• YAKHAK HOEJI
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• v.34 no.5
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• pp.348-364
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• 1990

The activities of twenty-one flavonoids and their related compounds on the hypersensitivity reaction against various antigens were studied in vitro and in vivo. 1. Generally flavonoids inhibited significantly the homologous passive cutaneous anaphylaxis (PCA) induced by reaginic antibody as compared as anaphylaxis by compound 48/80-induced mast cell degranulation, and so more strongly active in the IgE-mediated anaphylaxis than non-IgE-mediated anaphylaxis. 2. Flavonids inhibited remarkably Arths reaction, hemolysin titer, delayed hypersensitivity, haemagglutinin titer, rosette forming cells and plague forming cells against sheep red blood cells, and so it exhibited that flavonoids inhibited type 2, 3 and 4 hypersensitivity. 3. Quercetin, kaempferol, hesperetin, disodium cromoglycate, malvin and baicalein were active dose-dependently in the all types of hypersensitivity. Fisetin, daidzein, morin, narigin, flavone, catechin, rutin, hesperidin, neophsperidin, apigenin and chrysin were significantly active in the various types of hypersensitivity, but apigenin, rutin and catechin were less active in the delayed hypersensitivity. Taxifolin was significantly active in PCA and histamine-induced anaphylaxis except other types of hypersensitivity. Rotenone and cyanin also inhibited all types of hypersensitivity, but they are toxic. 4. Based on these results from hypersensitivity, the following flavonoid structure-activity relationships became apparent. 1) Flavonoids with $C_{2-3}$ double bond in C-ring were more active than that of $C_{2-3}$ saturation. 2) Flavonoids with $C_4$ ketone group in C-ring were more active than abscence of them except catechin and malvin. 3) Flavonoids with benzene ring at positions 2 or 3 in C-ring exhibited same activities. 4) Flavonoids with opening of the C-ring does not abolish their activities. 5) The glycosylated flavonoids in position 3 or 7 was less active than their aglycone. 6) Flavonoids with the more hydroxy group in A and B-ring were more active. 7) Flavonoids with or without $C_3-OH$ did not change their activities.

• The Korean Journal of Health Service Management
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• v.4 no.2
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• pp.63-72
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• 2010

The present study purposed to prevent oral diseases and to improve oral health in children. For this purpose, we selected 70 cases who are 5~7 years old preschoolers at the kindergarten affiliated to G College in Gyeongsangbukdo, and analyzed the general patterns of oral care and the relation of the patterns with dental plaque and deciduous dental caries in the children. Specifically, we conducted oral examination and applied pit and fissure sealant according to the eruption of deciduous molar and first molar. In addition, we executed the 1st and 2nd tooth brushing instruction (TBI), and surveyed S-OHI and PHP twice. Excluding 14 preschoolers who did not appear in the 2nd survey, we performed the study with 56 preschoolers and drew conclusions as follows. 1. The number of decayed or missed or filled teeth among deciduous teeth was 3 or more in 42.9% of female children, and 46.4% of male children, so male children showed a slightly higher rate. 2. The degree of dental plaque formation was $1.64{\pm}1.22$ among the surveyed children. 3. The oral health index was lower after TBI than before in all the children (P<.001). 4. Change in the oral health index was particularly larger in 7 year old female children (p<.005). 5. The patient hygiene performance index was lower after TBI than before in both the buccal surface and lingual surface of the children (p<.005). 6. The patient hygiene performance index was lower after TBI than before in all of male children's teeth except the right maxillary first deciduous molar (p<.001).

• Korean Journal of Health Education and Promotion
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• v.16 no.2
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• pp.93-104
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• 1999

