• Korean Journal of Hospice Care
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• v.5 no.2
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• pp.15-21
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• 2005

Purpose: This study was designed to evaluate the perception of cancer in aspirants for hospice volunteer. Methods: Aspirants for hospice volunteer were surveyed by questionnaire before education of hospice program in September 2005 at Pyongan Hospice Center of Sam Anyang Hospital. The questionnaire was composed of total 28 items. Ten items were general characteristics and the remaining 18 items knowledge, attitude and practice of cancer and cancer pain. The data were analyzed by SPSS WIN 11.0 program using frequency, mean, percentage. Results: Eighty nine questionnaires were returned. There were 6 males and 83 females, and median age of aspirants was 46 years. Forty five aspirants(51%) had a cancer patient in th family or relatives and the others 44(49%) not. Forty eight(54%) had favorable attitude about modern clinical medicine for cancer treatment and the others 39(44%) unfavorable. Fifty eight(65%) had favorable attitude about complementary and alternative medicine for cancer treatment and the others 20(23%). In response to the question about 'How illness is a cancer', 25 aspirants(25%) responded to chronic disease, 42(47%) suffering incurable disease, the others 17(19%) death sentence, respectively. A number of aspirants had wrong knowledge and understanding of cancer, cancer pain and opioid analgesics. Seventy one percent aspirants feared cancer pain. Conclusion: The credibility to modern clinical medicine for cancer treatment was relatively low in aspirants for hospice volunteer compared with complementary and alternative medicine. They recognized a cancer as suffering incurable disease and death sentence than chronic disease. A number of aspirants had wrong knowledge of cancer, cancer pain and opioid analgesics. Therefore, further studies and trial will be warranted to evaluated the causes of these results and improve the credibility of modern clinical medicine for cancer treatment in general population.

• Journal of dental hygiene science
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• v.20 no.4
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• pp.206-212
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• 2020

Background: A Teachable Machine is a kind of machine learning web-based tool for general persons. In this paper, the feasibility of Google's Teachable Machine (ver. 2.0) was studied in the diagnosis of the tooth-marked tongue. Methods: For machine learning of tooth-marked tongue diagnosis, a total of 1,250 tongue images were used on Kaggle's web site. Ninety percent of the images were used for the training data set, and the remaining 10% were used for the test data set. Using Google's Teachable Machine (ver. 2.0), machine learning was performed using separated images. To optimize the machine learning parameters, I measured the diagnosis accuracies according to the value of epoch, batch size, and learning rate. After hyper-parameter tuning, the ROC (receiver operating characteristic) analysis method determined the sensitivity (true positive rate, TPR) and specificity (false positive rate, FPR) of the machine learning model to diagnose the tooth-marked tongue. Results: To evaluate the usefulness of the Teachable Machine in clinical application, I used 634 tooth-marked tongue images and 491 no-marked tongue images for machine learning. When the epoch, batch size, and learning rate as hyper-parameters were 75, 0.0001, and 128, respectively, the accuracy of the tooth-marked tongue's diagnosis was best. The accuracies for the tooth-marked tongue and the no-marked tongue were 92.1% and 72.6%, respectively. And, the sensitivity (TPR) and specificity (FPR) were 0.92 and 0.28, respectively. Conclusion: These results are more accurate than Li's experimental results calculated with convolution neural network. Google's Teachable Machines show good performance by hyper-parameters tuning in the diagnosis of the tooth-marked tongue. We confirmed that the tool is useful for several clinical applications.

• Restorative Dentistry and Endodontics
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• v.45 no.4
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• pp.45.1-45.8
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• 2020

