• 대한지역사회영양학회지
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• 제13권3호
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• pp.374-385
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• 2008

A study has been performed to provide the basic information about the current dietary habits, health related behaviors, and body indices and to bring forward the importance of this information to the people's attention based upon the relation between employee's life patterns and health conditions in their daily lives. Three hundred and five department store workers were examined from August 2006 to September 2006. With the average BMI values $23.9{\pm}2.2$ for males and $20.0{\pm}1.9$ for females, both gender groups were in normal, but 62.2% of the males were overweight and 15.4% of the females were under-weight. Regarding dietary and health related factors on how they perceive themselves, as normal were 204 (66.9%) the most and bad and very bad were respectively 43 (14.1%) and 5 (1.6%). Half of the subjects (43.2%) perceived sleeping hours to be insufficient, and 64.4% of them need to exercise regularly. As problems related to eating habits, they reported irregular meal times, overeating, preference of hot and spicy food, skipping meal, unbalanced meals. Regarding weight control they have attempted were the most (73.0%), after weight reduction, 51.2% of the subjects had side effects, such as gastrointestinal troubles, anemia, dizziness, sense of fatigue, constipation, physiological disorder, and diarrhea, etc. In the food habit score, it was shown that overall average score of the subjects was $62.63{\pm}9.86$ which is lower than other studies. Female ($62.76{\pm}10.15$) had better score than male ($61.67{\pm}8.06$). While the item with the highest point was eat all three meals of the day, that was the lowest point, exercise every day. The food habit score of the younger group had lower than older group, and also they preferred sweet foods to other group. The results suggest that nutrition education for workers at specific working fields needs to be more focused on the improvement of dietary habits and health status of workers.

• Applied Biological Chemistry
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• 제47권2호
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• pp.244-250
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• 2004

본 연구는 탄닌 성분을 다량 함유한 지유를 각종 효소학적 생리활성을 검토함으로서 식품 및 화장품산업에 응용 시 제품의 안정성과 기능성을 나타낼 수 있는 천연소재로서의 역할을 검토하였다. 효소학적 생리활성 실험에서의 전자공여능은 10 ppm에서는 54.9%, 50 ppm이상의 시료농도에서는 90% 이상의 높은 전자 공여능을 나타내었고, SOD-유사활성능은 1000 ppm에서 65.4%의 높은 활성이 나타내었으며, 농도가 증가함에 따라 유의적인 차이를 나타내었다. Xanthine oxidase의 저해활성을 관찰한 결과 200 ppm의 농도에서 17.9%로 나타내었으며, 500 ppm에서는 36.9%로 비교적 낮은 저해효과를 나타내었으나, 지방 산패도 측정 결과 시료농도 모두 지방 산패를 저해하는 능력이 뛰어 났으며, 지방 산화 촉진인자인 $Fe^{2+},\;Cu^{2+}$ 이온에 대한 금속이온 포집능력을 관찰한 결과 $Fe^{2+}$보다 $Cu^{2+}$ 이온의 포집 능력이 뛰어 났으며,시료농도 모두 50 ppm에서 40% 이상의 포집능력을 나타내었다. 이와 같이 지유 추출물은 기능성이 우수한 것으로 나타나 식품 및 화장품 제조시 유용하게 사용할 수 있어 천연소재로서의 개발가능성을 보여주었다.

• 동의생리병리학회지
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• 제20권6호
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• pp.1732-1741
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• 2006

