• 공업화학
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• 제3권3호
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• pp.371-376
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• 1992

• Applied Biological Chemistry
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• 제41권3호
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• pp.258-263
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• 1998

본 연구는 polyyne계 항생물질의 분자 구조와 활성관계를 체계적으로 살펴본 최초의 보고로서 친수성기와 tetrayne 부분을 갖고 있는 화합물이 강한 항균활성을 가질 것이라는 결과를 얻었다. 이와 같은 선행 연구결과를 바탕으로 보다 개선된 활성을 갖는 화합물을 합성하기 위하여 tetrayneol 부분 구조를 가지는 novel한 polyhydroxy 화합물인 당류 유도체를 합성하고 항균성과 구조와의 관계를 검토하였다.

• 약학회지
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• 제1권1호
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• pp.19-22
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• 1948

Yucca schotti, Samuela carnerosana, Agave strita 각부분에 있어 결실전후의 steroidal sapogenin 분포상태를 연구하여 결실후에는 monohydroxy steroid는 존재치 않고 단지복합 polyhydroxy steroid만이 존재함을 증명하였다.

• 대한화장품학회지
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• 제23권3호
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• pp.86-91
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• 1997

Some natural polyhydroxy aromatic compounds have inhibitory activity against tyrosinase, key enzyme for formation of melanin pigment. We examined the structure-activity relationship of the natural polyhydrowy aromatic compounds and synthesized a number of new derivetives through various methods. Skin lightening effects of these compounds were examined through inhibition of mushroom tyrosinase and inhibitory of melanogenesis on B-16 melanoma cells. These new compounds showed strong inhibitory activity against tyrosinase. Good lightening effects sue to inhibition of melanogenesis were observed from several resorcinol and pyrogallol derivatives. In toxicological tests such as skin primary irritation and sensitization, the above compounds were sufficiently safe for cosmetic use.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 1998년도 제38회 춘계학술발표대회
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• pp.47.2-47.2
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• 1998

• Natural Product Sciences
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• 제4권3호
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• pp.115-129
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• 1998

The chemical constituents and their biological activities of the sponge genus Dysidea has been reviewed.

• Korean Chemical Engineering Research
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• 제53권4호
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• pp.463-467
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• 2015

We investigated catalytic activity of ion-exchange resins in acetalization of 1,2-propylene glycol with acetaldehyde. The impacts of reaction variables, such as temperature, reaction time, catalyst loading and feedstock composition, on the conversion of 1,2-propylene glycol were measured. The life of the catalyst was also studied. Furthermore, the reaction kinetics of 1,2-propylene glycol acetalization was studied. It was found that reaction rate followed the first-order kinetics to acetaldehyde and 1,2-propylene glycol, respectively. Therefore, overall acetalization reaction should follow the second-order reaction kinetics, expressed as. Key words: 1,2-propylene Glycol, 2,4-dimethyl-1,3-dioxolane, Ion-exchange Resin, Polyhydroxy Compounds, Acetalization $r=kC^{nA}_AC^{nB}_B=19.74e^{\frac{-6650}{T}}C^1_AC^1_B$.

• Asian-Australasian Journal of Animal Sciences
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• 제2권3호
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• pp.537-539
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• 1989

• Journal of Applied Biological Chemistry
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• 제44권1호
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• pp.20-22
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• 2001

We have attempted to synthesize polyhydroxy stilbene compounds through the benzyl thioether moiety. During synthesis, we unexpectedly observed that demethylation of the compound under $AlCl_3$ in ethanethiol resulted in a regioselective addition of thiol to the double bond as well as complete demethylation. We report on the regioselective short synthesis for general structure and its structural identification.

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of the Pharmaceutical Society of Korea
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• pp.70-71
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• 2001

Naturally occurring azasugar and homologous compounds have been the object of numerous synthetic efforts because these classes of compounds have interesting bioloical activities and the flexibility for the synthesis of chiral alkaloid comounds. As part of a program directed toward the preparation of glycosidase inhibitors, we prepared bicyclic perhydrooxazino- and oxazolopyridine from aminoalcohols and epoxyaldehyde as a common synthetic intermediate.