• Journal of Chest Surgery
• /
• v.6 no.1
• /
• pp.15-22
• /
• 1973

The definition of cancer, its diagnosis and its prognosis all depend upon description of growth. To the layman a synonym for cancer is a "growth". There are no quantitative terms for the description of growth or growth rate in clinical use. There has been no attempt to assign values that would define "rapidly" or "slowly" growing. Estimates of growth potentiality are implied in the descriptive phrases "poorly differentiated" or "well differentiated", "highly malignant" or "low grade malignancy". and in systems of grading. These qualifying terms represent a personal impression, clinically useful in prognosis, but relative in nature. They do not lend themselves to uniform application or precise measurement for purpose of comparison. Growth is related to size and time. The volume of tumor depends upon the duration of the period of growth and the rate of growth. If the interval and change in volume are known. the average growth rate can be determined. If the growth rate is determined, and assumed to be constant., the duration of a given tumor and the time of inception can be estimated. The commonest concept of the origin of cancer is that as a result of a mutation involving a single cell, succeeding divisions of cells establish a colony with the characteristics recognizable as cancer. If the growth rate of the hypothetical tumor were constant it could be described in terms of "tumor volume doubling time". In the department of thoracic surgery of St. Mary hospital in Catholic Medical College, a clinical evaluation for the growth rate, degree of malignancy, resectability and prognosis was done on a total 24 cases of primary bronchogenic carcinoma which contour was significant on the chest X-ray film as possible estimating the tumor volume doubling time. The following results were obtained: 1. In the cases of 6.0cm or more in diameter of minor size at operation the resectability rate was lower and in the cases of 60 days or more in the tumor or volume doubling time the resectability rate was higher. 2. If differentiation of cancer cells was lower graded in tissue pathology, the tumor volume was shorter and the resectability rate was lower. 3. The tumor volume doubling time of the primary bronchogenic carcinoma occured more over 60 years of age was slightly shorter than under 60 years of age. 4. The tumor size at operation was more important to evaluate the survival time and prognosis than the tumor volume doubling time because the tumor growth was not always constant, we presume.mor volume doubling time because the tumor growth was not always constant, we presume.

• The Transactions of the Korea Information Processing Society
• /
• v.3 no.4
• /
• pp.877-882
• /
• 1996

The effects of periodic and chaotic behaviour in the Bonhoeffer-Van der Pol (BVP) oscillation of the nerve membrane driven by a periodic stimulating current A1 coswtare investigated through hardware implementation.For hardware implementation of the BVP model. real element values were escaled with computer simulation results to determine the parameter real value.As the parameter A1 varied in the range 0 to 1.3, the BVP model showed an ordinary and reversed period-doubling cascade and a chaotic state. At the low driving amplitude ofa1 the period-doubling showed and at the high driving amplitude of A1 the chaotic state occured. To analyse the BVP model for chaotic behaviour Phase Plane, Time series are used to verify that properties.

• Wind and Structures
• /
• v.7 no.4
• /
• pp.265-280
• /
• 2004

This paper presents some fundamental results on the dynamics of the periodic Karman wake behind a circular cylinder. The wake is treated like a dynamical system. External forcing is then introduced and its effect investigated. The main result obtained is the following. Perturbation of the wake, by controlled cylinder oscillations in the flow direction at a frequency equal to the Karman vortex shedding frequency, leads to instability of the Karman vortex structure. The resulting wake structure oscillates at half the original Karman vortex shedding frequency. For higher frequency excitation the primary pattern involves symmetry breaking of the initially shed symmetric vortex pairs. The Karman shedding phenomenon can be modeled by a nonlinear oscillator. The symmetrical flow perturbations resulting from the periodic cylinder excitation can also be similarly represented by a nonlinear oscillator. The oscillators represent two flow modes. By considering these two nonlinear oscillators, one having inline shedding symmetry and the other having the Karman wake spatio-temporal symmetry, the possible symmetries of subsequent flow perturbations resulting from the modal interaction are determined. A theoretical analysis based on symmetry (group) theory is presented. The analysis confirms the occurrence of a period-doubling instability, which is responsible for the frequency halving phenomenon observed in the experiments. Finally it is remarked that the present findings have important implications for vortex shedding control. Perturbations in the inflow direction introduce 'control' of the Karman wake by inducing a bifurcation which forces the transfer of energy to a lower frequency which is far from the original Karman frequency.

