• Title/Summary/Keyword: point of impact

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Osteosarcopenic Obesity in Elderly: The Cascade of Bone, Muscle, and Fat in Inflammatory Process

  • Du, Yang;Oh, Chorong;No, Jae-kyung
    • Culinary science and hospitality research
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    • v.23 no.6
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    • pp.173-183
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    • 2017
  • Conditions related to body composition and aging, such as osteopenic obesity, sarcopenia/ sarcopenic obesity, and the newly termed osteosarcopenic obesity(triad of bone, muscle and adipose tissue impairment), are beginning to gain recognition. Currently, it has begun to attract the attention of scholars from all over the world, however, for this disease, it still needs a more clear understanding and perception. Therefore, this article considered the osteoporosis, muscle depression, and obesity, these diseases as a gate to study the relationship among muscle, bone, and fat. In addition, in the aging process, the formation of IGF-cortisol, testosterone, and estrogen is sensitive. These hormones can not only absorb muscle protein metabolism, but also affect alienation. The decrease in IGF-cortisol in the elderly resulted in increased visceral fat, decreased muscle mass and bone mineral density, and then affected decreased skeletal muscle atrophy and decreased quality. The reduction of skeletal muscle quality and strength and increase body fat affected the adipose tissue to produce inflammatory cytokines, thereby reduced skeletal muscle, promoted cardiovascular disease, metabolic syndrome and insulin resistance in chronic diseases. Almost all chronic inflammatory diseases were associated with bone, muscle and fat. These mechanisms were complex and interrelated. Inflammation reduces bone formation, increases fat and reduces muscle mass. And thus not only had a significant impact on the motor system, but also made the incidence increase of fracture, osteoporosis, fragile syndrome, fall, osteomalacia and other bone disease. This article aimed to start from the interaction between the muscles and bones of the elderly, extended to obesity, muscle deficiency, osteoporosis and other diseases, finally, from a nutritional point of view, to discuss how to treat osteoporosis obesity.

Future Scenario and Issues in Online Game Industry under the Digital Convergence (컨버전스 환경하의 온라인 게임 환경 변화 시나리오 도출 및 산업 내 이슈 (IPTV 서비스 도입에 따른 변화를 중심으로))

  • Han, Chang-Hee;Kim, Min-Kwan;Kim, Jung-Min
    • Journal of Korea Game Society
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    • v.9 no.2
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    • pp.69-80
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    • 2009
  • In this research, we analyze change of directions and issues in future game industry. We start to analyze change of game contents and platform about impact of game industry under the digital convergence, and then we spread out a point of view about game user, game company, distribution of game industry over the length and breadth of game industry. In this paper, we analyze the future state of changing and the issues in online game industry under the digital convergence. For this research, we develop the on-line game industry's changing scenario. On the basis of the issue analysis about the future of the On-line game industry, we aim to provide some implications for business strategy of on-line game companies and policy of the government.

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Evaluation of the Fracture Toughness Transition Characteristics of RPV Steels Based on the ASTM Master Curve Method Using Small Specimens (소형시험편의 Master Curve 방법을 이용한 원자로 압력용기강의 파괴인성 천이특성평가)

  • Yang, Won-Jon;Heo, Mu-Yeong;Kim, Ju-Hak;Lee, Bong-Sang;Hong, Jun-Hwa
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.24 no.2 s.173
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    • pp.303-310
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    • 2000
  • Fracture toughness of five different reactor pressure vessel steels was characterized in the transition temperature region by the ASTM E1921-97 standard method using Charpy-sized small specimens. T he predominant fracture mode of the tested steels was transgranular cleavage in the test conditions. A statistical analysis based on the Weibull distribution was applied to the interpretation of the scattered fracture toughness data. The size-dependence of the measured fracture toughness values was also well predicted by means of the Weibull probabilistic analysis. The measured fracture toughness transition curves followed the temperature-dependence of the ASTM master curve within the expected scatter bands. Therefore, the fracture toughness characteristics in the transition region could be described by a single parameter, so-called the reference temperature (T。), for a given steel. The determined reference temperatures of the tested materials could not be correlated with the conventional index temperatures from Charpy impact tests.

