• Title/Summary/Keyword: photothermal

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Clinical Application of Gold Nanoparticles for Diagnosis and Treatment

  • Baek, Seung-Kuk
    • Medical Lasers
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    • v.10 no.2
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    • pp.61-67
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    • 2021
  • Advances in nanobiotechnology have presented numerous possibilities of more effective diagnostic and therapeutic options. In particular, gold nanoparticles have demonstrated the potential for application in molecular imaging and treatment of cancers, including drug delivery system of certain target molecules, enhancement of radiation therapy, and photothermal treatment. This review discusses the properties, mechanism of action, and clinical application of gold nanoparticles. Although the safety of nanoparticles is yet to be ascertained, there is no doubt that in the future, nanotechnology will play an important role in the development and enhancement of a wide range of diagnostic and treatment modalities.

Observation of Methyl Radical Recombination Following Photodissociation of CH3I at 266 nm by Time-Resolved Photothermal Spectroscopy

  • Suh, Myung-Koo;Sung, Woo-Kyung;Li, Guo-Sheng;Heo, Seong-Ung;Hwang, Hyun-Jin
    • Bulletin of the Korean Chemical Society
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    • v.24 no.3
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    • pp.318-324
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    • 2003
  • A time-resolved probe beam deflection (PBD) technique was employed to study the energy relaxation dynamics of photofragments produced by photodissociation of $CH_3I$ at 266 nm. Under 500 torr argon environment, experimental PBD transients revealed two energy relaxation processes; a fast relaxation process occurring within an acoustic transit time (less than 0.2 ㎲ in this study) and a slow relaxation process with the relaxation time in several tens of ㎲. The fast energy relaxation of which signal intensity depended linearly on the excitation laser power was assigned to translational-to-translational energy transfer from the photofragments to the medium. As for the slow process, the signal intensity depended on square of the excitation laser power, and the relaxation time decreased as the photofragment concentration increased. Based on experimental findings and reaction rate constants reported previously, the slow process was assigned to methyl radical recombination reaction. In order to determine the rate constant for methyl radical recombination reaction, a theoretical equation of the PBD transient for a radical recombination reaction was derived and used to fit the experimental results. By comparing the experimental PBD curves with the calculated ones, the rate constant for methyl recombination is determined to be $3.3({\pm}1.0)\;{\times}\;10^6\;s^{-1}torr^{-1}$ at 295 ± 2 K in 500 torr Ar.

Observation of Residual PMMA on Graphene Surface by Using IR-Absorption Mapping

  • Oh, Hye Min;Kim, Yong Hwan;Kim, Hyojung;Park, Doo Jae;Lee, Young Hee;Jeong, Mun Seok
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.292.2-292.2
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    • 2013
  • Graphene, a two-dimensional graphite material consisting of sp2-hybridized carbons. The properties of graphene such as extremely high carrier mobility, high thermal conductivity, low resistivity, large specific make it a promising materail of divices and material. Typically, poly (methyl methacrylate) (PMMA) is used when graphene transfer to other substrates. To remove PMMA on graphene, people used to dip the graphene into the acetone. However, it is known that the remove of PMMA on the graphene is difficult to completely using the acetone. Therefore, to remove the PMMA on the graphene surface, many research groups have employed various methods such as the thermal treatment, photothermal method, and other solvent. Nevertheless, a part of PMMA still remain on graphene surface. Usually, to observe the residual PMMA on graphene surface, topography of graphene surface scanned by atomic force microscopy is used. However, in that case, we can not distinguish PMMA and other particles. In this study, to confirm the residual PMMA on graphene surface, we employed novel measurement technique which is available to distinguish PMMA and other particles by means of photothermal effect.

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A Study on the Radius of Curvature of Concave Optical Fiber Tips fabricated by Laser-Induced Photothermal Effect (레이저 유도 광열 효과를 이용하여 제작된 오목한 광섬유 팁의 곡률 반경에 관한 연구)

  • Choi, Ji-Won;Son, Gyeong-Ho;Yu, Kyoung-Sik
    • The Journal of the Korea institute of electronic communication sciences
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    • v.14 no.5
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    • pp.871-876
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    • 2019
  • We fabricated concave optical fiber tips using hydrofluoric acid solution and photothermal effect induced by $1.55{\mu}m$ wavelength laser applied to an optical fiber. The radius of curvature of the concave optical fiber tips fabricated with different applied laser power, etching time, and concentration of hydrofluoric acid was measured with an optical microscope. Then, we analyzed how the radius of curvature changes for those three variables. In addition, the reliability of the measurement method using a microscope was verified through a free spectral range(FSR) and a scanning electron microscope(SEM). Through this paper, the radius of curvature can be adjusted by the variables of the fabrication process of concave optical fiber tips; thus, it is overcoming the limitations of conventional optical fiber etching methods using hydrofluoric acid solutions.

Modeling of Pulsed Laser Heating of Tissue: Implications or Skin Resurfacing (Pulsed Laser를 이용한 생체조직 가열을 위한 모델링 : Skin Resurfacing을 위한 연관성)

  • Kwon, Y.H.;Rastegar, S.
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.11
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    • pp.375-379
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    • 1997
  • Pulsed Er:YAG and $CO_2$ lasers induced temperature rise of tissue are studied using axisymmetric, two-dimensional, and transient Pennes' bio-heat equation or the implications of skin resurfacing. Model results indicate that Er:YAG laser induced temperature has much higher but more shallow distribution in tissue than that of the $CO_2$ laser because of its higher absorption coefficient. The increase of repetition rate does not affect the temperature rise too much because these laser modalities have much shorter heat diffusion time than the temporal length of each off-pulse. This model works as a tool to understand the photothermal effect in the laser-tissue interaction.