• Proceedings of the KSRS Conference
• /
• v.1
• /
• pp.340-343
• /
• 2006

Remote sensing science is a rapidly growing field of Earth sciences. Since emergence and to present day, an extensive literature has evolved which traces the wide application of remote sensing in human activities. According to the ISI Web of Science in the 1975-2005 time span more then 20,000 papers were published on remote sensing. The number of papers grew exponentially with doubling period of about 6 years. Notwithstanding all specialized proceedings, there is a lot more remote sensing papers published in a vast list of source titles (up to 350 proceedings). Only 25% of retrieved papers are published in 10 proceedings which ISI assigns to subject category of remote sensing. In 2005 all these proceedings published 1291 articles and received cca 24,000 citations. Average impact factor of the proceedings is equal to 1.181 and average cited half-life is 7.1. It means that an average paper in remote sensing proceedings is cited more then once per year and half of citations the paper receive within the next 7 years after publication. The time line of remote sensing periodicals issued in 1927-1995 shows an exponential growth with doubling period about 15 years. After 1995 there is a prominent deviation from the exponential curve which shows the demand saturation for specialized proceedings. The features revealed are discussed in terms of dynamics and impact of remote sensing in current Earth sciences development.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.24 no.9
• /
• pp.1210-1218
• /
• 2000

Thermal convection in a horizontal annulus is considered, and the bifurcation phenomena of flows from time-periodic to chaotic convection are numerically investigated. The unsteady two-dimensional streamfunction-vorticity equation is solved with finite difference method. As Rayleigh number is increased, the steady flow bifurcates to a time-periodic flow with a fundamental frequency, and afterwards a period-tripling bifurcation occurs with further increase of the Rayleigh number. Chaotic convection is established after a period-doubling bifurcation. A periodic convection with period 4 appears after the first chaotic convection. At still higher Rayleigh numbers, chaotic flows reappear.

• Biomaterials and Biomechanics in Bioengineering
• /
• v.3 no.2
• /
• pp.105-114
• /
• 2016

The purpose of this study is to evaluate the effects of cryopreservation on dental pulp-derived stem cells (DPSC) viability over a period of three years. Dental pulp-derived stem cells were isolated and cultured from thirty-one healthy teeth. DPSC isolates were assessed for doubling-time and baseline viability prior to cryopreservation and were assessed again at three time points; one week (T1), 18 months (T2), and 36 months (T3). DPSC can be grouped based on their observed doubling times; slow (sDT), intermediate (iDT), and rapid (rDT). Viability results demonstrated all three types of DPSC isolates (sDT, iDT and rDT) exhibit time-dependent reductions in viability following cryopreservation, with the greatest reduction observed among sDT-DPSCs and the smallest observed among the rDT-DPSC isolates. Cryopreserved DPSCs demonstrate time-dependent reductions in cellular viability. Although reductions in viability were smallest at the initial time point (T1) and greatest at the final time point (T3), these changes were markedly different among DPSC isolates with similar doubling times (DTs). Furthermore, the analysis of various DPSC biomarkers - including both intracellular and cell surface markers, revealed differential mRNA expression. More specifically, the relative high expression of Sox-2 was only found only among the rDT isolates, which was associated with the smallest reduction in viability over time. The expression of Oct4 and NANOG were also higher among rDT isolates, however, expression was comparatively lower among the sDT isolates that had the highest reduction in cellular viability over the course of this study. These data may suggest that some biomarkers, including Sox-2, Oct4 and NANOG may have some potential for use as biomarkers that may be associated with either higher or lower cellular viability over long-term storage applications although more research will be needed to confirm these findings.

• Journal of KSNVE
• /
• v.8 no.6
• /
• pp.1144-1149
• /
• 1998

A two degree-of-freedom model of suspended cables is studied for forced resonant response. The method of averaging is used to obtain first-order approximations to the response of the system. A bifurcation analysis of the averaged system is performed in the case of 2-to-1 internal resonance. Nonlinear coupled-mode motions are found to bifurcate from single-mode responses and further bifurcate to limit cycle motions via Hopf bifurcations. The limit cycle solutions undergo period doubling bifurcations to chaos.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2004.08a
• /
• pp.48-48
• /
• 2004

• The Bulletin of The Korean Astronomical Society
• /
• v.36 no.2
• /
• pp.123-123
• /
• 2011

Kepler 우주망원경으로 관측한 RR Lyr 변광성의 경우 절반 이상이 Blazkho 효과를 보이며, Period-doubling 등 새로운 사실이 알려졌다. KMTNet 망원경을 이용한 24시간 연속된 BVRI 다파장 관측은 구상성단 내의 많은 RR Lyr 변광성에서 이러한 현상을 밝히고, 중원소 함량, 주기변화 등 물리량을 얻는데 큰 도움이 될 것이다. 또한 구상성단에서 많이 관측되는 SX Phe 변광성과 같은 단주기 변광성의 체계적인 탐사 등에도 유용할 것이다.

• Journal of the Korean Vacuum Society
• /
• v.21 no.5
• /
• pp.249-257
• /
• 2012

Nonlinear dynamical behaviors of plasma in the Pierce diode are investigated by a numerical code developed using a one dimensional fluid model. The plasma in Pierce diode is alternately stable and unstable as Pierce parameter is changed. The dynamical characteristics of neutral and non-neutral Pierce system is examined analytically and numerically. It alternately has growing and oscillatory mode as Pierce parameter varies. As Pierce parameter is decreased, each oscillatory mode undergoes a sequence of subharmonic period-doubling bifurcation and then culminate in a chaotic strange attractor. The analysis for this nonlinear behavior can be used as a model for understanding of beam-plasma interaction in more complex geometries and a data for chaos control.