• Asian-Australasian Journal of Animal Sciences
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• v.24 no.7
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• pp.1019-1025
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• 2011

Toll-like receptors (TLRs) play an important role in the recognition of invading pathogens and the modulation of innate immune responses in mammals. The TLR4 and TLR7 are well known to recognize the bacterial lipopolysaccharide (LPS) and single stranded (ssRNA) ligands, respectively and play important role in host defense against Gram-negative bacteria and ssRNA viruses. In the present study, coding exon fragments of these two TLRs were identified, cloned, sequenced and analyzed in terms of insertion-deletion polymorphism, within bovine TLRs 4 and 7, thereby facilitating future TLR signaling and association studies relevant to bovine innate immunity. Comparative sequence analysis of TLR 4 exons revealed that this gene is more variable, particularly the coding frame (E3P1), while other parts showed percent identity of 95.7% to 100% at nucleotide and amino acid level, respectivley with other Bos indicus and Bos taurus breeds from different parts of the world. In comparison to TLR4, sequence analysis of TLR7 showed more conservation among different B. indicus and B. taurus breeds, except single point mutation at 324 nucleotide position (AAA to AAM) altering a single amino acid at 108 position (K to X). Percent identity of TLR7 sequences (all 3 exons) was between 99.2% to 100% at nucleotide and amino acid level, when compared with available sequence database of B. indicus and B. taurus. Simple Modular Architecture Research Tool (SMART) analysis showed variations in the exon fragments located in the Leucine Rich Repeat (LRR) region, which is responsible for binding with the microbial associated molecular patterns and further, downstream signaling to initiate anti-microbial response. Considering importance of TLR polymorphism in terms of innate immunity, further research is warranted.

• Journal of Korea Game Society
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• v.17 no.6
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• pp.89-102
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• 2017

This study aims at examining our social recognition on and the topographic map of a game through the discourse analysis on games shown from the Korean media coverage. Media don't reflect the reality as a mirror but represent it in certain manner. If so, how Korean media organize and represent the meaning of a game? This study analyzed the game discourse from 479 articles on games by 5 daily newspapers including Chosun, Joongang, Dong-A, Kyunghyang and the Hankyoreh during 4 years' Park Geun-hye administration. Research findings show that as a single issue frames of game addiction, addiction damages and AR games including $Pok\acute{e}mon$ Go counted for much reaching up to nearly half but discourse on the play culture as an essence of a game occupied only 3.8%.

• International Journal of Oral Biology
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• v.36 no.2
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• pp.43-50
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• 2011

Voltage dependent calcium channel (VDCC), one of the most important regulator of $Ca^{2+}$ concentration in neuron, play an essential role in the central processing of nociceptive information. The present study investigated the antinociceptive effects of L, T or N type VDCC blockers on the formalin-induced orofacial inflammatory pain. Experiments were carried out on adult male Sprague-Dawley rats weighing 220-280 g. Anesthetized rats were individually fixed on a stereotaxic frame and a polyethylene (PE) tube was implanted for intracisternal injection. After 72 hours, 5% formalin ($50 \;{\mu}L$) was applied subcutaneously to the vibrissa pad and nociceptive scratching behavior was recorded for nine successive 5 min intervals. VDCC blockers were administered intracisternally 20 minutes prior to subcutaneous injection of formalin into the orofacial area. The intracisternal administration of 350 or $700{\mu}g$ of verapamil, a blocker of L type VDCC, significantly decreased the number of scratches and duration in the behavioral responses produced by formalin injection. Intracisternal administration of 75 or $150 \;{\mu}g$ of mibefradil, a T type VDCC blocker, or 11 or $22\; {\mu}g$ of cilnidipine, a N type VDCC blocker, also produced significant suppression of the number of scratches and duration of scratching in the first and second phase. Neither intracisternal administration of all VDCC blockers nor vehicle did not affect in motor dysfunction. The present results suggest that central VDCCs play an important role in orofacial nociceptive transmission and a targeted inhibition of the VDCCs is a potentially important treatment approach for inflammatory pain originating in the orofacial area.

• Journal of Korea Game Society
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• v.15 no.4
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• pp.49-58
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• 2015

Due to the improving mobile environments, we can play RPG in not only computer online field but also mobile field. It is difference from hardware environment between them so that mobile RPG has been changed and modified to play in mobile environment except RPG's frame and basic element. This Study has investigated the model to evaluate the balance of battle that is based on the RPG. Although there is an assessment model studied with a focus on the MMORPG, It is difficult to apply to the entire balance in RPG especially mobile RPG. Former model has used only basic element because there were so many kinds of variables such as user's controls, other players and objects in game. The reason why that model just gave a guide line about battle balance. In this paper, the new assessment model to include the balance factors such as BUFF, NURF and PASSIVE could be possible for applying the balance of mobile RPG on recent trends. As a result, the new model can measure numerical calculations compared to the previous model.

• Korean journal of communication and information
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• v.49
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• pp.57-80
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• 2010

This study examines how national newspapers interpret, evaluate and report the Korean grand canal and rebuilding four major rivers through the news writings. For this research, ChosunIlbo, the Hankyoreh Shinmun and HankukIlbo are selected. A total of 961 news writings are analyzed by using the concept of news frame designed by Gamson(1993). As a result, the findings are as follows: First, the most frequently reported news frame for ChosunIlbo is economic consequence; the Hankyoreh for ecological environment, and HankukIlbo for authoritative political execution by the administrative. Second, the most frequently interviewed group through all of the papers is the administrative and the ruling Grand National Party, the main body of rebuilding the Korean grand canal. On the country, voices of environmental protection groups, non-profit civic organizations and the ordinary people are reported rarely. Third, the ratio of authoritative political execution by the administrative and economic consequence are very high. Finally, in terms of the framing activity by the interviewed groups in the newspapers, ChosunIlb reports 'Outcome' the most frequently, the Hankyoreh does 'Loss-gain' & 'Process' and HankukIlbo 'Process' & 'Substantive'. Thus it concluded that ChosunIlbo does not play a role as a social mediator for the social disputes. However, the Hankyoreh and HankukIlbo try to represent environmental and civic organizations fairly.

