• 한국광학회지
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• 제3권1호
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• pp.27-36
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• 1992

주파수 변조 분광학을 이용하여 레이저 주파수의 안정화를 위한 초공진기의 주파수 변조 신호를 검출하였다. 단일모드 헬륨네온 레이저와 1.5MHz로 구동하는 전기광학 변조기를 이용하여 150kHz($3 \times 10^{-10}$)의 고분해능을 갖는 초공진기의 주파수 변조 신호를 검출하였다. 또 위상민감검출기에 의한 기준신호의 위상이 각각 $0^{\circ}$(동위상, in-phase)$900^{\circ}$(직각ㅇ위상, quardrature-phase)인 두개의 주파수 변조 신호 성분을 X축 및 Y축으로 하는 위상공간에서 주파수 변조 신호의 벡터궤적을 측정하고 주파수 변조 분광 신호를 해석하였다. 측정한 벡터궤적은 잠김증폭기의 기준 신호의 위상과 같은 각도로 회전함을 알았고 Bjorklund등이 제시한 계수 측정 대신에 이 벡터 궤적을 이용할 경우 쉽게 주파수 변조 신호는 공진기 투과 중심 주파수 근방 $\pm$1.5MHz이내에서 헬륨 네온 레이저 주파수가 존재할 때 이 주파수를 공진기의 투과 곡선의 중심에 안정화할 수 있는 주파수 분별곡선으로 사용할 수 있음을 보였다.

• 한국동물위생학회지
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• 제18권3호
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• pp.13-28
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• 1995

This study was carried out to explore the most sensitive and useful method for simultaneous determination of five sulfa drugs(sulfamethazine, sulfamerazine, sulfamonomethoxine, sulfadimethoxine, sulfaquinoxaline) in livestock productions(pork muscle, bovine muscle, chicken muscle, milk ) by HPLC with UV detector and reverse phase column. The results obtained were as follows：1. For mobile phase acetonitrile-0.01M ammonium acetate (23：77) showed more applicable sensitivity and retention times than acetonitrile-1% acetic acid(23：77). Thus acetonitrile-0.01M ammonium acetate(23：77) selected and applied to the modification test, from which it was found pH 6.75 was the most adequate. 2. Optimal wavelength of UV for SMT(sulfamethazine), SMR(sulfamerazine), SMM(sulfamonomethoxine), SD(sulfadimethoxine), and SQ(sulfaquinoxaline) were 266, 266, 265, 269 and 250nm, respectively, and that for simultaneous application it was 263nm. 3. The average recovery rate by extractant(chloroform, dichloromethane, chlorform+dich-loromethane) in the classic method was not significantly different(p>0.05) but that by chloroform higher than the others. Thus chloroform was found to be adequate as extractant in this classic method. 4. The average recovery rate was 86.5% by the MSPD(matrix solid phase disperse) method, which was significantly higher than that by the classic method(p<0.05). Also the recovery rates by method were significantly different(p<0.05) in accordance with sample and type of drug. The MSPD method was much superior to classic method on clean-up.

• Biomolecules & Therapeutics
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• 제15권2호
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• pp.123-126
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• 2007