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A PRELIMINARY STUDY OF PULSED LASER HEATING OF TISSUE FOR THE IMPLICATIONS OF SKIN RESURFACING

  • Kwon,Yong-Hoon;Kim, You-Young
    • Journal of Photoscience
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    • v.5 no.1
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    • pp.39-43
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    • 1998
  • Pulsed Er: YAG and CO$_2$ lasers induced temperature rise of tissue is studied using axisymmetric, two-dimensional, and transient Pennes bio-heat equation for elucidating the implications of skin resurfacing. Modeling indicates that Er:YAG laser induced temperature has much higher but more shallow distribution in tissue than that of the CO$_2$ laser because of much higher absorption coefficient. The increase of repetition rate does not much affect on temperature rise because these laser modalities have much shorter heat diffusion time than the temporal length of each off-pulse. This model works as a tool to understand the photothermal effect in the laser-tissue interaction.

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A Theoretical Study for the Thermal Diffusivity Measurement Using Photothermal Deflection Scheme (광열편향법을 이용한 열확산계수 결정에 대한 이론적 연구)

  • 전필수;이은호;유재석;목재균;최강윤
    • Journal of Energy Engineering
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    • v.10 no.1
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    • pp.63-70
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    • 2001
  • 재료의 열확산계수를 비접촉적인 방법으로 구하기 위하여 광열편향법에 대한 3차원 모델을 해석하였다. 이 방법은 가열빔이 재료에 광학적으로 흡수될 때 검사빔의 초기궤적이 시편과 시편주의 매질의 온도상승으로 인하여 나타나는 굴절지수의 구배에 의하여 검사빔이 편향되는 원리를 이용하는 것이다. 기존의 연구에서는 주로 가열빔과 검사빔의 상대거리를 변화시키면서 편향의 위상각을 측정하여 열확산계수를 결정하였다. 하지만 본 연구에서는 고정된 상대거리에서 가열빔의 변조주파수를 변화시키면서 편향의 위상각을 계산하여 열확산계수를 구할 수 있는 관계식을 제시하였다. 본 연구에서 제시한 열확산계수 결정 방법은 다른 방법에 비하여 실험과 해석이 간단하고 비교적 측정하기가 어려운 상대거리에 영향을 받지 않는 방법이다.

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Photoprimary Processes and Nanometer-Nanosecond Morphological Dynamics of Polymer Films Studied by Pump and Probe Measurement

  • Mito, Takashi;Masubuchi, Tomokazu;Tada, Takuji;Fukumura, Hiroshi;Masuhara, Hiroshi
    • Journal of Photoscience
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    • v.6 no.3
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    • pp.109-115
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    • 1999
  • Intense excimer laser irradiation of polymer films results in expansion and the following contraction , recovering ithe initial flat surface. The morphological dynamics is meausred directly by nanosecond time-resolved interferometry for polystyrene(PS), polyurethane, and polyimide films. The expansion proceeds with a speed of a few nm/ns , while the contraction depends upon the polymer ; very low contraction for PS, rapid 2 component shrinking for polyurethane, and rapid monotonous decay for polymide. These characteristic behavior are considered from viewpoints of interpenetrating structures of polymers, glass-rubber phase transitioni, thermal diffusion, and photothermal mechanism.

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Laser Ablation : Fundamentals and applications in Micropatterning and Thin Film Formation

  • J. Heitz;D. Bauerle;E. Arenholz;N. Arnold;J.T. Dickinson
    • Journal of Photoscience
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    • v.6 no.3
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    • pp.103-108
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    • 1999
  • We present recent results on ablation mechanism, single-pulse laser micropatterning , pulsed-laser deposition(PLD) and particulates formation accompanying laser ablation, with special emplasis on polymers, in particular polymide, (PI), and polytetrafluoroethylene, (PTFE). Ablation of polymers is described on the basis of photothermal bond breaking within the bulk material. Here, we assume a first order chemical reaction, which can be described by an Arrhenius law. Ablation starts when the density of broken bonds at the surface reaches a certain critical value. Single-pulse laser ablation of polyimide shows a clear-length dependence of the threshold fluence. This experimental result strongly supports a thermal ablation model. We discuss the various possibilities and drawbacks of PLD and describe the morphology, physical properties and applications of PTFE films.

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Analysis of photothermal response in a two-dimensional semiconducting material thermally excited by pulse heat flux

  • Saeed, Tareq;Abbas, Ibrahim
    • Structural Engineering and Mechanics
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    • v.82 no.4
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    • pp.469-476
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    • 2022
  • A mathematical model of Lord-Shulman photo-thermal theorem induced by pulse heat flux is presented to study the propagations waves for plasma, thermal and elastic in two-dimensional semiconductor materials. The medium is assumed initially quiescent. By using Laplace-Fourier transforms with the eigenvalue method, the variables are obtained analytically. A semiconductor medium such as silicon is investigated. The displacements, stresses, the carrier density and temperature distributions are calculated numerically and clarified graphically. The outcomes show that thermal relaxation time has varying degrees of effects on the studying fields.