• Journal of Pharmaceutical Investigation
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• v.34 no.5
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• pp.363-368
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• 2004

In order to investigate the effect of bovine serum albumin (BSA), as a pore former, on the controlled release of an antibiotic from a biodegradable polymeric device, polycaprolactone (PCL)-cefadroxil matrices were prepared by the solvent casting method. The amount of cefadroxil released from various formulations at $37^{\circ}C$ was measured by HPLC. The duration of antimicrobial activity of matrices against S. aureus was evaluated by measuring the diameters of the inhibition zone. The morphology of the matrices was investigated by scanning electron microscopy (SEM). The release rate and extent of cefadroxil from PCL matrix increased as the loading dose and particle size of BSA/cefadroxil mixture powder increased. Cefadroxil released from the matrix exhibited antibacterial activity for up to 4 days. SEM of the cross-section of matrix showed the typical channel formation after 3 days of release study. Thus, a biodegradable polymeric matrix loaded with antibiotic/BSA mixture can effectively prevent bacterial infection on its surface, thereby bringing about an enhancement of biocompatibility of biomaterials.

• Journal of Adhesion and Interface
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• v.9 no.2
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• pp.1-7
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• 2008

Using biodegradable polycaprolactone, the microcapsules were prepared by solvent evaporation method. Retinol was selected as a core material, which was used as an important ingredient material in cosmetic fields. Poly(vinyl alcohol) was used as a stabilizer. The shape and property of the microcapsules were characterized by scanning electron microscope and differential scanning calorimeter, and the release rate of the microcapsule was measured by UV spectrophotometer. The microcapsules were prepared, changing the concentration of wall material, the stirring rate, and the concentration of stabilizer. Under the optimum condition, the microcapsules were formed, which showd 5~6 um in diameter and got the homogeneous sphere shape.

• Journal of Adhesion and Interface
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• v.18 no.4
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• pp.179-182
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• 2017

Waterborne polyurethanes(WPU) based on castor oil were successfully prepared using polycaprolactone diol(PCL), castor oil(CO) and 4,4'-methylene dicyclohexyl diisocyanate($H_{12}MDI$) as soft segment part, dimethylolbutanoic acid (DMBA) as emulsifier, and trimethylamine(TEA) as neutralizer based on different molecular weight of prepolymer. The various properties such as mechanical strength and surface reforming were evaluated using UTM, contact angle, FE-SEM based on the different molecular weight of polyol. Waterborne polyurethanes based on castor oil could be considered as a promising candidate to be applied the various adhesion fields.

• Restorative Dentistry and Endodontics
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• v.16 no.1
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• pp.226-235
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• 1991

Therapeutic use of antibiotics in the pulpal disease should reduce the clinical symptoms and pathogenic microflora in the pulp. The purpose of this study was focused on local drug delivery into the root canal in endodontic therapy. Monolithic films from polycaprolactone and polyethylene glycol preparations with minocycline were prepared, and then the antimicrobial effect of these films on necrotic canal was tested. A total 17 necrotized pulp teeth were sampled before and 1 week after insertion of film into the pulp. Bacterial culture were performed with anaerobical condition and seeded in the 5 selective and non - selective media for 7 days in $37^{\circ}C$ of anaerobic chamber. Bacterial identification were performed with Gram staining, biochemical test, and API kit There was significantly decreased of anaerobic and aerobic microflora of 13 among 17 patients after therapy. Among the identified microflora, Streptococcus species, black - pigmented species and Fusobacterium species were significantly reduced 1 week after treatment with local delivery antibiotics. Furthermore, clinical symptoms included in pain and local swelling were continuousely reduced after therapy. These results suggest that local drug delivery with minocycline is effeicient to treat the endodontic involved teeth for releasing clinical symptoms and microbiological shifting.

• The Journal of Engineering Research
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• v.7 no.1
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• pp.79-87
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• 2005

[TEACOOH]-Montmorillonite intercalations complex obtained from Na-Montmorillonite and 10-Carboxy-n-decyldimethylethylammonium bromide(organic cation) was reacted with the monomer($\varepsilon$-caprolactone) to achieve the [TEACOOH]-$\varepsilon$-caprolactone-Montmorillonite intercalations complex. From intercalations complex Montmorillonite/Polycaprolactone Nanocomposite in which montmorillonite(inorganic material) is chemically linked with the polycaprolactone(organic polymer) was formed at $220^{\circ}C$ for 48 h. The basal spacing for the sample obtained after polymerization, extraction with methanol and dried at $65^{\circ}C$ in high vacuum for 24 h was 50.7 $\AA$.

• Journal of Radiation Industry
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• v.5 no.2
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• pp.107-112
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• 2011

Electron beam-induced crosslinking of polycaprolactone (PCL) films containing various crosslinking agents (CAs) was investigated in this study. PCL films containing various CAs prepared by a solution casting method were irradiated by electron beams at various absorption doses and the irradiated PCL films were investigated in terms of their crosslinking degree, thermal and mechanical properties, and biodegradability. Based on the results of the crosslinking degree measurement, triallyl isocyanurate was found to be most effective for the electron-beam induced crosslinking of PCL films. The results of the UTM, DMA, and TMA revealed that the thermal and mechanical properties of the crosslinked PCL films were greatly improved in comparison to those of the pure PCL. The results of the enzymatic degradation test revealed that the biodegradability of the crosslinked PCL films was reduced in comparison to that of the pure PCL.

