• Title/Summary/Keyword: penetrating

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Development of bio-fusion materials with skin penetrating property derived from Aurelia aurita (경피 침투율이 높은 보름달 물해파리 유래 바이오 융합 소재 개발)

  • Kim, Hyoung Sik;Seo, Hyo Hyun;Lee, Seo-Hui;Lim, Hyun Jung;Shin, Jeong Won;Kim, Seop Ri;Moh, Sang Hyun;Kim, Kwang-Hwan
    • Journal of the Korea Convergence Society
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    • v.8 no.1
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    • pp.35-42
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    • 2017
  • Previously, we reported LVH peptiede derived from Aurelia aurita as cosmecetuticals with anti-winkle activity. In this study, we synthesized pal-LVH using palmitic acid to enhance skin permeability of LVH and examined the effects as cosmeceuticals of pal-LVH. To evaluate these effects, we performed cell toxicity, wound healing, and patch test for skin irritation with LVH and pal-LVH and compared these results for their effects. As a result. pal-LVH was not showed in cytotoxicity and allergenic effect like as LVH. Besides, pal-LVH had almost same excellent anti-ageing properties in high concentration and anti-winkle effect in low concentrationwas as LVH. These results suggested synthesis of palimitic acid and LVH did not affect any functions as cosmeceuticals with increasing skin permeability. Therefore, pal-LVH can be adaptable as new cosmecetuticals with anti-winkle and anti-ageing materials and applied in the development of medicine through various convergence study.

A Study on the Preparation of Solvent-Free Low Foaming Scouring Agents (무용제형 저기포성 정련제의 제조에 관한 연구)

  • Keun, Jang-Hyoun;Kim, Seung-Jin;Hahm, Hyun-Sik;Park, Hong-Soo
    • Applied Chemistry for Engineering
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    • v.4 no.4
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    • pp.760-769
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    • 1993
  • Solvent-free low foaming scouring agents(LFSA) were prepared by blending of polyoxyethylene(30) octadecylbenzylammonium chloride(POAC), block copolymer of propylene oxide-ethylene oxide[p(PO-b-EO) glycol], Sedlan FF-200(FF-200) and sulfonic acid-amine condensate of polyoxyethylene(10) nonylphenyl ether(PSAC). In consequence of several tests, FF-200/POAC/p(PO-b-EO) glycol/PSAC/water (20g/10g/5g/5g/60g) mixture (LFSA-5) showed good cleaning power, penetrating ability, emulsifiability and stability to alkali, and gave less problem in water pollution. Scouring effect of LFSA-5 was investigated by the change of percentage of exhaustion before and after scouring at various dyeing temperatures. The percentage of exhaustion of the unscoured PET fabric was 4.5% at $70^{\circ}C$, while that scoured with LFSA-5 was 1.3% at the same temperature, which proved LFSA-5 to be a good scouring agent. Moreover, the foaming power of LFSA-5 measured by Ross and Miles method was 6mm foam height immediately after foaming, and that measured by Ross and Clark method was less than 300mm foam height at $30^{\circ}C$, and 20mm at $80^{\circ}C$. As a result, LFSA-5 proved a good low foaming scouring agent.

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Fast Detection of Finger-vein Region for Finger-vein Recognition (지정맥 인식을 위한 고속 지정맥 영역 추출 방법)

  • Kim, Sung-Min;Park, Kang-Roung;Park, Dong-Kwon;Won, Chee-Sun
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.46 no.1
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    • pp.23-31
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    • 2009
  • Recently, biometric techniques such as face recognition, finger-print recognition and iris recognition have been widely applied for various applications including door access control, finance security and electric passport. This paper presents the method of using finger-vein pattern for the personal identification. In general, when the finger-vein image is acquired from the camera, various conditions such as the penetrating amount of the infrared light and the camera noise make the segmentation of the vein from the background difficult. This in turn affects the system performance of personal identification. To solve this problem, we propose the novel and fast method for extracting the finger-vein region. The proposed method has two advantages compared to the previous methods. One is that we adopt a locally adaptive thresholding method for the binarization of acquired finger-vein image. Another advantage is that the simple morphological opening and closing are used to remove the segmentation noise to finally obtain the finger-vein region from the skeletonization. Experimental results showed that our proposed method could quickly and exactly extract the finger-vein region without using various kinds of time-consuming filters for preprocessing.

