• Structural Engineering and Mechanics
• /
• 제83권5호
• /
• pp.681-692
• /
• 2022

The vibrational response of the two bones in a Volleyball player's arm under ball impact is conducted. The two bones in hand, Ulna and Radius, are modeled as two cylindrical shells. The formulations associated with the shells' vibration are obtained using the energy method. Then, the results are extracted with the aid of the two-dimensional form of DQM in conjunction with Runge-Kutta. The results are validated by means of a published paper. Lastly, the role of parameters in determining vibrational frequency as well as deflection is explored through parametric studies. It was shown that the impactor speed and the time of the impact could be essential factors in determining the vibration behavior of the bones. This work can be used in the further investigation of the behavior of bones and physiological structures.

• 센서학회지
• /
• 제31권2호
• /
• pp.71-78
• /
• 2022

Wearable devices have the potential to revolutionize future medical diagnostics and personal healthcare. The integration of biosensors into scalable form factors allow continuous and noninvasive monitoring of key biomarkers and various physiological indicators. However, conventional wearable devices have critical limitations owing to their rigid and obtrusive interfaces. Recent developments in functional biocompatible materials, micro/nanofabrication methods, multimodal sensor mechanisms, and device integration technologies have provided the foundation for novel skin-interfaced bioelectronics for advanced and user-friendly wearable devices. Nonetheless, it is a great challenge to satisfy a wide range of design parameters in fabricating an authentic skin-interfaced device while maintaining its edge over conventional devices. This review highlights recent advances in skin-compatible materials, biosensor performance, and energy-harvesting methods that shed light on the future of wearable devices for digital health and personalized medicine.

• Animal Bioscience
• /
• 제36권2_spc호
• /
• pp.374-384
• /
• 2023

Skeletal muscle metabolism regulates homeostatic balance in animals. The metabolic impact persists even after farm animal skeletal muscle is converted to edible meat through postmortem rigor mortis and aging. Muscle metabolites resulting from animal growth and postmortem storage have a significant impact on meat quality, including flavor and color. Metabolomics studies of postmortem muscle aging have identified metabolisms that contain signatures inherent to muscle properties and the altered metabolites by physiological adaptation, with glycolysis as the pivotal metabolism in postmortem aging. Metabolomics has also played a role in mining relevant postmortem metabolisms and pathways, such as the citrate cycle and mitochondrial metabolism. This leads to a deeper understanding of the mechanisms underlying the generation of key compounds that are associated with meat quality. Genetic background, feeding strategy, and muscle type primarily determine skeletal muscle properties in live animals and affect post-mortem muscle metabolism. With comprehensive metabolite detection, metabolomics is also beneficial for exploring biomarker candidates that could be useful to monitor meat production and predict the quality traits. The present review focuses on advances in farm animal muscle metabolomics, especially postmortem muscle metabolism associated with genetic factors and muscle type.

• 대한방사성의약품학회지
• /
• 제6권2호
• /
• pp.116-130
• /
• 2020

The aging society is globally one of biggest issue because it is related with various degenerative brain disease such as dementia, Parkinson's disease, Alzheimer's disease, multiple sclerosis, and cerebrovascular disease. These diseases are characterized by misfolded-protein aggregation; another pathological trait is "neuroinflammation". In physiological state, the resting microglia cells are activated and it removes abnormal synapses and cell membrane debris to maintain the homeostasis. In pathological state, however, microglia undergo morphological change form 'resting' to 'activated amoeboid phenotype' and the microglia cells are accumulated by neuronal damage, the inflammatory reactions induced nerve metamorphosis with a variety of neurotoxic factors including cytokines, chemokines, and reactive oxygen species. Thus, the activated microglia cell with various receptors (TSPO, COX, CR, P2XR, etc.) was perceived as important biomarkers for imaging the inflammatory progression. In this review, we would like to introduce the current status of the development of radiotracers that can image activated microglia.