For studying on the actual condition of the oral health control of the old there were invastigations on the Questions with the college of the old in Chonbuk as the central figure from June 1 to June 30, 1998 and the analyses about the frequency and the mutual relation through χ²-test. The results are as follow: 1. According to the result of the investigation into the actual condition about the oral health of the old, two times a day in the frequency of tooth brush per day was the highest at the rate of 50.35％, the use of dentifrice was 45.4％, and the exchanging time of tooth-brush after six months was the highest at the rate of 19.7％. And 96.1％ didn't use dental floss and 73.6％ didn't do scaling. It is thought that since 50％ used tooth sticks and match sticks we have to inform the old of the necessity of dental plague and period oral examination. 2. In oral health situation, it showed that the number of people who were very week was the highest at the rate of 37％ and there was the mutual relation between the use of tooth sticks and match sticks and present situation of oral health. And 54.93％ visited the dental clinic wethin a year, and 22.3％ among them made full denture. There was the mutual relation between the visit of dental clinic within a year and the consultation content and the number of people who teld that the consultation expense was very expensive was the higest at the rate of 27.8％ and 87％ didn't experience the oral education. So it is thought that we have to make an systematic education about the oral to the old and inform them of the necessity of oral health control. 3. We think it needs the establishment and plane of the systematic basis material and the oral education which is necessary in oral public industry for the dental preventive suitable to the characteristic of the old.

• Journal of the Korean Society of Food Culture
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• v.18 no.4
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• pp.303-310
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• 2003

This study was conducted to investigate immunofunctional activity of the polyphenol fractions isolated from Korean pear. In the experimental of Rosette forming cell, the results showed that all the polyphenol fractions enhance the cell count compared with the control group. Especially polyphenol fraction II and III showed highly significant effect on Rosette forming cell, and allergy inhibition. After antigen challenge, histamine content of blood of the polyphenol groups was lowered to near the normal group.

• Journal of Korean society of Dental Hygiene
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• v.15 no.2
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• pp.319-324
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• 2015

Objectives: The purpose of this study was to verify the oral environmental change in using the natural oral cleaner containing propolis and prevention effect of oral disease. Methods: The subjects were 60 university students in Gangwon province. The groups consisted of 30 students of experimental group and 30 students of control group. The subjects were those who did not take the antipsychotic, diuretic, antihistamine, and anesthetic. The students rinsed their mouth with propolis mixture of oral cleanser for 4 weeks after receiving informed consent from October 1 to November 2, 2012. Collected saliva was measured for amount, salivary consistency, pH, plague index, gingival index, and halitosis. Results: The amount of salivary in propolis mixture of oral cleansing group remarkably increased (t=2.16, p<0.05). pH was alkaline in the group with oral cleaner containing the propolis (t=2.80, p<0.01). The bad breath remarkably decreased in the group with oral cleaner containing the propolis (t=-5.77, p<0.001). Conclusions: The use of the oral cleaner containing the propolis increased the amount of salivary and pH. The use of oral cleaner containing the propolis reduces halitosis and maintains good quality of oral hygiene.

• Journal of Service Research and Studies
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• v.6 no.3
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• pp.123-139
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• 2016

As competition continues to increase, it becomes even more important for companies to improve customer satisfaction to survive. Many companies have tried to improve customer satisfaction in their own ways. This case study focuses on the market for used products, and introduces the case of the start-up company, SELL-IT, a company that has made great efforts to solve the problems commonly facing their customers and has been rewarded by improved customer satisfaction. Focusing on improving communications between buyers and sellers, the root of many problems in any market, SELL-IT has introduced a number of new systems to solve the problems that plague the secondhand market. This case study provides marketers with practical implications to improve customer satisfaction in the secondhand market.

• Journal of dental hygiene science
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• v.19 no.2
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• pp.107-112
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• 2019

Background: Good oral health is important for systemic body health and quality of life. Spray oral cleansers are increasingly preferred because of their convenience of carrying and the ease of oral hygiene management. In addition, many kinds of oral cleanser products containing various ingredients with antibacterial, washing, and moisturizing effects are being manufactured. However, concerns about the safety and side effects of oral sprays are increasing, and there is very little information regarding the use and care of oral sprays is available to consumers. This study aimed to investigate the effects of oral spray on oral bacteria and tissue to elucidate the factors that need to be considered when using oral sprays. Methods: The effects of oral spray on the growth of dental plaque bacteria was assessed using disk diffusion assays. Cytotoxicity and morphological changes in oral epithelial cells were observed by microscopy. The effects of oral spray on dental plaque growth were also confirmed on specimens from permanent incisors of bovines by Coomassie staining. Results: The pH of spray products, such as Perioe Dental Cooling, Cool Sense, and Dentrix, were 3.65, 3.61, and 6.15, respectively. All tested spray products showed strong toxicity to dental plaque bacteria and oral epithelial cells. Compared with those on the control, dental plaque bacteria deposits on the enamel surface increased following the use of oral spray. Conclusion: Three types of oral spray, namely Perioe Dental Cooling, Cool Sense, and Dentrix, strongly inhibited the growth of dental plaque bacteria and oral epithelial cells. The oral spray ingredient enhanced dental plaque growth on the enamel surface. Users should be informed of precautions when using oral sprays and the need for oral hygiene after its use.

