• Title/Summary/Keyword: pi

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Phosphoinositide turnover in Toll-like receptor signaling and trafficking

  • Le, Oanh Thi Tu;Nguyen, Tu Thi Ngoc;Lee, Sang Yoon
    • BMB Reports
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    • v.47 no.7
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    • pp.361-368
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    • 2014
  • Lipid components in biological membranes are essential for maintaining cellular function. Phosphoinositides, the phosphorylated derivatives of phosphatidylinositol (PI), regulate many critical cell processes involving membrane signaling, trafficking, and reorganization. Multiple metabolic pathways including phosphoinositide kinases and phosphatases and phospholipases tightly control spatio-temporal concentration of membrane phosphoinositides. Metabolizing enzymes responsible for PI 4,5-bisphosphate (PI(4,5)P2) production or degradation play a regulatory role in Toll-like receptor (TLR) signaling and trafficking. These enzymes include PI 4-phosphate 5-kinase, phosphatase and tensin homolog, PI 3-kinase, and phospholipase C. PI(4,5)P2 mediates the interaction with target cytosolic proteins to induce their membrane translocation, regulate vesicular trafficking, and serve as a precursor for other signaling lipids. TLR activation is important for the innate immune response and is implicated in diverse pathophysiological disorders. TLR signaling is controlled by specific interactions with distinct signaling and sorting adaptors. Importantly, TLR signaling machinery is differentially formed depending on a specific membrane compartment during signaling cascades. Although detailed mechanisms remain to be fully clarified, phosphoinositide metabolism is promising for a better understanding of such spatio-temporal regulation of TLR signaling and trafficking.

Effect of alignment layer on pretilt angle generation and EO performance (프리틸트각의 발생과 전기광학 특성에 있어서의 배향층의 효과)

  • 박태규;서대식
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1999.11a
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    • pp.537-540
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    • 1999
  • Effect of alignment layers on pretilt angle generation and electrical characteristics in nematic liquid crystal(NLC) by using photo-alignment techniques on polyimide (PI) surface with side chain were studied. The generated pretilt angle of the NLC on rubbed PI surface with 1-layer is almost the same as that of the 2-layers. However, the generated pretilt angle of the NLC on photo-induced PI surface with 2-layers is larger than that of the 1-layer. Therefore, the pretilt angle of the NLC on photo-induced PI surface is attributed to surface roughness due to photo-depolymerization of the polymer with UV light irradiation on PI surface. Next we observed the same characteristics of voltage-transmittance (V-T) and response time for 1- and 2-layers on PI surface. We also observed the same voltage holding ratio (VHR) characteristics for 1- and 2-layers on photo-aligned PI surface. Consequently, we suggest that the VHR of photo-aligned TN-LCD is higher than that of the rubbing-aligned TN-LCD.

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Speed Control of Permanent Magnet Synchronous Motor Using PI Auto-tuning Method (자동동조 Pl 기법을 적용한 영구자석형 동기전동기의 속도 제어)

  • 전인효
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.2 no.2
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    • pp.231-239
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    • 1998
  • In this paper, we designed a current controlling servo system for speed control of a PMSM. In existing auto-tuning methods for PI controller parameters, the output response is delayed and the overshoot is generated. By solving these existing problems in this paper, a new PI auto-tuning method is applied to the speed controller for fast-response and reduced overshoot. PMSM servo systems offer a great advantage in unmanned factories where a great number of servo motors are employed, because of its easy maintenance characteristics and controllability. The implemented servo system is composed of absolute position detecting circuits of a rotor, a new auto-tuning PI control algorithm, a speed controller by using DSP, and power driving section. The proposed servo system is verified for it's practical availability by considering experimental results.

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Study on Environmental Monitoring in Stack Room for Paper Storage Using the Preservation Index (보존 환경 평가 지수를 이용한 종이 보존 서고 환경 모니터링 연구)

  • Shin, Hyun-Chang;Yoon, Man-Young
    • Journal of the Korean Graphic Arts Communication Society
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    • v.29 no.1
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    • pp.61-74
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    • 2011
  • Critical environmental elements for long term preservation of a paper are temperature, humidity, dust, light, contaminants in air, and mold. Especially, temperature and humidity need special care, because they can not only directly degrade paper but also affect the degradation of the other elements. Therefore methods to monitor variation of temperature and relative humidity were studied. One of the methods was to use preservation index for evaluating preservation environment. Since the evaluation for preservation environment of a stack room investigated firstly by D. K. Sebera, PI(preservation index) and TWPI(Time-Weighted Preservation Index) by IPI is made to evaluate relatively preservation environment in a stack room. T. Padfield developed method which could calculate easy PI and TWPI. In this study, the preservation environment of stack rooms for paper storage in NAK(National Archives Korea) was evaluated by PI and TWPI. PI and TWPI of stack rooms for paper storage in NAK maintained good condition but PI depended on season. Then the preservation environment of stack rooms for paper storage in NAK was required to maintain continuously PI and TWPI regardless of season change.

