• 제목/요약/키워드: phototherapy

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Phototherapy in Allergic Rhinitis: From In Vitro Studies to Clinical Trials

  • Yoo, Shin Hyuk;Chung, Young-Jun;Bae, Jun-Sang;Mo, Ji-Hun
    • Medical Lasers
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    • 제9권2호
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    • pp.95-102
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    • 2020
  • Phototherapy has a profound immunosuppressive effect and is widely used for the treatment of inflammatory skin diseases. Since allergic rhinitis (AR) shares several common pathologic features with atopic dermatitis, intranasal phototherapy is a novel approach for treating AR. Phototherapy reduces the antigen presenting capacity of dendritic cells, induces apoptosis of immune cells, and inhibits synthesis and release of pro-inflammatory mediators from inflammatory cells. The effectiveness of phototherapy for AR has been extensively researched: from in vitro studies to several clinical trials. Data indicates the potential of intranasal phototherapy as an alternative treatment for AR as well as other inflammatory mucosal diseases. In this review, we introduce the in vitro, in vivo studies, and clinical trials which demonstrated the effect of phototherapy on AR.

알레르기 비염의 비강 내 광 치료 : 체계적 문헌고찰 (Intranasal Phototherapy for Allergic Rhinitis : a systematic review)

  • 강정인;민경진;이동효
    • 한방안이비인후피부과학회지
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    • 제33권4호
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    • pp.55-73
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    • 2020
  • Objectives : We investigated the effectiveness and safety of intranasal phototherapy for allergic rhinitis (AR). Methods : We searched 8 electronic databases (PubMed, Cochrane Library, CNKI, CiNii Articles, OASIS, NDSL, KISS, KMbase) to identify randomized controlled trials (RCTs) that reported the use of intranasal phototherapy for AR from their inception until May 30, 2020. Two investigators independently searched, collected, and screened the RCTs. We performed data extraction and evaluation for risk of bias using the Cochrane risk-of-bias tool. Results : This study included 12 RCTs; six studies compared intranasal and sham phototherapy, of which four studies reported a significant inter group difference and two studies reported a significant difference partially. No significant changes in symptoms were observed between the phototherapy and conventional therapy groups. The phototherapy and concurrent acupuncture treatment group showed a significantly higher effectiveness rate compared with the group that received only acupuncture. Both the phototherapy and laser acupuncture group showed significant improvement in the symptom severity scale scores. Six studies reported mild adverse effects, such as dryness and nasal pain in the intranasal phototherapy group; however, no severe adverse effects were reported. Conclusions : This study confirmed the safety and effectiveness of intranasal phototherapy for symptom relief and improved quality of life in patients with AR. However, further studies are needed on this topic in order to demonstrate it clearly.

신생아 황달의 광선 요법 투여시간에 따른 혈청 빌리루빈 하강 효과 (The Effect of Radiation hours on Serum Total Bilirubin Decrements in the Phototherapy for Neonatal Physiologic Jaundices.)

  • 이자형
    • 모자간호학회지
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    • 제3권2호
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    • pp.95-101
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    • 1993
  • The purpose of this study is to define the effect of radiation hours on the physiologic jaundice infants. Since there in no full explanation of the way of phototherapy. Data was collected from February, 1993 through August, 1993 at E University Hospital. The subjects consisting of 179 normal newborn who is to receive phototherapy due to bilirubinemia in the early postnatal period. Six groups compared the effectiveness of phototherapy based on hours of radiation ; 6hrs, 9hrs, 12hrs, 15hrs, 18hrs, 21hrs. The results were as follows 1) Effectiveness of phototherapy which means serum total bilirubin decrements were significantly different in groups (F=9.812 p=.000). And follow up study was showed the subset in less than 15hrs groups and more than 15hrs groups. 2) There was no significant difference on the effect of phototherapy between aged after birth. 3) An hours of radiation and the number of stools was not revealed the relationship. The results obtained from this study suggest that 15hrs radiation per day is effective in phototherapy. In the furture, more replication of this study will be contribute for neonatal nursing care.