Objective: The aim of this study was to introduce a gelatin/bovine serum albumin (BSA) tissue standard, which provides dissolution properties identical to those of biological tissues. Further, the study evaluated whether the utilization of endodontic activating devices led to enhanced phantom dissolution rates. Materials and Methods: Bovine pulp tissue was obtained to determine a benchmark of tissue dissolution. The surface area and mass of samples were held constant while the ratio of gelatin and BSA were varied, ranging from 7.5% to 10% gelatin and 5% BSA. Each sample was placed in an individual test tube that was filled with an appropriate sodium hypochlorite solution for 1, 3, and 5 minutes, and then removed from the solution, blotted dry, and weighed again. The remaining tissue was calculated as the percent of initial tissue to determine the tissue dissolution rate. A radiopaque agent (sodium diatrizoate) and a fluorescent dye (methylene blue) were added to the phantom to allow easy quantification of phantom dissolution in a canal block model when activated using ultrasonic (EndoUltra) or sonic (EndoActivator) energy. Results: The 9% gelatin + 5% BSA phantom showed statistically equivalent dissolution to bovine pulp tissue at all time intervals. Furthermore, the EndoUltra yielded significantly more phantom dissolution in the canal block than the EndoActivator or syringe irrigation. Conclusions: Our phantom is comparable to biological tissue in terms of tissue dissolution and could be utilized for in vitro tests due to its injectability and detectability.

• Korean Journal of Environment and Ecology
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• v.28 no.5
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• pp.566-573
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• 2014

Decay rate and nutrient dynamics during leaf litter decomposition of deciduous broad leaf Quercus mongolica and evergreen needle leaf Pinus densiflora were investigated for 69 months from December 2005 to September 2011 in Mt. Worak National Park as a part of National Long-Term Ecological Research Program in Korea. Percent remaining weight of Q. mongolica and P. densiflora leaf litter after 69 months elapsed was $35.4{\pm}2.3%$ and $16.1{\pm}1.3%$, respectively. Decomposition of P. densiflora leaf litter was significantly faster than that of Q. mongolica leaf litter. Decay constant (k) of Q. mongolica and P. densiflora leaf litter after 69 months elapsed was 5.97 and 10.50, respectively. Initial C/N and C/P ratio of Q. mongolica leaf litter was 43.1 and 543.9 respectively. After 69 months elapsed, C/N and C/P ratio of decomposing Q. mongolica leaf litter decreased to 8.7 and 141.2, respectively. Initial C/N and C/P ratio of P. densiflora leaf litter was 151.2 and 391.4, respectively. After 69 months elapsed, C/N and C/P ratio of decomposing P. densiflora leaf litter decreased to 22.9. and 136.5. respectively. Initial concentration of N, P, K, Ca and Mg in leaf litter was 9.30, 0.23, 2.36, 3.14, 1.11 mg/g in Q. mongolica, and 3.02, 0.09, 1.00, 3.84, 0.62 mg/g in P. densiflora, respectively. Initial concentration of N and P in Q. mongolica leaf litter was significantly higher than those in P. densiflora. After 69 months elapsed, remaining N, P, K, Ca and Mg in decomposing leaf litter were 73.8, 60.9, 17.2, 20.3, 35.1 % in Q. mongolica, and 69.5, 75.3, 12.3, 10.9, 10.8 % in P. densiflora, respectively.

• Korean Journal of Environment and Ecology
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• v.26 no.1
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• pp.74-81
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• 2012

Decay rate and nutrient dynamics during leaf litter decomposition of deciduous Quercus acutissima and evergreen Quercus mysinaefolia were studied for 24 months from December 2008 to December 2010 in Gongju, Chungnam Province, Korea. Percent remaining weight of Q. acutissima and Q. mysinaefolia leaf litter after 24 months elapsed was $46.3{\pm}5.4%$ and $37.8{\pm}2.5%$, respectively. Decomposition of evergreen Q. mysinaefolia leaf litter was significantly faster than that of deciduous Quercus acutissima leaf litter. Decay constant(k) of Q. acutissima and Q. mysinaefolia leaf litter after 24 months elapsed was 0.38 and 0.49, respectively. Initial C/N and C/P ratio of Q. mysinaefolia leaf litter was significantly lower than those of Q. acutissima leaf litter. Initial C/N and C/P ratio of Q. acutissima leaf litter was 46.8 and 270.9, respectively. After 24 months elapsed, C/N and C/P ratio of decomposing Q. acutissima leaf litter decreased to 22.5 and 104.2, respectively. Initial C/N and C/P ratio of Q. mysinaefolia leaf litter was 22.4 and 41.7, respectively. After 24 months elapsed, C/N and C/P ratio of decomposing Q. mysinaefolia leaf litter decreased to 16.7 and 89.7, respectively. Initial concentration of N, P, K, Ca and Mg in leaf litter was 8.31, 0.44, 4.18, 9.38, 1.37 mg/g in Q. acutissima, and 19.88, 2.73, 7.06, 8.24, 2.61 mg/g in Q. mysinaefolia, respectively. Initial concentration of N and P in Q. mysinaefolia leaf litter was significantly higher than those in Q. acutissima. After 24 month elapsed, remaining N, P, K, Ca and Mg were 100.91, 114.75, 32.99, 50.63, 15.51% in Q. acutissima, and 43.22, 11.35, 12.98, 82.22, 44.23% in Q. mysinaefolia, respectively. N and P in decomposing leaf litter was immobilized in Q. acutissima, and mineralized in Q. mysinaefolia.