• Korean Journal of Materials Research
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• v.31 no.5
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• pp.278-285
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• 2021

This study produces electroconductive polycaprolactone (PCL)-based film with different amounts of graphene (G) through electrospinning, and the characteristics of the produced G/PCL composites are investigated. The G/PCL results are analyzed by comparing them with those obtained using pure PCL electrospun film as a control. The morphology of electrospun material is analyzed through scanning electron microscopy and transmission electron microscopy. Mechanical and electrical properties are also evaluated. Composites containing 1 % graphene have the highest elongation rate, and 5 % samples have the highest strength and elasticity. Graphene contents > 25 % show electro-conductivity, which level improves with increase of graphene content. Biological characteristics of G/PCL composites are assessed through behavioral analysis of neural cell attachment and proliferation. Cell experiments reveal that compositions < 50 % show slightly reduced cell viability. Moreover, graphene combinations facilitated cell proliferation compared to pure PCL. These results confirm that a 25 % G/PCL composition is best for application to systems that introduce external stimuli such as electric fields and electrodes to lead to synergistic efficiency of tissue regeneration.

• Biomaterials and Biomechanics in Bioengineering
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• v.4 no.1
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• pp.33-44
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• 2019

This paper presents a novel structural composition for artificial bone scaffolds with an appropriate biocompatibility and biodegradability capability. To achieve this aim, carbon nanotubes, due to their prominent mechanical properties, high biocompatibility with the body and its structural similarities with the natural bone structure are selected in component of the artificial bone structure. Also, according to the piezoelectric properties of natural bone tissue, the barium titanate, which is one of the biocompatible material with body and has piezoelectric property, is used to create self-healing ability. Furthermore, due to the fact that, most of the bone tissue is consists of hydroxyapatite, this material is also added to the artificial bone structure. Finally, polycaprolactone is used in synthetic bone composition as a proper substrate for bone growth and repair. To demonstrate, performance of the presented composition, the mechanical behaviour of the bone scaffold is simulated using ANSYS Workbench software and three dimensional finite element modelling. The obtained results are compared with mechanical behaviour of the natural bone and the previous bone scaffold compositions. The results indicated that, the modulus of elasticity, strength and toughness of the proposed composition of bone scaffold is very close to the natural bone behaviour with respect to the previous bone scaffold compositions and this composition can be employed as an appropriate replacement for bone implants.

• Archives of Plastic Surgery
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• v.41 no.6
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• pp.638-646
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• 2014

Background The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing. Methods 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two $3.0{\times}3.0cm$ full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration. Results Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): $8.33cm^2$, $4.90cm^2$, $3.12cm^2$, $1.84cm^2$; Mepitel (n=6): $10.29cm^2$, $5.53cm^2$, $3.63cm^2$, $2.02cm^2$; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups. Conclusions BPM is comparable to Mepitel as a safe and efficacious wound dressing.

• Journal of Periodontal and Implant Science
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• v.23 no.3
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• pp.411-421
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• 1993

The purpose of this study was to assess the effect of polycaprolactone strip with minocycline on the periodontal pocket in humans and the various clinical parameters in rapidly progressive periodontitis. Nine patients with rapidly progressive periodontitis were selected for the study. They had not taken antibiotics for 6 months and had no history of dental treatment for 6 months before the study. They were in good general health. By the split-mouth method, patients received a supragingival scaling, experimental group (9sites) were subjected to subgingival placement of polycaprolactone strips(1 strip) containg 30% minocyclne and control group (9 site) were subjected to subgingival placement of not polycaprolactone strips(1 strip) containing 30 A Minocycline. Strips were replaced with freshly filled ones at 1 week and 2 week. All strips were removed from pockets at 3 week Clinical examination (plaque index, gingival index, probing pocket depth) and distribution on the bacteria morphology of subgingival plaque were monitored on baseline (0 week), 1, week, 2 week, 4 week and 8 week. The result were as follows : 1. Plaque index in experimental group was not significantly reduced during all weeks(P<0.05), but slightly reduced at 2, 4 and 8 weeks and that in control group was not significantly reduced during monitoring period. 2. Probing pocket depth was significantly reduced at 2, 4 and 8 weeks(P<0.05) in experimental group, but that in control group was not siginificantly changed during monitoring period. 3. Gingival index was significantly improved at 2, 4 and 8 weeks(P<0.05) in experimental group but that in control group was not significantly changed. 4. Percentage of cocci was significantly increased at 2, 4 and 8 weeks in experimental group but that in control group was not significantly changed. 5. Percentage of non-motile rods in both group were not significantly changed when compared with those of baseline(0 week) (P<0.05). 6. Percentage of motile rods was siginificantly reduced at 1, 2 and 4 weeks in experimental group (p<0.05) but that in control group was not significantly changed. 7. Percentage of spirochetes was siginificantly reduced during all weeks(P<0.05) but that in control group was not significantly changed. The result showed that polycaprolactone containing 30% minocycline effect the clinical index and bacterial morphotype.