Obesity is chronic disease which influenced on health severly. The causes of obesity have been known as life change, lack of excercise, genetic factor, mental and social economic factors. Especially the obesity of women increased the risk of the diseases such as DM, osteoarthritis, cardiovascular disease, breast cancer and infertility. The limitations of the widely used negative definition of health as the absence of disease and WHO's 1946 definition of health as total social, psychological and physical well-being have long been recognized (WHO 1958). The Quality of Life (QoL) includes functional ability, the degree and quality of social and community interaction, psychological well-being as somatic sensation and life satisfaction. I investigated to compare the differences between obese women (n=63), non-obese women (n=37) in clinic and general women (n=43, control) on baseline characteristics and WHO QoL-BREF. The purpose of this study is to assist the diagnosis and treatment of obesity. WHO QoL-BREF is self administered type which consisted of 26 questions. The prospective question is calculated with 5 scores by Likert's method. The results are as follows : The means of physical, psychological, social, overall and total scores of QoL were significant among BMI group (P<0.05). The score of control group (BMI < 25) was higher than other groups significantly (P<0.05). In multiple regression analysis, the variable of high school/below middle school was significant in environmental and overall domain of QoL scores (P<0.05). The variable of college/below middle school was significant in environmental, overall domain and total score of QoL scores (P<0.05). The variable of above university/below middle school was significant in physical health, environmental, overall domain and total score in QoL scores (P<0.05). The variable of Health perception (moderate/bad) was positively significant in physical health, environmental, overall domain and total score of QoL scores (P<0.05). The variable of Health perception (good/bed) was positively significant in physical health, environmental, social, overall domain and total score of QoL scores (P<0.05). The variable as BMI non-=obese women/control was negatively significant in social domain of QoL scores (P<0.05). Above the results, It suggests that the variable as BMI did't affect on the QoL in patients and control, but the variables as education and health perception affected on the QoL scores. Further study is required to conduct QoL differences between before and after treatment of obese patients.

• 동의생리병리학회지
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• 제29권1호
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• pp.27-32
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• 2015

Streptococcus mutans triggers dental caries establishment by two major factors. One is synthesis of organic acids which demineralize dental enamel and the other is synthesis of glucans which mediate the attachment of bacteria to the tooth surface. In the present study, we evaluated the effect of the ethanol extracts of Aconitum koreanum (A. koreanum ) on the growth and acid production of S. mutans. Ethanol extracts of the A. koreanum showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition at the concentration of 0.016 mg/ml compared to the control groups (p<0.05). The extracts inhibited S. mutans adherence to hydroxyapatite treated with saliva, and cell adherence was repressed by 50%, 54% at the concentration of 0.063, 0.125 mg/ml. On the study of activation of glucosyltransferase which synthesizes water insoluble glucan form sucrose, the ethanol extract of A. koreanum showed remarkable inhibition over the concentration of 0.016, 0.031, 0.063 and 0.125 mg/ml (p<0.05). Especially on the concentration of 0.063, 0.125 mg/ml, the extracts suppressed the glucan synthesis by 100%. We analyzed the component of the extracts of A. koreanum. The results showed that the extract of A. koreanum had strong phenolic compound, glycosides and organic acids. These results suggest that A. koreanum may inhibit the caries-inducing properties of S. mutans, and which may be related with strong phenolic compound, glycosides and organic acids.

• 생명과학회지
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• 제22권3호
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• pp.428-436
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• 2012

단백질 인산화는 세포의 활동을 조절하는 보편적인 과정이다. 브라시노스테로이드(brassinostreoid)에 의해 매개되는 신호전달은 브라시노스테로이드에 의해 활성화된 세포막상의 protein kinase 로부터 인산화되어 있는 전사인자들을 탈인산화하는 연속적인 인산화/탈인산화 과정이다. 브라시노스테로이드에 의해 매개되는 신호전달의 연구는 인산화에 관여하는 kinase 기질상의 아미노산을 밝히고, 그와 관련된 돌연변이체의 표현형을 알아봄으로써 급속하게 발전하였다. BRI1과 BAK1의 자기인산화(autophosphorylation), 상호인산화(transphosphorylation), 타이로신 인산화(tyrosine phosphorylation)를 밝힘으로써 그들의 조절작용을 식물의 생리학적, 발생학적 과정을 더 이해할 수 있는 장이 열렸다. 브라시노스테로이드에 의한 인산화는 수용체에 의해 매개되는 세포 내 함입(endocytosis)과 그에 뒤따르는 수용체의 파괴현상에서도 볼 수 있다. 인산화/탈인산화 과정에 관련하여 브라시노스테로이드에 의해 매개되는 신호전달은 더 연구할 여지가 많이 남아 있다. 이 총설은 단백질의 인산화/탈인산화 과정을 통한 브라시노스테로이드의 신호전달 연구의 최근 상황을 기술하였다.