• 간호행정학회지
• /
• 제5권3호
• /
• pp.477-500
• /
• 1999

Korean labor market has showed remarkable change of the increase in the amount of unemployment and contingent employment since IMF bailout agreement. There is a theoretical position to explain this increase in contingent employment at hospitals with the notion of flexibility. The high flexibility of employment due to the increase of contingent employees is becoming very important part in new business strategy of hospitals. The types of contingent employment of the nurse are part-time employment temporary employment, fixed-term employment, and internship which was introduced in early 1999. Recently, Korean health care industry managers have paid attention to the customer oriented service, rationalization of business administration, service quality control so that they can adjust their business to outer environment. Especially their efforts concentrate on the wage reduction through efficient and scientific control of man power because wage shares about 40% of total cost. This dissertation aims at verifying the phenomena of the contingent employment of the nurse and analyzing the related factors and problems. To rephrase these aims in ordinal: First, verifying the phenomena of contingent employment of the nurse. Second, verifying the problems of that phenomena. Third, analyzing the related factors of the contingent employment of the nurse. To accomplish these research goals, a statistical survey was executed. in which 384 questionnaires-66 for manager nurses, 318 for contingent nurses - were given to nurses working at 66 hospitals-which have at least 100 beds-in Seoul. Among them, 187 questionnaires-38 from manager nurses, 149 from contingent nurses'- 'were returned. Then, the data coded and submitted to T-test, $X^2$ -test, variance analysis(ANOVA), correlation analysis, multiple regression analysis, Logistic Regression with SAS program. The research results of the contingent nurses are followings: 1. The average career term at the present hospital 8.4 months: duty-on days per month are 24.2 days: working time per day is 7.9 hours. These results showed little difference from regular nurses. 2. Their wage level is about 70% of regular nurses except for internship nurses whose wage level is 41% of regular nurses. To break down the wage composition, part-time nurses and internship nurses get few allowance and bonus. And contingent nurses get very low level of additional pay except for fixed-term nurses who are under similar condition of employment to regular nurses. These results show that hospital managers are trying to reduce the labor cost not only through the direct way of wage reduction but through differential treatment of bonus, retirement allowance, and other additional pay. 3. The problem of contingent employment: low level of pay; high level of turn-over rate: weakening of union; low level of working condition: heavy burden of work; inhuman treatment. The contingent nurses consider these problems more seriously than manager nurses do. What manager nurses regard problematic is the absence of feeling-belonged and responsibility of the contingent nurses. 4. The factors strongly related with the rate of the number of contingent nurses for the number of regular nurses; gross turn-over nurses; average in-patients per day; staring wage of graduate from professional college: the type of hospital ownership; the number of beds; the gap between gross newcomer nurses and gross turn-over nurses. The factors related with their gross wage per month; the number of beds; applying of health insurance; applying of industrial casualty insurance; applying of yearly-paid leave; the type of hospital ownership; average out-patients per day; gross turn-over nurses. The meaningful factors which make difference by employment type: monthly-paid leave; physiological leave. The logistic regression analysis using these two factors shows that monthly-paid leave is related with the type of hospital ownership; the number of beds; average out-patient per day, and physiological leave is related with the gross newcomer nurses; gross turn-over nurses; the number of beds.

• The Korean Journal of Physiology
• /
• 제30권2호
• /
• pp.197-208
• /
• 1996

Endosomes lower their internal pH by an ATP-driven proton pump, which is critical to dissociation of many receptor-ligand complexes, the first step in the intracellular sorting of internalized receptors and ligands. Endosomes are known to exhibit n great range of pH values that can vary between 5.0 and 7.0 within a single cell although the factors that regulate endosomal pH remain uncertain. To evaluate the morphological and topological differences of endosomes in the different stages, confocal microscopy was used. The early endosomes labeled with fluorescein isothiocyanate-dextran for 10 min at $37^{\circ}C$ were identifiable at the peripheral and tubule-vesicular endosome compartment. In contrast, the late endosomes formed by 10 min pulse and 20 min trace were located deeper in the cytoplasm and showed more vesicular features than early endosomes. For the purpose of determining whether ATP-dependent acidification was heterogeneous and whether the differences in acidification were attributed to differences in the activity of $Na^{+}-K^{+}$-ATPase and/or $Cl^{-}$ channel, endocytic compartments were fractionated into subpopulation using percoll gradient and measured ATP-dependent acidification. While all fractions exhibited ATP-dependent acidification activity, both the initial rate of acidification and extent of proton translocation were lower in early endosomes and gradually increased in late endosomes. Phosphorylation by PKA and ATP enhanced ATP-dependent acidification in both early and late endosomes, hut there was no difference in the degree of enhancement by phosphorylation between two subpopulations. When ATP-dependent acidification was determined in the presence or absence of vanadate ($Na_{3}VO_{4}$) or ouabain, only early endosomes exhibited the vanadate or ouabain dependent stimulation of acidification activity, suggesting the inhibition of $Na^{+}-K^{+}$-ATPase. Therefore, it seems probable that the inhibition of early endosome acidification by $Na^{+}-K^{+}$-ATPase observed in vitro at least in part plays a physiological role in controlling the acidification of early endosomes in vivo.

• 한국산업융합학회 논문집
• /
• 제1권1호
• /
• pp.21-30
• /
• 1998

The purpose of this study is to clarify the floor temperature on the human body and to estimate thermal comfort zone in a heated room. In order to evaluate the effects of floor heating, a series of experiments were carried out using Korean subjects. The following experiments were conducted: 1) to obtain the effective radiation area and configuration factors of the person in the sitting posture on a floor to get the mean radiant temperature, 2) to measure contacted area of the person to the floor to calculate conduction heat rate, 3) to measure convective heat transfer coefficient of the body and 4) to know the thermal comfort zone of indoor environment heated by ON-DOL. Subjects were exposed to the following conditions: combinations of air temperature $20^{\circ}C$, $22.5^{\circ}C$, $25^{\circ}C$, and floor temperature $20^{\circ}C$, $22.5^{\circ}C$, $25^{\circ}C$, $27.5^{\circ}C$, $30^{\circ}C$, $32.5^{\circ}C$, $35^{\circ}C$, $37.5^{\circ}C$, $40^{\circ}C$ under still air and 50% relative humidity in the controllable artificial climate chamber. To evaluate the effect of heat conduction between the body and a floor modified mean skin temperature was defined. Weighting coefficient to calculate mean skin temperature were modified with the contacted area. The experiments revealed a positive correlation between the modified operative temperature and the modified mean skin temperature. The modified mean skin temperature can indicate the effect of heat conduction between body and a floor surface.