• Archives of Pharmacal Research
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• v.21 no.6
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• pp.712-717
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• 1998

The complete nucleotide sequence of the cDNA clone encoding rat skeletal muscle myosin- binding protein H (MyBP-H) was determined and amino acid sequence was deduced from the nucleotide sequence (GenBank accession number AF077338). The full-length cDNA of 1782 base pairs(bp) contains a single open reading frame of 1454 bp encoding a rat MyBP-H protein of the predicted molecular mass 52.7kDa and includes the common consensus 1CA__TG' protein binding motif. The cDNA sequence of rat MyBP-H show 92%, 84% and 41% homology with those of mouse, human and chicken, respectively. The protein contains tandem internal motifs array (-FN III-Ig C2-FN III- Ig C2-) in the C-terminal region which resembles to the immunoglobulin superfamily C2 and fibronectin type III motifs. The amino acid sequence of the C-terminal Ig C2 was highly conserved among MyBPs family and other thick filament binding proteins, suggesting that the C-terminal Ig C2 might play an important role in its function. All proteins belonging to MyBP-H member contains `RKPS` sequence which is assumed to be cAMP- and cGMP-dependent protein kinase A phosphorylation site. Computer analysis of the primary sequence of rat MyBP-H predicted 11 protein kinase C (PKC)phosphorylation site, 7 casein kinase II (CK2) phosphorylation site and 4N-myristoylation site.

• Structural Engineering and Mechanics
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• v.32 no.5
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• pp.635-648
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• 2009

This paper describes fire performance of eight axially restrained reinforced concrete (RC) columns under a combination of two different load ratios and two different axial restraint ratios. The eight RC columns were all concentrically loaded and subjected to ISO834 standard fire on all sides. Axial restraints were imposed at the top of the columns to simulate the restraining effect of the rest of the whole frame. The axial restraint was effective when the column was expanding as well as contracting. As the results of the experiments have shown, the stiffness of the axial restraint and load level play an important role in the fire behaviors of both HSC and NSC columns. It is found that (a) the maximum deformations during expanding phase were influenced mostly by load ratio and hardly by axial restraint ratio, (b) For a given load ratio, axial restraint ratio had a great impact on the development of axial deformation during contraction phase beyond the initial equilibrium state, (c) increasing the axial restraint increased the value of restraint force generated in both the NSC and HSC columns, and (d) the development of column axial force during the contracting and cooling phase followed nearly parallel trend for columns under the same load ratio.

• ETRI Journal
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• v.35 no.1
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• pp.69-79
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• 2013

For real-time interactive multimedia operations, such as video uploading, video play, fast-forward, and fast-rewind, solid state disk (SSD)-based storage systems for video streaming servers are becoming more important. Random access rates in storage systems increase significantly with the number of users; it is thus difficult to simultaneously serve many users with HDD-based storage systems, which have low random access performance. Because there is no mechanical operation in NAND flash-based SSDs, they outperform HDDs in terms of flexible random access operation. In addition, due to the multichannel architecture of SSDs, they perform similarly to HDDs in terms of sequential access. In this paper, we propose a new SSD-based storage system for interactive media servers. Based on the proposed method, it is possible to maximize the channel utilization of the SSD's multichannel architecture. Accordingly, we can improve the performance of SSD-based storage systems for interactive media operations.

• Proceedings of the IEEK Conference
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• 2004.08c
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• pp.528-531
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• 2004

This paper presents the design and implementation of a QoS based IrDA in mobile phones. The IrDA standards have arised from the need to connect various mobile devices together. But currently, we have a difficult to connecting various mobile devices together. The difficult thing is to adjust the minimum turn around time. The minimum turn around time in IrDA deals with the time needed for a receiver circuit to recover following saturation by transmissions from the same device (turn around latency). This parameter corresponds to the required time delay between the last byte of the last frames sent by a station and the point at which it is ready the first byte of a frame from another station. This parameter comes into play when the link is turned around and is negotiated independency for each station. We solve this matter by using the Dynamic Adjustment Algorithm (DAA). The dynamic adjustment algorithm adjusts the minimum turn around time according to the numbers of devices. We apply our direct adjustment algorithm to our QoS based IrDA in mobile phones and show the improved performance of connection with various mobile phones together.

• International Journal of Costume and Fashion
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• v.17 no.1
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• pp.59-72
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• 2017

This study aimed to analyze the dilemmas of aging and down-aging by the senior street look, and to examine the styling, psychology, and attitudes of the elderly through socio-cultural discussions. It was conducted through a multidisciplinary literature review and empirical analysis of seniors featured in fashion photos collected from SNS. With respect to seniors' fashion attitudes, firstly, they make personal/social records of dress as a means of recording aging and to reminiscence. Secondly, they attempt to down-age kidult play using mature humor. Thirdly, they try to express a perfect, moderate, and mature beauty to positively adapt themselves to aging. Fourthly, they adopt a regional and ethnic look to escape from the dilemmas accompanying aging and down-aging. This may be regarded as an attitude for repositioning themselves and planning a new life by escaping from a long-standing frame. Finally, they show a desire to stop and enjoy the moment of aging. While recording their cherished everyday lives, they enjoy the present rather than becoming concerned about the past or the future and use styling as a cure for their lives.