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사진치료 집단상담 프로그램이 여중생의 자기지각 및 자아존중감 향상에 미치는 효과 (Effect of a Group Counseling Program With Phototherapy on Enhancing the Self-Perception and Self-Esteem of Female Middle School Students)

  • 김수지;조경숙
    • 아동학회지
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    • 제38권2호
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    • pp.177-190
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    • 2017
  • Objective: The purpose of this study was to verify the effectiveness of a group counseling program with phototherapy for enhancing the self-perception and self-esteem of female adolescents. Methods: The participants of this study were 40 female middle school students with 20 in the experimental group and 20 in the control group. We conducted an 8-week program with a 4-week follow-up session for the participants. Collected data were analyzed with t-tests, ANCOVA, and ANOVA with PASW Statistics 18.0 (SPSS Inc., Chicago, IL). Results: The findings showed that the self-perception and self-esteem of the experimental group increased after the program whereas the control group showed no difference. In addition, the phototherapy group counseling program showed that the treatment effect was maintained even after 4 weeks. Conclusion: The group phototherapy program helped the female middle school students' to build a more positive self-concept, with respect to both self-perception and self-esteem.

Burn Wound Successfully Treated with 830-nm Light Emitting Diode Phototherapy Combined with Epidermal Growth Factor Solution

  • Lee, Hae-Jin;Kim, Young Koo
    • Medical Lasers
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    • 제8권2호
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    • pp.94-96
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    • 2019
  • Burns are one of the most extensive injuries of soft tissues as well as skin, occasionally resulting in extensive, deep wounds and death. Burn wounds can lead to severe physical and psychological distress because of excessive scarring and skin contractures. Treatment of burn wounds has always been a challenging problem and many different methods have been used to treat such injuries. We report here on treating a patient with a burn wound using 830-nm light emitting diode (LED) phototherapy combined with epidermal growth factor (EGF) solution. After five daily sessions of LED with EGF solution treatment, the patient demonstrated nearly complete improvement with no remarkable side effects. We suggest that LED phototherapy combined with EGF solution could be an effective and safe treatment option for treating burn wounds.

토끼에서의 청형광 광선에 의한 실험적 급성 망막독성 (Acute Phase Retinal Phototoxicity Induced by Blue Fluorescent Light)

  • 박영훈;차순철;한덕기
    • Journal of Yeungnam Medical Science
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    • 제12권1호
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    • pp.75-83
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    • 1995
  • 광선치료는 신생아 황달의 효과적인 치료방법이나 광선에 의한 망막손상을 예방하기 위해 양안에 적절한 차폐를 실시하여야 한다. 광선치료후 급성기의 망막 손상정도와 차폐의 역할을 조사하기 위하여, 저자들은 토끼를 이용하여 광선치료시간, 조사방법, 차폐 유무 등을 변화 시키면서 광선치료를 실시하고 즉시, 간접검안경을 이용한 안저검사와 전자현미경 검사를 실시하여 광선치료후 수시간에서 수일후에 검사한 보고들과 비교 하였다. 모든 실험 토끼에서 안저검사상 정상소견을 나타 내었으나, 전자 현미경 검사상 12시간 이상 조사한 모든 실험군에서 광수용체 부종 및 망막내층의 부종 및 팽윤이 있었으나 광선치료후 수일이 경과한 후 검사하였던 경우에서 볼 수 있었던 광수용체 배열의 변화, 광수용체 내외절의 파괴, microvilli의 확장및 유착 등의 소견은 볼 수 없었고, 노출시간이 증가 할수록 손상의 정도가 심해졌으며, 광선 조사량이 같은 경우 간헐적인 방법으로 조사를 실시한 경우에서 망막손상이 심한 것으로 나타났다. 산동시킨 경우에서, 손상의 정도는 산동시키지 않은 경우와 비슷 하였으나 손상의 범위가 더 넓게 관찰 되었으며 차폐를 실시한 경우 망막손상을 예방할 수 있었다.

