• Tuberculosis and Respiratory Diseases
• /
• 제57권6호
• /
• pp.599-603
• /
• 2004

원발성 악성 심막 중피종은 예후가 극히 불량하며 심막에 생기는 중배엽성 기원의 매우 드문 종양으로 주로는 심막염, 심낭 삼출액의 증상으로 나타나며 심낭 개창술 및 심낭 삼출액 세포진 검사에도 종양세포를 증명하기가 어렵고 이런 경우 심장 초음파와 흉부 전산화 단층 촬영만으로 심낭삼출액 및 심막염의 진단외에 양성 심막염과 악성 심막질환의 감별 진단이 어렵다. 최근 전신 양전자 방출 단층촬영(FDG-PET)이 양성과 악성 질환을 감별하는데 널리 이용되고 있으며 이는 원발성 악성 심막 종양의 감별 진단에도 유용하게 사용될 수 있다. 저자들은 호흡곤란과 흉통을 증상으로 내원한 55세 여자 환자에서 전신 양전자 방출 단층촬영(FDG-PET)을 이용하여 심막에 국한된 FDG 고흡착 소견의 원발성 심막 종양을 진단하고 조직검사상 원발성 악성 심막 중피종으로 진단하고 치료한 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
• /
• 제38권8호
• /
• pp.576-578
• /
• 2005

38세 남자 환자가 호흡곤란과 좌측의 어깨 통증을 주소로 내원하였다. 심장 초음파 등의 검사로 이의 원인을 결핵성 심낭염으로 판단하고 약 1년 반 동안 내과 치료를 하였다. 내과 치료에 반응하지 않아 심낭 절제술을 시행하였고, 이를 통한 조직 검사 결과 악성 심낭 중피종으로 진단하였다. 종양은 심외막 및 심근에 심하게 유착되어 있어 완전 절제는 불가능하였으며, 환자는 현재 항암제 치료를 받고있다.

• Journal of Chest Surgery
• /
• 제38권5호
• /
• pp.392-395
• /
• 2005

Primary pericardial mesothelioma is extremely rare and the incidence is low among the mesotheliomas that originate from other parts of the body. The prognosis of the tumor is unfavorable due to its late presentation, difficulties in early diagnosis and complete resection, and the limited treatment options. Herein, we report a case of pericardial mesothelioma. The patient is a 55-year-old woman who presented with chronic cough and dyspnea. During the examination, pericardial effusion was found and pericardial window formation was followed. She visited our hospital because of persistent dyspnea, with right shoulder and chest pain. Four discrete masses were discovered in the chest CT. CT guided-fine needle aspiration biopsy was negative for malignancy. Right exploratory thoracotomy and partial resection of 3${\times}$3 cm mass abutting pericardium was performed and was histologically diagnosed as malignant mesothelioma, biphasic type. Pericardial mesothelioma is rare, but it should be remembered as an important differential diagnosis in patients with persistent pericardial effusion and symptoms of dyspnea and constrictive pericarditis.

• 한국임상수의학회지
• /
• 제41권3호
• /
• pp.170-177
• /
• 2024

An adult male dog was presented for hemorrhagic pericardial effusion. Echocardiography and computed tomography revealed nodule-like lesions on the pericardium. Cytology of pericardial effusion and excisional pericardial lesions indicated neoplastic effusion. Histopathology indicated an inflamed neoplasm with a primary differential diagnosis of hemangiosarcoma and malignant mesothelioma (MM). Immunohistochemistry showed that atypical cells were positive for cytokeratin and vimentin, but negative for CD31, strongly favoring pericardial MM. Postoperative NT-proBNP level remained increased, which led to the administration of epirubicin to minimize potential cardiotoxicity. During the 4 cycles of epirubicin treatment, a total cumulative dose of 108 mg/m² was administrated and no effusion recurrence was observed. After a month post-completion of chemotherapy, however, pleural effusion was detected with cardiac masses. The owner requested no further diagnostic investigations and chemotherapy. Due to deteriorating conditions, the dog died 132 days after the first presentation. Our case is the first notable attempt to treat canine malignant mesothelioma with epirubicin, providing the clinicopathologic, diagnostic routine, and clinical course of the affected dog.

• Journal of Chest Surgery
• /
• 제30권4호
• /
• pp.432-436
• /
• 1997

심낭의 원발성 악성 중피종은심종양보다더 드문 질환으로 비록 와그너에 의해 1870년 처음 기술되었지만, 중피종이라는 용어는 아담에 의해 1910년 처음 사용되었다 대부분의 보고된 예들은 부검에 의해 진단 되었다. 생존시 진단은 세계적으로도 단지 40례 정도에 불과하다. 코헨에 의하면 부검한 예 중 500,000례에서 2.2례의 빈도를 보고하였다. 최근의 고찰된 분석을 보면 생존시 진단율은 전체 예 중 19-25%정도이다. 이 보고서는 심낭의 악성 중피종의 본 흉부외과학교실의 경험한 1예이다.

