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Pharmacological Actions of New Wonbang Woohwangchungsimwon Pill on Cardiovascular System (신원방우황청심원의 심혈관계에 관한 약효)

  • 조태순;이선미;김낙두;허인회;안형수;권광일;박석기;김상호;신대희
    • YAKHAK HOEJI
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    • v.43 no.2
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    • pp.237-250
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    • 1999
  • In order to investigate the pharmacologic properties of New Wonbang Woohwangchungsimwon Pill(NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not affect significantly the relaxing effects of NSCH and SCH. NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effects that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA), $V_{max}$ and resting membrane potential (RMP) at low doses, whereas inhibitory the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

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The Effect of Combined Oral Contraceptive Steroids on Serum Levels of Lipids (복합경구피임제 복용이 혈청 지질함량에 미치는 영향)

  • Kim, J.H.;Kim, W.J.
    • The Korean Journal of Pharmacology
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    • v.17 no.2
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    • pp.69-74
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    • 1981
  • Increased incidence of myocardial infarction, arteriosclerosis and hypertension in oral contraceptive steroids users has been recognized as serious problem. Evidence have been accumulated that oral contraceptive steroids cause an increase in serum lipid levels, mainly triglyceride as well as an increase in serum cholesterol concentration in some women. Effect of oral contraceptives on serum lipids have been predominantly confirmed in Europian and American women. It should be emphasized that effects of contraceptives may he influenced by differences in nutrition, climate, socioeconomic status and race. The present study was, therefore, attempted to determine the effect of oral contraceptive steroids on serum lipid levels in Korean women and also to demonstrate whether the duration of pill treatment may affect serum lipid levels. Ten women, who had never taken contraceptive steroids, served as a control. One hundred women on combined oral contraceptive steroids were grouped according to the duration of pill use: duration of less than one year(14 women), 1-2 years(12 women), 2-5 years(29 women), 5-10 years(33 women) and more than 10 years(13 women). Serum levels of cholesterol, phosholipid and triglyceride were measured by enzymatic method, Fiske-SubbaRow method and Sugiura method respectively. The results obtained are as follows; 1) Oral contraceptive steroids increased serum cholesterol concentration by 4.8% as compared with cholesterol value of control group. But this increase was not statistically significant. 2) As compared with control value, concentration of serum phospholipid in pill-treated women decreased by 14.3%, which was statistically significant (p<0.05). 3) Concentration of serum triglyceride in pill-treated women increased by 10.6% over control value, but this increase was not statistically significant. 4) Duration of pill-treatment did not affect serum concentrations of cholesterol, phospholipid and triglyceride. From the results mentioned above, it may be concluded that combined oral contraceptive steroids, at least used for subjects involved in this study, decreased serum phospholipid significantly, thereby influencing serum lipid concentration.

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Relationship between the oral contraceptive pill and periodontal disease in Korean women: The 5th Korean National Health and Nutrition Survey data analysis phase3(2012) (경구피임약을 복용하는 한국여성과 치주질환의 관련성 연구: 제5기 3차년도(2012) 국민건강영양조사 자료 분석)

  • Lee, Jong-Hwa;Yoo, Jin-Yeong;Jung, Gi-Ok;Park, Ji-Young
    • Journal of Korean society of Dental Hygiene
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    • v.14 no.6
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    • pp.795-804
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    • 2014
  • Objectives: The purpose of the study was to investigate the relationship between the oral contraceptive pill and periodontal disease in Korean women aged from 19 to 50 years old. Methods: This study selected 1,579 women of childbearing age from 19 to 50 years old from the 5th National Health and Nutrition Survey data analysis(phase 3, 2012) taking the oral examination. The questionnaire consisted of socioeconomic demographic characteristics, health behavior, use of oral contraceptive pills, and periodontal disease. Socioeconomic demographic characteristics included age, marital status, education, monthly income, and vocation. The health behavior included obesity, stress, smoking, subjective oral health status, use of dental floss, tooth brushing, and diabetes mellitus by fasting blood sugar level. Use of oral contraceptive pills was recorded by monthly use and duration. The periodontal disease was documented by yes or no and selected as dependent variable by logistic regression analysis. Results: After revising the taking period of oral contraceptive pill for this study, there was the correlation between the prevalence of periodontal disease and odds ratio(95% CI) 1.288(1.027-1.617). Conclusions: This study will contribute to the direction of policy for an oral contraceptive pill and provide the basic data for counseling for the oral health and the side effects of oral contraceptive pills.