Suggestion of a Decision Support System for Implementing the Water Quality Trading Policy to Developing Urban Areas (개발예정 도시의 수질교환법 적용을 위한 정책결정 시스템 제시)

  • Shin, Yee-sook
    • Ecology and Resilient Infrastructure
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    • v.3 no.1
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    • pp.54-61
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    • 2016
  • There are many pilot programs and projects to implement the water quality trading (WQT) policy. But actual trading is relatively rare. The main reason of the scarce applications of WQT policy is the difficulty in determining the equalities between the trading sites. The uncertainty of the impacts of the nonpoint sources pollutant discharges between up and downstream urban development areas also makes the implementation of the policy harder. The simulated results from the watershed modeling program will be used to calculate the point and nonpoint sources pollutants of the future urban development scenarios. The amount of suspended sediments resulting from the urban developments and rainfall intensities will be used to indicate the environmental impacts of the water body between upstream and downstream. The water quality impacts after development scenarios to the outlet of the watershed were transferred to the trading units between two sites. The recommended trading units can be used as a decision support system for policy makers and stakeholders to carry out better WQT practices.

A Study on the Effect of User Experience on Smartphone GUI Design Elements Research: Focused on the 20 Generation Smartphone Users in China (스마트폰 GUI 디자인 요소가 사용자경험 요인에 미치는 영향에 대한 연구 -중국 20대 사용자를 대상으로)

  • Huang, Chao;Go, Jung-Wook
    • The Journal of the Korea Contents Association
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    • v.17 no.10
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    • pp.647-656
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    • 2017
  • It is obvious that the sales of smart phones are increasing every year whereas the growth rate is decreasing year by year from 2010 through the investigation of the current situation of the smartphone market. Therefore, the GUI design of smartphones has gradually become the major design difference and selling point. In this research background, the purpose of this paper is to investigate and analyze the relationship between GUI design and user experience which takes the 20 generation smartphone users in China as the research objects, so as to understand the impact of GUI design on user experience. In this paper, five visual elements of GUI design are derived from prior study, and five essential factors of user experience are educed by using online review text analysis and KJ. Finally, this thesis makes a questionnaire survey on the 20 generation smartphone users in China, and analyzes the influence of GUI design on the user experience. Meanwhile, we put forward some suggestions for improving the user experience on the basis of the survey results.

A Study of Visual-psychological Effect of Wood on the Human - For the Virtual Small Room - (목재가 인간에게 미치는 시각심리적 영향에 관한 기초적 연구 - 가상의 작은 방을 대상으로 -)

  • Nam, Young-Sook;Kim, Eun-Il
    • Journal of the Korean housing association
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    • v.23 no.5
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    • pp.95-102
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    • 2012
  • We studied in order to find out suitable amounts of board by visual effects to establish indoor boards and human psychological effects by several board designs. Thirty students of C university were tested in constant temperature/humidity room and interviewed after tests. The experimental visual images were projected from 54' TV. As a result, the board length that showed high preference and satisfaction was the 90cm both horizontal and vertical direction. We found that vertical board gave an impression of a linear and narrow shape and the horizontal board gave wide space and cool feeling from psychological analytical study. The factors affecting satisfaction in horizontal direction were refreshing, intimacy, beauty, area, splendor and those in vertical direction were a sense of security, beauty, texture, intimacy, continuity, extensity, natural feeling. We got 5 factors from the result of factor analysis in order to get psychological factor axis. Those were pleasantness, artificiality, openness, dynamics, refinement. By multiple regression analysis, the factor pleasantness had the highest impact on visual satisfaction on scenary. The study on psychological factor difference by analysis of variance showed that psychologically feeling amount about pleasantness, artificiality, dynamics, refinement, and openness had statistically meaningful difference despite of board direction. We found that the 90cm had a tendency as a changing point leading image change by the investigative analysis of board direction based on factor points.