• 한국의사학회지
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• 제25권2호
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• pp.63-96
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• 2012

The PingMaiFa chapter, which is the second chapter of SongBon ShangHanLun, is the scholarly description(專論) of the pulse and pathological mechanism but has not been studied and published yet. This study is about article 1-13 which is the first part of The PingMaiFa chapter. We compared the original texts within the editions, comparing and analyzing the annotations of successive dynastic medical group. The articles of The SongBon ShangHanLun PingMaiFa chapter 1-13 is consisted as is shown: article 1 states about the general features of normal pulse (平脈) and its physiological mechanism and the morbid pulses (病脈) caused by wind, cold, retained fluid, pain and heat vexation, article 1,10 state about the normal pulses of Five viscera (lung, heart, spleen, liver and kidney) and their manipulations in pulse taking, article 2 states about the differentiations of deficiency and excess syndrome according to pulse conditions, article 3, 4 state about the estimation of good prognoses and a factitious disorder by the combination of pulses and symptoms, article 6 states about Latent qi (伏氣) and its diagnostic features, article 5 states about inspection and listening examination as co-diagnostic methods of the pulse diagnosis, article 7, 8, 9 state that the emotions, such as fear and shame, and the dietary are important factors to consider for making diagnosis, article 11 states about the overwhelming pulse (相乘脈) which indicates the abnormal correlations between five phases and appears in four patterns as the dissolute(縱), the unrighteous(橫), the unfavorable(逆) and the favorable(順), article 12 states about 6 harmful pulses(殘賊脈), which are string-like pulse(弦脈), tight pulse(緊脈), floating pulse(浮脈), slippery pulse(滑脈), sunken pulse(沈脈), rough pulse(澁脈), article 13 states about "JaeGoe"(災怪) which is an unexpected response after treatment and it comes because of the formulas that had before. Throughout all these articles, The PingMaiFa chapter not only offers great value for Pulse-taking diagnosis, but also leads to a better understanding of clinical applications.

• 원예과학기술지
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• 제33권1호
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• pp.114-123
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• 2015

식물은 다양한 생화학적 및 생리적 과정에 속한 유전자들의 발현 수준을 조절함으로써 저온 스트레스에 반응 및 적응을 할 수 있다. 이러한 스트레스 환경은 막 기능 손실, 세포벽의 변화, 대사 속도 변화 등과 같이 부정적인 영향을 초래한다. 따라서 본 연구는 배추(Brassica rapa ssp. pekinensis)에서의 시간 변화에 따른 저온 스트레스 반응 기작 관련 유전자 상호발현 네트워크를 구축하였다. 배추의 저온 스트레스 네트워크는 2,030개 node, 20,235개 edge, 및 34개 connected component로 구성되었으며, 구축된 네트워크는 배추에서 저온에 관여하는 유전자가 생육도 조절한다는 것을 보여 주었다. 구축한 네트워크를 이용하여 배추에서 저온 스트레스($4^{\circ}C$) 처리가 미치는 영향을 분석한 결과 WRKY 전사인자와 살리실산 신호에 의해 chitinase 부동 단백질이 활성화되고, 전신적 획득저항성을 작동하기 위해 기공 개폐 및 탄수화물 대사과정이 조절됨을 확인하였다. 또한 저온 처리 후 48시간 후에 저온 스트레스가 영양생장에서 생식 생장 및 분열 조직 단계의 변화를 초래하는 것으로 나타났다. 본 연구에서 구축한 네트워크 모델은 배추에서 저온 저항성 관련 유전자들의 발현 패턴을 정확히 유추하는 데 이용될 수 있을 것이다.

• 한국토양비료학회지
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• 제44권3호
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• pp.380-386
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• 2011

시설재배 부추의 잎끝마름증상 발생에 영향을 미치는 인자를 구명하기 위하여 포항지역 부추 재배지 토양 132 개소의 토양특성을 분석하였고 통계적 방법으로 관련인자를 조사한 결과, pH는 7.0, 유기물함량 $41g\;kg^{-1}$로 적정 범위에 비해 높은 편이었으며 점토함량이 많은 식질토양인 Alfisols에서 pH, 치환성 양이온, 전기전도도, 질산태 질소함량이 높았고 잎끝마름증 발생비율이 높았으며 pH와 치환성 칼슘함량과 매우 높은 연관성을 나타내었다. pH가 높고 암모니아태 질소함량이 높을수록 암모니아 가스의 생성이 증가하였으며, 질산태질소와 토양유기물은 암모니아 가스 생성에 직접적인 영향은 없으나 토양의 pH 변화에 따라 질산태질소의 암모니아태 질소로 환원 및 유기태질소의 무기화에 따른 암모니아태 질소의 농도변화에 영향을 미치는 것으로 나타났다. 부추의 잎끝마름증은 토양 pH 변화에 따른 무기태질소의 환원에 따른 암모니아 가스생성에 따른 것으로 사료된다.