THE OPEN-ORIENTED CHARACTERISTICS OF THE NEW TOWN HOUSE 'MACHIYA' IN KYOTO FROM ITS 'HUKI-NUKE' SPACE POINT OF VIEW (일본국(日本國) 경도(京都)의 정가(町家) 유형(類型) 연구(硏究) -신경정가(新京町家)의 "후끼누께" (취발(吹拔))를 통하여 본 "열림" 성향(性向)에 대하여-)

  • Kim, Tai-Young
    • Journal of architectural history
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    • v.5 no.1 s.9
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    • pp.50-72
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    • 1996
  • The typical Japanese house has the characteristics of open dwellings to make them cool in the hot and humid summer. And then the traditional town house 'Machiya', being built very closely to each other and walled up both sides, it has taken the open-oriented characteristics in itself. The purpose of this study is to clarify that the open-oriented of traditional 'Machiya' has been succeeded to the new 'Machiya' in the latest. The new 'Machiya' shows the open-oriented, taking the ventilative 'Huki-nuke' space of traditional 'Machiya' as the new spatial formal elements, in the changes such as scale material space organization. The characteristics of 'Huki-nuke' space are represented as follows ; 1. The facade of the traditional 'Machiya', which has taken on a semitransparent qualty, has been generally changed to the closing qualty except for the open parts of shop and garage. This facade of the new 'Machiya' has been taken to be in keeping with the existing town as much as possible. 2. A series of three rooms, composed of shop/living dining kitchen/room from the road, have been dispersed to every floors in a building with a very extensive scale. But this serial and linear type remains as the loosefit space, and the long dwellings of the upper stories are divided by type each dwelling unit. 3. 'Tori-niwa', which is a consecutive and penetrating space, connects the road with the rooms of dwelling and functions as the circulation of man thing energy, The new 'Machiya' changed to the multi-story, the corridor and the stair have been fumed up as the elements in the place of 'Tori-niwa' The 'Huki-nuke' space was locted in the hall, stairwell, living dining kitchen room, and so on. 4. The small court yard 'Tsubo-niwa' and back yard 'Ura-niwa' at the both ends of living spaces would be made a hole in a series of rooms and enclosed by the neighboring 'Machiya'. On the contrary the new 'Machiya' at present takes in the private and closing organization enclosing the innercourt. 5. The open-oriented ${\ulcorner}$In${\lrcorner}$ or ${\ulcorner}$Out${\lrcorner}$ is not brought out because of the delicate spatial formal configuration in the traditional 'Machiya'. But the open-oriented ${\ulcorner}$In${\lrcorner}$, all sides being closed by walls, is well brought out in the new 'Machiya'.

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PULSE OXIMETER AS A DIAGNOSTIC TEST OF PULP VITALITY (Pulse Oximeter를 이용한 치수생활력측정)

  • Koo, Bon-Kyung;Lee, Jae-Ho;Lee, Jong-Gap
    • Journal of the korean academy of Pediatric Dentistry
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    • v.27 no.1
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    • pp.103-107
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    • 2000
  • Traditionally, EPT and thermal tests were used as diagnostic methods for pulp vitality test. The thermal and electrical stimulation tests are the methods to determine the vitality of a tooth based on its neuronal response. These have certain limitations, one of them is the difficulty of approaching the correct result in case of treatment of children. The reason is management problem caused by the unpleasant stimulation. Also, the response from patients are not objective, and false positive or false negative could be happened. Recently, laser doppler flowmetry and pulse oximeter which evaluate vascular integrity are introduced in an effort of overcoming to limitation of traditional methods. The principle of pulse oximeter is to and out level of oxygen saturation by ratio of the two pulses between emitted light and detected light penetrating them to the termination of body, such as ears or fingers. From this point of view, it can be applied to a tooth to determine its vitality. The objective of this study lies mainly on varifying pulse oximeter as a method of determining tooth vitality and providing basic data of its clinical implementation. The result of the research showed that level of oxygen saturation in vital teeth was average of 96.3% and 0.0% in pulpless teeth. As a comprehensive result, pulse oximeter could be an useful diagnostic equipment in determining of tooth vitality.