• Clinical and Experimental Pediatrics
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• v.48 no.2
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• pp.186-190
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• 2005

Purpose : The purpose of this study was to evaluate the responses and toxicities of risk-adapted chemotherapy in pediatric intracranial germ cell tumors(IC-GCT). Methods : Fourteen patients who were diagnosed as IC-GCT from October 2002 to December 2003 received chemotherapy as an initial treatment modality. The low risk(LR) group was defined as follows : Pure germinoma and normal AFP level. Beta-hCG level 50 mIU/mL or less. The others belonged to the high risk(HR) group. Chemotherapy was composed of cisplatin, cyclophosphamide, etoposide and vincristine. Double doses of cisplatin and cyclophosphamide was used in HR patients. Results : Pathologic confirmation was done in all but one. Median age at diagnosis was 11.6 yr (1.2-18.7 yr), and nine patients belonged to the HR group. Tumor markers were normalized after chemotherapy in all patients whose tumor markers had been elevated. Four LR patients(80 percent) and seven HR patients(77.8 percent) showed complete response(CR) at the end of chemotherapy. An additional two of the three patients with partial response(PR) achieved CR after radiation therapy (RT), and the remaining one relapsed before RT. Four LR and all HR patients experienced infectious episodes that required hospitalization. Four of the nine HR patients(44.4 percent) suffered from tinnitus, three of whom developed sensorineural hearing loss. All but one are surviving, event-free, with a median follow-up of 13.9 mo(8.1-22.3 mo). Conclusion : Risk-adapted cisplatin-based chemotherapy was effective even in HR patients, but regimen modification seems to be necessary to avoid an unacceptably high toxicity rate.

• Korean Journal of Weed Science
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• v.11 no.1
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• pp.3-10
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• 1991

Several rice herbicides were evaluated to determine the herbicidal efficacy on dry seeded paddy rice. The time of herbicide application was within 1 day after seeding(DAS), 18 DAS, and 40 DAS. Under the upland conditions 30 DAS(before permanent flooding) dominant weed species were Echinochloa sp., Digitaria sp., Leptochla sp., weedy rice and other several annual broadleaved weeds belonging to Cruciferae, but after flooding Echinochloa sp., Aeschynomene sp., Eleocharis kuroguwai, Cyperus sorotinus, Ludwigia prostrata, Aneilema japonica were dominat. Early application (1 DAS) of thiobencarb, pyrazolate/butachlor, or chlomethoxyfen/butachlor resulted in very good herbicidal efficacy only during the first 30 days, but not thereafter. Application of propanil+butachlor on 18 DAS did not control the late occurring weeds effectively. Application of bentazone/quinchlorac on 40 DAS successfully suppressed weed growth throughout the remaining rice growing season and showed similar grain yield as hand weeded plot. Weed growth reduced the plant height, panicle number, 1000-grain weight, percent ripened grains, and grain yield of rice by 7, 82, 19, 55 and 87% respectively. There was a positive linear relationship between weed weight and lodging index of rice.

