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Study of moxibustion stimulation in the ovariectomized rat model

  • Kanai, Shigeyuki;Taniguchi, Norimasa;Kanda, Kayo;Matsuhata, Izuru
    • Advances in Traditional Medicine
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    • v.5 no.3
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    • pp.195-200
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    • 2005
  • In order to examine the effectiveness of moxibustion stimulation for climacteric disturbance, we administered moxibustion stimulation to ovariectomized (OVX) rats, and compared the tail surface temperature, laboratory parameters, and the level of locomotor activity with those of untreated rats. Twenty-four female Wistar rats (8 weeks old, 160 - 180 g) were divided into three groups. The rats in the OVX-M group underwent moxibustion stimulation after ovariectomy. The rats in the OVX-C group underwent ovariectomy but did not receive moxibustion stimulation. The rats in the Normal group received neither ovariectomy nor moxibustion stimulation. The level of locomotor activity was determined by a metabolism measuring system. The tail surface temperature was significantly lower in the OVX rats before moxibustion stimulation than in the Normal group. In the OVX rats before moxibustion stimulation, there was no clear difference in the level of locomotor activity between the active and resting phases, and the pattern of locomotor activity was irregular. After moxibustion stimulation, the tail surface temperature of the OVX-M group did not significantly differ from that of the Normal group, and the pattern of locomotor activity of the OVX-M group became diphasic with clear active and resting phases, similar to that observed in the Normal group. These results demonstrate that moxibustion stimulation is effective for the treatment of climacteric disturbance.

The Analysis of Statistical Behavior in Concrete Creep (콘크리트 크리프의 확률론적 거동 해석)

  • Kim, Doo-Hwan;Park, Jong-Choul
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.5 no.1
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    • pp.237-246
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    • 2001
  • This study is to measure the creep coefficient by 3 days, 7 days and 28 days in the age when loading for the quality assessment of $350kgf/cm^2$ in the high-strength concrete. And it is to analyze the behavior of creep coefficient by applying the experimental data though the compressive strength test, the elastic modulus test and the dry shrinkage test to the ACI-209, AASHTO-94 and CEB/FIP-90, the prediction mode, and the basis of concrete structural design. Also it is to analyze the behavior of short-term creep coefficient during 91 days in the age when loading through the experiment by using the regression analysis, the statistical theory. As applying it to the long-term behavior during 365 days and comparing with the creep prediction mode and examining it, the result from the analysis of the quality of the concrete is as follows. As the result of comparison and analysis about the ACI-209, AASHTO-94 and CEB/FIP-90, the prediction mode, and the basis of concrete structural design, the normal Portland cement class 1 shows the approximate value with the prediction of GEE/PIP-90 and the basis of concrete structural design, but in case of the prediction of ACI-209 and AASHTO-94, there would be worry of underestimation in the application.

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Study of acupuncture stimulation on experimental osteopenia

  • Kanai, Shigeyuki;Taniguchi, Norimasa;Kanda, Kayo;Higashino, Hideaki
    • Advances in Traditional Medicine
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    • v.6 no.2
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    • pp.79-85
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    • 2006
  • In order to study the effect of acupuncture stimulation on bone mineral density (BMD), using the ovariectomized (OVX) rat model, we assessed the degree of osteopenia by dual-energy X-ray absorptiometry, measured the level of locomotor activity using a metabolism measuring system, and performed histological studies of bone tissue. Twenty-four female Wistar rats (8 weeks old, 160 - 180 g)were divided into three groups. Rats in the OVX-A group underwent ovariectomy followed by acupuncture stimulation. The OVX rats in the Vehicle control group were not treated with acupuncture as a control. The rats in the control group received neither ovariectomy nor acupuncture. Acupuncture stimulation for 12 weeks in the OVX-A group inhibited the reduction in BMD of the femoral bones caused by ovariectomy. Moreover, in the two OVX groups, there was no clear difference in the level of locomotor activity between the active and resting phases prior to acupuncture stimulation in each rat, and the pattern of locomotor activity was irregular. After acupuncture stimulation of the OVX-A rats, the pattern of locomotor activity became diphasic with clear active and resting phases, as was observed in the Control group. On histological studies, the continuity of trabecular bone was maintained more favorably and bone mass was higher in the OVX-A group than in the vehicle control group. These results suggest that the increased locomotor activity that had been induced by acupuncture stimulation increased the BMD.

