• 인간식물환경학회지
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• 제21권6호
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• pp.575-589
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• 2018

This study analyzed the changes in Electroencephalogram(EEG) and Electrocardiogram(ECG) depending on the healing environment in order to find a way to improve the forest healing program based on the healing environment in response to the demand for qualitative improvement of the program since the program is a charged service. This study selected eight sites running forest healing programs at four national healing forests (i.e., Saneum, Cheongtaesan, Daegwanryeng, and Jangseong) - two routes per national healing forest - considering forest environments. This study chose NUMBER standard sampling plots ($20{\times}20m$) and measured three atmospheric environment items, seven physical environment items, two soil environment items, and eight vegetation environment items including forest sound and anion at each plot to evaluate physiological changes in it. EEG and ECG, which have been widely used in forest healing evaluation, were utilized as criteria. Seventy three subjects were selected with taking the age, drug, caffeine, smoking, and the time of last meal into consideration. As a result, EEG changes were correlated with three atmospheric environment items, six physical environment items, one soil environment item, and two vegetation environment items. ECG changes were significantly correlated with two atmospheric environment items, six physical environment items, two soil environment items, and two vegetation environment items (p<.05). It is expected that 11 environmental factors such as temperature, density, and altitude affecting EEG (e.g., alpha balance and gamma balance) and ECG (e.g., HRV mean) could be used as effective tools in developing more differentiated programs for improving healing effects.

• Journal of Periodontal and Implant Science
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• 제51권5호
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• pp.316-328
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• 2021

Purpose: This study aimed to examine the prevalence and abundance of 9 representative periodontal pathogens in the saliva samples of periodontally healthy subjects (PH) and patients with periodontitis who underwent supportive periodontal therapy (SPT). The age-specific distribution of these pathogens in periodontally healthy individuals was also analyzed. Methods: One hundred subjects (aged >35 years) were recruited (50 each in the PH and SPT groups) between August 2016 and April 2019. The prevalence and abundance of periodontal pathogens in the PH group were compared with those in periodontally healthy young subjects (94 subjects; aged <35 years), who were included in our previous study. DNA copy numbers of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Treponema denticola (Td), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn), Campylobacter rectus (Cr), Peptostreptococcus anaerobius (Pa), and Eikenella corrodens (Ec) were analyzed using real-time polymerase chain reaction. Results: The detection frequencies of all pathogens, except Aa, were high in the PH and SPT groups. The ranking order of pathogen DNA copy numbers was similar in both groups. In both groups, Fn had the highest abundance, Aa had the lowest abundance. Additionally, Td was significantly more abundant in men than in women in both groups (P<0.05). Compared with the PH group, the SPT group exhibited significantly lower total bacteria and Fn abundance and higher Pg abundance (P<0.05). The age-specific pathogen distribution analysis revealed a significantly low Aa abundance and high Tf and Cr abundance in the PH group. Conclusions: The clinical parameters and microbial profiles were similar between the SPT and PH groups. However, patients with periodontitis require supportive care to prevent recurrence. As the abundance of some bacteria varied with age, future studies must elucidate the correlation between age-related physiological changes and periodontal bacterial composition.

• The Korean Journal of Physiology and Pharmacology
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• 제21권4호
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• pp.407-413
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• 2017

Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine in the abdominal aorta of young rats. Although these COXs are found in many tissues, their distribution and role in vascular reactivity are not clear. At a vascular level, they take part in the homeostasis functions involved in many physiological and pathologic processes (e.g., arterial pressure and inflammatory processes). The aim of this study was to analyze changes in the contractile response to phenylephrine of thoracic/abdominal aorta and the coronary artery during aging in rats. Three groups of rats were formed and sacrificed at three distinct ages: prepubescent, young and old adult. The results suggest that there is a higher participation of prostanoids in the contractile effect of phenylephrine in pre-pubescent rats, and a lower participation of the same in old rats. Contrarily, there seems to be a higher participation of prostanoids in the contractile response of the coronary artery of older than pre-pubescent rats. Considering that the changes in the expression of COX-2 were similar for the three age groups and the two tissues tested, and that expression of COX-1 is apparently greater in older rats, COX-1 and COX-2 may lose functionality in relation to their corresponding receptors during aging in rats.