Investigation of Alpha 1-Proteinase Inhibitor in Serum and Specimen of Lung Cancer Patients (폐암 환자의 혈청과 조직 표본상에서 Alpha 1-Proteinase Inhibitor의 조사 연구)

  • 김송명
    • Journal of Chest Surgery
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    • v.27 no.5
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    • pp.364-373
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    • 1994
  • Alpha 1-Proteinase inhibitor[PI] was known as a major protective enzyme against to excessive hydrolytic and proteolytic reaction. So, it was suggested that Alpha 1-PI may implicated in growth of bronchogenic cancer. This study was undertaken to investigate the role of Alpha 1-PI in local invasion of bronchogenic cancer. Three groups of patients were studied; Preliminary research group of 15 bronchogenic cancer patients, Main research group of 13 bronchogenic cancer patients and Normal control group of 10 nephrectomy donor. Serum Alpha 1-PI level was observed in each group of patients during pre-and postoperative days. Pre-operative serum Alpha 1-PI level in preliminary research group [329.2$\pm$14.21mg/dl]and main research group[406.2$\pm$39.30mg/dl] were higher than in normal control group[236.2$\pm$19.55mg/dl] significantly[p<0.005]. Serial Alpha 1-PI level in each group during pre-and postoperative days shows peaked at 3rd. postoperative day in preliminary and main research group, thereafter decreased gradually. Immunohistochemical study for Alpha 1-antitrypsin[A1AT] was carried out by ABC[avidin-biotin peroxidase complex] method using Alpha-1 antitrypsin DAKOR to tumor tissues of 13 lung cancer patients in main research group. 6 cases[46.2%, squamous cell ca.;5, adenocarcinoma;1] of above 13 cases show positive immunoreactivity for A1AT. In conclusion, alpha 1-PI and elastase are disclosed that have defined actions for lung cancer growing or spreading.

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Ion Beam-based Surface Modification of Polyimide Films for Adhesion Improvement with Deposited Metal Layer

  • Cho, Hwang-Woo;Jung, Chan-Hee;Hwang, In-Tae;Choi, Jae-Hak;Nho, Young-Chang
    • Journal of Radiation Industry
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    • v.4 no.4
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    • pp.335-339
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    • 2010
  • In this study, the surface of polyimide (PI) films was modified using ion implantation to enhance its adhesion to a deposited copper (Cu) layer. The surfaces of the PI films were implanted with 150 keV $Xe^+$ ions at fluences varying from $1{\times}10^{14}$ to $1{\time}10^{16}ions\;cm^{-2}$. The Cu layers were then deposited on the implanted PI. The surface properties of the implanted PI film were investigated based on the contact angle measurements, Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). Furthermore, the adhesive strength between the deposited Cu layer and PI film was estimated through a scratch test using a nanoindenter. As a result, the surface environment of the PI film was changed by the ion implantation, which could have a significant effect on the adhesion between the deposited Cu layer and the PI.

Characterization of Weed Occurrence in Major Horticultural Crops - III. Phenological Aspects of Major Weeds (원예경작지(園藝耕作地)에서의 잡초발생(雜草發生) 특성에 관(關)한 연구(硏究) - III. 주요잡초종(主要雜草種)의 발생계절성(發生季節性))

  • Woo, I.S.;Pyon, J.Y.;Guh, J.O.
    • Korean Journal of Weed Science
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    • v.9 no.2
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    • pp.130-140
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    • 1989
  • 1) Dormancy brocken weed seeds were planted in soil at 15 days interval from June to December in 1986 and 1987 and test of normality and normal distribution curve were made to determine seasonal distribution characteristics of weed emergence in fields. Monthly emergence distribution pattern of each species can be concluded as following normal distribution equations. E. crusgalli $y={\frac{1}{2.52{\sqrt{2{\pi}}}}}e^{-{\frac{(x-10.057)^2}{12.7}}}$ E. indica $y={\frac{1}{2.17{\sqrt{2{\pi}}}}}e^{-{\frac{(x-9.16)^2}{9.45}}}$ A. lividus $y={\frac{1}{7.74{\sqrt{2{\pi}}}}}e^{-{\frac{(x-10.06)^2}{15.46}}}$ S. nigrum $y={\frac{1}{2.7{\sqrt{2{\pi}}}}}e^{-{\frac{(x-9.695)^2}{14.58}}}$ C. busrsa-pastoris $y={\frac{1}{2.83{\sqrt{2{\pi}}}}}e^{-{\frac{(x-9.02)^2}{16.02}}}$ D. sanguinalis $y={\frac{1}{2.8{\sqrt{2{\pi}}}}}e^{-{\frac{(x-8.58)^2}{15.67}}}$ S. viridis $y={\frac{1}{2.72{\sqrt{2{\pi}}}}}e^{-{\frac{(x-9.36)^2}{14.8}}}$ C. album $y={\frac{1}{2.596{\sqrt{2{\pi}}}}}e^{-{\frac{(x-8.07)^2}{13.48}}}$ P. oleraeda $y={\frac{1}{2.45{\sqrt{2{\pi}}}}}e^{-{\frac{(x-10.83)^2}{12.01}}}$ 2) Emergence peak period of weed species tested were from the end of May to early August and yearly variation of emergence was observed in E. crus-galli, S. viridis, S, nigrum, and P. oleracea and this fact may more related to rainfall pattern rather than temperature.