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Characteristics of Induced Resistance to Erysiphe graminis f. sp. hordei in Near-Isogenic Barley Lines. (근 동질유전자 보리계통에서 보리흰가루 병에 대한 유도저항성의 특성)

  • Cho Baik Ho
    • Korean Journal Plant Pathology
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    • v.1 no.1
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    • pp.79-84
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    • 1985
  • Some characteristics of the resistance induced by Erysiphe graminis f. sp. hordei on near-isogenic barley leaves were evaluated. Inoculation of heat-killed incompatible inducer conidia did not protect barley leaves against compatible challenger race when the inducer inoculum was removed prior to inoculation of challenger. However, the colony formation of challenger race was greatly reduced by 87.1 to $91.2\%$ when the heat-killed inducer inoculum was not removed from the leaves. Although incompatible inducer conidia were removed before they penetrate the host cell, colony formation of challenger was markedly decreased without change in its infection type. After penetrating the host cell by inducer, however, a change in infection types occurred on the challenged leaves. Irrespective of compatibility of previously inoculated inducer on middle part of leaves, there was no reduction in colony formation of challenger race both on the adjacent acropetal and basipetal parts of the same leaves free of inducer inoculation. The colonies formed on the basipetal part by challenger race showed normal 4 type, whereas the infection type of colonies formed on the acropetal part was somewhat changed, thereby sporulation being reduced. The possibility of translocation of resistance-inducing factors was discussed.

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Design for Installation of Suction Piles in Sand Deposits for Mooring of Floating Offshore Structures (부유식 해상구조물의 계류를 위한 사질토 지반의 석션파일 설계)

  • Park, Chul-Soo;Lee, Ju-Hyung;Baek, Du-Hyun;Do, Jin-Ung
    • Journal of the Korean Geotechnical Society
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    • v.30 no.10
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    • pp.33-44
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    • 2014
  • The preliminary design of suction pile as the supporting system for concrete floating structures was performed for the pilot project of the southwest coast area in Korea. Prior to starting design work, site conditions of the area including ground and hydraulic conditions, and a 100-year return period external force were throughly evaluated. The suction pile for mooring of the offshore floating structures has to satisfy the lateral resistance against external force as well as the penetration ability according to the soil conditions such as soil types, shear strengths, effective stresses, and seepage forces. In the design, the required penetration depths, which were stable for lateral resistance, were evaluated with the diameters of cylindrical suction pile as the final installing ones. And the design suction pressures at each penetrating depths, at which sand boiling did not occur, were assessed through the comparison of penetration and penetrationresistance forces. As a result, it was impossible for suction piles with the diameter range of 3.0~5.0 m to penetrate into required penetration depths. On the other hand, suction piles with the diameter range of 6.0 m and 7.0 m satisfied both the horizontal stability and the penetration ability by design suction pressures at the required penetration depths of 8.5 m and 8.0 m, respectively.

Development and characterization of a fully functional small anti-HER2 antibody

  • Gao, Jie;Li, Bohua;Li, Huimei;Zhang, Xunmin;Zhang, Dapeng;Zhao, Lei;Wang, Chong;Fang, Chen;Qian, Weizhu;Hou, Sheng;Kou, Geng;Wei, Huafeng;Shi, Shu;Wang, Hao;Guo, Yajun
    • BMB Reports
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    • v.42 no.10
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    • pp.636-641
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    • 2009
  • The penetrating of monoclonal antibodies (mAbs) into solid tumor may be hampered by their large size. The antibody mimetics, composed of two complementarity-determining regions (CDRs) through a cognate framework region (FR), have been demonstrated to have the capacity to penetrate tumors superior to its parental intact IgG. In this study, we used CDR and FR sequences from the humanized anti-HER2 monoclonal antibody trastuzumab to design four antibody mimetics. Then these antibody mimetics were fused to human IgG Fc to generate mimetics-Fc small antibodies. One of the four mimetics-Fc antibodies binds well to HER2-overexpressing SK-BR3 cells and effectively inhibits the binding of trastuzumab. This mimetics-Fc, denoted as HMTI-Fc, was shown to be effective in mediating antibody-dependent cellular cytotoxicity and exhibit an antiproliferative effect in SK-BR3 cells. To our knowledge, the HMTI-Fc antibody shown here is the smallest fully functional antibody and may have a potential for treatment of cancer.