• 한국산림과학회지
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• 제113권1호
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• pp.107-117
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• 2024

본 연구는 시간에 따른 산림환경의 물리환경요소 변화와 이에 따른 온열환경 쾌적성, 인체의 생리·심리적 반응의 차이를 종합적으로 규명하기 위하여 수행되었다. 9시부터 18시까지 산림환경의 물리환경요소(공기온도, 평균복사온도, 풍속, 상대습도)와 예상평균한서감지수(PMV), 예상불만족률(PPD)를 연속 측정하고, 1시간 간격으로 남자 대학생 30명(평균 연령: 21.7±1.9세)이 눈을 감고 5분 동안 안정을 취할 때의 생리·심리적 반응(심박변이도, 심박수, 구강체온, 혈압, 맥박수, 주관적 온열감과 쾌적감 및 인상)을 조사하였다. 더불어 물리환경요소와 생리적 반응 사이의 상관관계를 조사하였다. 그 결과, ① 공기온도, 평균복사온도, 풍속, 상대습도 모두 시간에 따라 유의하게 변화하였다. ② PMV와 PPD도 시간에 따라 유의하게 변화하였다. 주관적 온열감은 PMV와 일치하였으나, 주관적 쾌적감은 PPD와 일치하지 않았다. ③ 생리적 반응 중 ln(HF), ln(LF/HF), 심박수, 이완기혈압이 시간에 따라 유의하게 변화하였다. 공기온도가 가장 높았던 14~16시에 ln(HF)는 가장 낮았고, ln(LF/HF)는 가장 높았다. ④ 공기온도, 평균복사온도, 풍속은 ln(HF)와 음의 상관관계, ln(LF/HF)와 양의 상관관계를 나타내었다. 이를 통해 산림환경을 이용하는 시간대에 따라 이용객의 쾌적감과 생리·심리적 안정 효과가 달라질 수 있으며, 시간에 따른 산림환경의 물리환경요소 변화가 이러한 차이에 영향을 미친다는 사실이 밝혀졌다.

• Asian-Australasian Journal of Animal Sciences
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• 제19권5호
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• pp.734-738
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• 2006

The present study was conducted to determine the effect of cold stress on broiler performance and ascites susceptibility. Male chicks were obtained from a commercial strain of broiler breeders. The trial was divided into two treatments (control and cold stress groups). Ascites was induced in broiler chickens in the trial by exposing the chickens to low temperature (Ta) and by supplying a pelleted diet. The two experimental treatments consisted of: 1) Control group, $33.3^{\circ}C$ the $1^{st}$ wk, $30.2^{\circ}C$ the $2^{nd}$ wk, and $27.5^{\circ}C$ the $3^{rd}$ wk. 2) Cold stress group, $29.0^{\circ}C$ the $1^{st}$ wk, $26.4^{\circ}C$ the $2^{nd}$ wk, and $23.1^{\circ}C$ the $3^{rd}$ wk. From the end of the $3^{rd}$ wk all broilers were reared to 6 wk of age at a constant temperature of $21^{\circ}C$. There was significant difference in live BW during wk 1 to 5. The control group was consistently the heaviest; however, at 6 wk of age, both groups weighed the same. Body weight gain up to 3 wk was significantly decreased by cold stress. During wk 3 and 6 the chicks in the cold stress group had greater BW gain compared with the chicks in the control group. There were significant differences in mortality due to ascites between the groups. During wk 3 and 6 the cold stress group exhibited the most ascites mortality (9.52%) when compared with the control group (1.90%). At 5 wk of age cold stress condition caused significant changes in packed cell volume (PCV), hemoglobin (Hb) and red blood cell counts (RBC). Right ventricle weight was significantly heavier in the cold stress group than the control. There were also significant differences in right ventricle/total ventricle (RV/TV) ratios at 5 wk. the right ventricle/total ventricle ratios in the cold stress group was higher (0.25) than the control group (0.20). It was concluded that, fast growth and cold temperatures are the primary triggers for ascites during commercial broiler production.