Pharmacological Actions of New Woohwangchungsimwon Pill on Cerebral Ischemia and Central Nervous System (신우황청심원의 뇌허혈 및 중추신경계에 대한 약효)

  • Cho, Tai-Soon;Lee, Sun-Mee;Lee, Eun-Bang;Cho, Sung-Ig;Kim, Yong-Kee;Shin, Dae-Hee;Park, Dai-Kyu
    • YAKHAK HOEJI
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    • v.41 no.6
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    • pp.817-828
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    • 1997
  • In order to investigate pharmacological properties of New Woohwangchungsimwon Pill (NWCH) and Woohwangchungsimwon Pill(WCH), effects of NWCH and WCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in Mongolian gerbils. The histological observations showed preventive effect of NWCH and WCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by NWCH and WCH treatment. In contrast to what was seen with ATP, the lactate and lipid peroxide were both elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NWCH and WCH treatments. In central nervous system, NWCH and WCH had sedative effect in rotarod and spontaneous activity test, but no effects on the hexobarbital-induced sleeping time. And, NWCH and WCH had weak anticonvulsion effects in electric shock- and pentetrazol-induced convulsion test. NWCH and WCH increased the respiration rate, but decreased the respiration depth in rats. Furthermore, NWCH and WCH showed antistress effect. Our findings suggest that the pharmacological profiles of NWCH on cerebral ischemia and central nervous system are similar to that of WCH.

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Revision Volume of Square-inch-spoon, Jeon-bi and Firmiana-Seed-sized Pill Preparations in 『Treatise on Cold Damage Diseases』 (『상한론』에서 산제의 방촌비와 전비, 환제의 오동자대 크기 수정치)

  • Kim, In-Rak
    • The Korea Journal of Herbology
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    • v.37 no.5
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    • pp.75-81
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    • 2022
  • Objectives : In 『Treatise on Cold Damage Diseases』, the volume of preparation dosage measured in Hap was 6.5mL. This study aimed to confirm that a square-inch-spoon, which measures powder preparation dosage, was 1/3 Hap, and that Jeon-bi was 1/8 square-inch-spoon. Based on these values, this study also aimed to adjust the diameter of Firmiana-Seed-sized pill preparation, currently known as 6.5mm, so that one square-inch-spoon of powder preparation creates 16 pills. Methods : Calculated the ratio between the floor areas of square-inch-spoon and Jeon-bi and measured the ratio of volume; assumed that powder preparations were stacked as much as possible in the shape of a square pyramid when scooped comfortably, then calculated the slopes of 1/3 Hap and 1/4 Hap; measured the volumes of powdered Oryeongsan and Lijungwhan in square-inch-spoon and Jeon-bi; created the powders into Firmiana-Seed-sized pill preparation; adjusted the diameter of Firmiana Seed so that 16 pills could be created. Results : Inferring from the floor areas, the volume of square-inch-spoon is 9.2 times that of Jeon-bi; one square-inch-spoon should be 1/3 Hap for the powder to reach its maximum slope of 47° and, according to actual measurement of powder preparations, reach its maximum volume; when created into Firmiana-Seed-sized pill preparations, one square-inch-spoon should be 1/3 Hap so that approximately 16 pills were created. Conclusions : One square-inch-spoon of powder preparation was 1/3 Hap(2.17mL), Jeon-bi was 1/8 square-inch-spoon(0.27mL), and the diameter of Firmiana-Seed-sized pill preparation was 5.5mm.

Noneffective Results of Steinernematid and Hoterorhabditid Nematodes Agains Pill bug, Armadillidium vulgare (Isopoda : Armadillidae) (Steinernematid와 Heterorhabditid 선충의 쥐며느리에 대한 비효용적결과)

  • 추호렬;이동운;허은영;김준범
    • Korean journal of applied entomology
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    • v.35 no.1
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    • pp.91-93
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    • 1996
  • Steinemematid and heterorhabditid nematodes were not effective to control the piU bug, Armadillidium vulgare although these nematodes were able to infect pill bugs. Steinernema carpocapsae Pocheon strain and S. glaseri Dongrae strain were more effective than S. carpocapsae AU strain or Heterorhabditis bacteriophora. Nematode concentration was more important factor than host density to develop infectivity.