• Journal of Yeungnam Medical Science
• /
• 제3권1호
• /
• pp.301-306
• /
• 1986

저자들은 1986년 7월 2일 본 영남대학교 의과대학 부속 병원 내과에 입원한 혈액성 심낭 삼출액및 심막 비후 환자에서 심낭 개창술시 심막 조직 검사상 심막 악성 중피종으로 진단되고 급격한 임상 경과를 보이고 사망한 예를 경험하였다.

• Journal of Chest Surgery
• /
• 제15권1호
• /
• pp.118-123
• /
• 1982

Fourteen cases of pericardia I tumor were clinically experienced from June 1966 to July 1981, for 15 years in St. Mary's Hospital, Department of Thoracic and Cardiovascular Surgery, Catholic Medical College. There were three primary tumors of the pericardium, liposarcoma, teratoma and malignant mesothelioma, and 11 metastatic pericardial tumors. In metastatic pericardial tumors, eight were originated from the lung, one was breast, and the other two cases were unknown origin. There were 6 adenocarcinoma, one small cell carcionoma ~nd one alveolar cell carcinoma in 8 cases from the lung, and 5 male and 3 female patients were composed the metastatic pericardial cancer from the lung. In clinical symptoms were dyspnea in all cases, and 9 cases had the generalized edema and enlarged liver size. Six patients had been operated, three of the primary pericardial tumor and three of metastatic pericardial tumor. Two of the primary tumors were cured satisfactorily by the mass removal, but one died due to cardiac arrest at postoperative one day. In metastatic tumors, operation were performed as two pericardial window formation and one left lower lobectomy with pericardial fenestration, but one was died in second operative day. Other nine metastatic tumors were diagnosed by needle biopsy in one case and by cell block of effusion in eight cases.

• Journal of Chest Surgery
• /
• 제43권4호
• /
• pp.437-440
• /
• 2010

심장에서 발생한 중피종은 아주 드문 질환으로 초기에 비특이적인 증상으로 진단이 어렵다. 본원에서는 협착성 심막염으로 진단하여 심막 절제술을 시행후 중피종으로 확진된 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 4개월과 10년간의 호흡곤란을 호소하였고 흉부 전산화 촬영상 소량의 심낭 삼출액과 전체 심장을 둘러싸는 심막의 비후를 보였으나 뚜렷한 종괴의 소견은 보이지 않았다. 정중 흉골 절개하에 수술을 진행했으며 전반적으로 심막의 두께가 10 mm 이상 두꺼워져 있었다. 양측 횡격막신경을 경계로 하여 부분 심막 절제술을 시행하였다. 술후 조직검사상 악성 중피종으로 진단되었다. 첫번째 환자는 술후 7개월째 심막 주위로 재발하였으며 호흡 부전증으로 술후 11개월 째 사망하였고 두번째 환자는 항암치료후 술후 16개월째 생존하고 있다. 심막의 중피종은 아주 드문 질환이나 협착성 심막염과 비슷한 임상 양상으로 초기 감별 진단되어야 할 질환으로 보인다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권8호
• /
• pp.4169-4173
• /
• 2016

Background: Mesotheliomas are relatively rare tumors in Lebanon. The only previous study goes back to 14 years ago, when we published epidemiological characteristics of mesotheliomas in Lebanon, showing that the pleural location accounted for the vast majority of cases, with clear evidence of asbestos exposure from the Eternit factory of Chekka region. The objective of this current study was to estimate the incidence of mesothelioma in the past decade and to identify its epidemiological, clinical and therapeutic characteristics, making comparisons with our first study published in 2001. Materials and Methods: Between 2002 and 2014, patients diagnosed with malignant mesothelioma at Hotel-Dieu de France University Hospital were investigated. Epidemiological data focusing on asbestos exposure history were collected from medical records and interviews with the families. Results: A total of 26 patients were diagnosed with mesothelioma, 21 of which were successfully investigated. The mean age of these 21 patients is 62.5 (19-82). Only 3 (14.29%) are women. 18 (85.71%) were smokers. Among the 21 available mesotheliomas, 15 (71.4%) are pleural, while 5 (23.8%) are peritoneal and 1 (4.8%) pericardial. Only 60% of patients with pleural mesothelioma and 50% of those with an obvious exposure to asbestos lived and/or worked in Chekka region. The mean time of asbestos exposure in patients with mesothelioma is 24.5 (1-50) years and the mean latency is 37.4 (4-61) years. Of the 21 patients, 10 (47.6%) underwent surgery during their treatment, 16 (76.2%) received chemotherapy and 3 (14.3%) received best supportive care. Conclusions: Compared to the previous study (1991-2000), substantial changes in the epidemiology of mesothelioma in Lebanon were observed, such as an increase in peritoneal localizations and a lower correlation with Chekka region asbestos contamination.