• 한국환경농학회지
• /
• 제38권4호
• /
• pp.219-224
• /
• 2019

BACKGROUND: Soil bacteria play important roles in organic matter decomposition and nutrient cycling during the non-growing season. The purpose of this study was to investigate the effects of soil management and chemical properties on the utilization of carbon sources by soil bacteria in paddy fields. METHODS AND RESULTS: The Biolog EcoPlate was used for analyzing community-level carbon substrate utilization profiles of soil bacteria. Soils were collected from the following three types of areas: plain, interface and mountain areas, which were tested to investigate the topology effect. The results of canonical correspondence analysis and Kendall rank correlation analysis showed that soil C/N ratio and NH₄⁺ influenced utilization of carbon sources by bacteria. The utilization of carbohydrates and complex carbon sources were positively correlated with NH₄⁺ concentration. Cultivated paddy fields were compared with adjacent abandoned fields to investigate the impact of cultivation cessation. The level of utilization of putrescine was lower in abandoned fields than in cultivated fields. Monoculture fields were compared with double cropping fields cultivated with barley to investigate the impact of winter crop cultivation. Cropping system altered bacterial use of carbon sources, as reflected by the enhanced utilization of 2-hydroxy benzoic acid under monoculture conditions. CONCLUSION: These results show that soil use intensity and topological characteristics have a minimal impact on soil bacterial functioning in relation to carbon substrate utilization. Moreover, soil chemical properties were found to be important factors determining the physiological profile of the soil bacterial community in paddy fields.

• Asian-Australasian Journal of Animal Sciences
• /
• 제33권5호
• /
• pp.848-855
• /
• 2020

Objective: Shearing is one of the practices that is applied periodically to fiber producing animals, which can also alter resistance of animals to high temperatures in especially summer months. This study aimed to investigate effects of shearing on some physiological and hormonal parameters in Akkaraman sheep during summer season. Methods: This study was carried out on 39 non-pregnant Akkaraman ewes (aged 1.5 years at the beginning of experiment). The 39 ewes were chosen randomly from the flock belonging to the Erciyes University and they were assigned to two groups as follows: i) group A (n = 20) designed as the control group, they were shorn and group B (n = 19) designed as the experimental group, they were unshorn. Prior to the shearing (-1 day) and on days 1, 7, 15, 30, 45, 60, 75, and 90 following the shearing, blood samples were taken from the vena jugularis of each sheep. Cortisol, β-endorphin, growth hormone (GH), thyroxine (T₄), triiodothyronine (T₃), and heat shock protein 70 (HSP-70) concentrations were determined using the enzyme immunoassay method. Body weight (BW), rectal temperature (RT), pulse rate (PR), and respiratory rate (RR) of each sheep were recorded at the same time. The data obtained were analyzed using two-way repeated measures analysis of variance. Results: Statistical analysis showed a significant effect of shearing×period interaction (p<0.01) and a significant effect of period (p<0.01) on BW, HSP-70, cortisol, T₄ and RT, PR, GH, β-endorphin, T₃, respectively. Also these analysis showed no significant effect of shearing×period interaction or period on RR. Conclusion: The results showed that the thermoregulation abilities of sheep were affected by shearing treatment and the shorn ewes were less affected by heat stress. In conclusion, based on the data of this study, shearing can be considered as a necessary management practice that requires protection for sheep from the effect of heat stress.

• 한국작물학회지
• /
• 제30권4호
• /
• pp.412-418
• /
• 1985

육성연대가 다른 보리품종의 생리, 형태적 특성변화와 수량성과의 관계를 구명하여 육종 및 재배법개선의 기초자료로 삼고져 보리 9품종을 2시비수준에서 재배하여 조사, 분석한 결과는 다음과 같다. 1. 근년에 육성된 품종들은 과거에 육성된 품종들에 비하여 엽록소함량, 엽신질소함량, 근활력, 근중, 비엽중(SLW) 및 순동화율이 높은 반면 엽면적지수는 낮았다. 2. 근년에 육성된 품종의 건물생산은 NAR보다 LAI와 밀접한 관계가 있었으나 과거에 육성된 품종은 반대의 경향이었다. 3. 엽층의 분포가 신품종들은 상하부에 고르게 분포되어 있으나 과거에 육성된 품종은 중상부에 집중되어 있었다. 4. 수량과 상관이 높았던 요인들은 엽록소함량, 근활력, 순동화율, 엽신질소함량 등이었으며, Stepwise multiple regression분석에서 엽록소함량, 근활력, 지상부건물중이 회귀식에 들어갔을 때 분산의 90% 정도가 되었다.