• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2201-2205
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• 2013

Colorectal cancer (CRC) is one of the most common cancers in many parts of the world. Its development is a multi-step process involving three distinct stages, initiation that alters the molecular message of a normal cell, followed by promotion and progression that ultimately generates a phenotypically altered transformed malignant cell. Reports have suggested an association of the phosphoinositide-3-kinase (PI3K)/Akt pathway with colon tumorigenesis. Activation of Akt signaling and impaired expression of phosphatase and tensin homolog (PTEN) (a negative regulator of Akt) has been reported in 60-70% of human colon cancers and inhibitors of PI3K/Akt signaling have been suggested as potential therapeutic agents. Around 80% of human colon tumors possess mutations in the APC gene and half of the remainder feature ${\beta}$-catenin gene mutations which affect downstream signaling of the PI3K/Akt pathway. In recent years, there has been a great focus in targeting these signaling pathways, with natural and synthetic drugs reducing the tumor burden in different experiment models. In this review we survey the role of PI3K/Akt/mTOR and Wnt signaling in CRC.

• Journal of the Institute of Electronics and Information Engineers
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• v.54 no.1
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• pp.131-136
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• 2017

In this study, we design a controller that regulates the water leveling system which suffers from the disturbance. A number of control techniques have been reported which can reduce the amplitude of disturbance. But due to input-delay, these methods do not perform as expected. To overcome the problem, this paper introduces a filter and proposes a proportional and integral (PI) controller that combined with the filter (modifed PI controller). Moreover, we combine the controller with disturbance observer (DOB) that can estimate and eliminate disturbance. The proposed controller and combined the controller with DOB are tested using MATLAB.

• Journal of international Conference on Electrical Machines and Systems
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• v.3 no.4
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• pp.367-373
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• 2014

The most common current controller for the Switched Reluctance Motor (SRM) is the hysteresis controller. This method, however, suffers from such drawbacks as variable switching frequency, consequent audible noise and high current ripple. These disadvantages make this controlling method undesirable for many applications. The alternative solution is the PI controller. Since the fixed gain PI current controller can only be optimized for one operating point, and on the other hand, SR motor is highly nonlinear, PI controller gain should be adjusted according to incremental inductance. This paper presents a novel method for PI current controller gain adaptation which is simple and yields a good performance. The proposed controller has been implemented on a test bench using a eZdsp F28335 board. The performance of the current controller has been investigated in both simulation and experimental tests using a four-phase 8/6 4KW SRM drive system.

• Journal of Astronomy and Space Sciences
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• v.32 no.4
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• pp.305-310
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• 2015

In this study, we examined a morningside Pi2 pulsation, with a non-substorm signature, that occurred in very quiet geomagnetic conditions (Kp = 0) at 05:38 UT on December 8, 2012, using data obtained by Van Allen Probes A and B (VAP-A and VAP-B, respectively) and at a ground station. Using 1 sec resolution vector magnetic field data, we measured the X-component of the pulsation from the Abu Simbel ground station (L = 1.07, LT = UT +2 hr, where LT represents local time) in Egypt. At the time of the Pi2 event, Abu Simbel and VAP-A (L = 3.3) were in the morning sector (07:38 LT and 07:59 MLT, respectively, where MLT represents magnetic local time), and VAP-B was in the postmidnight sector (04:18 MLT and L = 5.7). VAP-A and VAP-B observed oscillations in the compressional magnetic field component (Bz), which were in close agreement with the X-component measurements of the Pi2 pulsation that were made at Abu Simbel. The oscillations observed by the satellites and on the ground were in phase. Thus, we concluded that the observed morningside Pi2 pulsation was caused by the cavity resonance mode rather than by ionospheric current systems.

• Proceedings of the Korean Vacuum Society Conference
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• 2015.08a
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• pp.132-132
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• 2015

Virtual metrology (VM) model based on plasma information (PI) parameter for C4F8 plasma-assisted oxide etching processes is developed to predict and monitor the process results such as an etching rate with improved performance. To apply fault detection and classification (FDC) or advanced process control (APC) models on to the real mass production lines efficiently, high performance VM model is certainly required and principal component regression (PCR) is preferred technique for VM modeling despite this method requires many number of data set to obtain statistically guaranteed accuracy. In this study, as an effective method to include the 'good information' representing parameter into the VM model, PI parameters are introduced and applied for the etch rate prediction. By the adoption of PI parameters of b-, q-factors and surface passivation parameters as PCs into the PCR based VM model, information about the reactions in the plasma volume, surface, and sheath regions can be efficiently included into the VM model; thus, the performance of VM is secured even for insufficient data set provided cases. For mass production data of 350 wafers, developed PI based VM (PI-VM) model was satisfied required prediction accuracy of industry in C4F8 plasma-assisted oxide etching process.

