• Journal of Ginseng Research
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• v.18 no.1
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• pp.44-48
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• 1994

In adrenaline-stimulated human platelets, panaxadiol (PD) and panaxatriol (PT) from Panax ginseng C.A. Meyer did not inhibit the $Ca^{2+}$-innux, but inhibited the formation of thromboxane $A_2$ and the platelet aggregations. It seems that PD and PT block a pathyway interconvefing arachidonic acids (20:4) to thromboxane $A_2$ (TX $A_2$), because the amount of $Ca^{2+}$ which phospholipase C or phospholipase $A_2$ requires to liberate 20 : 4 from membrane phospholipids was increased by PD and PT. These results mean that PH and PT have an antiplatelet effect by Inhibiting the formation of TX $A_2$.

• Journal of Applied Biological Chemistry
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• v.63 no.4
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• pp.339-345
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• 2020

Euchrestaflavanone A (EFA) is a flavonoid found in the root bark of Cudrania tricuspidata. C. tricuspidata extract, widely used throughout Asia in traditional medicine, has been investigated phytochemically and biologically and is known to have anti-obesity, anti-inflammatory, and anti-tumor effects. It has been reported that C. tricuspidata extract also possesses anti-platelet effects; however, the mechanism of its anti-platelet and anti-thrombotic activities is yet to be elucidated. In this study, we investigated the effects of EFA on the modulation of platelet function using collagen-induced human platelets. Our results showed that EFA markedly inhibited platelet aggregation. Furthermore, it downregulated glycoprotein IIb/IIIa (αIIb/β3)-mediated signaling events, including platelet adhesion, granule secretion, thromboxane A2 production, and clot retraction, but upregulated the cyclic adenosine monophosphate-dependent pathway. Taken together, EFA possesses strong anti-platelet and anti-thrombotic properties and is a potential therapeutic drug candidate to prevent platelet-related thrombosis and cardiovascular disease.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.193.3-194
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• 2003

Platelets play critical roles in both hemostasis and thrombosis. It was reported that platelet aggregation is associated with an increase in superoxide production and can be inhibited by hydroxyl radical scavengers. In the course of our search for the anti-platelet, anti-coagulant and/or anti-oxidative components from plants, the MeOH extract of Crassula cv. "Himaturi" (Crassulaceae) was observed to have both anti-aggregatory and anti-coagulant effects. A novel compound, 12-O-(4'-O-methyl-galloyl)-bergenin (1), was isolated as an active component from the EtOAC soluble fraction. (omitted)

• Clinical and Experimental Reproductive Medicine
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• v.49 no.3
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• pp.168-174
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• 2022

Refractory thin endometrium and recurrent implantation failure are among the most challenging infertility-related factors hindering successful pregnancy. Several adjuvant therapies have been investigated to increase endometrial thickness and the pregnancy rate, but the treatment effect is still minimal, and for many patients, these treatment methods can be quite costly and difficult to approach. Platelet-rich plasma (PRP) is an autologous concentration of platelets in plasma and has recently been elucidated as a better treatment option for these patients. PRP is rich in cytokines and growth factors, which are suggested to exert a regenerative effect at the level of the injured tissue. Another advantage of PRP is that it is easily obtained from the patient's own blood. We aimed to review the recent findings of PRP therapy used for patients with refractory thin endometrium and recurrent implantation failure.

• Steel and Composite Structures
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• v.46 no.5
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• pp.611-619
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• 2023

In the present work, the flutter characteristics of porous nanocomposite cylindrical shells, reinforced with graphene platelets (GPLs) in supersonic airflow, have been investigated. Different distributions for GPLs and porosities have been considered which are named uniform and non-uniform distributions thorough the shell's thickness. The effective material properties have been determined via Halpin-Tsai micromechanical model. The cylindrical shell formulation considering supersonic airflow has been developed in the context of first-order shell and first-order piston theories. The governing equations have been solved using Galerkin's method to find the frequency-pressure plots. It will be seen that the flutter points of the shell are dependent on the both amount and distribution of porosities and GPLs and also shell geometrical parameters.