• The Journal of Korean Medical History
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• v.31 no.2
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• pp.53-62
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• 2018

It is known that the development of medical science is influenced by various social environmental factors. Historically, Chinese Medicine developed the most during the Song Yuan dynasty, and the reason for this was known to be due to socio-political factors. According to recent studies, however, this period also had severe changes in climate and environment. Therefore, this study was conducted under the premise that this change in climate and environment influenced medical development. When looking at the coldness of the 11th~12th century and data indicating warming before and after this period, the Song Yuan dynasty went through drastic periods of climate change. Therefore, diseases related to heat such as bubonic plague, measles, and malaria were common. Furthermore, due to occasional wars during the Song Yuan dynasty, social unrest was aggravated and infectious diseases spread due to land development and environmental pollution. As the health of people were threatened due to these factors, the printing and distribution of medical text were encouraged, and during this process, the great 4 doctors of Jin-Yuan appeared. The reason why they studied cures for infectious diseases due to heat was related to climatic environment change. The development in medical science is closely related to socio-political factors, however the change in climatic environments are inevitably related to disease emergence as well. Therefore, it should always be taken into consideration as an important factor that promotes development in medical science.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.18 no.1
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• pp.139-148
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• 2008

Information technology have led to change the automation of large industrial control system as well as business system and environments. Industrial control system(ICS) is vital components of most nation's critical infrastructures such as electricity, natural gas, water, waste treatment, transportation and communication that are based of national security, safety of citizen and development of national economy According to the change of business environment, organizational management pushed integration all of the system include MIS and ICS. This situation led to use standard information technologies for ICS, this transition has been to expose ICS to the same vulnerabilities and threats that plague business system. Recently government obliged owners of the public information system to audit for safety, efficiency and effectiveness, and also obliged the owners of national infrastructure to improve their system security as a result of vulnerability analysis. But there doesn't prepare a security architecture and information security auditing framework of ICS fur auditing. In this paper, I suggested the security architecture and information security auditing framework for ICS in order to prepare the base of industrial system security auditing.

• Journal of English Language & Literature
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• v.56 no.4
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• pp.691-717
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• 2010

Chaucer's Troilus and Criseyde is a tale of love framed by an overarching pattern of death, set in the war-torn and doomed Troy, from which the lovers cannot separate their fate. Compared with Boccaccio's poem, the attention paid to death in Chaucer's version underlies his complex treatment of love. Above all, the language of death in Chaucer's poem provides the thread from which the entangled web of love is woven. Death together with desire pervades the language and rhetoric of the poem, prominent not only in the courtly love tropes, but also in the characters' asides and speeches. The prominence of these two concepts, desire and death, seem to be central to the various issues that the poem contains explicitly and implicitly. That is, two concepts are the basis for the breadth and depth of Chaucer's examination of love in light of the social and political realities of late fourteenth century England. The language of death in Chaucer's poem reflects the powerful influence on his imagination. With the devastation wrought by the plague and the changing fortunes of England in the war with France, Chaucer's world was once saturated in death, and one that could amply parallel the turn from prosperity to downfall. In particular, Chaucer's poem is suffused with the language of contagion and death in connection with desire. Troilus's lovesickness mimics the progress of a viral infection. Once breached, his body performs its newly compromised identity through fever, loss of appetite, and physical disintegration. On the other hand, Chaucer depicts Boccaccio's conventional portrait of Criseyde into a elaborate paramour of a pathogen. She is characterized as the contaminant that infects male hero. In addition, Criseyde is cast as sole earthly cure of illness that Troilus suffers from. In spite of Criseyde's role as nurturer and healer, Troilus longs for his own death and feels death clutching his heart. Finally, Troilus's love toward Criseyde is doomed to death.