• Journal of the Korea Society of Computer and Information
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• v.8 no.3
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• pp.61-65
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• 2003

In this paper, a novel watermarking technique that based on wavelet packet transform using PIM is proposed for the copyright of the digital images. We divide wavelet packet coefficients into detailed blocks and calculate the complexity of each block using PIM. Because human is impervious to the change in the complex area, the embedding watermark to the selected coefficients using PIM enhances invisibility. From the experimental results, the proposed algorithm shows better invisibility and robustness performance in a general signal processing such as JPEG and SPIHT lossy compression, median filtering. Especially, it demonstrates better performance for the low bit-rate compression in the images that include many high frequency components.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3325-3331
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• 2015

Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple human cancers and involved in Myc-induced tumorigenesis. However, little is known regarding its expression and biological function in human ovarian cancer. In this study we showed that the clinical significance and biological functions of Pim-3 in ovarian cancer and found that higher Pim-3 mRNA level are detected in ovarian cancer tissues than those in normal ovarian tissues. There are significant correlations between higher Pim-3 expression levels with the FIGO stage, histopathological subtypes, and distant metastasis in ovarian cancer patients. Lentivirus-mediated gene overexpression of Pim-3 significantly promotes the proliferation and migration of SKOV3 cell lines. Furthermore, MACC1 and Pim-3 expression were significantly correlated in human ovarian cancer cells, and overexpression of Pim-3 in ovary cancer cells increased MACC1 mRNA and protein expression. The data indicate that Pim-3 acts as a putative oncogene in ovary cancer and could be a viable diagnostic and therapeutic target for ovarian cancer.

• Korean Journal of Clinical Pharmacy
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• v.24 no.2
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• pp.115-125
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• 2014

Purpose: The purpose of the present study was to assess the incidence of the potentially inappropriate medication (PIM) use in Korean elderly patients with heart failure, and to evaluate factors that influence PIM use. Method: Korean National Health Insurance claims database between January 2009 and December 2009 was used. Using 2012 updated Beers criteria, PIM use in heart failure patients aged 65 years or older was examined. Result: The incidence of PIM use in elderly heart failure patients was higher than in overall elderly patients. Among the 12,759 elderly patients with heart failure, 46.2% of study subjects were prescribed PIM(s) at least once. The number of PIM per 10 medications that patients received per patient was 1.53. The most commonly used PIMs in elderly heart failure patients were benzodiazepines (30.9%), non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors (16.3%), digoxin (9.9%), and spironolactone (9.0%). Women (odds ratio, 1.20; 95% CI, 1.17-1.24), medical aid (odds ratio, 1.11; 95% CI, 1.08-1.13), and long-term facilities (odds ratio, 2.69; 95% CI, 2.44-2.96) were revealed to be important factors associated with PIM use. In addition, patient's age also seems to influence PIM use. Conclusion: Elderly heart failure patients are at a greater risk for adverse drug events attributed by inappropriate medication use. Efforts to increase awareness of PIM use in elderly heart failure patients are needed. In addition, various comprehensive strategies and policies to identify and prevent PIM use should be established nationwide.

• Journal of the Semiconductor & Display Technology
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• v.22 no.3
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• pp.78-83
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• 2023

This paper proposes a lightweight trace-driven Processing-In-Memory (PIM) simulator, TP-Sim. TP-Sim is a General Purpose PIM (GP-PIM) simulator that evaluates various PIM system performance-related metrics. Based on instruction and memory traces extracted from the Intel Pin tool, TP-Sim can replay trace files for multiple models of PIM architectures to compare its performance. To verify the availability of TP-Sim, we estimated three different system configurations on the STREAM benchmark. Compared to the traditional Host CPU-only systems with conventional memory hierarchy, simple GP-PIM architecture achieved better performance; even the Host CPU has the same number of in-order cores. For further study, we also extend TP-Sim as a part of a heterogeneous system simulator that contains CPU, GPGPU, and PIM as its primary and co-processors.

• Journal of the Korea Society of Computer and Information
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• v.17 no.6
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• pp.131-144
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• 2012

MDD is suitable to satisfy constraints of development of mobile applications. So, there are various studies about applying MDD to the developments of mobile application but systematic development methods about UML profile for PIM/PSM of mobile applications and model transformation techniques are needed. This paper suggests that a development technique about UML profile for PIM/PSM of mobile applications and a model transformation techniques with the profiles. We classify stereotypes by the characteristics of mobile application to compose profiles and suggest development guidelines of profiles for PIM/PSM. On the suggested model transformation process, the PIM with the profiles is transformed to the intial PSM with the mapping rules and the PSM is transformed to the refined PSM with templates which reflected detailed information of a mobile platform. We developed a location based service mobile application with the suggested techniques on the Android platform and compared with other techniques to validate usefulness of the suggested techniques.