• The Korean Journal of Ecology
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• v.8 no.1
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• pp.1-5
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• 1985

The plastochron index (PI) provides possibility on studies of the effects of various environmental factors on morphological and physiological development of plants. The PI of Erickson and Michemlini(1957) could be used merely when leaf n is longer an leaf n+1 is smaller than the references length at any time. If both the lengths of leaf n and n+1 are smaller or longer than the reference length, it could not estimated. In this study, the PI of Erickson and Michelini was complemented and the linear patterns according to leaf arrangement was represented, PI is n-(lnLR-lnLn)/(lnLn-lnLn+1). And when both the lengths of leaf n and n+1 are longer than the length of reference, PI is n+1+(ln Ln+1-lnLR)/(lnLn-lnLn+1). The linear model of PI is changed by the various environmental factors and the linear patterns are different according to leaf arrangement. According to leaf arrangement, the equation of the general regression lines is Yin-(i-j)=a-(n-1)(q1+...+qi-1)-(q1+...+qj-1)+rt+$\varepsilon$. Where Y:the logarithmic of the leaf length in question, i:leaf number hang on the one node, n:the number counting from base, q:spacing on the Y-axis, j:0, 1, 2, ..., r:slope, t:time, $\varepsilon$:error.

• International Journal of Air-Conditioning and Refrigeration
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• v.15 no.3
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• pp.129-136
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• 2007

In this paper, we suggest PI control with the Smith predictive controller to improve transient response of a variable speed refrigeration system (VSRS). As the refrigeration system has long dead time inherently, it is difficult to get fast responses of super-heat and reference temperature. We incorporated the Smith predictive controller into PI to compensate the effect of the long dead time of the system. At first, we introduced the decoupling model of the system to control capacity and superheat simultaneously and independently. Next, we designed the predictive controller of the superheat based on PI control law. Finally, the control performance by the proposed method was investigated through some numerical simulations and experiments. The results of the simulations and experiments showed that the proposed PI control with the predictive controller could obtain acceptable transient behaviour for the system.

• Journal of Advanced Marine Engineering and Technology
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• v.24 no.1
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• pp.67-74
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• 2000

Recently, PTFE-polymide composites are being used self-lubricating parts for industrial field. Thus, this study is mainly concerned with friction and wear properties for the piston ring of non-lubricating air compressor which made of PTFE-polymide composites. The friction and wear test was carried out for the different composition ratio under the atomsphere room temperature and constant load of 7.69N and their friction and wear properties were compared with each other at various sliding speed. notable results are summarized as follows. PTFE 100% showed that friction coefficient was almost same values at 0.94 and 1.88m/s but the value was decreased at 2.83m/s because the friction temperature is higher than low speed. PTFE 80%-PI 20% showed the lowest mean friction coefficient at 2.83m/s. PTFE 20-PI 80% showed the highest friction coefficient at 0.94m/s and the value was decreased at high speed but the value is higher than other materials except PTFE 100 %. PI 100% showed the highest friction coefficient at 0.94 and 1.88m/s becuase adhesive wear mainly occurred that speed. PTFE 100% showed highest specific wear rate on the whole. Specific wear rate of PTFE 80%-PI 20% was almost the same value with PTFE 20%-PI80%. PI 100%showed the lowest value at high sliding speed because the friction surface was thicken and carbonated by high friction temperature.

• The Korean Journal of Food And Nutrition
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• v.14 no.4
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• pp.287-292
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• 2001

The purpose of this study was to investigate the effect of roasted soy f1our on the characteristics of Mandu-pi. Various Mandu-pi samples were prepared with wheat flour along with the addition of different amount of roasted soy flour. and then instrumental characteristics and sensory evacuation were investigated. As a result of amylography study, there were no difference In the initial pasting and maximum viscosity temperatures between samples. And maximum viscosity decreased with the increase of flour addition. In farinography study, the addition of roasted sop f1our did not affect the gelatinization temperature, while stability and developing time of dough increased by addition of soy flour level. Besides cooked weight, cooked volume and water absorption of Mandu-pi were also higher significantly than control. The more soy flour was added, the less lightness and more redness and yellowness were obtained. The result of sensory evaluation revealer that there were no differences between samples in beano aroma, smoothness, and chewness. However Mandu-pi added roasted soy flour showed higher scores in surface appreance, nutty aroma, nutty taste. sweet taste, and overall preferance than control.

• The Transactions of the Korean Institute of Power Electronics
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• v.20 no.2
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• pp.175-181
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• 2015

In this study, a lithium polymer battery (LiPB) is simply expressed by a primary RC equivalent model. The PI state observer is designed in Matlab/Simulink. The non-linear relationship with the OCV-SOC is represented to be linearized with 0.1 pu intervals by using battery parameters obtained by constant-current pulse discharge. A state equation is configured based on battery parameters. The state equation, which applied Peukert's law, can estimate SOC more accurately. SOC estimation capability was analyzed by utilizing reduced Federal Test Procedure (FTP-72) current profile and using a bi-directional DC-DC converter at temperature ($25^{\circ}C$). The PI state observer, which is designed in this study, indicated a SOC estimation error rate of ${\pm}2%$ in any of the initial SOC states. The PI state observer confirms a strong SOC estimation performance despite disturbances, such as modeling errors and noise.