• 핵의학기술
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• 제17권2호
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• pp.101-106
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• 2013

Purpose: As UBC IRMA is being tested, patients out of the reference value are reacting within the value again a few days later the urine collection tested, which causes the reliability of the test to decrease as a result. In this study, we can assume that the physiological changes in the factors would affect the results. The purpose of the study is to find out whether hematuria and proteinuria in the sample as well as the interval time (3 hours or more recommended) have affected the results. As a result, we could discover the changes in factors and increase the reliability of the test. Materials and Methods: 468 people (female: 249, male: 219) who came for the check-up were presented herein for medical examination from 2013.3.15 to 2013.1.2. Some people out of 468 who have reacted onto the reference value were divided into group low titer zone, ow-middle titer zone, and middle-high titer zone and tested for hematuria and proteinuria. During that period, 48 outpatients were asked to fill in a questionnaire regarding the urination interval time. The reagents used were (IDL Biotech AB, Sweden) and UBC IRMA. Results: Of the patients that are formed in the reference value of ($0.1-34.0{\mu}g/L$) turn out to be 52.7 years average age in their low concentration, ($mean{\pm}SD$) of the value of $0.10{\pm}0.02{\mu}g/L$. Among 80 people (50.8%, female: 49.2%), 16 patients (20%) have shown reaction to microscopic hematuria and 10 patients (12.5%) responded to proteinuria. In the average low concentration under 52.5 years of average age, 43 people (53%) have shown reaction to microscopic hematuria and 21 people (26.3%) are proteinuric patients out of 80 patients (male: 50.8%, female: 51.3%). In the middle high concentration of $11.8{\pm}4.82{\mu}g/L$ under the average age 51.7 years, 35 patients (53%) have responded to the microscopic hematuria and proteinuric patients are 26 people (39.3%) out of 66 people (men: 44%, women: 56%). In addition, in the concentration of $51.7{\pm}43.5{\mu}g/L$, some patients who get out of the reference value are observed as the average age of 52.0. 11 patients (78.6%) out of 14 (male: 35.7%, female: 64.3%) react to the microscopic hematuria. There show 6 people (42.8%) who turn out to be as proteinuric patients. As for the interval time, $1.67{\pm}3.71{\mu}g/L$ was the average value among 48 patients (female: 45.8%, male: 54.2%). Conclusion: We cannot see if proteinuria and hematuria directly affect abnormal results of inspection of 8,18 cytokeratin; however, we can find out that they statistically have an influence on highly generating UBC among several mechanisms. Also, although urination interval time was various every 15 minutes, we it does not affect these results.

• 생명과학회지
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• 제34권1호
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• pp.68-77
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• 2024

다양한 원인에 의하여 발생하는 미세먼지(particulate matter, PM)는 강력한 환경 오염 물질로 대두되고 있다. PM은 서로 다른 구성과 크기의 고체 입자와 액체 방울로 구성되며, 유해 화학 성분에는 원소 및 유기 탄소, 유기 화합물, 생물학적 화합물 및 금속이 포함된다. 급성 및 만성 PM 노출 시 생체 내 생리학적 시스템에 의하여 유입되고 축적되어 세포내 소포체 스트레스, 미토콘드리아 기능 장애, 산화 스트레스, 염증, 지질 축적 및 세포 주기 정지와 함께 세포 구조 변화를 촉진한다. 궁극적으로 이러한 세포 반응은 노화의 주요 특성을 발달시키는 원인으로 작용하며, 세포 노화와 관련된 자가포식 플럭스 및 리소좀 기능 장애를 향상시킨다. 선행 연구에서 PM과 사망률 증가 또는 수명 감소 사이의 긍정적인 연관성을 강조했지만, 노화에 대한 PM의 직접적인 증거는 여전히 제한적이다. 이 총설에서는 관찰 연구뿐만 아니라 노화 진행 및 연령 관련 질병 발병에 대한 PM의 시험관 내 및 생체 내 증거를 평가하였다. 이러한 평가는 소포체 스트레스, 미토콘드리아 기능 장애, 산화 스트레스, 염증, 지방 축적, 자가포식을 포함하여 PM 노출과 노화 사이의 연관성을 강화하는 연령 관련 세포 변화를 기반으로 한다. 이러한 자료는 PM에 따른 기본적인 세포 반응의 이해를 토대로 PM으로 인한 노화에 대한 새로운 치료법 개발에 기여할 수 있을 것이다.