• Proceedings of the Korean Information Science Society Conference
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• 2003.04c
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• pp.88-90
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• 2003

OMG에서 제안한 MDA는 시스템의 설계와 명세를 기술 플랫폼 독립적인 모델인 PIM으로 작성하고. 매핑을 통해서 실제 구현과 관련된 모델인 PSM을 만들어냄으로써 시스템을 보다 효율적으로 유지 및 통합할 수 있다. 이를 지원하기 위해 본 논문에서는 EDOC 프로파일 기반의 PIM 변환기를 제안하여 메타 모델 단위의 매핑을 통한 PSM으로 변환 과정의 자동화를 지원하고자 한다. 변환기의 입력인 PIM은 분산 컴퓨팅 환경에 대해 OMG에서 채택한 EDOC 프로파일을 적용하였으au, 매핑 결과인 PSM은 UML Profile for EJB를 적용하였다. 또한 자동화된 PIM 모델 변환을 위해 EDOC to J2EE/EJB 매핑 규칙을 정의하였으며, 이를 지원하는 도구를 구현하여 회의실 예약 시스템 예제에 적용시켜 검증했다.

• Journal of KIISE:Information Networking
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• v.28 no.4
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• pp.498-507
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• 2001

For the Internet multicast routing, there are some protocols researched. This paper presents a new protocol called DPIM (Delay-bounded PIM) to support QoS of delay in multicast routing. This protocol is based on PIM-SM. When the specified delay bound is not satisfied by dynamic membership, the RP (Rendezvous Point) of shared tree is changed and the shared tree is reconstructed. Therefore, the QoS of delay is always supported in this protocol. Through performance analysis and comparison with other protocol, we certify that this protocol is pertinent.

• Clinical and Experimental Pediatrics
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• v.51 no.11
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• pp.1158-1164
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• 2008

Purpose : To investigate the discriminative ability of pediatric index of mortality 2 (PIM2) and pediatric risk of mortality III (PRISM III) in predicting mortality in children admitted into the intensive care unit (ICU). Methods : We retrospectively analyzed variables of PIM2 and PRISM III based on medical records with children cared for in a single hospital ICU from January 2003 to December 2007. Exclusions were children who died within 2 h of admission into ICU or hopeless discharge. We used Students t test and ANOVA for general characteristics and for correlation between survivors and non-survivors for variables of PIM2 and PRISM III. In addition, we performed multiple logistic regression analysis for Hosmer-Lemeshow goodness-of-fit, receiver operating characteristic curve (ROC) for discrimination, and calculated standardized mortality ratio (SMR) for estimation of prediction. Results : We collected 193 medical records but analyzed 190 events because three children died within 2 h of ICU admission. The variables of PIM2 correlated with survival, except for the presence of post-procedure and low risk. In PRISM III, there was a significant correlation for cardiovascular/neurologic signs, arterial blood gas analysis but not for biochemical and hematologic data. Discriminatory performance by ROC showed an area under the curve 0.858 (95% confidence interval; 0.779-0.938) for PIM2, 0.798 (95% CI; 0.686-0.891) for PRISM III, respectively. Further, SMR was calculated approximately as 1 for the 2 systems, and multiple logistic regression analysis showed ${\chi}^2(13)=14.986$, P=0.308 for PIM2, ${\chi}^2(13)=12.899$, P=0.456 for PRISM III in Hosmer-Lemeshow goodness-of-fit. However, PIM2 was significant for PRISM III in the likelihood ratio test (${\chi}^2(4)=55.3$, P<0.01). Conclusion : We identified two acceptable scoring systems (PRISM III, PIM2) for the prediction of mortality in children admitted into the ICU. PIM2 was more accurate and had a better fit than PRISM III on the model tested.

• Journal of the Korea Society of Computer and Information
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• v.10 no.5 s.37
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• pp.103-108
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• 2005

In this Paper, we proposed a novel robust watermarking technique using PIM and 2D barcode for the copyright of the digital images. Because human is impervious to the change in the complex area, the embedding watermark to the selected coefficients using PIM enhances invisibility. A 2D barcode image is used for watermark in this research. The 2D barcode contains more information than conventional ID barcode and includes the error correction algorithm. Therefore the watermarking algorithm using 2D barcode enhances the robustness of watermark. From the experimental results , the proposed algorithm shows better invisibility and robustness performance in a general signal Processing such as JPEG and SPIHT lossy compression.

• Journal of Korean Biological Nursing Science
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• v.24 no.3
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• pp.161-170
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• 2022

Purpose: The purpose of this study was to investigate polypharmacy and potentially inappropriate medication (PIM) use in elderly patients admitted to hospitals after falls. Methods: The study surveyed 283 patients 65 or older admitted January 1-December 31, 2016. Data were collected from electronic medical records, and medications administered immediately prior to admission were examined. PIM use for patients was investigated using the Beers criteria, and data were analyzed by Chi-square test and independent ttest. Results: The average age of participants was 79.42± 8.16, and the study included 226 women (79.9%) and 57 men (20.1%). The average number of self-administered medications daily was 4.94± 3.68, and 55.1% took five or more medications. PIM use was found in 107 patients (37.8%). There was a significant difference in polypharmacy according to age, and the proportion of medical aid beneficiaries and prevalence of cardiocerebrovascular, endocrine, and other chronic diseases were higher in the polypharmacy and PIM use patients than in the non-polypharmacy and non-PIM use patients. The number of chronic diseases and medications taken were significantly high among polypharmacy and PIM use patients. Conclusion: It is necessary to minimize polypharmacy and PIM use, and establish a system for systematically evaluating and managing medication use to prevent falls in the elderly.