• The Korean Journal of Mycology
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• v.13 no.4
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• pp.227-233
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• 1985

Studies on the varietal resistance and effects of nutrients for fungal growth were carried out in order to obtain basic materials for breeding resistant variety and control measures of the red pepper anthracnose disease caused by Colletotrichum dematium f. sp. capsicum. Four cultivars such as Kumchang No. 2, Bulamhouse, Pakistan, Hongilpum were resistant among twenty-one pepper cultivars, and five cultivars including Taiwan pepper were moderate. The remaining twelve cultivars including H-038 and Saegochu were susceptible. These susceptible cultivars were mostly belonged to sweet taste cultivars. Glucose was known the best source for fungal growth, and near 3 percent of carbon concentration was the best for mycelial growth of the fungus. Conidial sporulation was rather decreased by adding high concentrations of C-source, whereas fungal dry weight was a positive tendency in proportion to increasing carbon concentrations. N-sources and vitamins were not remarkable as that for carbon, and rather a decreasing trend for mycelial growth by adding N-source. Especially, the lowest of mycelial growth was in the case of Czapek-Dox plus ammonium sulfate. The medium plus vitamins either niacin or thiamine was slightly increased to mycelial growth.

• Biomolecules & Therapeutics
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• v.10 no.2
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• pp.104-113
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• 2002

The effects of enzyme inhibitors and penetration enhancers on the permeation of leucine enkephalin (Leu-Enk) and its synthetic analog, [${D-ala}^2$]-leucine enkephalinamide (YAGFL) across the nasal, rectal and vaginal mucosae were evaluated. Enzyme inhibitors and penetration enhancers employed for Leu-Enk permeation study were amastatin(AM), thimerosal(TM) and ethylenediaminetetraacetic acid disodium salt(EDTA), and sodium taurodihydrofusidate (STDHF). Those for YAGFL permeation study were TM, benzalkonium chloride(BC) and EDTA, and STDHF, sodium deoxycholate(SDC), sodium glycholate(SGC), glycyrrhizic acid ammonium salt (GAA), L-$\alpha$-Iysophosphatidylcholine(LPC) and mixed micelle (MM, STDHF: linoleic acid = 15 mM : 5 mM). The addition of TM alone on the donor and receptor solutions for Leu-Enk permeation study across all the three kinds of mucosae failed to inhibit the degradation; it completely degraded in 6 hrs, and no permeation occurred. However, with addition of three kinds of inhibitors together, the fluxes across nasal, rectal and vaginal mucosae were $\20.7{pm}2.5$>/TEX>,$\0.3{pm}0.05$>/TEX> and $\1.4{pm}0.5$ $\mu$\mid$textrm{m}$/$\textrm{cm}^2$/hr, respectively. Moreover, the addition of STDHF in the presence of the above three inhibitors enhanced permeation across nasal, rectal and vaginal mucosae 1.3, 15 and 1.3 times, respectively. YhGFL also degraded in the donor and receptor solutions rapidly as time went. With mixed inhibitors of TM and EDTA, the percents of YAGFL remaining in the donor solutions facing nasal, rectal and vaginal mucosae were 69.7, 69.8 and 79.8%, respectively; the percent permeated increased to 10, 2.1 and 5.7%, respectively. The addition of STDHF in the presence of either BC/EDTA or TW/EDTA increased the permeation 2.2, 11.0 and 2.9 times, and 2.21, 14.0 and 2.7 times for nasal, rectal and vaginal mucosae, respectively. With SDC, SGC, GAA, LPC ud MM in the presence of TM/EDTA increased permeation; especially, they increased permeation across vaginal mucosae effectively, and the enhancement factors were 12.5, 7.6, 8.7, 5.7 and 5.5, respectively. The degradation extent of YAGFL was correlated with protein concentrations in the epidermal and serosal extracts. The flux of YAGFL across nasal mucosa increased dose-dependently.

• Applied Biological Chemistry
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• v.1
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• pp.55-61
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• 1960

The amino acid compositions of the protein and the nonprotein fractions obtained from a marine brown alga, 'Undaria pinnatifida' were determined by use of Ion Exchange Column Chromatography. The protein nitrogen in the alga was about ten times of the nonprotein nitrogen. Nonprotein fraction obtained from the extraction with 80 percent ethanol contains considerable amount of tree citrulline. Alanine content in the alga was the highest (about 1 per cent in dry weight) and one third of which was found in free state. The amino acid composition of the alga was well balanced and the content of the essential amino acids were relatively higher, than soybean protein. In addition, several peptide like substances were fractionated from nonprotein fraction, in which one way identified as a naturally occurring new tripeptide composed of alanine, glutamic acid and aspartic acid, and the remaining unknown substances are under investigation for the further information.