A sensitive, simple and highly selective liquid chromatography method of determination for extraction of pseudoephedrine hydrochloride from Allegra D tablet was developed. The chief benefit of the present method is the minimal sample preparation, as the procedure is only filtering through pore syringe filter. Two drugs (pseudoephedrine hydrochloride, fexofenadine) were separated on a C$_{18}$ column and analyzed by high performance liquid chromatography (HPLC). The method had a chromatographic run time of 8.0 min. 1 ml of pseudoephedrine hydrochloride solution (1 mg/ml) was filtered through 0.22 um pore syringe filter. 50 ul of filtering solution was injected to HPLC pump and we knew the retention time (1.85 min) of separating of pseudoephedrine hydrochloride using UV detector at 280 nm. We used C$_{18}$ column (4.6 mm${\times}$250 mm), mobile phase solution (<0.05 mol/L NaH$_2$PO$_4$, 2 ml/L H$_3$PO$_4$>/CH$_3$CN / sodium dodesyl sulfate = 60 ml / 40 ml / 1 g). We separated psedoephedrine hydrochloride at run time of 1.85 min from Allegra D tablet solution (1 mg/ml) filtered through 0.22 um pore syringe filter using UV detector at 280 nm. Flow rate was set at 1.0 ml/min and the column temperature was set at 40$^{\circ}C$. Psedoephedrine hydrochloride solution (1 mg/ml) separated from Allegra D tablet was filtered through 0.22 um pore syringe filter and injected 50 ul. We confirmed the peak of psedoephedrine hydrochloride at same retention time and the separating solution was freeze-dried. In conclusion, A simple isocratic reverse-phase HPLC method has been developed that provides excellent separation of pseudoephedrine from Allegra D tablet.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 C
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• pp.1848-1850
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• 2004

변압기에 사용되는 절연유의 열화정도를 변압기의 운전정지 없이 실시간으로 측정할 수 있는 전기용량을 이용한 센서를 개발하였다. 개발된 전기용량형 센서는 3-전극형의 구조와 변압기에 센서의 외부상자가 접지 될 때 2중의 정전차폐가 되도록 하여 외부로부터의 잡음에 영향을 받지 않도록 하였다. 또한 변압기에서 절연유의 온도변화에 따른 유전율 변화를 보상하기위하여 기준용 센서와 측정용 센서를 한개의 변압기에 장착함으로 온도보상이 되도록 하였다. 제작된 센서는 변압기에서 절연유의 사용기간에 따른 유전율의 변화를 정확히 측정하였으며, 절연유의 체적저항의 변화도 감지 할 수가 있다. 따라서 센서에서 출력되는 신호를 phase sensitive detector를 사용하여 유전율의 변화로 혹은 체적저항의 변화로도 나타내 보일 수가 있다.

• 비파괴검사학회지
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• 제26권6호
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• pp.380-389
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• 2006

A new laser-based ultrasonic receiver that is based on multi-channel interferometry is shown to be well suited for robust and sensitive detection of ultrasound in industrial environment. The proposed architecture combines random-quadrature detection with detector arrays and parallel multi-speckle processing. The high sensitivity is reached, thanks to the random phase distribution of laser speckle caused by surface roughness. High-density parallel signal processing is achieved by using a simple demodulation technique based on signal rectification. This simple detection scheme is also demonstrated for rejection of the laser intensity noise, making possible the use of lower cost laser without reduction in performances. Results demonstrating this new principle of operation and its performances are presented.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2004년도 Asia Navigation Conference
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• pp.29-36
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• 2004

The paper describes recent experimental results on the development of Digital Magnetic Compass (DMC), which can provide smart automatic correction functions to the magnetic interferences. The design methodology of magnetic sensing circuit with ring-core fluxgate sensor is represented. The performance results of the sensing circuits are discussed with error analysis by polynomial regressions. As test results, the sensing circuit filtered only the second harmonic signal that is proportional to the direction of earth's magnetic field, and it leads to the obtainment of bearing information. In addition, the total residual errors of DMC can be analyzed by the adoption of polynomial regressions. It shown that the possibility of high precise DMC, in the future.

• 한국분무공학회지
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• 제20권4호
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• pp.230-235
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• 2015

The demands for reliable particle cloud temperature measurement exist in many process industries and scientific researches. Particle cloud temperature measurements depend on radiation thermometry at two or more color bands. In this study, we developed a sensitive, fast response and compact online infrared two-color probe to measure the temperature of a particle cloud in a phase of two field flow (solid-gas). The probe employs a detector contained two InGaAs photodiodes with different spectral responses in the same optical path, which allowed a compact probe design. The probe was designed to suit temperature measurements in harsh environments with the advantage of durability. The developed two-color probe is capable of detecting particle cloud temperature as low as $300^{\circ}C$, under dynamic conditions.