Synaptic Vesicle Protein 2 (SV2) Isoforms

  • Bandala, Cindy;Miliar-Garcia, A.;Mejia-Barradas, C.M.;Anaya-Ruiz, M.;Luna-Arias, J.P.;Bazan-Mendez, C.I.;Gomez-Lopez, M.;Juarez-Mendez, S.;Lara-Padilla, E.
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.10
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    • pp.5063-5067
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    • 2012
  • New molecular markers of cancer had emerged with novel applications in cancer prevention and therapeutics, including for breast cancer of unknown causes, which has a high impact on the health of women worldwide. The purpose of this research was to detemine protein and mRNA expression of synaptic vesicle 2 (SV2) isoforms A, B and C in breast cancer cell lines. Cultured cell lines MDA-MB-231, SKBR3, T47D were lysed and their protein and mRNA expression analyzed by real-time PCR and western blot technique, respectively. SV2A, B proteins were identified in non-tumor (MCF-10A) and tumor cell lines (MDA-MB-231 and T47D) while SV2C only was found in the T47D cell line. Furthermore, the genomic expression was consistent with protein expression for a such cell line, but in MDA-MB-231 there was no SV2B genomic expression, and the SV2C mRNA and protein were not found in the non tumoral cell line. These findings suggest a possible cellular transdifferentiation to neural character in breast cancer, of possible relevance to cancer development, and point to possible use of SV2 as molecular marker and a vehicle for cancer treatment with botulinum toxin.

A Case Study on the VE/LCC for selection on Improvement of Soft Soil Ground (연약지반처리공법 선정을 위한 VE/LCC 사례 분석)

  • Kim, Yong-Deuk;Lee, Young-Dae;Acharya, Nirmal Kumar
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • 2006.11a
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    • pp.271-273
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    • 2006
  • Because effect of value elevation is great as it is fast that construction VE is enforcement, VE at the design phase is more and more important more than construction process phase. But, is exerting negative impact for construction process phase by various problem that happen at design phase, and is causing discord to between project partners. Therefore, quality security in design phase is important first of all. Hereupon, this study emphasized that need VE at the design phase of extension plan forward more and more because achieved process that derive conceptional estimation by quantitative value calculating value index (V) through provision of design function point (F) and LCC expense (C) by comparison method of construction and chooses optimum method of construction through VE/LCC analysis example in improvement of soft soil ground method choice process of design phase.

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Suggestion on the Prototype of the Korean Barriers through the Investigation and Modeling of RC Protective Installments in Contact Areas (접적지역 RC형 방호시설 조사와 모델링을 통한 한국형 방호벽 설계안의 제시)

  • Park, Young Jun;Lee, Min Su;Lee, Hui Man
    • Journal of the Korea Institute of Building Construction
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    • v.16 no.4
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    • pp.341-348
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    • 2016
  • The aim of this study is to suggest design requirements on the military barriers which are installed to reduce critical damage on protective facilities against sudden pin-point attacks caused by North Korean artilleries. For this purpose, site investigation and review of design drawings associated with barriers built in the contact areas are conducted. With identified data concerning barriers, the geometric modeling, which is used in the structural analysis, is performed. And then, the possible threat of North Korea is determined based on intelligence preparation of battlefields. Once the structural modeling and threat analysis are completed, structural damage on barriers and protective facilities are assessed in terms of impact, penetration, scabbing, and blast pressure effects. According to the analysis results, the thickness of barriers should be 450mm at least and current established barriers need to be structurally reinforced via sectional enlargement.

SMB Work Innovation and Ripple Effect Analysis: Focusing on Smart Working Case (중소기업의 업무혁신과 파급효과 분석: 스마트워킹 사례를 중심으로)

  • Lee, Jung-Hwan;Seoung, Jeong-Eun;Han, Yeong-Do
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.36 no.4B
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    • pp.322-331
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    • 2011
  • Recently, the social issues such as low birth rate, an aging population has brought about decreasing labor productivity and productive population. To relieve these problems, the government has planned to set up smart working infrastructure and will raise the number of smart worker to around 30 percent of the total working population by 2015. This study scrutinizes to the meaning of smart working with the concepts of new work pattern and open innovation. The empirical analysis result shows 56.9% of SMBs thought a need for such system and 60.1% of them answered to adopt it. And the market related to smart working of SMBs will increase to 17.5% every year to the point that by 2014. It will be worth 1.54 trillion won and create up to 38,000 job positions. While prior researches on SMB suggested key drivers and guideline for innovation, this study gives some implications of impact and ripple effect of smart working as an innovation factor based on empirical analysis.