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Functionalized Graphene/Polyimide Nanocomposites under Different Thermal Imidization Temperatures (열 이미드화 온도에 따른 작용기화 그래핀/폴리이미드 나노복합재료)

  • Ju, Jieun;Chang, Jin-Hae
    • Polymer(Korea)
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    • v.39 no.1
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    • pp.88-98
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    • 2015
  • 4-Amino-N-hexadecylbenzamide-graphene sheets (AHB-GSs), used in the preparation of the polyimide (PI) nanocomposite films, were synthesized by mixing a dispersion of graphite oxide with a solution of the ammonium salt of AHB. The atomic force microscope image of functionalized-GS on mica and a profile plot revealed the average thickness of AHB-GS to be ~3.21 nm. PI films were synthesized by reacting 4,4'-biphthalic anhydride and bis(4-aminophenyl) sulfide. PI nanocomposite films containing various contents of AHB-GS over the range of 0-10 wt% were synthesized using the solution intercalation method. The PI nanocomposite films under different thermal imidization temperatures, 250 and $350^{\circ}C$, were examined. The graphenes, for the most part, were well dispersed in the polymer matrix despite some agglomeration. However, micrometer-scale particles were not detected. The average thickness of the particles was <10 nm, as revealed from the transmission electron microscope images. Only a small amount of AHB-GS was required to improve the gas barrier, and electrical conductivity. In contrast, the glass transition and initial decomposition temperatures of the PI hybrid films continued to decrease with increasing content of AHB-GS up to 10 wt%. In general, the properties of the PI hybrid films heat treated at $350^{\circ}C$ were better than those of films heat treated at $250^{\circ}C$.

Speed Control for BLDC Motors Using a Two-Degree-of-Freedom Optimal Control Technique (2자유도 적분형 최적제어법을 이용한 BLDC 모터의 속도제어)

  • 권혁진;정석권
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.36 no.3
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    • pp.257-265
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    • 2000
  • Brushless DC(BLDC) motors are widely used as AC servo motors in factory automation fields because of their quick instantaneous mobility, good energy saving efficiency and easiness of design for control system comparing with induction motors. Recently, a Two-Degree-of-Freedom(2DOF) PI control law has been adopted to some application parts to accomplish an advanced speed control of BLDC motors. The method can treat the two conflicting performances, minimum tracking errors versus reference inputs without large overshoot and rejection of some disturbances including modeling errors, independently. However, the method can not design the optimal system which is able to minimize tracking errors and energy consumption simultaneously. In this paper, a 2DOF integral type optimal servo control method is investigated to promote the speed control performances of BLDC motors considering energy consumption. In order to applicate the method to the speed servo system of the BLDC motor, the motor is modeled in the state space using the vector control and decoupling technique. To verify the validity of the suggested method, some simulations and experiments are performed.

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On the Trade-off Between Composition and XOR of Random Permutations (랜덤 순열의 직렬 합성과 병렬 합성 사이의 트래이드오프에 관한 연구)

  • Lee Eon-Kyung
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.3C
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    • pp.286-292
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    • 2006
  • Both composition and XOR are operations widely used to enhance security of cryptographic schemes. The more number of random permutations we compose (resp. XOR), the more secure random permutation (resp. random function) we get. Combining the two methods, we consider a generalized form of random function: $SUM^s - CMP^c = ({\pi}_{sc} ... {\pi}_{(s-1)c+1}){\oplus}...{\oplus}({\pi}_c...{\pi}_1)$ where ${\pi}_1...{\pi}_{sc}$ are random permutations. Given a fixed number of random permutations, there seems to be a trade-off between composition and XOR for security of $SUM^s - CMP^c$. We analyze this trade-off based on some upper bound of insecurity of $SUM^s - CMP^c$, and investigate what the optimal number of each operation is, in order to lower the upper bound.