• Steel and Composite Structures
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• v.46 no.5
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• pp.659-667
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• 2023

Nonlinear forced vibration behaviors of sandwich plates having graphene platelets (GPL) based face sheets have been researched in this article. Possessing low weight together with low stiffness, square honeycomb cores are mostly constructed by aluminum. Herein, the square shaped core has been fortified by two skins of GPL-based type in such a way that the skins have uniform and linearly graded GPL dispersions. The square shaped core has the effective material specification according to the relative density concept. The whole formulation has been represented based upon classical plate theory (CPT) while harmonic balance approach is applied for solving the problem and plotting the amplitude-frequency curves. The forced vibration behaviors of such plates are influenced by square-shaped core and the relative density, skin's height and GPL fortification.

• Structural Engineering and Mechanics
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• v.86 no.2
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• pp.157-165
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• 2023

In the present work, the vibration characteristics of sandwich nanocomposite shells, fortified with graphene platelets (GPLs) have been researched. The shell has been considered as the stadium roof shape with double curvatures under vibration due to earthquake. The nanocomposite has the matrix of concrete which is fortified with uniform or linear dispersions of GPLs. Also, the core possesses cellular type square architecture for which the effective elastic modulus has been defined in the context of relative density based relations. Based upon the classic shell strains containing two identical curvatures, the governing equations have been established and solved through differential quadrature approach. It will be seen that the vibrational frequencies rely on the core relative density, height of layers, the amount and dispersions of GPLs and even shell geometric parameters.

• Structural Engineering and Mechanics
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• v.87 no.1
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• pp.85-94
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• 2023

In the present work, thermal buckling and post-buckling behaviors of imperfect graphene platelet reinforced metal foams (GPRMFs) doubly curved shells are examined. Material properties of GPRMFs doubly curved shells are presumed to be the function of the thickness. Reddy' shell theory incorporating geometric nonlinearity is utilized to derive the governing equations. Various types of the graphene platelets (GPLs) distribution patterns and doubly curved shell types are taken into account. The nonlinear equations are discretized for the case of simply supported boundary conditions. The thermal post-buckling response are presented to analyze the effects of GPLs distribution patterns, initial geometric imperfection, GPLs weight fraction, porosity coefficient, porosity distribution forms, doubly curved shell types. The results show that these factors have significant effects on the thermal post-buckling problems.

• Pediatric Infection and Vaccine
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• v.31 no.1
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• pp.122-129
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• 2024

Chediak-Higashi syndrome (CHS) is a rare haematological and immunodeficiency disorder that occurs in childhood leading to recurrent infections, bleeding tendencies and progressive neurological dysfunction. Partial oculocutaneous albinism occurs in almost all cases. The exact prevalence is unknown, and the disease is caused by over 70 identified mutations in the lysosomal trafficking regulator gene. The presence of a bright polychromatic appearance from hair shaft and abnormally large intracytoplasmic granules, especially within neutrophils and platelets in the bone marrow is highly suggestive. Treatment is largely supportive, and the only curative treatment is through an allogeneic hematopoietic stem cell transplant. Without transplant, most patients will enter an accelerated phase of hemophagocytic lymphohistiocytosis (HLH) which carries a high mortality rate. We present a young male with CHS who we had followed through and eventually developed a fulminant accelerated phase. We believe this is only the second reported case of CHS in Malaysia.

• Earthquakes and Structures
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• v.27 no.2
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• pp.155-164
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• 2024

Studying the propagation characteristics of waves in circular plates has important engineering value. In this paper, graphene sheet reinforced foam (GPLRMF) circular plates are taken as the research object, and the propagation characteristics of shear and bending waves in the structure are analyzed. In the process of research, we assume that the material properties are closely related to temperature, and use the first-order shear deformation theory (FSDT) to establish the dynamic model of GPLRMF circular plates. Considering the simply supported boundary conditions, the relationship between phase velocity/group velocity and wave number was obtained through Laplace transform. Subsequently, the influence of material and geometric parameters on wave propagation characteristics was analyzed, and the results showed that the porosity coefficient and temperature had a significant impact on the characteristics of wave propagation in circular plates.