JXTA based P2P Framework using Mobile Agents (모바일 에이전트를 이용한 JXTA 기반의 P2P 프레임워크)

  • Min, Su-Hong;Cho, Dong-Sub
    • Proceedings of the KIEE Conference
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    • 2003.11c
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    • pp.384-387
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    • 2003
  • In this paper, we have designed the integrated wire and wireless P2P framework using mobile agents to share efficiently resources as media file. Most of the P2P applications are used on the wire network. We propose the integrated wire and wireless P2P framework. Proposed P2P platform is based on JXTA of Sun Microsystems. But JXTA is pure peer-to-peer network model, so it sends message other peers as broadcast style to request resources. In this way, there are some problems as massage overload, bandwidth loss, etc. In order to solve this problem, we propose a hybrid peer-to-peer network model using mobile agent. Proposed scheme also solve existing hybrid pEp model's flaws which have the delay and low rate due to concentrated server. In proposed scheme, mobile agents that have autonomy and mobility are used to search the location of resources. Besides, mobile agents could solve the loss problem of the search result. To improve P2P QoS(Quality of Service), we could monitor peer's state information using PIP(Peer Information Protocol) of JXTA.

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A constant tendon moment arms finger model in the sagittal plane

  • Lee, K.H.
    • Proceedings of the ESK Conference
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    • 1992.10a
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    • pp.46-53
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    • 1992
  • Finger movements in the sagittal plane mainly consist of flexion and extension about the metacarpophalangeal(MCP) and proximal interphalangeal(PIP) joints. A kinematic finger model was developed with the assumption of constant tendon moment arms. Equations of static equilibrium were derived for the finger model using the principle of virtual work. Equations of static equilibrium for the finger model were indeterminate since only three equations were available for five unknown variables(forces). The number of variables was reduced based on information on muscular activities in finger movements. Then the amounts of forces which muscles exerted to maintain static equilibrium against external loads were computed from the equilibrium equations. The muscular forces were expressed mathematically as functions of finger positions, tendon moment arms, lengths of phalanges, and the magnitude and direction of external load. The external finger strength were computed using the equations of muscular forces and anatomical data. Experiments were performed to measure finger strengths. Measurements were taken in combinations of four finger positions and four directions of force exertions. Validation of the finger models and of procedure to estimate finger strengths was done by comparing the results of computations and experiments. Significang differences were found between the predicted and measured finger strengths. However, the trends of finger strengths with respect to finger positions were similar inboth the predicted and measured. These findings indicate that the finger model and the procedure to predict finger strengths were correctly developed.

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Authoring Tool for Web Content Development by Python Education (Python 교육을 통한 Web 콘텐츠 개발을 위한 저작도구)

  • Jeong, Je-Hyeon;Oh, Seong-Min;Gu, Bon-Woo
    • Proceedings of the Korea Information Processing Society Conference
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    • 2022.05a
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    • pp.699-701
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    • 2022
  • 프로그래밍 교육에서 Python 교육은 현재 기본으로 다루고 있다. PIP 의 우수한 확장성에 의해 수많은 분야에서 Python 을 이용하여 연구 및 개발을 수행하고 있다. 게임 개발에서도 Python 은 적극 활용되고 있다. 메모리관리와 최적화를 위한 Low Level 개발 부분에서는 C/C++, C#, JAVA 를 사용하지만, 게임 시스템 기획자의 경우 프로그래머에게 직결되는 문서를 작업하기 위해 객체지향적 시점을 작성해야 하기 때문에 Python 을 통해 기획자와 프로그래머의 의사소통 향상으로 인해 결과적으로 개발 시간을 단축하는 효과를 볼 수 있다. 본 논문에서는 Python 교육과 접근성이 좋은 Web Contents 를 개발하기 위하여 KM Engine 을 개발하였다. 경민 대학교 게임콘텐츠과 학생들을 대상으로 교육과 Web Contents 를 개발한 결과 Unity, Unreal 에 비해 학생들이 매우 편하게 개발하는 것을 확인 할 수 있었다. KM Engine 은 경민 대학교 학생 들 뿐 아니라 게임 제작을 배우고 싶어하는 이들과 이들을 학습시킬 목적을 가진 이들에게 기여하길 바란다.

Synthesis, crystal structure, and thermal property of piperazine-templated copper(II) sulfate, {H2NCH2CH2NH2CH2CH2}{Cu(H2O)6}(SO4)2

  • Kim, Chong-Hyeak;Park, Chan-Jo;Lee, Sueg-Geun
    • Analytical Science and Technology
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    • v.18 no.5
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    • pp.381-385
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    • 2005
  • The title compound, $\{H_2NCH_2CH_2NH_2CH_2CH_2\}\{Cu(H_2O)_6\}(SO_4)_2$, I, has been synthesized under solvo/hydrothermal conditions and their crystal structure analyzed by X-ray single crystallography. Compound I crystallizes in the monoclinic system, $P2_1/n$ space group with a = 6.852(1), b = 10.160(2), $c=11.893(1){\AA}$, ${\beta}=92.928(8)^{\circ}$, $V=826.9(2){\AA}^3$, Z = 2, $D_x=1.815g/cm^3$, $R_1=0.031$ and ${\omega}R_2=0.084$. The crystal structure of the piperazine templated Cu(II)-sulfate demonstrate zero-dimensional compound constituted by doubly protonated piperazine cations, hexahydrated copper cations and sulfate anions. The central Cu atom has a elongated octahedral coordination geometry. The crystal structure is stabilized by three-dimensional networks of the intermolecular $O_{water}-H{\cdots}O_{sulfate}$ and $N_{pip}-H{\cdots}O_{sulfate}$ hydrogen bonds between the water molecules and sulfate anions and protonated piperazine cations. Based on the results of thermal analysis, the thermal decomposition reaction of compound I was analyzed to have three distinctive stages.

