• 제목/요약/키워드: phytolaccoside A, B and D

검색결과 3건 처리시간 0.017초

Saponins from the Callus Mass of Phytolacca americana

  • Chi, Hyung-Joon;Kim, Hyun-Soo
    • Archives of Pharmacal Research
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    • 제8권1호
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    • pp.15-20
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    • 1985
  • Strong anti-inflammatory saponins Phytolacca americana (Phytolaccaceae) wereobtained from callus mass derived from the stems and also from that derived from the roots of cultivated Phytolacca americana (which were designated as PAS and PAR, respectively). The callus were grown on Linsmair and Skoog's agar medium supplemented with 1ppm OF 2, 4-dichlorophenoxyacetic acid. Phytol accoside B and D were obtained from PAS and phytolaccoside A and B from PAR. The thin layer chromatograms of the crude saponins from PAS and PAR were similar to those of original plants. PAS contained phytolaccoside B as a major component while phytolaccoside E was a major saponin in original plants.

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Enhancement of Heparin and Heparin Disaccharide Absorption by the Phytolacca americana Saponins

  • Cho, So-Yean;Sim, Joon-Soo;Kang, Sam-Sik;Jeong, Choon-Sik;Linhardt, Robert-J;Kim, Yeong-Shik
    • Archives of Pharmacal Research
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    • 제26권12호
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    • pp.1102-1108
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    • 2003
  • We studied the effects of phytolaccosides, saponins from Phytolacca americana, on the intestinal absorption of heparin in vitro and in vivo. The absorption enhancing activity of these compounds (phytolaccosides B, $D_2$, E, F, G and I) was determined by changes in transepithelial electrical resistance (TEER) and the transport amount of heparin disaccharide, the major repeating unit of heparin, across Caco-2 cell monolayers. With the exception of phytolaccoside G, all of them decreased TEER values and increased the permeability in a dose-dependent and time-dependent manner. In vitro, phytolaccosides B,$D_2$, and E showed significant absorption enhancing activities, while effects by phytolaccoside F and I were mild. In vivo, phytolaccoside E increased the activated partial thromboplastin time (APTT) and thrombin time, indicating that phytolaccoside E modulated the transport of heparin in intestinal route. Our results suggest that a series of phytolaccosides from Phytolacca americana can be applied as pharmaceutical excipients to improve the permeability of macromolecules and hydrophilic drugs having difficulty in absorption across the intestinal epithelium.

상륙성분(商陸成分)에 관(關)한 연구(硏究)(I) -항염증성(抗炎症性) Saponin에 대(對)하여- (Constituents of Phytolacca Species (I) -Anti-inflammatory Saponins-)

  • 우원식;신국현;강삼식
    • 생약학회지
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    • 제7권1호
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    • pp.47-50
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    • 1976
  • Ten saponins named phytolaccoside $A{\sim}I$ and O were separated and shown to contain only $_D-glucose$ as sugar except phytolaccoside A which contains only $_D-xylose$. Phytolaccagenic acid was found to be a genin for phytolaccosides A and D, phytolaccagenin for B, E and F, jaligonic acid for G, and esculentic acid for C, H, I and O, respectively. The total saponin fraction exhibited strong anti-inflammatory activity.

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