Detection of Groundwater Table Changes in Alluvium Using Electrical Resistivity Monitoring Method (전기비저항 모니터링 방법을 이용한 충적층 지하수위 변동 감지)

  • 김형수
    • The Journal of Engineering Geology
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    • v.7 no.2
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    • pp.139-149
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    • 1997
  • Electrical resistivity monitoring methods were adopted to detect groundwater table change in alluvium. Numerical modelling test using finite element method(FEM) and field resisfivity monitoring were conducted in the study. The field monitoring data were acquired in the alluvium deposit site in Jeong-Dong Ri, Geum River where pumping test had been conducted continuously for 20 days to make artificial changes of groundwater table. The unit distance of the electrode array was 4m and 21 fixed electrodes were applied in numerical calculation and field data acquisition. "Modified Wenner" and dipole-dipole array configurations were used in the study. The models used in two-dimensional numerical test were designed on the basis of the simplifving geological model of the alluvium in Jeong Dong Ri, Geum River. Numerical test results show that the apparent resistivity pseudosections were changed in the vicinity of the pootion where groundwater table was changed. Furthermore, there are some apparent resistivity changes in the boundary between aquifer and crystalline basement rock which overlays the aquifer. The field monitoring data also give similar results which were observed in numerical tests. From the numerical test using FEM and field resistivity monitoring observations in alluvium site of Geum River, the electrical monitoring method is proved to be a useful tool for detecting groundwater behavior including groundwater table change. There are some limitations, however, in the application of the resistivity method only because the change of groundwater table does not give enough variations in the apparent resistivity pseudosections to estimate the amount of groundwater table change. For the improved detection of groundwater table changes, it is desirable to combine the resistivity method with other geophysical methods that reveal the underground image such as high-resolution seismic and/or ground penetrating radar surveys.

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Clinical Evaluation of Thoracostomy Treatment on the Pathological Changes in Pleural Cavity (흉강병변에 대한 흉강삽관술 246례의 임상적 고찰)

  • Rhee, Chong-Bae;Kim, Geun-Ho
    • Journal of Chest Surgery
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    • v.10 no.2
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    • pp.205-213
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    • 1977
  • In order to evaluate the therapeutic effect of thoracostomy on the patients with pathological changes in pleural cavity which were caused by various etiological factors, a clinical study was carried out during a period of 5 and half years from May 1972 to September 1977 in the department of thoracic surgery, Hanyang University Hospital, and the following results were obtained. Of a total of 264 patients, 205 cases were male, and 59 female, exhibiting the ratio of male to female being 3.5 to 1. The pathological changes in pleural cavity could occur at any age from 4 months after birth to 76 years old, the peak incidence being in the third decade in either male or female. The incidence decreased in the second, fifth and fourth decade in order. The type of pathological changes observed and their frequencies of occurrences were 93 cases [35.2%] in pneumothorax, 62 cases [23.5%] in hemothorax, 48 cases [18.2%] in pyothorax, 46 cases [17. 4%] in hemopneumothorax, 13 cases [4.9%] in hydropneumothorax, and one case each in hydrothorax and chylothorax. The incidence of the primary diseases which predisposed the pathological changes in pleural cavity were, 119 cases [45-1%] in trauma, 64 cases [24.2%]in lung tuberculosis, 38 cases [14.4%] in pneumonia or empyema, 14 cases [5.3%] in lung emphysema and blebs, 13 cases [4.9%] in process after thoracotomy, 3 cases [1.1%] each in lung malignant tumor and lung paragonimiasis, one case in mechanical ventilator and 9 cases [3.4%] in unknown origin. The pathological changes in pleural cavity were located in the right side of the cavity in 124 cases, in the left side in 133 cases and in both sides in 7 cases, indicating that the difference between the incidence of the left and rightside occurences was insignificant. Of 93 cases of pneumothorax studied, 63 cases were found to have been tension pneumothorax and 30 cases non-tension pneumothorax, showing greater prevalence of tension type over non-tension type. Of 119 cases of trauma observed, 82 cases were accompanied with rib fractures and 37 cases were without any fracture [non-bone fracture]. Patients with the rib fractures were characterized by multiple rib fractures and multiple double fractures of ribs, accompanying with or without fracture of bones other than ribs, and patients with non-bone fracture were characterized by penetrating stab wound and blunt trauma. Of 264 cases who received thoracostomy, 207 cases [78.4%] demonstrated that their pathological changes in pleural cavity were removed and subsided by a simple measure of thoracostomy. In 43 cases [16.3%], various surgical measures including radical operation and thoracotomy were required for complete healing, since their pathological changes were not abolished by thoracostomy alone. The rest 14 cases [5.3%] were expired following thoracostomy.

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