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알레르기 비염의 비강 내 광치료에 관한 논문 경향 분석 (Reviewing Research on the Application of Intranasal Phototherapy in Allergic Rhinitis)

  • 이동효;김남권;송정모
    • 한방안이비인후피부과학회지
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    • 제27권1호
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    • pp.99-116
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    • 2014
  • Objective : The purpose of this study is to analyze research trends on the effects of intranasal phototherapy on allergic rhinitis. Methods : We searched potentially relevant studies using electronic databases, such as PubMed, OASIS, KMbase, and RISS. Our review of clinical research in allergic rhinitis was restricted to an analysis of papers published within the last 5 years. Independent reviewers extracted data using a standardized form. Results : In total, twenty four studies were included. Eleven studies were analyzed, and five randomized trials were identified. They suggested to be effective and no serious side-effects. Conclusions : Intranasal phototherapy can be effectively used as an alternative to the treatment of allergic rhinitis. Further studies are needed on this topic in order to demonstrate the effectiveness clearly.

고관절 골절 수술 이후 광선치료를 포함한 한방치료 3예 보고 (Korean Medical Treatment including Phototherapy after Hip Fracture Surgery: Three Case Reports)

  • 장호경;김형석;김수전;김세윤;박재현;배준형;신우철;윤예지;이한솔;정원석
    • 한방재활의학과학회지
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    • 제28권4호
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    • pp.113-124
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    • 2018
  • This study is designed to report three cases of postoperative care after hip surgery using conventional Korean Medicine treatments including phototherapy. Three patients undergone hip fracture surgery were treated with acupuncture, herbal medicine, and phototherapy. We used Visual analogue scale (VAS), EuroQol five dimension scale (EQ-5D), and hip disability and osteoarthritis outcome score (HOOS) to evaluate treatment effectiveness. After the treatment, VAS score was improved in all three cases, while EQ-5D and HOOS showed different results by items. EQ-5D (pain/discomfort) and HOOS (pain, symptoms, activities of daily living) were improved in all three cases. EQ-5D (self-care) and HOOS (quality of life) showed improvements in two cases. EQ-5D (mobility, usual activities, anxiety/depression) and HOOS (sports/recreation) were improved in one case. Conventional Korean Medicine treatments including phototherapy can be effectively used to alleviate pain and symptoms after hip fracture surgery.

Low Dose Ultraviolet Al (340-400 nm) Phototherapy for Erythrodermic Cutaneous T-cell Lymphoma

  • Uede, Koji;Hiroi, Akihisa;Nakamura, Tomoyuki;Kishi, Tomoo;Yamamoto, Yuki;Furukawa, Fukumi
    • Journal of Photoscience
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    • 제9권2호
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    • pp.503-505
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    • 2002
  • Three patients suffering from widespread erythrodermic cutaneous T-cell lymphoma were treated with low-dose UVAI phototherapy with a single dose of 20 - 30J/$cm^2$, resulting in cumulative doses of 520 - 1890 J/$cm^2$. Two patients showed complete responses, while other had a partial improvement.

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Effect of Synbiotic on the Treatment of Jaundice in Full Term Neonates: A Randomized Clinical Trial

  • Ahmadipour, Shokoufeh;Baharvand, Parastoo;Rahmani, Parisa;Hasanvand, Amin;Mohsenzadeh, Azam
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제22권5호
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    • pp.453-459
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    • 2019
  • Purpose: Jaundice accounts for most hospital admissions in the neonatal period. Nowadays, in addition to phototherapy, other auxiliary methods are used to reduce jaundice and the length of hospitalization. This study aimed to investigate the effect of probiotics on the treatment of hyper-bilirubinemia in full-term neonates. Methods: In this randomized clinical trial, 83 full-term neonates, who were admitted to the hospital to receive phototherapy in the first 6 months of 2015, were randomly divided into two groups: synbiotic (SG, n=40) and control (CG, n=43). Both groups received phototherapy but the SG also received 5 drops/day of synbiotics. Serum bilirubin, urine, stool, feeding frequency, and weight were measured daily until hospital discharge. A p-value<0.05 was considered statistically significant. Results: The mean total serum bilirubin in the SG was lower than that in the CG ($9.38{\pm}2.37$ and $11.17{\pm}2.60mg/dL$, respectively). The urine and stool frequency in the SG was significantly higher than that in the CG (p<0.05). The duration of hospitalization in the SG was shorter than that in the CG. Conclusion: Use of synbiotics as an adjuvant therapy had a significant treatment effect on jaundice in full-term neonates. Further studies including larger samples with long follow-up periods are essential to confirm the benefits of routine use of synbiotics in neonatal patients with jaundice.