• Archives of Pharmacal Research
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• 제19권6호
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• pp.475-479
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• 1996

Diethylcarbamazine (DEC, 1-diethylcarbamyl-4-methylpiperazine) is an antiparasitic piperazine derivative used in the treatment of lymphatic filariasis caused by Wuchereria bancrofti, Brugia malayi or grugia timori. DEC-N-oxide is a major metabolite in humans and has antifilarial activity. In carrying out pharmacokinetic studies, gas chromatographic analysis of DEC in plasma can be complicated by the presence of the metabolite, since the thermally unstable DEC-N-oxide is converted back to a material which coelutes with DEC under the conditions of the analysis. We now report a method to separate DEC-N-oxide from DEC in plasma using solid phase extraction with subsequent gas chromatographic analysis using a nitrogen specific detector. One-diethylcarbamyl-4-ethylpiperazine (E-DEC) was the internal standard. The standard curve of DEC was linear in the range of 10 to 200 ng/ml as described by Y=0.0350+0.0128X, $R^2=0.999$. The limit of quantitation was 4 ng/mL. Reproducibility at 10, 100 and 200 ng/mL concentration points of the standard curve gave coefficient variations of 6.1%, 7.8% and 1.6%, respectively. The recovery following solid phase extraction was 99.3% for DEC and 94.8% for the internal standard. This sensitive and specific analytical method is suitable for pharmacokinetic studies of DEC.

• 비파괴검사학회지
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• 제14권4호
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• pp.237-243
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• 1995

고체 시료를 대상으로 하여 silicon wafer에는 $90^{\circ}$ wedge형 진동자를 사용하고 압전재료인 $LiTaO_3$에는 interdigital transducer(IDT)를 사용하였으며, knife edge를 이용한 광학적 검지(optical probing)법을 써서 표면탄성파의 발생 및 측정하는 기법으로써 재료에서의 표면탄성파의 감쇠를 검출하는 방법을 연구하였다. IDT1 및 IDT2로는 20.8 MHz와 14.5 MHz를, $90^{\circ}$ wedge형 진동자로부터는 20.0 MHz의 표면탄성파를 발생시켰으며 표면탄성파로 생기는 표면의 굴곡을 검출하는데 He-Ne laser beam을 이용하였다. Optical chopper로 변조시킨 laser beam을 같은 주파수로 변조시킨 표면탄성파에 입사시켜 산란되는 광을 같은 주파수로 동조된 lock-in amplifier로 검출하였다. 이와 같이 함으로써 검출할 표면탄성파와 검출에 사용된 laser beam 및 측정기기인 위상감지기(Phase Sensitive Detector : PSD)를 같은 주파수로 변조하여 동기시킬 수 있었으며 측정계를 단순화하였다. IDT1, IDT2에서 발생된 표면탄성과의 감쇠계수는 각각 $0.62{\sim}0.75dB/mm,\;0.60{\sim}0.72dB/mm$였으며 wedge형 진동자에서는 $0.83{\sim}1.28dB/mm$인 값을 얻었다.

• 대한환경공학회지
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• 제37권5호
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• pp.293-302
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• 2015

HNMs는 독성이 강한 소독부산물들 중의 하나로 최근에 다양한 연구가 진행되고 있다. 본 연구에서는 headspace-solid phase microextraction (SPME) 전처리장치와 GC-ECD를 이용하여 9종의 HNMs를 동시분석할 수 있는 분석법을 개발하였다. 9종의 HNMs에 대한 검출한계(LOD)는 90~260 ng/L였으며, 정량한계(LOQ)는 270~840 ng/L였다. 수돗물과 해수를 이용하여 시료수의 matrix 영향을 살펴본 결과, 9종의 HNMs에 대해 80%~127%의 양호한 회수율을 나타내어 시료수의 matrix에 영향을 받지 않았다. 또한, 본 연구에서 개발된 headspace SPME GC-ECD 분석법은 용매류를 이용한 별도의 전처리 과정이 필요하지 않아서 친환경적이며 간편하고 빠른 자동화된 방법으로 HNMs 분석에 적합한 것으로 나타났다.