• 생명과학회지
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• 제31권10호
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• pp.960-968
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• 2021

미세조류 연구는 18세기 후반부터 시작된 이후 생물산업에서 가장 중요한 생물자원으로 인식되어 왔다. 특히 미세조류의 산업 활용에 초점을 맞춘 식품/사료 및 생리 활성 화합물에 대한 초기 주요 연구 분야는 현재 대체 에너지 자원, 탄소 배출 저감 및 폐수 처리를 포함한 환경 연구 분야로 더욱 확대되고 있다. 하지만 그 산업적 활용의 중요성에도 불구하고 미세조류 배양의 장기 보존과 관련된 기초 연구 분야는 많은 주목을 받지 못하고 있다. 그러나 생물학적으로 활성을 띄는 안정적인 미세조류 배양체 보존은 이러한 미세조류의 산업적 활용을 더욱 부각시킬 수 있는 핵심적인 성공요소이다. 따라서 본 총설은 조류(algae)의 분류체계에서 가장 큰 분류군을 차지하는 녹조류(Chlorophyceae)를 포함하여 현재까지 개발된 다양한 최첨단 미세조류 냉동보존기술을 조사하였다. 또한, 국내 생물자원은행 및 국제 미세조류 자원은행에 기탁된 생물학적으로 활성을 띄는 미세조류 배양체를 보존·유지하기 수행하고 있는 보존 기술과 함께 동결보존 시 온도조절 효과, 보존제 효과 등 미세조류의 성공적인 동결보존 기술과 관련된 주요 요인들을 조사하였다. 본 연구를 통해 확인된 결과를 살펴보면, 미세조류의 형태 및 생리학적 다양성으로 인해 현재로서는 범용적으로 사용할 수 있는 표준 미세조류 장기 보존 방법이 없다는 것을 확인하였다. 따라서, 이러한 문제를 극복하기 위해서는 미세조류의 분류학적 체계를 명확하기 위한 종 특이적 바이오마커의 개발과 종 특이적 동결보존 방법에 기반한 체계적인 접근을 위한 기초 연구 분야에 대해 훨씬 더 많은 노력이 필요함을 확인하였다.

• 대한임상독성학회지
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• 제19권2호
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• pp.72-82
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• 2021

Purpose: A high anion gap (AG) is known to be a significant risk factor for serious acid-base imbalances and death in acute poisoning cases. The strong ion difference (SID), or strong ion gap (SIG), has recently been used to predict in-hospital mortality or acute kidney injury (AKI) in patients with systemic inflammatory response syndrome. This study presents a comprehensive acid-base analysis in order to identify the predictive value of the SIG for disease severity in severe poisoning. Methods: A cross-sectional observational study was conducted on acute poisoning patients treated in the emergency intensive care unit (ICU) between December 2015 and November 2020. Initial serum electrolytes, base deficit (BD), AG, SIG, and laboratory parameters were concurrently measured upon hospital arrival and were subsequently used along with Stewart's approach to acid-base analysis to predict AKI development and in-hospital death. The area under the receiver operating characteristic curve (AUC) and logistic regression analysis were used as statistical tests. Results: Overall, 343 patients who were treated in the intensive care unit were enrolled. The initial levels of lactate, AG, and BD were significantly higher in the AKI group (n=62). Both effective SID [SIDe] (20.3 vs. 26.4 mEq/L, p<0.001) and SIG (20.2 vs. 16.5 mEq/L, p<0.001) were significantly higher in the AKI group; however, the AUC of serum SIDe was 0.842 (95% confidence interval [CI]=0.799-0.879). Serum SIDe had a higher predictive capacity for AKI than initial creatinine (AUC=0.796, 95% CI=0.749-0.837), BD (AUC=0.761, 95% CI=0.712-0.805), and AG (AUC=0.660, 95% CI=0.607-0.711). Multivariate logistic regression analyses revealed that diabetes, lactic acidosis, high SIG, and low SIDe were significant risk factors for in-hospital mortality. Conclusion: Initial SIDe and SIG were identified as useful predictors of AKI and in-hospital mortality in intoxicated patients who were critically ill. Further research is necessary to evaluate the physiological nature of the toxicant or unmeasured anions in such patients.