• 대한미세수술학회:학술대회논문집
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• 1993.10a
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• pp.95.2-95.2
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• 1993

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1036-1040
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• 2004

The purpose of the present study is to measure the effect of Tuber Pinelliae on EP(epinephrine) induced contraction of isolated rat thoracic aorta. Contractile force was measured with force displacement transducer under 1.5g loading tension. The mean percent increasing of rCBF was 11.4% (p<0.05) after 10㎎/㎏ Tuber Pinelliae. Contractions evoked by EP (ED50) and KCI 65.4mM were decreased significantly by Tuber Pinelliae. L-NNA, ODQ and atropine significantly altered the effect of Tuber Pinelliae, but propranolol and indomethacin did not change the relaxation of Tuber Pinelliae. These results indicate that Tuber Pinelliae can relax EP and KCI induced contraction of isolated rat thoracic aorta and that this decreasing contraction related to epithelium, nitric oxide, and parasympathetics.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1138-1142
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• 2002

Dansamchunghyul-tang(丹參淸血湯) is a new formula consist of Salviae Miltiorrhizae Radix and some oriental herbs to treatment of hyperlipidemia. In this study, we investigated the effects of the water extract of Dansamchunghyul-tang(DCT) on hyperlipidemia of the rat. We here studied the influence of DCT on hyperlipidemia in Sprague-Dawley rats. The hyperlipidemia was induced by Triton WR-1339 (tyloxapol) intravenous injection at 200mg/kg body weight. After 18 h, blood was collected for the determination of plasma total cholesterol, triglyceride, phospholipid, HDL-cholesterol, and LDL-cholesterol concentrations. In the model of hyperlipidemia induced by triton WR-1339 in rats, DCT showed decreasing effects on total cholesterol, triglyceride, phospholipid level significantly, in a dose-dependent fashion. DCT showed dose-dependent effects on HDL-cholesterol and LDL-cholesterol level insignificantly. In conclusion, DCT showed significant effects on hyperlipidemia, and the present findings indicate that DCT may prove potentially useful for treatment of hyperlipidemia.

• Korean Journal of Veterinary Pathology
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• v.1 no.1
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• pp.72-76
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• 1997

Histological investigation of the number of follicles following gonadotropin treatments for superovulation was carried out in mature Sprague-Dwaley(SD) rats. Routinely serial sections of paraffin-embedded ovaries were stained with hematoxylin-eosin and evaluated with light microscope. During the study unusual cases of microscopic alterations were observed in the medulla of ovaries in two rats. Case one: An ovum and its follicular fluid outflowed in medulla of ovary. The follicular fluid was densly proteinuous. Corona raiata consisted of 2-6 layers thick cells in the periphery of the ovum. While the cortical side of the follicular wall was intact with normal granulosa cell layer the meullary side of it was ruptured. Case two: A large cyst was present in medulla of ovary hilus. The cyst occupied the entire medulla displacing the ovarian archetecture and enclosed by connective tissue and smooth muscle wall.

• Natural Product Sciences
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• v.20 no.1
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• pp.29-32
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• 2014

In the present study, we examined the chemoprotective effects of different rice bran, which are produced by fermentation or not, on doxorubicin induced rat model, and detected the change of components of rice bran. Rats receiving fermented rice bran of 100 mg/kg by oral plus doxorubicin 10 mg/kg had greater weight gain as +24% than that observed with doxorubicin alone. In case of the treatment of non-fermented rice bran of 100 mg/kg by oral with doxorubicin of 10 mg/kg, fermented rice bran showed a -1.3% decrease in body weight. 100 mg/kg fermented rice bran decreased the incidence to 30%, and non-fermented rice bran decreased the incidence to 50%. In lethality, the rate of death of doxorubicin was 60%. 100 mg/kg fermented rice bran decreased to 10% in death rate and non-fermented rice bran to 30%. In gross gastrointestinal pathology, doxorubicin showed the gross gastrointestinal mucosal pathology in 70% of treated rats, fermented rice bran decreased to 40% and non-fermented rice bran to 50%. In the change of constituent, xylose concentration of fermented rice bran was detected to 59.33 mg/g while its concentration of non-fermented rice bran was 11.12 mg/g.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2003.10a
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• pp.8-8
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• 2003