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Pill Counting and Packaging Automation Using Non-contact Photo Sensor and Recognition of Characterized Feature (비접촉식 광학센서와 특징량 인식에 의한 알약 계수 및 포장 자동화)

  • 원민규;윤상천;이순걸
    • 제어로봇시스템학회:학술대회논문집
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    • 2000.10a
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    • pp.9-9
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    • 2000
  • Accurate counting and packaging pills is one of the most fundamental works of the pharmaceutical industry. But it is so labor consuming and very hard to be automated. As the pharmaceutical industry is growing bigger, the need of counting and packaging automation is increasing to obtain effective mass production. Precise and quick sensing is required in the counting and processing of quickly dropping pills to improve the productivity. There are many trials for this automation and automatic machine. But the performance of the existing counting machine varies with the size, shape and the dispersion degree of pills In this research, authors design the counting and packing machine of medicinal pills that is more accurate and highly trustworthy After getting analog signal from optical sensor, pill passage is discriminated from chosen characteristic feature using microprocessor.

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Multiobjective PI Controller Tuning of Multivariable Boiler Control System Using Immune Algorithm

  • Kim, Dong-Hwa;Park, Jin-Ill
    • International Journal of Fuzzy Logic and Intelligent Systems
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    • v.3 no.1
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    • pp.78-86
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    • 2003
  • Multivariable control system exist widely in many types of systems such as chemical processes, biomedical processes, and the main steam temperature control system of the thermal power plant. Up to the present time, Pill Controllers have been used to operate these systems. However, it is very difficult to achieve an optimal PID gain with no experience, because of the interaction between loops and gain of the Pill controller has to be manually tuned by trial and error. This paper suggests a tuning method of the Pill Controller for the multivariable power plant using an immune algorithm, through computer simulation. Tuning results by immune algorithms based neural network are compared with the results of genetic algorithm.

Study on the Acceptability and Effectiveness of an Oral Contraceptive Among Iud Drop-outs in Rural Korea

  • Yang, J.M.;Bang, S.;Song, S.W.;Youn, B.B.
    • Journal of Preventive Medicine and Public Health
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    • v.1 no.1
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    • pp.51-66
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    • 1968
  • During a period of about one year(November '66 to December '67), the Yonsei University College of Medicine conducted a field trial of the oral contraceptive(Ovulen) in order to study its acceptability and use-effectiveness among IUD drop-outs in Koyang county. We can summarize the outstanding findings from this investigation as follows; 1. 61.4% of the IUD drop-outs interviewed (911 women) wanted to use the pill. Most of the reasons for not wanting to use it(352 women) pertained to either use of other contraceptive methods(98) or subfecundity(150) following IUD terminations. Only 83 out of 911 women gave reasons related to the difficulty of obtaining pills. Therefore, we can state that most IUD drop-outs if still in need of a contraceptive methods are in favor of trying the pill, and especially so if this method is conveniently available. 2. The 467 women or 37% of those who terminated IUD use actually visited the clinic for medical screening, and only 11 of them or 2.4% were rejected because of pregnancy and other medical reasons such as cervical erosion, myoma, breast mass, etc. 5.5% or 25 of the 456 women who received the first cycle did not take a single pill during the study period. 3. When we defined those 431 women who accepted and took one or more tablets we found that women over age 30, with 4 or more children, and/or with a higher educational level were the best prospects for recruitment. 4. In accuracy of use, about two thirds of the users started taking the pill on the 5 th day as directed for the first three cycles, but the percentages rose sharply to about 80% in later cycles. Tardiness in starting pill use in the first cycle may have occurred partly because they had to return to the clinic monthly to get each new cycle. Among acceptors who did not quit between cycles, 80 to 90% were regular users, missing two or less tablets in each cycle. 5) More than 60% of the users felt well and sometimes lost their pre-acceptance symptoms. especially dysmenorrhea. However, 27.4% (58 women) had side effects attributable to the pill compund as nausea, vomiting, indigestion, breast tenderness, decreased lactation or breakthrough bleeding. 25.0% (53 women) also complained of medical diseases or symptoms not related to the pill, especially during the first three cycles. However, as the confidence and experience of the client and the field workers grew, the incidence of unrelated medical complaints quickly fell to a lower level in the later cycles. 6. As of the end of this study, on December 31, 1967, 49.2% (212 women) had discontinued the use of the pill for medical reasons as well as for the non medical reasons. Only one case terminated use due to a pregnancy after taking pills. The cumulative continuation rates (by the life table method), were 58.9%, 51.9%, 41.0% at the end of 3 months, 6 months and one year, respectively. These rates are lower than in the U.S. studies. Even when we add the retaking group to the first segment, the continuation rate goes up only about 5% above the first segment rates mentioned above. Possible explanations are different dosages, the newerness of the method and the use of only one point for pill distribution in the country together with a monthly return for cycle 1, 2, 3, and 4-6.

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