• Title/Summary/Keyword: pharmaceutical

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Inhibitory Principles from Magnolia officinalis on Tumor Necrosis $Factor-{\alpha}$ Production in Lipopolysaccharide-Activated RAW264.7 cells

  • Cho, Jae-Youl;Park, Ji-Soo;Chae, Sook-Hee;Lee, June-Goo;Yoo, Eun-Sook;Baik, Kyong-Up;Lee, Jong-Soo;Park, Myung-Hwan
    • Natural Product Sciences
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    • v.5 no.2
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    • pp.70-74
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    • 1999

  • In the course of a search for tumor necrosis factor $(TNF)-{\alpha}$ inhibitory compounds from medicinal plants, we identified neolignans, honokiol and magnolol, from the alcoholic extract of Magnolia offcinalis as active inhibitory principles. These compounds dose-dependently inhibited $TNF-{\alpha}$ production without displaying cytotoxicity and their inhibitory activities measured by $IC_{50}$ values were 53.7 and $61.4\;{\mu}M$, respectively.

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CNS Activities of the Aqueous Extract of Hydrilla verticillata in Mice

  • Pal, Dilipkumar;Balasaheb, Nimse Satish;Khatun, Samina;Bandyopadhyay, Pranab Kumar
    • Natural Product Sciences
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    • v.12 no.1
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    • pp.44-49
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    • 2006

  • The aqueous extract of Hydrilla verticillata (AEHV) was tested for possible pharmacological effects on experimental animals. AEHV significantly potentiated the sleeping time of mice induced by standard hypnotics viz. pentobarbitone sodium, diazepam, and meprobamate in a dose dependent manner. AEHV showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with AEHV caused significant protection against strychnine and leptazol-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the aqueous extract of H. verticillata.

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