Schwannoma is a neoplasm of the Schwann cells of the neural sheath [1]. Malignant schwannoma is most commonly seen in the subcutis of the flank or neck area near the salivary glands [2]. It also occurs in the thoracic and abdominal cavities, spinal cord, cranial cavity, the heart, etc. Here, we incidentally found a good case of malignant schwannoma in the subcutis of the lumbar and lumbosacral region in male F344 rat during the carcinogenicity study with diisodecyl phthalate (DIDP). Therefore, we tried to report this case as a good reference of malignant schwannoma. (omitted)

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.5
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• pp.870-875
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• 2011

Arthritis of the knee is the most common type of joint inflammatory disorder and it is associated with pain and inflammation of the joint capsule. The aim of present study was to investigate the endogenous effect of low intensity laser acupuncture on collagen-induced arthritis in rats. Forty Sprague-Dawley rats were randomly divided into normal group, arthritis group, low laser group with 10 rats in each group. Arthritis in rats was induced by subcutaneous injection of type II collagen combined with complete Freund's adjuvant. Here we investigated the effects of low intensity laser therapy in experimentally induced rat knee arthritis. To evaluate preventive and therapeutic effects of low intensity laser acupuncture on collagen-induced arthritis rats. In collagen induced arthritic rats, there was significant increase in rat paw volume and decrease in body weight increment, whereas low intensity laser therapy groups, showed significant reduction in paw volume and normal gain in body weight. The altered biochemical parameters(blood urea, serum creatinine, total proteins and acute phase proteins) in the arthritic rats were significantly brought back to near normal by the low intensity laser therapy. Therefore, low intensity laser acupuncture may be a useful treatment in the prevention and treatment of collagen-induced arthritis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.4
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• pp.895-897
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• 2009

Lonicera japonica has been widely used for chronic inflammatory diseases in many Asian countries. Its analgesic effect has not been explored yet. This study aimed to test the analgesic potential of methanol extracts from Lonicera japonica (MELJ) in rat neuropathic mctel. Neuropathic pain was pacts ed by partial sciatic nerve injury. Two weeks after surgery, neuropathic rats received oral administration of MELJ at doses of either 0.0 g/kg, 0.2 g/kg or 0.4 g/kg. At dose of 0.0 g, rats were administered with saline only and used as conracl. The behavioral tests for f 0.0 g, raand ccld hs were adma were weformed up to 2 hours after treatment. The MELJ at the dose 0.4 g/kg dmg gfg, ntly alleviated f 0.0 g, rahyperalgesia, but not cold hyperalgesia. These results showed that the MELJ had, although transient, analgesic effect on mechanical hyperalgesia in the rat neuropathic model.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.2
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• pp.431-437
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• 2008

Sengmaek-san(Shengmai-san; SMS) is used in oriental medicine as one of the key herbal medicine for treating diverse symptoms including cardiovascular and neurological disorders. In the present study, the effects of SMS on axonal regeneration were investigated in the rat model given sciatic nerve injury. SMS treatment enhanced axonal regrowth into and the number of non-neuronal cells in the distal area after crush injury. GAP-43 protein levels were increased in the injured sciatic nerve compared to intact nerve and further upreguated by SMS treatment. GAP-43 protein was increased similarly in the dorsal root ganglion (DRG) at lumbar 4 - 6 by nerve injury and SMS treatment, suggesting GAP-43 induction at gene expression level. SMS-mediated increase in phospho-Erk1/2 protein was observed in the DRG as well as in the injured nerve implying its retrograde transport into the cell body as the process of lesion signal transmission. The present findings suggest that SMS may be involved in enhanced axonal regeneration via dynamic regulation of regeneration-associated proteins.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.431-435
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• 2004

The purpose of this study was to examine the effects of Salviae Miltiorrhizae Radix on the high fat diet-induced hyperlipidemia in rats. Sixty male Sprague-Dawley rats, around 270g of B.W., were divided into normal, control, sample A and sample B group. Normal and control groups were orally administrated with saline during 4 weeks, sample A and sample B with 252.5mg/kg(rat) and 420.1 mg/kg(rat) of solid extract of Salviae Miltiorrhizae Radix during 4 weeks respectively. Blood samples were collected from each of animals at 4 weeks, and used for the blood chemical analysis. Animals were sacrificed at 4 weeks, and chemical analysis was performed on the collected liver samples. The serum total cholesterol, HDL-cholesterol, LDL-cholesterol levels of sample A group were significantly decreased compared with the control group. On the basis of these of results, it is confirmed that Salviae Miltiorrhizae Radix has the curative effects on the hyperlipidemia in rats induced by high fat diet