores are, thereby degrading the mechanical features.

• Proceedings of the Korean Geotechical Society Conference
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• 2001.03a
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• pp.199-206
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• 2001

Landslides generally occur due to influences of the internal and external factors. Internal factors include ground characteristics, terrain and so on. External factors can also be divided into natural factors such as rainfall, ground water, earthquake and so on, and artificial factors resulting from cutting and embankments. Among these factors, rainfall becomes the most important external factors by means of which landslides occur in Korea. To appropriately deal with tile effects of pore water pressures due to rainfall, the method using the pore water pressure ratio(r$\_$u/) is generally applied in slope stability analysis or the design of slope reinforcements. Since tire value of r,, is in general not constant over the whole cross section, in most slope stability analyses the average values are used with little loss in accuracy. However, determination of the average values of r$\_$u/ to applied in the design is difficult problem. Therefore, in this study, tile average values of r$\_$u/ according to the intensity of rainfall and slope inclination is suggested based on results of the small scaled model tests using the artificial rainfall apparatus. It is found from the model tests that the average values of r$\_$u/ is about 0.07∼0.18(in case of the intensity of rainfall is 50mm/hr.), about 0.10∼0.28(in case of the intensity of rainfall is 100mm/hr.), and about 0.10∼0.33(in case of the intensity of rainfall is 150mm/hr.).

• Journal of the Korean Chemical Society
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• v.33 no.4
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• pp.350-356
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• 1989

The analysis of adsortion behaviors of some cigarett aerosol ingredients such as tar, nicotine, carbon monoxide and a number of organic acids has shown that the rates of adsorption of the adsorbates of lower boiling point had increased in accordance with increasing cumulative pore volume, while that of higher doiling point decreased with increasing pore volume of smaller radius. The adsorbents used here were charcoal, silica gel, alumina, and activated clay. The common principle that the adsorbents of greater specific surface area adsorb the larger amount of adsorbates appeared to be disturbed in the adsortion of higher boiling point adsorbates. This confirmation was made mainly by analyzing the adsorption behaviors with regard to the pore volume distributions evaluated on the bases of desorption isotherms.

• Corrosion Science and Technology
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• v.8 no.4
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• pp.143-147
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• 2009

In biomedical implants and dental fields, titanium has been widely utilized for excellent corrosion resistance and biocompatibility. However, Ti and its alloys are nonbioactive after being implanted in bone. In this study, for the purpose of improvement in biocompatibility the anodic $TiO_2$ layer on Ti-xNb alloys were fabricated by electrochemical method in phosphate solution, and the effect of Nb content on the pore size, the morphology and crystallinity of Ti oxide layer formed by the anodic oxidation method was investigated. The Ti containing Nb up to 3 wt%, 20 wt% and 40 wt% were melted by using a vacuum furnace. The sample were cut, polished, and homogenized for 24 hr at $1050^{\circ}C$ for surface roughness test and anodizing. Titanium anodic layer was formed on the specimen surface in an electrolytic solution of 1 M phosphoric acid at constant current densities ($30mA/cm^2$) by anodizing method. Microstructural morphology, crystallinity, composition, and surface roughness of oxide layer were observed by FE-SEM, XRD, EDS, and roughness tester, respectively. The structure of alloy was changed from $\alpha$-phase to $\beta$-phase with increase of Nb content. From XRD results, the structure of $TiO_2$ formed on the Ti-xNb surface was anatase, and no peaks of $Nb_2O_5$ or other Nb oxide were detected suggesting that Nb atoms are dispersed in $TiO_2$-based solid solution. Surface roughness test and SEM results, pore size formed on surface and surface roughness decreased as Nb content increased. From the line analysis results, intensity of Ti peak was high in the center of pore, whereas, intensity of O peak was high in the outside of pore center.

• Korean Membrane Journal
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• v.5 no.1
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• pp.43-53
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• 2003

The selectivity of a gas in the carbon molecular sieve membrane (CMSM) can be expressed as the ratio of the product of the diffusivity and the solubility of two different gases. The diffusivity is also expressed as the product of the entropy and the total energy (kinetic and potential energy) in the nano-sized pore of the membrane. The present study calculates the entropic-energy and selectivity of penetrant gases such as H$_2$, O$_2$, N$_2$, and CO$_2$ from the gas-in-a box theory to physically analyze the diffusivity of penetrant gas in slit-shaped pore of CMSM focusing on the restriction of gas motion based on the size difference between penetrant gas pairs. The contribution of each energy term is converted to entropic term separately. By the conjugated calculation for each entropic-energy, the entropic effects on diffusivity-selectivity for gas pairs such as H$_2$/N$_2$, CO$_2$/N$_2$, and O$_2$/N$_2$ were analyzed within active pore of CMSM. In the activated diffusion domain, the calculated value of entropic-selectivity lies between 9.25 and 111.6 for H$_2$/N$_2$, between 3.36 and 6.0 for CO$_2$/N$_2$, and between 1.25 and 16.94 for O$_2$/N$_2$, respectively. The size decrement of active pore in CMSM had the direct effect on the reduction of translational entropic-energy and the contribution of vibrational entropic-energy for N$_2$, O$_2$, and H$_2$ was almost negligible. However, the vibrational entropic term of CO$_2$ might extravagantly affect on the entropic-selectivity.