• 동의생리병리학회지
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• 제22권1호
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• pp.256-261
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• 2008

Anorexia is a common symptom in the elderly patients. Causes of anorexia in the elderly are very diverse and multifactorial. Causes include physiological changes associated with aging, mental disorders such as depression, anorexia tardive, dementia, medical diseases such as cancer(lung and gastrointestinal cancer), benign gastrointestinal disorders, cardiac disorders, pulmonary disease, thyroid disorders, infection. Medications such as digoxin, theophylline have also been implicated in the problem. No cause is found in about one quarter of patients. Management is directing at treating causes and providing nutritional support. In Oriental medicine, the appetite has close relation to Biwi. The main cause of anorexia is the insufficiency of Biwi. The physiology of Biwi is that Bi sends clarity(food essence) upward and Wi sends digested food downward. Specially if the physiologic function of Wi is disordered by various factors, Wi cannot send digested food downward. As a result, the anorexia can present by the disorder of Wi function. We experienced a case of an 74 years old female patient with ill-defined severe anorexia differentiated as Wijoongheohan. The patient was managed with fluid therapy and Jeonghyangsiche-tang. The anorexia and other symptoms improved continuously during hospitalization.

• 인간식물환경학회지
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• 제22권6호
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• pp.611-619
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• 2019

This study was conducted to investigate changes in the mental functions of the elderly in nursing facilities affected by a horticultural therapy program based on validation therapy. To meet the purpose, we conducted a horticultural therapy program based on validation therapy with 58 elderly participants (average age 79.12±6.84, men and women) once a week, 50 minutes per session, in a total of 10 sessions. Participants were divided into the control and experimental group with convenience sampling. The program was carried out from March 15 to November 22, 2018. Vibraimage 8 pro(ELSYS, 2014) is a recent, psychologically based, emotional-recognition visual imaging technology that measures pixels microvibration in terms of digital frequency and amplitude parameters. To examine the effects of the horticultural therapy program based on validation therapy, Vibraimage was used to assess aggression, stress, tension, suspect, balance, charm, energy, self-regulation, inhibition, neuroticism and positive, negative, physiological domains of mental functions before and after program. As a result, the mean score of the positive domain in the control group significantly decreased from 63.89±5.09 to 60.74±5.48, but it decreased without statistical significance in the experimental group from 63.98±5.45 to 61.39±6.02. The mean score of neuroticism in the experimental group significantly decreased from 31.64±10.94 to 22.87±13.79. Moreover, the mean score of the physiological domain in the experimental group also significantly decreased from 25.08±6.27 to 19.42±8.80. Accordingly, horticultural therapy program based on validation therapy can be utilized as a program to promote mental health, especially maintaining positive mental health function of the eldery, helping those who live in long-term care facilities enjoy a happier life more happier.

• 한국산림과학회지
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• 제103권4호
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• pp.664-669
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• 2014

본 연구는 도시림에서의 경관감상과 산책이 인체의 생리적 안정에 미치는 영향을 규명하기 위해 수행되었다. 실험은 대전광역시에 위치한 한밭수목원에서 실시하였으며, 대조실험은 대전시청 앞에서 실시하였다. 20대 남자 대학생 24명(평균나이 $21.1{\pm}2.5$세)이 피험자로 참여하였고, 피험자를 세 그룹으로 나누어 수목원 내 소나무 숲, 수목원 내 연못, 도시 세 장소에 무작위 배치하였으며, 자리에 앉아 10분간 경관을 감상한 후 15분 동안 산책을 실시하였다. 측정지표로써 HRV, 혈압, 맥박수를 이용하여 생리적 변화를 측정하였다. 그 결과 도심 수목원 내에서 경관감상과 산책을 했을 때 도심과 비교하여 통계적으로 유의한 HF 성분의 증가와 수축기 혈압의 감소를 확인할 수 있었다. 본 연구를 통해 도심 수목원에서의 경관감상 또는 산책과 같은 활동이 도시민의 생리적 안정감을 향상시키는데 효과가 있음을 알 수 있었다.