Impregnation Behavior of SiCf/SiC Composites Depending on the Polycarbosilane Precursor and Solvent (폴리카보실란의 종류와 용제에 따른 SiCf/SiC복합재의 충진 거동)

  • Kim, Sun-Han;Jung, Yang-Il;Park, Jeong-Yong;Kim, Hyun-Gil;Koo, Yang-Hyun;Hong, Sun-Ig
    • Korean Journal of Materials Research
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    • v.24 no.9
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    • pp.474-480
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    • 2014
  • Process conditions for the impregnation of polycarbosilane preceramic polymer into SiC-based composites were investigated. Two kinds of preceramic polymer (PCP) was impregnated into SiC-fiber fabrics with different solvents of n-hexane and divinylbenzene (DVB). Both microstructural observations and mechanical tests were conducted to evaluate the impregnation. The matrix phases were particulated in the case of hexane solvents. Apparent relative density of the matrix was about 78.8%. The density of matrix was increased to about 96.1-98.8% when the DVB was used; however, brittle fracture was observed during a bending test. The modulus of toughness was less than $0.74J/m^3$. The fabric impregnated with a mixed PCP-dissolved solution showed intermediate characteristics with relative high density of filling (apparent density of ~96.1%) as well as proper bending behavior. The modulus of toughness was increased to about $5.31J/m^3$. The composites developed by changing the precursor and solvent suggested the possibility of fabricating SiCf/SiC composites without a fiber to matrix interphase coating.

The Study on The Production Testing Equipment for the Improvement of System Test Reliability in FCS (사격통제장치 시스템 시험의 신뢰성 향상을 위한 생산시험장비에 관한 연구)

  • Choi, Kyungjin
    • Journal of the Institute of Electronics and Information Engineers
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    • v.53 no.11
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    • pp.139-147
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    • 2016
  • This study described the design scheme for each step of the production test for the Fire Control System(FCS) of the K-55A1 PIP business of Hanwha Thales since 2011. From the time of receipt of the product It is necessary to improve the FCS's reliability by using the Unit Test, burn-In test, System Test. FCS of K-55A1 acts as a 'head' that control the self-propelled howitzer, and connected with the electrical and physical connection of self-propelled howitzer's multiple unit (Inertial navigation systems(IN), Muzzle Velocity Radar (MVR)) for the normal operation without an inch of error in operating. We designed the production testing equipment automatically as much as possible and designed with the environment similar to the self-propelled howitzer. by using this production testing equipment, It should help for the strengthen national defense of the Republic of Korea.

Cromakalim Blocks Membrane Phosphoinositide Activated Signals in the Guinea Pig Lung Mast Cells Stimulated with Antigen-Antibody Reactions

  • Ro, Jai-Youl;Kim, Ji-Young;Kim, Kyung-Hwan
    • The Korean Journal of Physiology and Pharmacology
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    • v.2 no.2
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    • pp.251-260
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    • 1998
  • Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. It has been suggested that cromakalim, in part, inhibited mediator releases by inhibiting the initial increase of 1,2-diacylglycerol (DAG) produced by the activation of the other phospholipase system which is different from phosphatidylcholine-phospholipase D pathway. The aim of this study is to further examine the inhibitory mechanism of cromakalim on the mediator release in the mast cell activation. Guinea pig lung mast cells were purified by using enzyme digestion and percoll density gradient. In purified mast cells prelabeled with $[^3H]PIP_2$, phospholipase C (PLC) activity was assessed by the production of $[^3H]$insitol phosphates. Protein kinase C (PKC) activity was assessed by measuring the protein phosphorylated from mast cells prelabeled with $[{\gamma}-32P]ATP$, and Phospholipase $A_2\;(PLA_2)$ activity by measuring the lyso-phosphatidylcholine produced from mast cell prelabeled with 1-palmitoyl-2-arachidonyl $phosphatidyl-[^{14}C]choline$. Histamine was assayed by fluorometric analyzer, and leukotrienes by radioimmunoassay. The PLC activity was increased by activation of the passively sensitized mast cells. This increased PLC activity was decreased by cromakalim pretreatment. The PKC activity increased by the activation of the passively sensitized mast cells was decreased by calphostin C, staurosporine and cromakalim, respectively. The $PLA_2$ activity was increased in the activated mast cells. The pretreatment of cromakalim did not significantly decrease $PLA_2$ activity. These data show that cromakalim inhibits histamine release by continuously inhibiting signal transduction processes which is mediated via PLC pathway during mast cell activation, but that cromakalim does not affect $PLA_2$ activity related to leukotriene release.

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